Extended abstract: gender differences in leader's compliant behaviour: selection into leadership and dishonest behaviour of leaders: a gender experiment

Das erweiterte Abstract beinhaltet die Abschnitte 'Leaders and their incentives to behave non-compliantly', 'the relevance of gender for leader's compliance', die dazu durchgeführte Studie sowie deren Auswertung.The extended abstract consists of two clauses 'leaders and their incentives to behave non-compliantly', 'the relevance of gender for leader's compliance', as well as the related experimental study and it's conclusion

Dual Laser Beam Processing of Semiconducting Thin Films by Excited State Absorption

We present a unique dual laser beam processing approach based on excited state absorption by structuring 200 nm thin zinc oxide films sputtered on fused silica substrates. The combination of two pulsed nanosecond-laser beams with different photon energies—one below and one above the zinc oxide band gap energy—allows for a precise, efficient, and homogeneous ablation of the films without substrate damage. Based on structuring experiments in dependence on laser wavelength, pulse fluence, and pulse delay of both laser beams, a detailed concept of energy transfer and excitation processes during irradiation was developed. It provides a comprehensive understanding of the thermal and electronic processes during ablation. To quantify the efficiency improvements of the dual-beam process compared to single-beam ablation, a simple efficiency model was developed

Modern Michelson-Morley experiment using cryogenic optical resonators

We report on a new test of Lorentz invariance performed by comparing the resonance frequencies of two orthogonal cryogenic optical resonators subject to Earth's rotation over 1 year. For a possible anisotropy of the speed of light c, we obtain 2.6 +/- 1.7 parts in 10^15. Within the Robertson-Mansouri-Sexl test theory, this implies an isotropy violation parameter beta - delta - 1/2 of -2.2 +/- 1.5 parts in 10^9, about three times lower than the best previous result. Within the general extension of the standard model of particle physics, we extract limits on 7 parameters at accuracies down to a part in 10^15, improving the best previous result by about two orders of magnitude

Selection into Leadership and Dishonest Behavior of Leaders: a Gender Experiment

Leaders often weigh ethical against monetary consequences. We experimentally study such a dilemma where leaders can benefit their groups at the expense of moral costs. First, we measure individual dishonesty preferences and, second, leaders' reporting decisions for a group by using payoff-reporting games. We focus on an endogenous leadership setting, where subjects can apply for leadership. Women have less pronounced dishonesty preferences than men, but increase dishonesty as leaders. The increase disappears when leadership is randomly assigned. A follow-up study reveals that women leaders behave dishonestly when they believe their group members prefer dishonesty

Improvement in the decadal prediction skill of the North Atlantic extratropical winter circulation through increased model resolution

In this study the latest version of the MiKlip decadal hindcast system is analyzed, and the effect of an increased horizontal and vertical resolution on the prediction skill of the extratropical winter circulation is assessed. Four different metrics – the storm track, blocking, cyclone and windstorm frequencies – are analyzed in the North Atlantic and European region. The model bias and the deterministic decadal hindcast skill are evaluated in ensembles of five members in a lower-resolution version (LR, atm: T63L47, ocean: 1.5∘ L40) and a higher-resolution version (HR, atm: T127L95, ocean: 0.4∘ L40) of the MiKlip system based on the Max Planck Institute Earth System model (MPI-ESM). The skill is assessed for the lead winters 2–5 in terms of the anomaly correlation of the quantities' winter averages using initializations between 1978 and 2012. The deterministic predictions are considered skillful if the anomaly correlation is positive and statistically significant. While the LR version shows common shortcomings of lower-resolution climate models, e.g., a storm track that is too zonal and southward displaced as well as a negative bias of blocking frequencies over the eastern North Atlantic and Europe, the HR version counteracts these biases. Cyclones, i.e., their frequencies and characteristics like strength and lifetime, are particularly better represented in HR. As a result, a chain of significantly improved decadal prediction skill between all four metrics is found with the increase in the spatial resolution. While the skill of the storm track is significantly improved primarily over the main source region of synoptic activity – the North Atlantic Current – the other extratropical quantities experience a significant improvement primarily downstream thereof, i.e., in regions where the synoptic systems typically intensify. Thus, the skill of the cyclone frequencies is significantly improved over the central North Atlantic and northern Europe, the skill of the blocking frequencies is significantly improved over the Mediterranean, Scandinavia and eastern Europe, and the skill of the windstorms is significantly improved over Newfoundland and central Europe. Not only is the skill improved with the increase in resolution, but the HR system itself also exhibits significant skill over large areas of the North Atlantic and European sector for all four circulation metrics. These results are particularly promising regarding the high socioeconomic impact of European winter windstorms and blocking situations

LncRNA RUS shapes the gene expression program towards neurogenesis

The evolution of brain complexity correlates with an increased expression of long, noncoding (lnc) RNAs in neural tissues. Although prominent examples illustrate the potential of lncRNAs to scaffold and target epigenetic regulators to chromatin loci, only few cases have been described to function during brain development. We present a first functional characterization of the lncRNA LINC01322, which we term RUS for RNA upstream of Slitrk3. The RUS gene is well conserved in mammals by sequence and synteny next to the neurodevelopmental gene Slitrk3. RUS is exclusively expressed in neural cells and its expression increases during neuronal differentiation of mouse embryonic cortical neural stem cells. Depletion of RUS locks neuronal precursors in an intermediate state towards neuronal differentiation resulting in arrested cell cycle and increased apoptosis. RUS associates with chromatin in the vicinity of genes involved in neurogenesis, most of which change their expression upon RUS depletion. The identification of a range of epigenetic regulators as specific RUS interactors suggests that the lncRNA may mediate gene activation and repression in a highly context-dependent manner

FGF2 Affects Parkinson's Disease-Associated Molecular Networks Through Exosomal Rab8b/Rab31

Ras-associated binding (Rab) proteins are small GTPases that regulate the trafficking of membrane components during endocytosis and exocytosis including the release of extracellular vesicles (EVs). Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorder in the elderly population, where pathological proteins such as alpha-synuclein (alpha-Syn) are transmitted in EVs from one neuron to another neuron and ultimately across brain regions, thereby facilitating the spreading of pathology. We recently demonstrated fibroblast growth factor-2 (FGF2) to enhance the release of EVs and delineated the proteomic signature of FGF2-triggered EVs in cultured primary hippocampal neurons. Out of 235 significantly upregulated proteins, we found that FGF2 specifically enriched EVs for the two Rab family membersRab8bandRab31. Consequently, we investigated the interactions ofRab8bandRab31using a network analysis approach in order to estimate the global influence of their enrichment in EVs. To achieve this, we have demarcated a protein-protein interaction network (PPiN) for these Rabs and identified the proteins associated with PD in various cellular components of the central nervous system (CNS), in different brain regions, and in the enteric nervous system (ENS). A total of 126 direct or indirect interactions were reported for two Rab candidates, out of which 114 areRab8binteractions and 54 areRab31interactions, ultimately resulting in an individual interaction score (IS) of 90.48 and 42.86%, respectively. Conclusively, these results for the first time demonstrate the relevance of FGF2-induced Rab-enrichment in EVs and its potential to regulate PD pathophysiology