ISBS 2018 AUCKLAND CONFERENCE WORKSHOPS PROGRAMME

FORCEDECKS WORKSHOP - COMMERCIALISATION & FUNDING by Philip Graham Smith This workshop aims to improve your ability to attract and create commercialisation and funding opportunities. This workshop will challenge delegates to identify their real areas of expertise and consider ways in which they can attract and create funding opportunities. The aim is to help academics of all ages to focus their expertise, to manage their time more effectively and to explore new avenues to make their careers more rewarding, fulfilling and hopefully less stressful. Having been a former Head of Department and Associate Head of School (Business & Engagement), Dr Graham-Smith has been in the trenches and acknowledges the increasing demands and pressures of working in academia. The workshop will help delegates to strip back the various aspects of their roles, and to examine ways in which their teaching, research, consultancy and funding expectations can be managed successfully. Phil will be reflective on his own career and share experiences of working in academia, professional sport and private industry. SPRINZ WORKSHOP - ORAL PRESENTATION FEEDBACK by Joshua McGeown, Gillian Weir, Professor Mike McGuigan and SPRINZ PhD students This workshop aims to help you engaging your audience during your ISBS presentation. This workshop aims to provide delegates with tips and feedback as to how best present their research for the ISBS 2018 congress. This interactive workshop will help delegates to learn how to distill and communicate complex ideas, structure your narrative and how to best visualize your data. Participants are encouraged to bring their ISBS presentations to practice and receive constructive feedback. NZ HERALD WORKSHOP - HOW TO WORK WITH THE MEDIA TO AMPLIFY YOUR WORK by Dylan Cleaver, Editor at large with the New Zealand Herald This workshop will help delegates be able to interact with media to be able to amplify their work. Never before has there been so much attention given to the injury toll in elite sport, with the spotlight firmly centered on head injuries and the potential for long-term cognitive damage to those afflicted. With so much important research being done in the field of sports injury, it is important to know how to work with the media to highlight it. This workshop aims to give a brief overview of the fast-changing modern media landscape. It will offer advice as to how to establish contacts in the media and how to use those contacts wisely. It will demonstrate how to get your key messages across using simple language, without dumbing down the issue. It will traverse ethical issues and, finally, what to do when the message goes wrong. Attendees will use the lessons learnt from the examples, to workshop during the session how they can work with media to amplify their work. WORKSHOP - JAPAN COLLABORATION by Sayumi Iwamoto, Erika Ikeda, Ryu Nagahara, and Aaron Uthoff Do you want to share your experience with other researchers who are keen to conduct international research collaboration? The workshop will share experiences and key tips to enable successfully working together. “There are many positives with working with Japanese researchers, but the one that stands out the most to me is their willingness to share knowledge and lend a helping hand.” (Aaron Uthoff) AUT ENGINEERING WORKSHOP - AI CHALLENGES by Boris Bacic & Russell Pears from Auckland University of Technology Engineering School This workshop will help you to consider pushing your boundaries of biomechanics and sport science by embracing artificial intelligence (Dr Boris Bačić and Assoc. Prof Russel Pears, Auckland University of Technology, NZ). Pushing the boundaries of biomechanics and sport science also means embracing artificial intelligence (AI) to advance and augment ways in which sport is coached, played, promoted, broadcasted and commercialised. Technologies capable of capturing human motion enable the advancement of research and can create strategic differences in elite sport, which is reflected by their increasing presence in the growing market of sport gadgets, exergames and rehabilitation technologies. Data-driven machine-learning AI approaches have the potential to provide insights from data, find patterns in specific contexts, generate knowledge, validate expert’s common-sense rules, and offload support decisions and automate cognitive activities. The workshop will provide a theoretical introduction and a set of analytical and model-designing visual tools for getting started. For those interested in Matlab or other languages, code samples will be provided. The participants will be able to use free open source software alternatives as part of hands-on exercises in a supervised lab. SPRINGER WORKSHOP - WHAT MAKES A SUCCESSFUL PAPER – AN EDITOR’S PERSPECTIVE by Steve McMillan from Springer’s Sports Medicine journal This workshop will help delegates increase their likelihood of success in publishing in journals such as Sports Medicine. From a compelling cover letter to a concise conclusion, Sports Medicine’s Co-Editor in Chief, Steve McMillan, will provide an editor’s perspective on what makes a successful paper. Sports Medicine receives over 600 submissions a year and can publish only a quarter of these … How do the editors decide which manuscripts to send to peer review? Which manuscripts survive peer review? What details are essential to enable readers to best understand your research and allow for potential replication? What information is required from an ethical perspective? Why do word counts matter anyway?! This interactive workshop will guide you on how to produce an impressive manuscript and increase your chances of getting published in a reputable journal. NORAXON WORKSHOP - ELECTROMYOGRAPHY IN SPORTS PERFORMANCE by Coleman Bessert and Erin Feser from NORAXON. Noraxon USA (www.noraxon.com) will be hosting a workshop on electromyography (EMG) use in sports performance settings. “You will be able to develop a better understanding of how EMG fits into an athlete monitoring program or research investigation by learning what can, and cannot, be determined with EMG data and reporting. Participants will see hands-on use of precision EMG systems and biomechanics analysis software with practical, sport-specific examples.” Erin Feser , Director of Education for Noraxon USA

