Lincolnshire diversity in the arts: research and development

Lincolnshire Diversity in the Arts: Research and Development is an Arts Council England funded project, undertaken by the University of Lincoln, aimed at exploring ways to develop cultural/artistic diversity in rural England, by taking Lincolnshire as a case study. The project commenced on 01 April 2016 and completed on 12 November 2017. The project was co-directed by 1) Dr Arya Madhavan, Senior Lecturer, University of Lincoln and 2) Dr Sreenath Nair, Senior Lecturer, University of Lincoln. The project: 1. Produced and toured an Edinburgh Fringe Award-winning (1982) Indian play, Charandas Chor (Charandas Chor: The Honest Thief) in selected arts centres around Lincolnshire and studied its impact among the audience using qualitative and quantitative analytical methods. 2. Organised a one-day symposium bringing together cultural and community leaders as well as artists in an event of artistic exchange, around the theme of diversity. 3. Analysed the cultural strategies employed by Tara Arts, London; Black Country Touring, West Bromwich; Kali Theatre, London; Yellow Earth, London; as well as two artists, Shane Shambhu (a British Asian dancer and choreographer) and Ni Made Pujawathi (a South East Asian dancer and choreographer) in developing their rural audience

Performance anxiety in actors: symptoms, explanations and an Indian approach to treatment

There are numerous examples of renowned performers across the arts (actors and musicians) and in sports, which become news items in the media due to their performance anxiety (also called stage fright in English, or Lampenfieber in German). Given the number of celebrity actors suffering from stage fright, the number of those actors who do not make the news headlines in relation to their stage fright but nevertheless suffer from it must be even higher. In t his essay we provide an up to date account of the symptoms of stage fright, possible explanations for it and a range of known approaches to treatment. This is followed by an original approach to treating stage fright, based on Indian performance techniques, using details of a study undertaken in 2005.This multi-author journal article provides an in-depth analysis into the nature and treatment available for performance anxiety. The article offers examples of numerous artists and singers, including Sir Laurence Olivier, who had experienced stage fright for the duration of his performances of the title role in Ibsen’s The Master Builder (1965). The article run a clear analysis of the symptoms of stage fright and explain the nature of this psychophysical anxiety using clinical evidences and therapeutic methods. The key focus of the article is to compare and contrast two therapeutic methods for deducing stage anxiety: NLP, a well-established method, and SIT, which is an emerging method developed by Sreenath Nair using South Indian Bodily traditions. The article is based on a project carried out by Emerita Elizabeth Valentine and Daniel Meyer-Dinkgräfe in 2005, funded by the British Academy and the University of Wales Aberystwyth. The project compared two distinct methods of reducing stage fright in stage actors (Valentine et.al. 2006), one of them based on Indian approaches (South Indian Techniques, SIT) and the other Neuro Linguistic Programming (NLP). The SIT approach makes use of a range of psychophysical approaches deriving from the martial and performance traditions of Kerala. The study concludes that although many of the results were not statistically significant, ten of the eleven main effects were in the predicted direction, i.e. a greater effect for SIT than NLP. This multi-author journal article provides an in-depth analysis into the nature and treatment available for performance anxiety. The article offers examples of numerous artists and singers, including Sir Laurence Olivier, who had experienced stage fright for the duration of his performances of the title role in Ibsen’s The Master Builder (1965). The article run a clear analysis of the symptoms of stage fright and explain the nature of this psychophysical anxiety using clinical evidences and therapeutic methods. The key focus of the article is to compare and contrast two therapeutic methods for deducing stage anxiety: NLP, a well-established method, and SIT, which is an emerging method developed by Sreenath Nair using South Indian Bodily traditions. The article is based on a project carried out by Emerita Elizabeth Valentine and Daniel Meyer-Dinkgräfe in 2005, funded by the British Academy and the University of Wales Aberystwyth. The project compared two distinct methods of reducing stage fright in stage actors (Valentine et.al. 2006), one of them based on Indian approaches (South Indian Techniques, SIT) and the other Neuro Linguistic Programming (NLP). The SIT approach makes use of a range of psychophysical approaches deriving from the martial and performance traditions of Kerala. The study concludes that although many of the results were not statistically significant, ten of the eleven main effects were in the predicted direction, i.e. a greater effect for SIT than NLP. The study is a practice-based research demonstrating a highly relevant contribution to a therapeutic practice reducing stage fright. The research combines science and humanities indicating direct and wider impact

