'Fair Dinkum' Migration Policy: Lessons from Australia

For most of its history, the Australian Federation has embraced large-scale immigration as an imperative of population growth and a development opportunity. Although it is often seen as one of the most immigrant-welcoming nations in the world, Australia has also applied a comprehensive migration governance regime comprising discriminatory immigration and integration strategies, policies and procedures aimed at ensuring that migrant flows are controlled to facilitate best economic outcomes for the country as well as the smooth integration of new arrivals into its socio-economic fabric. This governance regime favours particular categories of newcomers, mostly younger and skilled, and discourages others by means of a harsh system of border controls that reticulates to offshore detention centres all entry-seekers who are considered unauthorised and/or illegal. Thus, despite its enviable record of immigrant acceptance and assimilation, Australia’s tough border controls have attracted a great deal of international opprobrium. The Australian electorate has long supported such tough measures providing the overall migration governance system is ‘fair dinkum’ – ‘transparent, equitable and honest’ in local vernacular. And, in contrast to many other countries, Australia has also learnt much faster from its experience and has therefore been more politically bipartisan and effective at addressing problems of mass, cross-border mobility as they emerge. This chapter reviews the history of Australian migration governance to highlight those aspects that should be of interest to other nations, in particular the EU

Conducting Comparative Research into Defence Capability Formation

The world appears to be searching for a new, multipolar model of global security. In this context, the provision of  impartial data on military capability formation to be used in disarmament proposals and balance of power negotiations will be critical to effective security management in the prevailing uncertain international environment. In their recent research paper on the relationship between military expenditure (milex), government spending and economic growth in the Indo-Pacific Asia region the authors argued that milex’ high level of aggregation often masked important changes in national military capabilities and proposed limited disaggregation of military expenditure data to highlight national spending on military force structure and preparedness so as to facilitate better understanding of military capability formation. In this paper the authors develop this perspective a step further by reviewing alternative approaches to the production of data on military capability formation. It is suggested that the milex data are disaggregated one level down to differentiate between investments in the future force and expenditure on the readiness and sustainment of the force in being

Comparison of body composition components and anaerobic performance parameters of elite male motorcycle speedway riders between pre- and post-competitive season

The purpose of this study was to compare body composition components and anaerobic capacity indices in elite motorcycle speedway riders before and after the competitive season. This study included 12 volunteer male motorcycle speedway riders from the highest speedway league in Poland (PGE Speedway Ekstraliga) (age: 22.7 ± 6.0 years, body height: 171.3 ± 4.0 cm, body weight: 62.5 ± 3.1 kg). Before and after the competitive season, an assessment of body composition and Wingate test (WAnT) on a cycle ergometer with analysis of acute cardiorespiratory and biochemical responses was conducted. Sport level for all riders was defined by the number of heats won (WS), the total number of points scored in all heats including bonus points (PTS + B), and the percentage of heats won (%W). The motorcycle speedway riders participated in an average of 75.3 ± 15.0 total heats (HS) and obtained PTS + B equal 136.8 ± 48.2. The anaerobic performance, body composition, cardiorespiratory and biochemical responses did not changed after the competitive season. The significant statistical correlations were noted between the differences in the Fatigue Index during WAnT and total number of heats (r = −0.61) and with PTS + B (r = −0.58). Positively correlations were observed also between HS and differences: fat mass (FM) (r = 0.60) and percentage of fat mass (r = 0.61) (all p < 0.05). These findings reveal that the HS during the competitive season is related to the stabilization of anaerobic capacity in the WAnT. The HS is positively correlated with an increase in fat mass, and additional fat mass can adversely affect athletic performance in speedway

Sauna-Induced Body Mass Loss in Young Sedentary Women and Men

The aim of the study was to evaluate the relationship between body mass index (BMI) and body mass loss (BML) induced by thermal stress in a dry sauna. The study was conducted on a group of 674 sedentary students, 326 women and 348 men aged 19-20. The correlations between BMI scores and BML were determined. The subjects were placed in supine position in a dry sauna for two sessions of 10 minutes each with a 5-minute break. The influence of BMI on the amount of BML in the sauna was determined by nonlinear stepwise regression. The smallest BML was noted in underweight subjects; students with normal weight lost more weight, whereas the greatest BML was reported in overweight and obese subjects. Persons with a high BMI are at higher risk of dehydration, and they should pay particular attention to replenishing fluids during a visit to the sauna. The proposed equations for calculating BML based on a person's BMI can be useful in estimating the amount of fluids that should be replenished by both men and women during a visit to a dry sauna

The importance of reaction time to the starting signal on race results in elite motorcycle speedway racing

The study aimed to determine whether the reaction time (RT) to the starting signal has an impact on the points scored by elite male motorcycle speedway riders, or whether it depends on the starting position (gate). Differences among junior and senior riders, and how it changes during a single match (15 heats) and in the subsequent phases of the competitive season (the main and knockout phases) were investigated. The database of reaction times to the starting signal obtained by motorcycle speedway riders was collected from a mobile application called PGE Ekstraliga ver. 1.0.66 (PGE Ekstraliga, Warsaw, Poland). The database included 1.261 results obtained by 65 male riders (age 25.9 ±7.6 years), competing in the highest league in Poland (PGE Speedway Ekstraliga) in the 2021 competitive season. Reaction time was measured using the Pegasus Speedway © telemetry system (Black Burst, Warsaw, PL). Riders scoring 3 points during a heat had the fastest reaction time (F(3,1257) = 8.90, p<0.001, η2 = 0.02), but RT did not influence the final result of the match (p<0.130). The times differ depending on the occupied starting position (F(3,1257) = 6.89, p<0.001, η2 = 0.02), with the fastest RT in the inner position–A compared to the B (p<0.05) and C (p <0.001) positions. Senior riders showed significantly faster RT (0.246s) compared to junior ones (0.258s) (p<0.001). The width of the starting line affects the reaction time (F(3,1257) = 7.94, p<0.001, η2 = 0.02). In the last (15th) heat of the match, RT was the fastest. The fast reaction time during the start affects the scoring of more points in a heat but depends on riders’ experience, the starting position and the straight width of the motorcycle speedway stadium. Coaches should pay attention to these factors when programming training measures

Genomic basis for RNA alterations in cancer.

Transcript alterations often result from somatic changes in cancer genomes1. Various forms of RNA alterations have been described in cancer, including overexpression2, altered splicing3 and gene fusions4; however, it is difficult to attribute these to underlying genomic changes owing to heterogeneity among patients and tumour types, and the relatively small cohorts of patients for whom samples have been analysed by both transcriptome and whole-genome sequencing. Here we present, to our knowledge, the most comprehensive catalogue of cancer-associated gene alterations to date, obtained by characterizing tumour transcriptomes from 1,188 donors of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)5. Using matched whole-genome sequencing data, we associated several categories of RNA alterations with germline and somatic DNA alterations, and identified probable genetic mechanisms. Somatic copy-number alterations were the major drivers of variations in total gene and allele-specific expression. We identified 649 associations of somatic single-nucleotide variants with gene expression in cis, of which 68.4% involved associations with flanking non-coding regions of the gene. We found 1,900 splicing alterations associated with somatic mutations, including the formation of exons within introns in proximity to Alu elements. In addition, 82% of gene fusions were associated with structural variants, including 75 of a new class, termed 'bridged' fusions, in which a third genomic location bridges two genes. We observed transcriptomic alteration signatures that differ between cancer types and have associations with variations in DNA mutational signatures. This compendium of RNA alterations in the genomic context provides a rich resource for identifying genes and mechanisms that are functionally implicated in cancer

High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.

The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA sequencing from a common set of 1220 cancer cases, we report hundreds of genes for which the presence within 100 kb of an SV breakpoint associates with altered expression. For the majority of these genes, expression increases rather than decreases with corresponding breakpoint events. Up-regulated cancer-associated genes impacted by this phenomenon include TERT, MDM2, CDK4, ERBB2, CD274, PDCD1LG2, and IGF2. TERT-associated breakpoints involve ~3% of cases, most frequently in liver biliary, melanoma, sarcoma, stomach, and kidney cancers. SVs associated with up-regulation of PD1 and PDL1 genes involve ~1% of non-amplified cases. For many genes, SVs are significantly associated with increased numbers or greater proximity of enhancer regulatory elements near the gene. DNA methylation near the promoter is often increased with nearby SV breakpoint, which may involve inactivation of repressor elements