12 research outputs found
Case Report Telescoping Intestine in an Adult
Protrusion of a bowel segment into another (intussusception) produces severe abdominal pain and culminates in intestinal obstruction. In adults, intestinal obstruction due to intussusception is relatively rare phenomenon, as it accounts for minority of intestinal obstructions in this population demographic. Organic lesion is usually identifiable as the cause of adult intussusceptions, neoplasms account for the majority. Therefore, surgical resection without reduction is almost always necessary and is advocated as the best treatment of adult intussusception. Here, we describe a rare case of a 44-year-old male with a diffuse large B-cell lymphoma involving the terminal ileum, which had caused ileocolic intussusception and subsequently developed intestinal obstruction requiring surgical intervention. This case emphasizes the importance of recognizing intussusception as the initial presentation for bowel malignancy
Telescoping Intestine in an Adult
Protrusion of a bowel segment into another (intussusception) produces severe abdominal pain and culminates in intestinal obstruction. In adults, intestinal obstruction due to intussusception is relatively rare phenomenon, as it accounts for minority of intestinal obstructions in this population demographic. Organic lesion is usually identifiable as the cause of adult intussusceptions, neoplasms account for the majority. Therefore, surgical resection without reduction is almost always necessary and is advocated as the best treatment of adult intussusception. Here, we describe a rare case of a 44-year-old male with a diffuse large B-cell lymphoma involving the terminal ileum, which had caused ileocolic intussusception and subsequently developed intestinal obstruction requiring surgical intervention. This case emphasizes the importance of recognizing intussusception as the initial presentation for bowel malignancy
Synthesis and pharmacological evaluation of 3-(3,5-dimethylisoxazol-4-yl)-2-arylthiazolidin-4-ones as potential antioxidant, anti-inflammatory and analgesic agents
109-1193-(3,5-Dimethylisoxazol-4-yl)-2-arylthiazolidin-4-ones 3a-l have been synthesized from 4-amino-3,5-dimethylisoxazole 1 by condensation with aromatic aldehydes, followed by cyclization with mercaptoacetic acid in excellent yields, and have been evaluated for in vitro antioxidant activity. Based on potential antioxidant property, compounds 3c, 3e, 3h, 3i, and 3l have been screened for in vivo anti-inflammatory and analgesic activity. Molecular docking studies have also been carried out to balance the bioactivity results. From these results it is evident that the compound 3c shows potential anti-inflammatory and analgesic activity
Characterization of Polymerized Liposomes Using a Combination of dc and Cyclical Electrical Field-Flow Fractionation
Characterization of polymerized liposomes (PolyPIPosomes)
was carried
out using a combination of normal dc electrical field-flow fractionation
and cyclical electrical field-flow fractionation (CyElFFF) as an analytical
technique. The constant nature of the carrier fluid and channel configuration
for this technique eliminates many variables associated with multidimensional
analysis. CyElFFF uses an oscillating field to induce separation and
is performed in the same channel as standard dc electrical field-flow
fractionation separation. Theory and experimental methods to characterize
nanoparticles in terms of their sizes and electrophoretic mobilities
are discussed in this paper. Polystyrene nanoparticles are used for
system calibration and characterization of the separation performance,
whereas polymerized liposomes are used to demonstrate the applicability
of the system to biomedical samples. This paper is also the first
to report separation and a higher effective field when CyElFFF is
operated at very low applied voltages. The technique is shown to have
the ability to quantify both particle size and electrophoretic mobility
distributions for colloidal polystyrene nanoparticles and PolyPIPosomes
Synthesis, spectral studies, DNA binding, photocleavage, antimicrobial and anticancer activities of isoindol Ru(II) polypyridyl complexes
Circuit modification in electrical field flow fractionation systems generating higher resolution separation of nanoparticles
Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila
Pax6 genes encode evolutionarily highly conserved transcription factors that are required for eye and brain development. Despite the characterization of mutations in Pax6 homologs in a range of organisms, and despite functional studies, it remains unclear what the relative importance is of the various parts of the Pax6 protein. To address this, we have studied the Drosophila Pax6 homolog eyeless. Specifically, we have generated new eyeless alleles, each with single missense mutations in one of the four domains of the protein. We show that these alleles result in abnormal eye and brain development while maintaining the OK107 eyeless GAL4 activity from which they were derived. We performed in vivo functional rescue experiments by expressing in an eyeless-specific pattern Eyeless proteins in which either the paired domain, the homeodomain, or the C-terminal domain was deleted. Rescue of the eye and brain phenotypes was only observed when full-length Eyeless was expressed, while all deletion constructs failed to rescue. These data, along with the phenotypes observed in the four newly characterized eyeless alleles, demonstrate the requirement for an intact Eyeless protein for normal Drosophila eye and brain development. They also suggest that some endogenous functions may be obscured in ectopic expression experiments