Comparison and agreement between arterial versus venous blood gas analysis and pulse oxymetry in children with acute asthma

Background: Blood gas analysis is critical in managing children in intensive care unit primarily in respiratory disorders. This study aimed to ascertain agreement between the arterial and peripheral venous measurement of pH, pCO2, pO2 and bicarbonate levels along with SpO2 in acute asthma.Methods: Hospital based cross sectional analytical study was conducted at Pushpagiri Institute of Medical Sciences in 50 children within the age group of 5-15 years who presented with symptoms suggestive of acute asthma with a modified PSI>6 after informed consent from parents and assent from child. SpO2 monitoring and ABG simultaneously with VBG were done immediately after admission. Statistical analysis was done to find out any correlation using Pearson correlation coefficient and Bland Altman plots were drawn to assess agreement.Results: 50 children in the age group 5 years to 15 years were included in the study. Arterial pH and venous pH were found to be correlated significantly, Pearson correlation coefficient r=0.438. There was a good correlation between the arterial and venous pCO2 with r= 0.610, bicarbonate values r=0.608. There was poor correlation between arterial PO2 and venous PO2 values (r=0.030). The bias plot for pH and pCO2 showed moderate agreement in with 95% limits of agreement being in acceptably narrow range. The mean bias in pH was 0.0242 (SD=0.04912, 95% limits of agreement = -0.0721 to 0.12045); bias in pCO2 was -4.04400 (SD=5.53616, 95% limits of agreement = -14.8949 to 6.8069), and in bicarbonate levels -0.0940 (SD=2.09, 95% limits of agreement = -4.1998 to 4.0119).Conclusions: Even though there was a good correlation and a moderate agreement between ABG and VBG parameters like pH, pCO2 and bicarbonate, VBG cannot be replaced for ABG in acute asthma. Pulse oximetry also has limitations in children with acute severe asthma as compared to ABG value.

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Insight into the gut microbiology of wild-caught Mangrove Red Snapper, Lutjanus argentimaculatus (Forsskal, 1775)

Documenting bacteria present in healthy individuals forms the first step in understanding the effects of microbial manipulation in aquaculture systems. Among the commensal microflora, gut microbiota has attracted extensive attention owing to their role in host metabolism and health maintenance. Basic knowledge on normal gut microbes within a particular host species is thus essential to determine how successfully these microbes can be manipulated and engineered for sustainable aquaculture systems. In spite of the good aquaculture potential of Mangrove red snapper, Lutjanus argentimaculatus, the information on microbial communities associated with the gut of this fish, and their contribution towards digestive efficiency and disease resistance is scarce. Therefore, an attempt was made to elucidate the abundance and diversity of cultivable gut microbes of wild caught L. argentimaculatus along with their digestive exoenzyme profiles and prohibitory effect against fish pathogens. Results on abundance showed similar gut bacterial loads as that of other marine fish imposing the less contribution of microflora to the volume of gut materials in fish. Eleven distinct bacterial species including two proposed novel vibrios were identified. An incidental observation of Morganella morganii throughout samples is an alarming signal, emphasizing the need for immediate de-gutting to avoid histamine intoxication. Abundance of digestive enzyme producers and excellent enzymatic potential of some isolates suggested the contribution of digestive enzymes may supplement to the symbiosis between gut flora and host and the information is of interest to aquaculture nutritionists/commercial industries. Interestingly, some isolates demonstrated estimable co-aggregation with aquatic pathogens, indicating their involvement in disease resistance and the results correlated well with gut microbial diversity. These findings highlight the significant role of gut microbes towards nutritional physiology and disease resistance of this aquaculture candidate in natural ecosystem. The culturable microbiota profiles of wild fish generated in the study can be applied for measuring the quality of husbandry routines in aquaculture facility of this marine fish. Overall, the present study fetches insights on the gut microbiome of healthy L. argentimaculatus which forms a platform for follow-up studies. The study may also help in the development of “functional” fish feeds for L. argentimaculatus. The investigation also demonstrated some potential digestive enzyme-producing isolates having probiotic applications in commercial aquaculture

Training Manual on "Know Your Marine Biodiversity and Environment (MarBiE 2)" Taxonomy of Marine Organisms

