Intervenção psicossocial em grupo de mulheres gestantes do Centro de Saúde da Mulher de Cacoal-RO

Apresentam-se os resultados de uma Intervenção Psicossocial de curta duração, junto a um grupo de mulheres gestantes usuárias do Sistema público de saúde, na cidade de Cacoal-RO.  Utilizando-se uma Intervenção Psicossocial, metodologia participativa e dinâmica, sobre temas:  gravidez, autoestima, cuidados com o corpo, sexualidade; percebeu-se uma produção discursivo subjetiva compreensiva e expressiva de sentimentos e experiências em torno da gravidez; percebeu se, ainda, maior autoconfiança e disposição para o enfrentamento da realidade, com repercussões diretas na sua autoestima. A metodologia escolhida pode favorecer aos integrantes do grupo a condição de sujeitos portadores de saberes sobre suas condições de vida, onde o facilitador tem o papel de incentivador, sistematizador, de apoio reflexivo e de informação, favorecendo que o encontro alcance uma dimensão pedagógica e terapêutica. Finalmente, defende-se a viabilidade e efetividade da intervenção psicossocial em pequenos grupos, em espaços institucionais, como modalidade de prevenção, educação e promoção da saúde

Study of comparative bioavailability among two formulations containing hydroxyzine hydrochloride in healthy volunteers after a single dose administration

The study was performed to compare the bioavailability of two hydroxyzine hydrochloride 25 mg tablet formulation in 16 volunteers of both sexes. The study was conducted open with randomized two period crossover design and a two weeks wash out period. Plasma samples were obtained over a 96 h interval. Hydroxyzine concentrations were analyzed by Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS). Bioequivalence between the products was determined by calculating 90 % confidence intervals (90 % I.C) for the ratio of AUC0-t , AUC0-inf and Cmax values for the test and reference products, using logarithmic transformed data. The 90 % confidence intervals were 81.89-105.85 %, 84.61-105.30 %, and 84.04-108.66 %, respectively. Since the 90 % confidence intervals for Cmax , AUC0-t and AUC0-inf were within the 80-125 % interval proposed by the Food and Drug Administration, it was concluded that the two hydroxyzine hydrochloride formulations are bioequivalent in their rate and extent of absorption.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Study of comparative bioavailability among two formulations containing hydroxyzine hydrochloride in healthy volunteers after a single dose administration

The study was performed to compare the bioavailability of two hydroxyzine hydrochloride 25 mg tablet formulation in 16 volunteers of both sexes. The study was conducted open with randomized two period crossover design and a two weeks wash out period. Plasma samples were obtained over a 96 h interval. Hydroxyzine concentrations were analyzed by Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS). Bioequivalence between the products was determined by calculating 90 % confidence intervals (90 % I.C) for the ratio of AUC0-t , AUC0-inf and Cmax values for the test and reference products, using logarithmic transformed data. The 90 % confidence intervals were 81.89-105.85 %, 84.61-105.30 %, and 84.04-108.66 %, respectively. Since the 90 % confidence intervals for Cmax , AUC0-t and AUC0-inf were within the 80-125 % interval proposed by the Food and Drug Administration, it was concluded that the two hydroxyzine hydrochloride formulations are bioequivalent in their rate and extent of absorption.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Oficina: Alfabetização Digital

O objetivo da oficina é ensinar para as crianças de ensino fundamental a utilização de recursos computacionais a seu favor, afim de desenvolver a lógica de raciocínio para a resolução de problemas habituais. Para tanto, buscar-se-á: - Alfabetizar o indivíduo com recursos computacionais básicos para a resolução de problemas habituais utilizando software. - Instruir os alunos nas ferramentas e demonstrar como podem ser utilizadas no cotidiano escolar. - Demonstrar que tais recursos computacionais estão presentes em qualquer software do gênero, independente de versão ou modelo. - Demonstrar conceitos, tendo como base o letramento caminhando em paralelo com a alfabetização digital. - Praticar exercícios básicos de digitação afim de desenvolver coordenação motora na utilização do teclado de um computador, assim como seus atalhos (exemplificando: ctrl+c. ctrl+v, alt gr.

Health literacy: importance of assessment in nephrology

Health literacy (HL) or basic reading and numeracy that allow an individual to function in the health care environment, is a relatively new topic, yet has increasingly been gaining interest over the past few years both in the research and policy agendas, particularly in the develop countries. Where studied, inadequate HL has been associated with poor health care quality and more cost. Yet many physicians do not recognize the problem or is not skilled enough to approach the subject with their patients. In this review, important aspects of HL, such as its epidemiology, associations with poor outcomes, assessment, determinants and interventions, particularly in nephrology, are discussed. Because it is common and associated to adverse clinical outcomes, inadequate HL should be incorporated into the list of assessments of patients with renal disease.Letramento em Saúde (LS) ou habilidade de leitura e numeramento que permite ao indivíduo transitar no ambiente de saúde, é um tema relativamente novo e que vem ganhando espaço nas agendas de pesquisa e política de saúde, particularmente nos países desenvolvidos. Onde estudado, o LS inadequado associa-se com cuidados de saúde de pior qualidade e maior custo. Mesmo assim, a maioria dos médicos não conseguem identificar o problema e não têm preparo para lidar com o paciente que apresenta LS inadequado. Na presente revisão, os autores discutem aspectos importantes do LS, tais como a sua epidemiologia, associações com desfechos clínicos, avaliação, determinantes e oportunidades de intervenções, particularmente na nefrologia. Por ser comum e associar-se com desfechos clínicos indesejáveis, o LS inadequado deveria ser regularmente avaliado nos pacientes com doença renal

