On Free-Electron Laser Growing Modes and their Bandwidth

Free-electron lasers play an increasing role in science, from generating unique femtosecond X- ray pulses for single short recording of the protein structures to amplifying feeble interactions in advanced cooling systems for high-energy hadron colliders. While modern Free-electron laser codes can describe their amplification mechanism, a deep analytical understanding of the mechanism is of extreme importance for a number of applications. Mode competition, their growth rates and amplification bandwidth are among the most important parameters of a free-electron laser. A dispersion relation, which defines these important characteristics, can be solved analytically only for a very few simple cases. In this letter we show that for a typical bell-shape energy distribution in electron beam there is no more that one growing mode. We also derive an analytical expression which determines the bandwidth of the free-electron laser.Comment: 4 pages, submitted to PR

Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver

Thyroid hormone (TH) acts through specific receptors (TRs), which are conditional transcription factors, to induce fibroblast growth factor 21 (FGF21), a peptide hormone that is usually induced by fasting and that influences lipid and carbohydrate metabolism via local hepatic and systemic endocrine effects. While TH and FGF21 display overlapping actions when administered, including reductions in serum lipids, according to the current models these hormones act independently in vivo. In this study, we examined mechanisms of regulation of FGF21 expression by TH and tested the possibility that FGF21 is required for induction of hepatic TH-responsive genes. We confirm that active TH (triiodothyronine (T3)) and the TRβ-selective thyromimetic GC1 increase FGF21 transcript and peptide levels inmouse liver and that this effect requires TRβ. T3 also induces FGF21 in cultured hepatocytes and this effect involves direct actions of TRβ1, which binds a TRE within intron 2 of FGF21. Gene expression profiles of WT and Fgf21-knockout mice are very similar, indicating that FGF21 is dispensable for the majority of hepatic T3 gene responses. A small subset of genes displays diminished T3 response in the absence of FGF21. However, most of these are not obviously directly involved in T3-dependent hepatic metabolic processes. Consistent with these results, T3-dependent effects on serum cholesterol are maintained in the Fgf21-/- background and we observe no effect of the Fgf21-knockout background on serum triglycerides and glucose. Our findings indicate that T3 regulates the genes involved in classical hepatic metabolic responses independently of FGF21

FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR)

Adenosylcobalamin, the coenzyme form of vitamin B12, is one Nature's most complex coenzyme whose de novo biogenesis proceeds along either an anaerobic or aerobic metabolic pathway. The aerobic synthesis involves reduction of the centrally chelated cobalt metal ion of the corrin ring from Co(II) to Co(I) before adenosylation can take place. A corrin reductase (CobR) enzyme has been identified as the likely agent to catalyse this reduction of the metal ion. Herein, we reveal how Brucella melitensis CobR binds its coenzyme FAD (flavin dinucleotide) and we also show that the enzyme can bind a corrin substrate consistent with its role in reduction of the cobalt of the corrin ring. Stopped-flow kinetics and EPR reveal a mechanistic asymmetry in CobR dimer that provides a potential link between the two electron reduction by NADH to the single electron reduction of Co(II) to Co(I)

Spatial field correlation, the building block of mesoscopic fluctuations

The absence of self averaging in mesoscopic systems is a consequence of long-range intensity correlation. Microwave measurements suggest and diagrammatic calculations confirm that the correlation function of the normalized intensity with displacement of the source and detector, $\Delta R$ and $\Delta r$, respectively, can be expressed as the sum of three terms, with distinctive spatial dependences. Each term involves only the sum or the product of the square of the field correlation function, $F \equiv F_{E}^2$. The leading-order term is the product, the next term is proportional to the sum. The third term is proportional to $[F(\Delta R)F(\Delta r) + [F(\Delta R)+F(\Delta r)] + 1]$.Comment: Submitted to PR

Wave Propagation in Stochastic Spacetimes: Localization, Amplification and Particle Creation

Here we study novel effects associated with electromagnetic wave propagation in a Robertson-Walker universe and the Schwarzschild spacetime with a small amount of metric stochasticity. We find that localization of electromagnetic waves occurs in a Robertson-Walker universe with time-independent metric stochasticity, while time-dependent metric stochasticity induces exponential instability in the particle production rate. For the Schwarzschild metric, time-independent randomness can decrease the total luminosity of Hawking radiation due to multiple scattering of waves outside the black hole and gives rise to event horizon fluctuations and thus fluctuations in the Hawking temperature.Comment: 26 pages, 1 Postscript figure, submitted to Phys. Rev. D on July 29, 199

Mid-Infrared Identifications of SCUBA Galaxies in the CUDSS 14-Hour Field with the Spitzer Space Telescope