Sustainable fisheries management aims to protect fishery resources to ensure the long-term viability of fish stocks and marine ecosystems. It combines theoretical disciplines, like population dynamics, with practical strategies, like avoiding overfishing and curbing illegal fishing practices. Correct taxonomy and systematics tools permit the classification of practically all fish species. This capacity is of particular value for fisheries management biological and ecological research as well as to issues related to fisheries products for human consumption. However, its usefulness is hindered by the lack of expertise in this area and the decrease in the number of taxonomists. Specimens have to be identified at species level using standard morphometric and meristic procedures applied by taxonomists. With sustainability being the critical issue of the hour, developing a younger breed of qualified taxonomists in the different marine realm is of outmost importance. It is physically difficult to identify and collect data on every organism in an ecosystem; therefore, taxonomic studies focus exclusively on specific taxonomic groups, which highlights their significance. The application of contemporary techniques will enhance our understanding of evolutionary linkages. This can entail educating a new generation of specialists on the systematics of the relevant group or persuading more experienced experts to write assessments of the group. The credibility of species occurrence records from current databases and literature needs to be thoroughly evaluated

3D-Beacons: decreasing the gap between protein sequences and structures through a federated network of protein structure data resources

While scientists can often infer the biological function of proteins from their 3-dimensional quaternary structures, the gap between the number of known protein sequences and their experimentally determined structures keeps increasing. A potential solution to this problem is presented by ever more sophisticated computational protein modeling approaches. While often powerful on their own, most methods have strengths and weaknesses. Therefore, it benefits researchers to examine models from various model providers and perform comparative analysis to identify what models can best address their specific use cases. To make data from a large array of model providers more easily accessible to the broader scientific community, we established 3D-Beacons, a collaborative initiative to create a federated network with unified data access mechanisms. The 3D-Beacons Network allows researchers to collate coordinate files and metadata for experimentally determined and theoretical protein models from state-of-the-art and specialist model providers and also from the Protein Data Bank

PDBe: improved findability of macromolecularstructure data in the PDB

© 2019 The Authors. Published by OUP. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1093/nar/gkz990The Protein Data Bank in Europe (PDBe), a founding member of the Worldwide Protein Data Bank (wwPDB), actively participates in the deposition, curation, validation, archiving and dissemination of macromolecular structure data. PDBe supports diverse research communities in their use of macromolecular structures by enriching the PDB data and by providing advanced tools and services for effective data access, visualization and analysis. This paper details the enrichment of data at PDBe, including mapping of RNA structures to Rfam, and identification of molecules that act as cofactors. PDBe has developed an advanced search facility with ∼100 data categories and sequence searches. New features have been included in the LiteMol viewer at PDBe, with updated visualization of carbohydrates and nucleic acids. Small molecules are now mapped more extensively to external databases and their visual representation has been enhanced. These advances help users to more easily find and interpret macromolecular structure data in order to solve scientific problems.The Protein Data Bank in Europe is supported by European Molecular Biology Laboratory-European Bioinformatics Institute; Wellcome Trust [104948]; Biotechnology and Biological Sciences Research Council [BB/N019172/1, BB/G022577/1, BB/J007471/1, BB/K016970/1, BB/K020013/1, BB/M013146/1, BB/M011674/1, BB/M020347/1, BB/M020428/1, BB/P024351/1]; European Union [284209]; ELIXIR and Open Targets. Funding for open access charge: EMB

PDBe-KB: a community-driven resource for structural and functional annotations.

The Protein Data Bank in Europe-Knowledge Base (PDBe-KB, https://pdbe-kb.org) is a community-driven, collaborative resource for literature-derived, manually curated and computationally predicted structural and functional annotations of macromolecular structure data, contained in the Protein Data Bank (PDB). The goal of PDBe-KB is two-fold: (i) to increase the visibility and reduce the fragmentation of annotations contributed by specialist data resources, and to make these data more findable, accessible, interoperable and reusable (FAIR) and (ii) to place macromolecular structure data in their biological context, thus facilitating their use by the broader scientific community in fundamental and applied research. Here, we describe the guidelines of this collaborative effort, the current status of contributed data, and the PDBe-KB infrastructure, which includes the data exchange format, the deposition system for added value annotations, the distributable database containing the assembled data, and programmatic access endpoints. We also describe a series of novel web-pages-the PDBe-KB aggregated views of structure data-which combine information on macromolecular structures from many PDB entries. We have recently released the first set of pages in this series, which provide an overview of available structural and functional information for a protein of interest, referenced by a UniProtKB accession

Encyclopedia of Asian theatre

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