Ultrasound-Assisted Preparation of Brazil Nut Oil-in-Water Emulsions Stabilized by Arabic Gum

 The objective of this work is to evaluate the stability of Brazil nut oil emulsions with gum Arabic using ultrasound-assisted homogenization. The emulsions were prepared in a completely randomized design varying the time (2 and 4 min) and the ultrasound power (30 and 40%). The physicochemical properties of the emulsions (pH, conductivity, turbidity, zeta potential, surface tension, rheology and optical microscopy) were evaluated after the homogenization process and 4 hours later. The results showed that more energetic homogenization processes (longer duration and higher ultrasound power) favored the physicochemical properties, keeping the emulsions more stable. Thus, Brazil nut oil emulsions prepared with ultrasound-assisted showed good physic-chemical characteristics that can guarantee good emulsion stability during spray drying, guaranteeing efficiency and protection of the physical and chemical properties of the Brazil nut oil

Study of comparative bioavailability among two formulations containing hydroxyzine hydrochloride in healthy volunteers after a single dose administration

The study was performed to compare the bioavailability of two hydroxyzine hydrochloride 25 mg tablet formulation in 16 volunteers of both sexes. The study was conducted open with randomized two period crossover design and a two weeks wash out period. Plasma samples were obtained over a 96 h interval. Hydroxyzine concentrations were analyzed by Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS). Bioequivalence between the products was determined by calculating 90 % confidence intervals (90 % I.C) for the ratio of AUC0-t , AUC0-inf and Cmax values for the test and reference products, using logarithmic transformed data. The 90 % confidence intervals were 81.89-105.85 %, 84.61-105.30 %, and 84.04-108.66 %, respectively. Since the 90 % confidence intervals for Cmax , AUC0-t and AUC0-inf were within the 80-125 % interval proposed by the Food and Drug Administration, it was concluded that the two hydroxyzine hydrochloride formulations are bioequivalent in their rate and extent of absorption.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Identification of Eschweilenol C in derivative of Terminalia fagifolia Mart. and green synthesis of bioactive and biocompatible silver nanoparticles

A green synthetic route was developed to prepare silver nanoparticles (AgNPs) in aqueous solution for biological applications. Eschweilenol C, a compound derivative ellagic acid was identified as the main constituent of the aqueous fraction of the ethanolic extract of Terminalia fagifolia Mart. by NMR analysis. In the green synthesis, the ethanolic extract of T. fagifolia and its aqueous fraction were used to promote silver reduction and nanoparticle stabilization. The synthesized AgNPs presented a spherical or polygonal morphology shape by TEM analysis and AgNPs showed high levels of antioxidant and considerable antibacterial and antifungal activities. Synthesized nanoparticles presented significant antioxidant activity by sequestration of DPPH and ABTS radicals, in addition to iron reduction (FRAP assay) and measurement of antioxidant capacity in ORAC units, in addition, AgNP synthesized with the aqueous fraction also demonstrated antioxidant potential in microglial cells. Gram-positive and Gram-negative bacteria were susceptible to growth inhibition by the nanoparticles, among which the AgNPs formed by the ethanolic extract was the most effective. The data obtained by AFM images suggested that AgNPs could lead to the lysis of bacteria and subsequent death. The antifungal assays showed high efficiency against yeasts and dermatophytes. This work represents the first description of antifungal activity by AgNPs against Fonsecaea pedrosoi, the etiologic agent of chromoblastomycosis. In relation to biocompatibility, the AgNPs induced lower haemolysis than AgNO3.We thank Herbert Kogler and Reinhard Wimmer for the identification of Eschweilenol C. The NMR laboratory at Aalborg University is supported by the Obel Family, SparNord and Carlsberg foundations.The authors are grateful to Carla Eiras (LIMAV/CT/UFPI) and to FCT and EU for financial support through project UID/QUI/50006/2013– POCI-01-0145-FEDER-007265 from COMPETE and projectNORTE-01-0145-FEDER-000011 from COMPETE. Thanks to Andreia Pinto for help with the TEM measurements at Instituto de Medicina Molecular (IMM). This work was supported by the Histology and Comparative Pathology Laboratory of the IMMinfo:eu-repo/semantics/publishedVersio