Something, nothing : space, substance, and sexual identity in Shakespeare

This paper argues that early, "preoedipal" anxieties about dependency, autonomy, the boundaries of the self, the dangerous interpenetration of inner and outer worlds--the outer world contaminating the inner self, the self afraid of losing the precious "substance" that keeps it alive--play a significant role in Shakespeare's plays, specifically Hamlet and King Lear. It argues further that childhood dependence on a mother influences later feelings about the opposite sex and sexual conflicts revive early anxieties about autonomy and independence, so that the attempt to establish a proper balance between inner and outer worlds is inextricably tied (in the plays) to conceptions of sexual identity. In broader social terms, these plays reflect the problem of being (1) a separate, self-conscious individual at a time when the old values of an ordered, hierar"chical society were giving way to a new, middle-class, Protestant ethic of "individualism" and (2) a man at a time when sexual roles were becoming polarized in new ways. As the plays themselves imply--and as the paper tries to show--we can't understand the dilemmas of modern "individualism" without understanding the sexual parameters (learned in early childhood, reinforced by social experience) in terms of which these dilenrnas are lived out

Watery words : language, sexuality,and motherhood in Joyce's fiction

The idea of a dangerous, dirty, or lifegiving stream of water, bodily fluids, or even words -- as if words were the essence of life itself -- recurs throughout Joyce's work and becomes the prevailing, dominant metaphor of Finnegans Wake. Indeed, the maternal sea in which Stephen Dedalus fears he may drown is also the sordid, seductive, sustaining tide of life or language which the Joycean artist, absorbing it into himself, penetrated by it, transforms into art. In a sense, Joyce'.s selfconscious emphasis, in ° Finnegans Wake, on the "literalness" of language and the Itmetaphoricity" of relations between things is both "logocentric" and "deconstructive," preserving a delicate balance between the knowledge that words are signs which need to be interpreted (in the context, it would seem, of childhood relationships) and the fantasy that they are a magical essence which one needs, simply, to possess. What may disappoint us, however, is that Joyce's preoccupation both with language and with infantile fantasy is so repetitive, so monotonous, so obsessive. In attempting to deal with personal relationships and personal conflicts by these means, he also to some extent avoids them. This may be the legacy of a shame-ridden, sexually confused culture, whose fathers were often unable to be adequate fathers and whose mothers -- in carrying out the role of what they believed a "good mother" to be -- may not have been so good for their children after all

Predictive Second Order Sliding Control of Constrained Linear Systems with Application to Automotive Control Systems

This paper presents a new predictive second order sliding controller (PSSC) formulation for setpoint tracking of constrained linear systems. The PSSC scheme is developed by combining the concepts of model predictive control (MPC) and second order discrete sliding mode control. In order to guarantee the feasibility of the PSSC during setpoint changes, a virtual reference variable is added to the PSSC cost function to calculate the closest admissible set point. The states of the system are then driven asymptotically to this admissible setpoint by the control action of the PSSC. The performance of the proposed PSSC is evaluated for an advanced automotive engine case study, where a high fidelity physics-based model of a reactivity controlled compression ignition (RCCI) engine is utilized to serve as the virtual test-bed for the simulations. Considering the hard physical constraints on the RCCI engine states and control inputs, simultaneous tracking of engine load and optimal combustion phasing is a challenging objective to achieve. The simulation results of testing the proposed PSSC on the high fidelity RCCI model show that the developed predictive controller is able to track desired engine load and combustion phasing setpoints, with minimum steady state error, and no overshoot. Moreover, the simulation results confirm the robust tracking performance of the PSSC during transient operations, in the presence of engine cyclic variability.Comment: 6 pages, 5 figures, 2018 American Control Conferance (ACC), June 27-29, 2018, Milwaukee, WI, USA. [Accepted in Jan. 2018

Preinfection in vitro chemotaxis, phagocytosis, oxidative burst, and expression of CD11/CD18 receptors and their predictive capacity on the outcome of mastitis induced in dairy cows with Escherichia coli.

Four to 6 wk after parturition, 12 cows in second, fourth, or fifth lactation were experimentally infected in one gland with Escherichia coli. The capacity of chemotaxis, phagocytosis, oxidative burst, and expression of CD11/CD18 receptors to predict the severity of IMI was measured. Bacterial counts in the infected quarter, expressed as area under the curve, and residual milk production in the uninfected quarters were compared to determine severity of the infection. Although these two outcome parameters were highly negatively correlated, regression models with preinfection tests for leukocyte function fitted best with bacterial counts as an outcome parameter. Of the preinfection tests for leukocyte function, chemotaxis best predicted the outcome of the IMI that had been experimentally induced by E. coli. The number of circulating peripheral leukocytes just prior to inoculation was used to predict 52 and 45% of the severity of IMI for bacterial counts and residual milk production, respectively. As a categorical variable, parity predicted 75 and 56% of the severity of IMI expressed as bacterial counts and residual milk production, respectively. Because of the strong effect of parity on the outcome of the experimentally induced mastitis, analysis was performed to discriminate between second parity cows and older cows. Significant differences were found for the number of circulating peripheral leukocytes and for the expression of CD11b/CDl8 and CD11c/CD18 receptors between younger and older cows

