ENSINO DE SISTEMA ORTOGONAL DE COORDENADAS CARTESIANAS COM A UTILIZAÇÃO DE UM JOGO DIDÁTICO

Jogos didáticos têm sido utilizados como mediadores no processo de ensino-aprendizagem da matemática. O uso dessa ferramenta pedagógica pode favorecer o desenvolvimento de diversas habilidades importantes para formação do indivíduo. O presente trabalho teve por objetivo descrever uma experiência de ensino com a utilização de um jogo para introduzir sistema ortogonal de coordenadas cartesianas. A experiência foi realizada por meio da aplicação de uma atividade a alunos do primeiro ano do Ensino Médio de uma escola estadual de Dourados/MS, no âmbito do subprojeto Licenciatura em Matemática do Programa Institucional de Bolsa de Iniciação à Docência (PIBID) da Universidade Federal da Grande Dourados (UFGD). Os resultados observados foram positivos e indicaram que a aplicação de metodologias interativas utilizando jogos pode proporcionar um ambiente de ensino-aprendizagem mais significativo. Palavras-chave: Jogos didáticos, Ensino, Coordenadas Cartesianas

Health-related quality of life in patients with type 1 diabetes mellitus in the different geographical regions of Brazil : data from the Brazilian Type 1 Diabetes Study Group

Background: In type 1 diabetes mellitus (T1DM) management, enhancing health-related quality of life (HRQoL) is as important as good metabolic control and prevention of secondary complications. This study aims to evaluate possible regional differences in HRQoL, demographic features and clinical characteristics of patients with T1DM in Brazil, a country of continental proportions, as well as investigate which variables could influence the HRQoL of these individuals and contribute to these regional disparities. Methods: This was a retrospective, cross-sectional, multicenter study performed by the Brazilian Type 1 Diabetes Study Group (BrazDiab1SG), by analyzing EuroQol scores from 3005 participants with T1DM, in 28 public clinics, among all geographical regions of Brazil. Data on demography, economic status, chronic complications, glycemic control and lipid profile were also collected. Results: We have found that the North-Northeast region presents a higher index in the assessment of the overall health status (EQ-VAS) compared to the Southeast (74.6 ± 30 and 70.4 ± 19, respectively; p < 0.05). In addition, North- Northeast presented a lower frequency of self-reported anxiety-depression compared to all regions of the country (North-Northeast: 1.53 ± 0.6; Southeast: 1.65 ± 0.7; South: 1.72 ± 0.7; Midwest: 1.67 ± 0.7; p < 0.05). These findings could not be entirely explained by the HbA1c levels or the other variables examined. Conclusions: Our study points to the existence of additional factors not yet evaluated that could be determinant in the HRQoL of people with T1DM and contribute to these regional disparities

Análise comparativa de propriedades mecânicas e de durabilidade de argamassas de revestimento mistas e aditivadas