We identify 17 possible 8.0 micron-selected counterparts to the submillimeter galaxies in the CUDSS 14-hour field, derived from deep imaging carried out with the IRAC and MIPS instruments aboard the Spitzer Space Telescope. Ten of the 17 counterparts are not the same as those previously identified at shorter wavelengths. We argue that 8.0 micron selection offers a better means for identifying counterparts to submillimeter galaxies than near-infrared or optical selection. Based on the panchromatic SEDs, most counterparts appear to be powered by ongoing star formation. Power-law fits to the SEDs suggest that five objects in the 8.0 micron-selected counterpart sample harbor dominant AGNs; a sixth object is identified as a possible AGN. The 3.6 to 8.0 micron colors of the infrared-selected counterparts are significantly redder than the general IRAC galaxy population in the CUDSS 14-hour field.Comment: 36 pages, 9 figures, accepted by the Astrophysical Journal. This version corrects the bibliography and typographical errors in the text and table

Growing Environmental Activists: Developing Environmental Agency and Engagement Through Children’s Fiction.

We explore how story has the potential to encourage environmental engagement and a sense of agency provided that critical discussion takes place. We illuminate this with reference to the philosophies of John Macmurray on personal agency and social relations; of John Dewey on the primacy of experience for philosophy; and of Paul Ricoeur on hermeneutics, dialogue, dialectics and narrative. We view the use of fiction for environmental understanding as hermeneutic, a form of conceptualising place which interprets experience and perception. The four writers for young people discussed are Ernest Thompson Seton, Kenneth Grahame, Michelle Paver and Philip Pullman. We develop the concept of critical dialogue, and link this to Crick's demand for active democratic citizenship. We illustrate the educational potential for environmental discussions based on literature leading to deeper understanding of place and environment, encouraging the belief in young people that they can be and become agents for change. We develop from Zimbardo the key concept of heroic resister to encourage young people to overcome peer pressure. We conclude with a call to develop a greater awareness of the potential of fiction for learning, and for writers to produce more focused stories engaging with environmental responsibility and activism

Super‐Resolution Microscopy Reveals Shape and Distribution of Dislocations in Single‐Crystal Nanocomposites

With their potential to offer new properties, single crystals containing nanoparticles provide an attractive class of nanocomposite materials. However, to fully profit from these, it is essential that we can characterise their 3D structures, identifying the locations of individual nanoparticles, and the defects present within the host crystals. Using calcite crystals containing quantum dots as a model system, we here use 3D stochastic optical reconstruction microscopy (STORM) to locate the positions of the nanoparticles within the host crystal. The nanoparticles are shown to preferentially associate with dislocations in a manner previously recognised for atomic impurities, rendering these defects visible by STORM. Our images also demonstrate that the types of dislocations formed at the crystal/substrate interface vary according to the nucleation face, and dislocation loops are observed that have entirely different geometries to classic misfit dislocations. This approach offers a rapid, easily accessed, and non‐destructive method for visualising the dislocations present within crystals, and gives insight into the mechanisms by which additives become occluded within crystals

Review of potential line-transect methodologies for estimating abundance of dolphin stocks in the eastern tropical Pacific

A twelve-year hiatus in fishery-independent marine mammal surveys in the eastern tropical Pacific Ocean (ETP), combined with a mandate to monitor dolphin stock status under international agreements and the need for reliable stock status information to set dolphin bycatch limits in the tuna purse-seine fishery, has renewed debate about how best to assess and monitor ETP dolphin stock status. The high cost of replicating previous ship-based surveys has intensified this debate. In this review, transect methods for estimating animal abundance from dedicated research surveys are considered, with a focus on both contemporary and potential methods suitable for surveying large areas for dolphin species that can form large, multi-species aggregations. Covered in this review are potential improvements to the previous ship-based survey methodology, other ship-based methods, alternative approaches based on high-resolution imagery and passive acoustics, and combinations of ship-based and alternative approaches. It is concluded that for immediate management needs, ship-based surveys, with some suggested modifications to improve precision, are the only reliable option despite their high cost. However, it is recommended that a top research priority should be development of composite methods. Pilot studies on the use of high-resolution imagery and passive acoustics for development of indices of relative abundance to be used in composite methods should be part of any future ship-based survey efforts

An Approach for Assessing the Signature Quality of Various Chemical Assays when Predicting the Culture Media Used to Grow Microorganisms

We demonstrate an approach for assessing the quality of a signature system designed to predict the culture medium used to grow a microorganism. The system was comprised of four chemical assays designed to identify various ingredients that could be used to produce the culture medium. The analytical measurements resulting from any combination of these four assays can be used in a Bayesian network to predict the probabilities that the microorganism was grown using one of eleven culture media. We evaluated combinations of the signature system by removing one or more of the assays from the Bayes network. We measured and compared the quality of the various Bayes nets in terms of fidelity, cost, risk, and utility, a method we refer to as Signature Quality Metric