Detection of subthreshold pulses in neurons with channel noise

Neurons are subject to various kinds of noise. In addition to synaptic noise, the stochastic opening and closing of ion channels represents an intrinsic source of noise that affects the signal processing properties of the neuron. In this paper, we studied the response of a stochastic Hodgkin-Huxley neuron to transient input subthreshold pulses. It was found that the average response time decreases but variance increases as the amplitude of channel noise increases. In the case of single pulse detection, we show that channel noise enables one neuron to detect the subthreshold signals and an optimal membrane area (or channel noise intensity) exists for a single neuron to achieve optimal performance. However, the detection ability of a single neuron is limited by large errors. Here, we test a simple neuronal network that can enhance the pulse detecting abilities of neurons and find dozens of neurons can perfectly detect subthreshold pulses. The phenomenon of intrinsic stochastic resonance is also found both at the level of single neurons and at the level of networks. At the network level, the detection ability of networks can be optimized for the number of neurons comprising the network.Comment: 14 pages, 9 figure

Merger, Akusisi dan Konsolidasi dalam Perspektif Hukum Persaingan Usaha

Mergers, acquisitions and consolidation is a business strategy that is commonly used in the business world to be able to build competitive advantage company, which in time can enhance shareholder value while maximizing the prosperity of the company owners or shareholders. To achieve the above objective normative, policy-makers need a plan and steps of strategic and accurate information to avoid the risk of failure. However, the strategy of merger, acquisition and consolidation of certain potentially inhibit fair competition conditions, thus becoming one of the objects that need to be regulated in Law no. 5 Year 1999 concerning Prohibition of Monopolistic Practices and Unfair Business Competition. Market impact of mergers, acquisitions and consolidation is important for analysis because it can have significant legal consequences for businesses, so that the research method used is the juridical normative and empirical approaches. In practice of mergers, acquisitions and consolidation intersect with regulation in other sectors, especially banking and capital markets. That is, there should be equality of perception and interpretation among the institutions that issued the policy

Teacher Twitter Chats: Gender Differences in Participants’ Contributions

Gender differences in participation were examined across four Twitter chats for social studies teachers. Analyses drawing on mixed methods revealed that while there was parity across most kinds of tweets, participants identified as men were more likely to use the examined Twitter chats to share resources, give advice, boast, promote their own blog/resource/website, and offer critique to another participants’ tweet. Participants identified as women were more likely to write tweets that included positive affirmations for other chat participants. These findings suggest that there are differences in the way that women and men tend to participate in teacher Twitter chat spaces

The non-vanishing effect of detuning errors in dynamical decoupling based quantum sensing experiments

Characteristic dips appear in the coherence traces of a probe qubit when dynamical decoupling (DD) is applied in synchrony with the precession of target nuclear spins, forming the basis for nanoscale nuclear magnetic resonance (NMR). The frequency of the microwave control pulses is chosen to match the qubit transition but this can be detuned from resonance by experimental errors, hyperfine coupling intrinsic to the qubit, or inhomogeneous broadening. The detuning acts as an additional static field which is generally assumed to be completely removed in Hahn echo and DD experiments. Here we demonstrate that this is not the case in the presence of finite pulse-durations, where a detuning can drastically alter the coherence response of the probe qubit, with important implications for sensing applications. Using the electronic spin associated with a nitrogen-vacancy centre in diamond as a test qubit system, we analytically and experimentally study the qubit coherence response under CPMG and XY8 dynamical decoupling control schemes in the presence of finite pulse-durations and static detunings. Most striking is the splitting of the NMR resonance under CPMG, whereas under XY8 the amplitude of the NMR signal is modulated. Our work shows that the detuning error must not be neglected when extracting data from quantum sensor coherence traces

Agile methods for agile universities

We explore a term, Agile, that is being used in various workplace settings, including the management of universities. The term may have several related but slightly different meanings. Agile is often used in the context of facilitating more creative problem-solving and advocating for the adoption, design, tailoring and continual updating of more innovative organizational processes. We consider a particular set of meanings of the term from the world of software development. Agile methods were created to address certain problems with the software development process. Many of those problems have interesting analogues in the context of universities, so a reflection on agile methods may be a useful heuristic for generating ideas for enabling universities to be more creative

Comparative study of design: application to Engineering Design

A recent exploratory study examines design processes across domains and compares them. This is achieved through a series of interdisciplinary, participative workshops. A systematic framework is used to collect data from expert witnesses who are practising designers across domains from engineering through architecture to product design and fashion, including film production, pharmaceutical drugs, food, packaging, graphics and multimedia and software. Similarities and differences across domains are described which indicate the types of comparative analysis we have been able to do from our data. The paper goes further and speculates on possible lessons for selected areas of engineering design which can be drawn from comparison with processes in other domains. As such this comparative design study offers the potential for improving engineering design processes. More generally it is a first step in creating a discipline of comparative design which aims to provide a new rich picture of design processes

Hidden in plain sight: a massive, dusty starburst in a galaxy protocluster at z=5.7 in the COSMOS field

We report the serendipitous discovery of a dusty, starbursting galaxy at $z=5.667$ (hereafter called CRLE) in close physical association with the "normal" main-sequence galaxy HZ10 at $z=5.654$. CRLE was identified by detection of [CII], [NII] and CO(2-1) line emission, making it the highest redshift, most luminous starburst in the COSMOS field. This massive, dusty galaxy appears to be forming stars at a rate of at least 1500$\,M_\odot$ yr$^{-1}$ in a compact region only $\sim3$ kpc in diameter. The dynamical and dust emission properties of CRLE suggest an ongoing merger driving the starburst, in a potentially intermediate stage relative to other known dusty galaxies at the same epoch. The ratio of [CII] to [NII] may suggest that an important ($\sim15\%$) contribution to the [CII] emission comes from a diffuse ionized gas component, which could be more extended than the dense, starbursting gas. CRLE appears to be located in a significant galaxy overdensity at the same redshift, potentially associated with a large-scale cosmic structure recently identified in a Lyman Alpha Emitter survey. This overdensity suggests that CRLE and HZ10 reside in a protocluster environment, offering the tantalizing opportunity to study the effect of a massive starburst on protocluster star formation. Our findings support the interpretation that a significant fraction of the earliest galaxy formation may occur from the inside out, within the central regions of the most massive halos, while rapidly evolving into the massive galaxy clusters observed in the local Universe.Comment: 16 pages, 9 figures, 4 tables, final version to appear on ApJ (accepted May 19, 2018

Systematic Review – Final: Have arid land springs restoration projects been effective in restoring hydrology, geomorphology, and invertebrates and plant species composition comparable to natural springs with minimal anthropogenic disturbance?

The aim of this review is to examine the effectiveness of springs restoration projects in the southwestern United States in restoring hydrology, geomorphology, and plant and invertebrates species composition to condiitions comparable with natural springs with minimal anthropogenic disturbances