448 research outputs found

    Deutsch-russische Zusammenarbeit in der Arktis

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    Seit 1993 wird im Rahmen zweier vom BMBF geförderter Projekte die Laptevsee in der russischen Arktis (nicht nur) biologisch untersucht. Von 1993 - 1997 wurde das am Institut für Polarökologie angesiedelte Projekt. Deutsch - Russische Untersuchungen zur Ökologie der Randmeere der Eurasischen Arktis" mit insgesamt 1,5 Mio. DM gefördert. In einer zweiten Phase, die 199 8 begann, wurde die biologische Forschung in der Laptevsee mit veränderten Forschungsschwerpunkten als Teilprojekt in das Verbundvorhaben "System Laptevsee 2000" eingebettet. Im folgenden soll ein kurzer Uberblick über die biologischen Forschungsaktivitäten im Rahmen dieser Projekte gegeben werden

    Bericht über die ISPOL-Expedition ANT XXII/2

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    SModelS v1.0: a short user guide

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    SModelS is a tool for the automatic interpretation of simplified-model results from the LHC. Version 1.0 of the code is now publicly available. This document provides a quick user guide for installing and running SModelS v1.0.Comment: The code is available for download at http://smodels.hephy.at

    A platform to support object database research

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    Databases play a key role in an increasingly diverse range of applications and settings. New requirements are continually emerging and may differ substantially from one domain to another, sometimes even to the point of conflict. To address these challenges, database systems are evolving to cater for new application domains. Yet little attention has been given to the process of researching and developing database concepts in response to new requirements. We present a platform designed to support database research in terms of experimentation with different aspects of database systems ranging from the data model to the distribution architecture. Our platform is based on the notion of metamodel extension modules, inspired by proposals for adaptive and configurable database management systems. However, rather than building a tailored system from existing components, we focus on the process of designing new components. To qualitatively evaluate our platform, we present a series of case studies where our approach was used successfully to experiment with concepts designed to support a variety of novel application domains

    Non-verbal behavior of children who disclose or do not disclose child abuse in investigative interviews

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    Objective: The study focused on children’s nonverbal behavior in investigative interviews exploring suspicions of child abuse. The key aims were to determine whether non-verbal behavior in the pre-substantive phases of the interview predicted whether or not children would disclose the alleged abuse later in the interview and to identify differences in the nonverbal behaviors of disclosing and non-disclosing children. Method: We studied DVD-recorded interviews of 40 alleged victims of child abuse. In all cases, there was external evidence strongly suggesting that abuse had occurred. However, half of the children disclosed abuse when interviewed using the NICHD Investigative Interview Protocol, whereas the other half did not. Two raters, unaware whether or not the children disclosed, independently coded the videotapes for nonverbal indices of positive and negative emotions, stress, and physical disengagement in each 15-second unit of the introductory, rapport building, and substantive interview phases. Results: Indicators of stress and physical disengagement increased as the interviews progressed while indices of positive emotions decreased. Non-disclosers showed proportionately more physical disengagement than disclosers in both the introductory and substantive phases. Conclusions: Awareness of non-verbal behavior may help investigators identify reluctant children early in forensic interviews. Practice implications: There is substantial evidence that, when questioned by investigators, many children do not disclose that they have been abused. The early detection of reluctance to disclose may allow interviewers to alter their behavior, helping the children overcome their reluctance by providing non-suggestive support before the possibility of abuse is discussed. Of course, nonverbal behavior alone should not be used to assess children in investigative interviews. However, nonverbal cues may nonetheless provide additional information to interviewers and assist them in identifying reluctant children

    Content warehouses

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    Nowadays, content management systems are an established technology. Based on the experiences from several application scenarios we discuss the points of contact between content management systems and other disciplines of information systems engineering like data warehouses, data mining, and data integration. We derive a system architecture called "content warehouse" that integrates these technologies and defines a more general and more sophisticated view on content management. As an example, a system for the collection, maintenance, and evaluation of biological content like survey data or multimedia resources is shown as a case study

    An Investigation into Creep Cavity Development in 316H Stainless Steel

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    Creep-induced cavitation is an important failure mechanism in steel components operating at high temperature. Robust techniques are required to observe and quantify creep cavitation. In this paper, the use of two complementary analysis techniques: small-angle neutron scattering (SANS), and quantitative metallography, using scanning electron microscopy (SEM), is reported. The development of creep cavities that is accumulated under uniaxial load has been studied as a function of creep strain and life fraction, by carrying out interrupted tests on two sets of creep test specimens that are prepared from a Type-316H austenitic stainless steel reactor component. In order to examine the effects of pre-strain on creep damage formation, one set of specimens was subjected to a plastic pre-strain of 8%, and the other set had no pre-strain. Each set of specimens was subjected to different loading and temperature conditions, representative of those of current and future power plant operation. Cavities of up to 300 nm in size are quantified by using SANS, and their size distribution, as a function of determined creep strain. Cavitation increases significantly as creep strain increases throughout creep life. These results are confirmed by quantitative metallography analysis

    Role of Src and Cortactin in Pemphigus Skin Blistering

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    Autoantibodies against desmoglein (Dsg) 1 and Dsg3 primarily cause blister formation in the autoimmune disease pemphigus vulgaris (PV). Src was proposed to contribute to loss of keratinocyte cohesion. However, the role and underlying mechanisms are unclear and were studied here. In keratinocytes, cell cohesion in response to autoantibodies was reduced in Src-dependent manner by two patient-derived PV-IgG fractions as well as by AK23 but not by a third PV-IgG fraction, although Src was activated by all autoantibodies. Loss of cell cohesion was progredient in a timeframe of 24 h and AK23, similar to PV-IgG, interfered with reconstitution of cell cohesion after Ca2+-switch, indicating that the autoantibodies also interfered with desmosome assembly. Dsg3 co-localized along cell contacts and interacted with the Src substrate cortactin. In keratinocytes isolated from cortactin-deficient mice, cell adhesion was impaired and Src-mediated inhibition of AK23-induced loss of cell cohesion for 24 h was significantly reduced compared to wild-type (wt) cells. Similarly, AK23 impaired reconstitution of cell adhesion was Src-dependent only in the presence of cortactin. Likewise, Src inhibition significantly reduced AK23-induced skin blistering in wt but not cortactin-deficient mice. These data suggest that the Src-mediated long-term effects of AK23 on loss of cell cohesion and skin blistering are dependent on cortactin-mediated desmosome assembly. However, in human epidermis PV-IgG-induced skin blistering and ultrastructural alterations of desmosomes were not affected by Src inhibition, indicating that Src may not be critical for skin blistering in intact human skin, at least when high levels of autoantibodies targeting Dsg1 are present
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