Metallicity of Red Giants in the Galactic Bulge from Near-Infrared Spectroscopy

We present K-band spectra of more than 110 M giants in Galactic bulge fields interior to -4 degrees and as close as 0.2 degrees of the Galactic Center. From the equivalent widths of three features in these spectra, EW(Na),EW(Ca), and EW(CO) we calculate [Fe/H] for the stars with a calibration derived from globular clusters Stephens et al (2000). The mean [Fe/H] for each field is in good agreement with the results from Frogel et al. (1999) based on the slope of the giant branch method. We find no evidence for a metallicity gradient along the minor or major axes of the inner bulge (R < 0.6 kpc). A metallicity gradient along the minor axis, found earlier, arises when fields located at larger galactic radius are included. However, these more distant fields are located outside of the infrared bulge defined by the COBE/DIRBE observations. We compute the [Fe/H] distribution for the inner bulge and find a mean value of -0.21 dex with a full width dispersion of 0.30 dex, close to the values found for Baade's Window (BW) by Sadler et al. (1996) and to a theoretical prediction for a bulge formed by dissipative collapse Molla et al (2000).Comment: 32 pages, 10 figures, AJ submitte

Dissecting the Physical Properties of the Chromatin Spring in Mitosis

During cell division it is essential that each daughter cell receives a full copy of the genome. The mitotic spindle apparatus, composed of microtubules and chromatin, faithfully segregates the duplicated genome equally between daughter cells. Microtubules bind to sister chromatids and exert extensional forces towards opposite poles. The pericentric chromatin surrounding the attachment site resists the microtubule forces with contractile spring-like prosperities. Tension generated from these opposing forces silences the spindle checkpoint to ensure accurate segregation. Using budding yeast as a model system we find that the chromatin spring is composed of the intramolecular pericentromere loop along with SMC protein complexes cohesin and condensin. Simulations of the pericentric chromatin as a non-linear spring accurately recapitulate in vivo spindle and chromatin dynamics. This is contrary to the dogma that the chromatin spring is linear. In addition, we find that the pericentromeres of the 16 different chromosomes in yeast physically interact and behave as an ensemble. The interlinked network of attachment sites in the yeast spindle provides insight as to how multiple attachments sites function in a mammalian kinetochore. Cohesin, condensin and the pericentromere compose an interlinked network of chromatin springs that equalizes tension over multiple dynamic attachment sites to aid the faithful segregation of the genome in mitosis.Doctor of Philosoph

High-speed quantum networking by ship

Networked entanglement is an essential component for a plethora of quantum computation and communication protocols. Direct transmission of quantum signals over long distances is prevented by fibre attenuation and the no-cloning theorem, motivating the development of quantum repeaters, designed to purify entanglement, extending its range. Quantum repeaters have been demonstrated over short distances, but error-corrected, global repeater networks with high bandwidth require new technology. Here we show that error corrected quantum memories installed in cargo containers and carried by ship can provide a flexible connection between local networks, enabling low-latency, high-fidelity quantum communication across global distances at higher bandwidths than previously proposed. With demonstrations of technology with sufficient fidelity to enable topological error-correction, implementation of the quantum memories is within reach, and bandwidth increases with improvements in fabrication. Our approach to quantum networking avoids technological restrictions of repeater deployment, providing an alternate path to a worldwide Quantum Internet.Comment: 7 Pages, 2 Figures 1 Table. Comments Welcome. Final Version, to Appear Sci. Re

Transmission comparison of ultra-long Raman fibre laser based amplification with first and dual order Raman amplification using 10×118 Gbit/s DP-QPSK

Experimental investigations of 10×118 Gbit/s DP-QPSK WDM transmission using three types of distributed Raman amplification techniques are presented. Novel ultra-long Raman fibre laser based amplification with second order counter-propagated pumping is compared with conventional first order and dual order counter-pumped Raman amplification. We demonstrate that URFL based amplification can extend the transmission reach up to a distance of 7520 km in comparison with 5010 km and 6180 km using first order and dual order Raman amplification respectively

The SUMO deconjugating peptidase Smt4 contributes to the mechanism required for transition from sister chromatid arm cohesion to sister chromatid pericentromere separation

The pericentromere chromatin protrudes orthogonally from the sister-sister chromosome arm axis. Pericentric protrusions are organized in a series of loops with the centromere at the apex, maximizing its ability to interact with stochastically growing and shortening kinetochore microtubules. Each pericentromere loop is ∼50 kb in size and is organized further into secondary loops that are displaced from the primary spindle axis. Cohesin and condensin are integral to mechanisms of loop formation and generating resistance to outward forces from kinesin motors and anti-parallel spindle microtubules. A major unanswered question is how the boundary between chromosome arms and the pericentromere is established and maintained. We used sister chromatid separation and dynamics of LacO arrays distal to the pericentromere to address this issue. Perturbation of chromatin spring components results in 2 distinct phenotypes. In cohesin and condensin mutants sister pericentric LacO arrays separate a defined distance independent of spindle length. In the absence of Smt4, a peptidase that removes SUMO modifications from proteins, pericentric LacO arrays separate in proportion to spindle length increase. Deletion of Smt4, unlike depletion of cohesin and condensin, causes stretching of both proximal and distal pericentromere LacO arrays. The data suggest that the sumoylation state of chromatin topology adjusters, including cohesin, condensin, and topoisomerase II in the pericentromere, contribute to chromatin spring properties as well as the sister cohesion boundary

