Mammals of Fort Leavenworth, Kansas: a 60-year followup to Brumwell (1951)

More than 60 years have elapsed since Brumwell\u27s (1951) comprehensive assessment during 193911940 of resident terrestrial vertebrates from Fort Leavenworth Military Rooervation in northeastern Kansas. Subsequent studies have been accomplished for the amphibians, reptiles, and birds. Our study is the first to assess intervening changes in the mammalian composition of this diverse local fauna. Notable observations include: the decline or extirpation of the black-tailed jackrabbit (Lepus californicus), Franklin\u27s ground squirrel (Spermophilus franklinii), muskrat (Ondatra zibethicus), long-tailed weasel (Mustela frenata) and eastern spotted skunk (Spilogale putorius); the return or recovery of locally extirpated gray fox (Urocyon cinereoargenteus), puma (Puma concolor), and white-tailed deer (Odocoileus virginianus), the increases of the once uncommon eastern chipmunk (Tamias striatus) and striped skunk (Mephitis mephitis), the invasion and establishment of the hispid cotton rat (Sigmodon hispidus), and the displacement of the eastern fox squirrel (Sciurus niger) by the eastern gray squirrel (S. carolinensis) as the most common squirrel. Documented species either not mentioned by Brumwell (1951) or listed by him as hypothetically occurring on the post, included northern myotis (Myotis septentrionalis), eastern pipistrelle (Pipistrellus subflavus), evening bat (Nycticeius humeralis), southern bog lemming (Synaptomys cooperi), and meadow jumping mouse (Zapus hudsonius)

Role of Kozak sequence polymorphism of platelet glycoprotein Ibα as a risk factor for coronary artery disease and catheter interventions

AbstractOBJECTIVESWe sought to determine the role of the −5T/C polymorphism of the platelet glycoprotein (GP) Ibα as a potential risk factor for coronary artery disease (CAD) and adverse events complicating a coronary catheter intervention.BACKGROUNDThe platelet GP Ib-IX-V receptor complex plays a crucial role in arterial thrombus formation. The −5T/C polymorphism of GP Ibα is associated with increased receptor density.METHODSWe genotyped 1,000 patients with angiographically confirmed CAD, as well as 1,000 age- and gender-matched control subjects, for this polymorphism by polymerase chain reaction/restriction fragment length polymorphism. Among the patients with CAD, 269 underwent percutaneous transluminal coronary angioplasty (PTCA), 103 underwent directional coronary atherectomy and 278 underwent stenting. This intervention group was followed for a 30-day composite end point of target vessel revascularization, myocardial infarction or death.RESULTSCarriers of the −5C allele were significantly over-represented in the group of patients developing acute coronary syndromes (relative risk [RR] 1.43, 95% confidence interval [CI] 1.05 to 1.95, p = 0.02). The −5C allele furthermore predicted an increased risk for developing complications after PTCA (RR 3.75, 95% CI 1.15 to 12.27, p = 0.029).CONCLUSIONSThe −5C allele of the GP Ibα Kozak polymorphism may represent a risk factor in clinical conditions in which thrombosis plays an important role, such as in acute coronary syndromes and in complications after PTCA

Small-scale convection signatures associated with strong plage solar magnetic field

In this work, we study and quantify properties of strong-field small-scale convection and compare observed properties with those predicted by numerical simulations. We analyze spectropolarimetric 630.25 nm data from a unipolar ephemeral region near sun center. We use line-of-sight velocities and magnetic field measurements obtained with Milne-Eddington inversion techniques along with measured continuum intensities and Stokes V amplitude asymmetry at a spatial resolution of 0.15 arcseconds to establish statistical relations between the measured quantities. We also study these properties for different types of distinct magnetic features, such as micropores, bright points, ribbons, flowers and strings. We present the first direct observations of a small-scale granular magneto-convection pattern within extended regions of strong (more than 600 G average) magnetic field. Along the boundaries of the flux concentrations we see mostly downflows and asymmetric Stokes V profiles, consistent with synthetic line profiles calculated from MHD simulations. We note the frequent occurrence of bright downflows along these boundaries. In the interior of the flux concentrations, we observe an up/down flow pattern that we identify as small-scale magnetoconvection, appearing similar to that of field-free granulation but with scales 4 times smaller. Measured RMS velocities are 70% of those of nearby field-free granulation, even though the average radiative flux is not reduced. The interiors of these flux concentrations are dominated by upflows.Comment: Accepted for publication in Astronomy and Astrophysic