ISBS 2018 AUCKLAND CONFERENCE SPORTS TECHNOLOGY SHOWCASE PROGRAMME

The coordinators Amber Taylor (AUT Ventures), Rosanne Ellis (AUT Research and Innovation Office), and Ryan Archibald (ATEED) have selected companies with new products to be explored by biomechanists. We hope you gain ideas for your research and learn how to commercialise your products at this showcase. ISBS 2018 Auckland Conference Industry Partner Tekscan are supporting the lunch during the showcase. Dr Jono Neville, Shelley Diewald, and Farhan Tinwala will be showcasing AUT Strain Gauge. AUT Strain gauge allows for a valid and reliable assessment of the strength of an entire class or team in a relatively short amount of time. Steve Leftly and Farshid Sarmast will be showcasing Myovolt which is a breakthrough muscle massage system that you wear. It delivers vibration therapy to any part of the body, it\u27s easy to use, lightweight and has benefits backed by clinical research. Parn Jones, Eric Helms and Wilson Huang will be showcasing Avice which is a wearable device that gives you real-time actionable feedback during weight training. It measures changes in muscle performance to inform you how close to muscular failure you are. Xiaoyou Lin and Bandt Li are showcasing Pressure Mat which is a new resistive-sensing contact mat for detecting the pseudo force, of sports activities such as running, jumping, stepping. Holly Sutich and Bradley Phagan will be showcasing Beta-Energy which is a healthier natural energy drink. It provides sustainable energy so you don’t get the crash that you do from a normal energy drink. Arien Hielkema and Yasir Al-Hilali will showcase MyBio Motion which is a smart wearable knee sleeve. It provides support for rehabilitation from post-operative or knee trauma, and prevention from a knee injury. Daniel Thomson and Emily Coates will showcase Circuband which has successfully paired Virtual Reality with Resistance Training to make fitness more engaging and stimulating for both athletes and the public. Colin Anderson will demonstrate Physio Wear

Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children

This article is made available for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing.BACKGROUND: Despite improved diagnostics, pulmonary pathogens in immunocompromised children frequently evade detection, leading to significant mortality. Therefore, we aimed to develop a highly sensitive metagenomic next-generation sequencing (mNGS) assay capable of evaluating the pulmonary microbiome and identifying diverse pathogens in the lungs of immunocompromised children. METHODS: We collected 41 lower respiratory specimens from 34 immunocompromised children undergoing evaluation for pulmonary disease at 3 children's hospitals from 2014-2016. Samples underwent mechanical homogenization, parallel RNA/DNA extraction, and metagenomic sequencing. Sequencing reads were aligned to the National Center for Biotechnology Information nucleotide reference database to determine taxonomic identities. Statistical outliers were determined based on abundance within each sample and relative to other samples in the cohort. RESULTS: We identified a rich cross-domain pulmonary microbiome that contained bacteria, fungi, RNA viruses, and DNA viruses in each patient. Potentially pathogenic bacteria were ubiquitous among samples but could be distinguished as possible causes of disease by parsing for outlier organisms. Samples with bacterial outliers had significantly depressed alpha-diversity (median, 0.61; interquartile range [IQR], 0.33-0.72 vs median, 0.96; IQR, 0.94-0.96; P < .001). Potential pathogens were detected in half of samples previously negative by clinical diagnostics, demonstrating increased sensitivity for missed pulmonary pathogens (P < .001). CONCLUSIONS: An optimized mNGS assay for pulmonary microbes demonstrates significant inoculation of the lower airways of immunocompromised children with diverse bacteria, fungi, and viruses. Potential pathogens can be identified based on absolute and relative abundance. Ongoing investigation is needed to determine the pathogenic significance of outlier microbes in the lungs of immunocompromised children with pulmonary disease

Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias

Preclinical data have confirmed that human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) can remuscularize the injured or diseased heart, with several clinical trials now in planning or recruitment stages. However, because ventricular arrhythmias represent a complication following engraftment of intramyocardially injected PSC-CMs, it is necessary to provide treatment strategies to control or prevent engraftment arrhythmias (EAs). Here, we show in a porcine model of myocardial infarction and PSC-CM transplantation that EAs are mechanistically linked to cellular heterogeneity in the input PSC-CM and resultant graft. Specifically, we identify atrial and pacemaker-like cardiomyocytes as culprit arrhythmogenic subpopulations. Two unique surface marker signatures, signal regulatory protein α (SIRPA)+CD90−CD200+ and SIRPA+CD90−CD200−, identify arrhythmogenic and non-arrhythmogenic cardiomyocytes, respectively. Our data suggest that modifications to current PSC-CM-production and/or PSC-CM-selection protocols could potentially prevent EAs. We further show that pharmacologic and interventional anti-arrhythmic strategies can control and potentially abolish these arrhythmias

[Avian cytogenetics goes functional] Third report on chicken genes and chromosomes 2015

High-density gridded libraries of large-insert clones using bacterial artificial chromosome (BAC) and other vectors are essential tools for genetic and genomic research in chicken and other avian species... Taken together, these studies demonstrate that applications of large-insert clones and BAC libraries derived from birds are, and will continue to be, effective tools to aid high-throughput and state-of-the-art genomic efforts and the important biological insight that arises from them

The Effectiveness of Incarceration-Based Drug Treatment on Criminal Behavior: A Systematic Review

Many, if not most, incarcerated offenders have substance abuse problems. Without effective treatment, these substance-abusing offenders are likely to persist in non-drug offending. The period of incarceration offers an opportunity to intervene in the cycle of drug abuse and crime. Although many types of incarceration-based drug treatment programs are available (e.g., therapeutic communities and group counseling), the effectiveness of these programs is unclear. The objective of this research synthesis is to systematically review quasi-experimental and experimental (RCT) evaluations of the effectiveness of incarceration-based drug treatment programs in reducing post-release recidivism and drug relapse. A secondary objective of this synthesis is to examine variation in effectiveness by programmatic, sample, and methodological features. In this update of the original 2006 review (see Mitchell, Wilson, and MacKenzie, 2006), studies made available since the original review were included in an effort to keep current with emerging research. This synthesis of evaluations of incarceration-based drug treatment programs found that such programs are modestly effective in reducing recidivism. These findings most strongly support the effectiveness of therapeutic communities, as these programs produced relatively consistent reductions in recidivism and drug use. Both counseling and incarceration-based narcotic maintenance programs had mixed effects. Counseling programs were associated with reductions in recidivism but not drug use; whereas, incarceration-based narcotic maintenance programs were associated with reductions in drug use but not recidivism. Note that our findings regarding the effectiveness of incarceration-based narcotic maintenance programs differ from a larger review of community-based narcotic maintenance programs (see Egli, Pina, Christensen, Aebi, and Killias, 2009). Finally, boot camp programs for drug offenders had negligible effects on both recidivism and drug use

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P &lt; 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely