M-Theory solutions with AdS factors

Solutions of D=7 maximal gauged supergravity are constructed with metrics that are a product of a n-dimensional anti-de Sitter (AdS) space, with n=2,3,4,5, and certain Einstein manifolds. The gauge fields have the same form as in the recently constructed solutions describing the near-horizon limits of M5-branes wrapping supersymmetric cycles. The new solutions do not preserve any supersymmetry and can be uplifted to obtain new solutions of D=11 supergravity, which are warped and twisted products of the D=7 metric with a squashed four-sphere. Some aspects of the stability of the solutions are discussed.Comment: 30 pages. References adde

The Geometry of D=11 Null Killing Spinors

We determine the necessary and sufficient conditions on the metric and the four-form for the most general bosonic supersymmetric configurations of D=11 supergravity which admit a null Killing spinor i.e. a Killing spinor which can be used to construct a null Killing vector. This class covers all supersymmetric time-dependent configurations and completes the classification of the most general supersymmetric configurations initiated in hep-th/0212008.Comment: 30 pages, typos corrected, reference added, new solution included in section 5.1; uses JHEP3.cl

Producing Enactable Protocols in Artificial Agent Societies

This paper draws upon our previous work [7, 16] in which we proposed the organisation of services around the concept of artificial agent societies and presented a framework for representing roles and protocols using LTSs. The agent would apply for a role in the society, which would result in its participation in a number of protocols. We advocated the use of the games-based metaphor for describing the protocols and presented a framework for assessing the admission of the agent to the society on the basis of its competence. In this work we look at the subsequent question: what information should the agent receive upon entry?. We can not provide it with the full protocol because of security and overload issues. Therefore, we choose to only provide the actions pertinent to the protocols that the role the agent applied for participates in the society. We employ branching bisimulation for producing a protocol equivalent to the original one with all actions not involving the role translated into silent (τ) actions. However, this approach sometimes results in non-enactable protocols. In this case, we need to repair the protocol by adding the role in question as a recipient to certain protocol messages that were causing the problems. We present three different approaches for repairing protocols, depending on the number of messages from the original protocol they modify. The modified protocol is adopted as the final one and the agent is given the role automaton that is derived from the branching bisimulation process

O-band QKD link over a multiple ONT loaded carrier-grade GPON for FTTH applications

We have successfully integrated an O-band commercial Quantum-Key-Distribution (QKD) system over a lit GPON testbed that replicates a carrier-grade Fiber-to-the-Home (FTTH) optical access network with multiple ONTs to emulate real-life FTTH operational deployments.Comment: 3 page

Loncastuximab tesirine in relapsed/refractory high-grade B-cell lymphoma: a subgroup analysis from the LOTIS-2 study

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Sprint Training Increases Muscle Oxidative Metabolism During High-Intensity Exercise in Patients With Type 1 Diabetes

OBJECTIVE—To investigate sprint-training effects on muscle metabolism during exercise in subjects with (type 1 diabetic group) and without (control group) type 1 diabetes

Setting priorities for EU healthcare workforce IT skills competence improvement

A major challenge for healthcare quality improvement is the lack of IT skills and knowledge of healthcare workforce as well as their ambivalent attitudes towards IT. This paper identifies and prioritises actions needed to improve the IT skills of healthcare workforce across the EU. 46 experts, representing different fields of expertise in healthcare and geolocations systematically list and scored actions that would improve IT skills among healthcare workforce. The Child Health and Nutrition Research Initiative methodology was used for research priority-setting. The participants evaluated the actions using the following criteria: feasibility, effectiveness, deliverability, and maximum impact on IT skills improvement. The leading priority actions were related to appropriate training, integrating eHealth in curricula, involving healthcare workforce in the eHealth solution development, improving awareness of eHealth and learning arrangement. As the different professionals’ needs are prioritised, healthcare workforce should be actively and continuously included in the development of eHealth solutions

Rapid overview of systematic reviews of nocebo effects reported by patients taking placebos in clinical trials

Background Trial participants in placebo groups report experiencing adverse events (AEs). Existing systematic reviews have not been synthesized, leaving questions about why these events occur as well as their prevalence across different conditions unanswered. Objectives (1) To synthesize the evidence of prevalence of AEs in trial placebo groups across different conditions. (2) To compare AEs in trial placebo groups with AEs reported in untreated groups within a subset of randomized trials. Search methods We searched PubMed for records with the word “nocebo” in the title and “systematic” in any field. We also contacted experts and hand-searched references of included studies. Study eligibility We included any systematic review of randomized trials where nocebo effects were reported. We excluded systematic reviews of non-randomized studies. Participants and interventions We included studies in any disease area. Study appraisal and synthesis methods We appraised the quality of the studies using a shortened version of the Assessment of Multiple Systematic Reviews tool (AMSTAR) tool. We reported medians and interquartile ranges (IQRs) of AEs. Among the trials within the review that included untreated groups, we compared the prevalence of AEs in untreated groups with the prevalence of AEs in placebo groups. Results We identified 20 systematic reviews. These included 1271 randomized trials and 250,726 placebo-treated patients. The median prevalence of AEs in trial placebo groups was 49.1% (IQR 25.7–64.4%). The median rate of dropouts due to AEs was 5% (IQR 2.28–8.4%). Within the 15 of trials that reported AEs in untreated groups, we found that the AE rate in placebo groups (6.51%) was higher than that reported in untreated groups (4.25%). Limitations This study was limited by the quality of included reviews and the small number of trials that included untreated groups. Conclusions and implications of key findings AEs in trial placebo groups are common and cannot be attributed entirely to natural history. Trial methodologies that reduce AEs in placebo groups while satisfying the requirement of informed consent should be developed and implemented