Vegan Diet and Bone Health—Results from the Cross-Sectional RBVD Study

Scientific evidence suggests that a vegan diet might be associated with impaired bone health. Therefore, a cross-sectional study (n = 36 vegans, n = 36 omnivores) was used to investigate the associations of veganism with calcaneal quantitative ultrasound (QUS) measurements, along with the investigation of differences in the concentrations of nutrition- and bone-related biomarkers between vegans and omnivores. This study revealed lower levels in the QUS parameters in vegans compared to omnivores, e.g., broadband ultrasound attenuation (vegans: 111.8 ± 10.7 dB/MHz, omnivores: 118.0 ± 10.8 dB/MHz, p = 0.02). Vegans had lower levels of vitamin A, B2, lysine, zinc, selenoprotein P, n-3 fatty acids, urinary iodine, and calcium levels, while the concentrations of vitamin K1, folate, and glutamine were higher in vegans compared to omnivores. Applying a reduced rank regression, 12 out of the 28 biomarkers were identified to contribute most to bone health, i.e., lysine, urinary iodine, thyroid-stimulating hormone, selenoprotein P, vitamin A, leucine, α-klotho, n-3 fatty acids, urinary calcium/magnesium, vitamin B6, and FGF23. All QUS parameters increased across the tertiles of the pattern score. The study provides evidence of lower bone health in vegans compared to omnivores, additionally revealing a combination of nutrition-related biomarkers, which may contribute to bone health. Further studies are needed to confirm these findings

Vegan Diet and Bone Health—Results from the Cross-Sectional RBVD Study

Scientific evidence suggests that a vegan diet might be associated with impaired bone health. Therefore, a cross-sectional study (n = 36 vegans, n = 36 omnivores) was used to investigate the associations of veganism with calcaneal quantitative ultrasound (QUS) measurements, along with the investigation of differences in the concentrations of nutrition- and bone-related biomarkers between vegans and omnivores. This study revealed lower levels in the QUS parameters in vegans compared to omnivores, e.g., broadband ultrasound attenuation (vegans: 111.8 ± 10.7 dB/MHz, omnivores: 118.0 ± 10.8 dB/MHz, p = 0.02). Vegans had lower levels of vitamin A, B2, lysine, zinc, selenoprotein P, n-3 fatty acids, urinary iodine, and calcium levels, while the concentrations of vitamin K1, folate, and glutamine were higher in vegans compared to omnivores. Applying a reduced rank regression, 12 out of the 28 biomarkers were identified to contribute most to bone health, i.e., lysine, urinary iodine, thyroid-stimulating hormone, selenoprotein P, vitamin A, leucine, α-klotho, n-3 fatty acids, urinary calcium/magnesium, vitamin B6, and FGF23. All QUS parameters increased across the tertiles of the pattern score. The study provides evidence of lower bone health in vegans compared to omnivores, additionally revealing a combination of nutrition-related biomarkers, which may contribute to bone health. Further studies are needed to confirm these findings

Stakeholder ownership: a theoretical framework for cross national understanding and analyses of stakeholder involvement in issues of substance use, problem use and addiction

This project contributes to understanding of the role of different stakeholder groups in the formulation and implementation of policy in the addictions field in Austria, Denmark, Finland, Italy, Poland and the UK. It comprises a number of case studies which draw on a range of theoretical frameworks to examine stakeholder dynamics at international, national and local levels. Mainly qualitative methods were used: interviews, policy and documentation analyses, webcrawler network analysis, and simple surveys; one case study was based on a survey only. The case studies fall into four main categories: three focus on controversial issues in drug treatment policy and practice – opioid substitution treatment, drug consumption rooms, and heroin assisted treatment; three look at stakeholder activity in alcohol control and public health; one pilot case study considers the potential role of researchers in the development of a scientific network around gambling; and one looks at the role of nurses in implementing brief interventions. In addition, themes explored across case studies included the role of evidence and stakeholder activity, drug users as stakeholders, and the role of external stakeholders on national policy. Professional stakeholders at implementation level and families and drug users as stakeholders are also considered. The case studies revealed that, in many instances, the addictions field is characterised by tensions between groups, by entrenched relationships between some addiction-specific stakeholder groups and powerful political stakeholders, and by the dominance of some forms of evidence over other forms of knowledge. Science and scientists are only influential in policy terms if their scientific findings ‘fit’ with the wider political context. Nevertheless, at least within the European context, there are opportunities for new stakeholder groups to emerge and gain policy salience and there are opportunities for stakeholders to challenge prevailing frames of understanding the addictions and prevailing modes of responding to problems of substance misuse and addiction