Conceptual frameworks linking agriculture and food security

Many conceptual frameworks have been developed to facilitate understanding and analysis of the linkages between agriculture and food security. Despite having usefully guided analysis and investment, these frameworks exhibit wide diversity in perspectives, assumptions and application. This Review Article examines this diversity, providing an approach to assess frameworks and suggesting improvements in the way they are specified and applied. Using criteria-based systems modelling conventions, we evaluate 36 frameworks. We find that many frameworks are developed for the purpose of illustration rather than analysis and do not clearly indicate causal relationships, tending to ignore the dynamic (stability) dimensions of agriculture and food security and lacking clear intervention points for improving food security through agriculture. By applying system modelling conventions to a widely used framework, we illustrate how such conventions can enhance the usefulness of a framework for overall illustration purposes, delineate hypotheses on agriculture–food security links and examine potential impacts of interventions.acceptedVersio

An Accurate, Easy to Use Abundace Scale for Globular Clusters Based on 2.2um Spectra of Giant Stars

We present a new method for the determination of [Fe/H] for globular clusters. This new method is based on moderate resolution (R~1500) near-IR spectroscopy in the K-band of 6 to 10 of the brightest giants in a cluster. Our calibration is derived from spectra of 105 stars in 15 globular clusters. From measurements of the equivalent widths of three features in these spectra, Na, Ca, and CO, we are able to reproduce the Zinn & West (1984) abundance scale as updated by Harris (1996) to better than 0.10 dex for clusters with near solar [Fe/H] down to an [Fe/H] of -1.8. Three advantages of this method are that it can be used for metal rich, heavily reddened globulars in crowded fields, it does not require any knowledge of any other cluster or stellar parameters such as reddening, distance, or luminosity, and it requires only minimal telescope time. If stellar (J-K)0 and MK values are available as well, the accuracy of the [Fe/H] estimate is further improved. Observations of as few as three stars per cluster still gives an [Fe/H] estimate wich is nearly as reliable as that based on two to three times as many stars. The accuracy of an [Fe/H] value based on observations of CO absorption alone is significantly less than that which results from the three spectroscopic indices. However, we predict that space-based observations of this feature in the integrated light of stellar systems will prove to be of great value for abundance determinations at distances as far as the Coma cluster of galaxies.Comment: 53 pages, 16 Postscript figures. Submitted to the A

Tension-dependent nucleosome remodeling at the pericentromere in yeast

Dynamics of histones under tension in the pericentromere depends on RSC and ISW2 chromatin remodeling. The underlying pericentromeric chromatin forms a platform that is required to maintain kinetochore structure when under spindle-based tension.Nucleosome positioning is important for the structural integrity of chromosomes. During metaphase the mitotic spindle exerts physical force on pericentromeric chromatin. The cell must adjust the pericentromeric chromatin to accommodate the changing tension resulting from microtubule dynamics to maintain a stable metaphase spindle. Here we examine the effects of spindle-based tension on nucleosome dynamics by measuring the histone turnover of the chromosome arm and the pericentromere during metaphase in the budding yeast Saccharomyces cerevisiae. We find that both histones H2B and H4 exhibit greater turnover in the pericentromere during metaphase. Loss of spindle-based tension by treatment with the microtubule-depolymerizing drug nocodazole or compromising kinetochore function results in reduced histone turnover in the pericentromere. Pericentromeric histone dynamics are influenced by the chromatin-remodeling activities of STH1/NPS1 and ISW2. Sth1p is the ATPase component of the Remodels the Structure of Chromatin (RSC) complex, and Isw2p is an ATP-dependent DNA translocase member of the Imitation Switch (ISWI) subfamily of chromatin-remodeling factors. The balance between displacement and insertion of pericentromeric histones provides a mechanism to accommodate spindle-based tension while maintaining proper chromatin packaging during mitosis

The Stellar Content of M31's Bulge

In this paper we analyze the stellar populations present in M31 using nine sets of adjacent HST-NICMOS Camera 1 and 2 fields with galactocentric distances ranging from 2' to 20'. These infrared observations provide some of the highest spatial resolution measurements of M31 to date; our data place tight constraints on the maximum luminosities of stars in the bulge of M31. The tip of the red giant branch is clearly visible at Mbol ~ -3.8, and the tip of the asymptotic giant branch (AGB) extends to Mbol ~ -5. This AGB peak luminosity is significantly fainter than previously claimed; through direct comparisons and simulations we show that previous measurements were affected by image blending. We do observe field-to-field variations in the luminosity functions, but simulations show that these differences can be produced by blending in the higher surface brightness fields. We conclude that the red giant branch of the bulge of M31 is not measurably different from that of the Milky Way's bulge. We also find an unusually high number of bright blueish stars (7.3/arcmin^2) which appear to be Galactic foreground stars.Comment: 28 pages, 20 figures (posted here with significantly reduced resolution), accepted to the A