Immediate early protein of equid herpesvirus type 1 as a target for cytotoxic T-lymphocytes in the thoroughbred horse

Cytotoxic T-lymphocytes (CTLs) are associated with protective immunity against disease caused by equid herpesvirus type 1 (EHV-1). However, the EHV-1 target proteins for CTLs are poorly defined. This limits the development of vaccine candidates designed to stimulate strong CTL immunity. Here, classical CTL assays using lymphocytes from horses of three defined MHC class I types that experienced natural infection with EHV-1 and a modified vaccinia virus construct containing an EHV-1 gene encoding the immediate-early (IE) protein are reported. Horses homozygous for the equine leukocyte antigen (ELA)-A2 haplotype, but not the ELA-A5 haplotype, produced MHC-restricted CTL responses against the IE protein. Previously, horses homozygous for the ELA-A3 haplotype also mounted CTL responses against the IE protein. Both haplotypes are common in major horse breeds, including the Thoroughbred. Thus, the IE protein is an attractive candidate molecule for future studies of T-cell immunity to EHV-1 in the horse

Eperythrozoonosis in Swine

Eperythrozoonosis means literally an infection with a parasite upon the erythrocytes. This appears to be a very common condition of swine in Kansas as indicated by the relative ease with which eperythrozoa can be recovered from adult hogs. Clinical evidence of this infection, referred to as acute eperythrozoonosis, occurs only sporadically. The acute condition is also known as icteroanemia, anaplasmosis-like disease, or yellow-belly of swine

The role of T cell subsets and cytokines in the regulation of intracellular bacterial infection

Cellular immune responses are a critical part of the host's defense against intracellular bacterial infections. Immunity to Brucella abortus crucially depends on antigen-specific T cell-mediated activation of macrophages, which are the major effectors of cell-mediated killing of this organism. T lymphocytes that proliferate in response to B. abortus were characterized for phenotype and cytokine activity. Human, murine, and bovine T lymphocytes exhibited a type 1 cytokine profile, suggesting an analogous immune response in these different hosts. In vivo protection afforded by a particular cell type is dependent on the antigen presented and the mechanism of antigen presentation. Studies using MHC class I and class II knockout mice infected with B. abortus have demonstrated that protective immunity to brucellosis is especially dependent on CD8+ T cells. To target MHC class I presentation we transfected ex vivo a murine macrophage cell line with B. abortus genes and adoptively transferred them to BALB/c mice. These transgenic macrophage clones induced partial protection in mice against experimental brucellosis. Knowing the cells required for protection, vaccines can be designed to activate the protective T cell subset. Lastly, as a new strategy for priming a specific class I-restricted T cell response in vivo, we used genetic immunization by particle bombardment-mediated gene transfer

7. Discovering Our Voice: A Manual to Accompany \u27Geraldo\u27

Geraldo is a story about what an immigrant undergoes when he leaves one culture and tries to \u27join\u27 another culture. An immigrant suffers a triple disruption: he loses his sense of place, he enters into an alien language, and he finds himself surrounded by beings whose social behavior, norms and traditions are very unlike, and sometimes even offensive to his own. The explanation of the leading ideas in this manual help students and teachers explore the philosophical themes in Geraldo. The discussion plans, exercises, and activities are designed to foster and cultivate the process of philosophical dialogue in the classroom.https://digitalcommons.montclair.edu/iapc_late_ele_curriculum/1004/thumbnail.jp

Getting heard? How employees learn to gain senior management attention in inclusive strategy processes

Research Summary: Recent trends toward inclusive strategy processes raise the issue of how employees acquire the discursive competence necessary to gain senior management attention. Building on the emergent dynamic attention‐based view's (DABV) emphasis on communicative interaction, we ethnographically track an inclusive strategy process in a large insurance company. We find that employees typically failed to gain CEO attention because they lacked the discursive competence to integrate their operational knowledge with the CEO's corporate themes. Employees acquired this competence by both experiential and vicarious learning. The CEO promoted employee learning more effectively by specific coaching than by generic coaching. We contribute primarily to the DABV by showing how interactions are sites for learning as well as communications and that communication channels can be both expandable and transparent.Managerial Summary: The benefits of increased employee inclusion in strategy processes depend upon participants being truly heard. This study of an inclusive strategy process in a large insurance company shows that top management attention to employee contributions cannot be assumed. Employees often fail to pitch ideas in a manner that top managers can work with. Employees learn to pitch ideas effectively both by receiving direct feedback from top management and by observing feedback on other employees' contributions. Top managers must also learn how to coach effectively, engaging with the specifics of employees' contributions rather than offering general advice. Designs for new inclusive strategy processes should include opportunities for top managers to improve their coaching and for employees to learn from both direct feedback and indirect observation