Exportado OPUSMade available in DSpace on 2019-08-14T02:52:45Z (GMT). No. of bitstreams: 1 mestrado_alessandra_tolentino_souza___versao_final_v5.pdf: 3839153 bytes, checksum: bf42ddee419fb0c75b77c7e1561b2004 (MD5) Previous issue date: 21Este estudo teve por finalidade analisar a influência de um conjunto de aditivos, usando como referência a argamassa mista de cal, para estabelecer uma proporção adequada de aditivos que forneça propriedades satisfatórias assim como a argamassa mista. Para atingir o objetivo, foi dosado um traço de argamassa mista utilizando areia natural, cimento CP II-F 32 e cal CHI, conforme a metodologia de SANTOS (2014). A seguir, tomando como base o traço misto, foi dosado o traço aditivado retirando a cal e adicionando diferentes proporções dos aditivos: retentor de água (R), incorporador de ar (I) e plastificante (P), conforme estabelecido pela metodologia SIMPLEX. Com os traços estabelecidos, foram realizados testes de consistência, densidade no estado fresco e endurecido, retenção de água, módulo de elasticidade, resistência à tração na flexão, à compressão, e de aderência à tração, absorção de água por imersão e por capilaridade, porosidade, ensaio de envelhecimento adaptado e análise da microestrutura através de microscópio digital. Ao fim deste estudo, ficou evidenciado que: o ar incorporado teórico e a porosidade total foram diretamente influenciados pelo aumento do I; a densidade no estado fresco e endurecido, e a porosidade aberta foram inversamente influenciadas por I, e diretamente por P; a resistência de aderência da argamassa aditivada (50%P + 50%R) apresentou resultado equiparado ao da argamassa mista, ressalta-se que apenas o uso do incorporador de ar ou do plastificante apresentou resultado insatisfatório; as resistências mecânicas foram diretamente influenciadas pelo uso do P; e o aumento do custo dos materiais das argamassas aditivadas ficou diretamente relacionado com o maior teor de R, mesmo assim foi mais barato que o custo de materiais da argamassa mista com cal. Constatou-se, por fim, a possibilidade (técnica e econômica) de substituir a argamassa mista por um traço de argamassa aditivado (50%P + 50%R) tão eficiente quanto a argamassa mista estudada.The purpose of this study was to analyze the influence of a set of additives in mortar coating, using mixed lime mortar as reference. To achieve this objective an adequate proportion of mortar was dosed, using natural sand, CP II-F 32 cement and CH I hydraulic lime, via SANTOS (2014) methodology. Afterwards, based on the hydraulic lime proportion the additive mortar proportion was dosed, adding different proportions of additives: water retainer (R), air entraining agent (I) and plasticizer (P), as established by SIMPLEX methodology. With the appropriate proportions some tests were conducted: consistency, density in the fresh and hardened state, water retention, modulus of elasticity, tensile strength in flexion, compression, adherence, water absorption by immersion and by capillarity, porosity, adapted aging test, and analysis of the microstructure through a digital microscope. At the end of this study, it was evidenced that: entrained air and total porosity were directly influenced by the increase of the air entraining agent; the density in fresh and hardned state and open porosity were inversely influenced by the air entraining, and directly by the plasticizer; using only air entraining or plasticizer presented an unsatisfactory adherences result, the highest result were with 50%P + 50%R, being this result as high as the one of mixed mortar; the mechanical resistance were directly influenced by the use of plasticizer; and the cost of materials were directly influenced by water retainer, however it was cheaper than mixed mortars cost of materials. In the end, it was verified the possibility (technical and economical) of replacing the mixed mortar with the additive mortar (50%P + 50%R) as efficiente as the mixed mortar studied

Análise da influência do tipo de agregado miúdo nas características e dosagem de argamassas mistas

As argamassas de revestimento e assentamento de alvenaria com uso de areia artificial de britagem tem se tornado uma alternativa viável nos últimos anos, contudo têm-se grandes divergências quanto a preceitos de dosagem adequada para esses materiais. Diante disso, este trabalho objetiva estudar argamassas mistas de revestimento e assentamento de alvenaria com areia artificial de britagem e areia natural, de forma a avaliar os efeitos desses agregados em propriedades do estado fresco e endurecido sob análise de um processo de dosagem mais eficiente. Foram realizados ensaios de teor de ar incorporado; resistências à compressão, tração na flexão e aderência; módulo de elasticidade; absorção de água; porosidade; fissurabilidade e testes estatísticos em três idades (14, 28 e 85 dias). Empregou-se CP-II-E-32, cal CH-I, areia artificial de britagem de gnaisse e areia natural quartzosa. Percebe-se que o tipo de agregado influencia significantemente nas propriedades analisadas e que se necessita de um método de dosagem que considere esses preceitos/condições para obtenção de argamassas mistas de boa qualidade e de acordo com as condições de uso

Synthesis, Cytotoxicity and Mechanistic Evaluation of 4-Oxoquinoline-3-carboxamide Derivatives: Finding New Potential Anticancer Drugs

Made available in DSpace on 2015-05-04T16:34:31Z (GMT). No. of bitstreams: 2 license.txt: 1914 bytes, checksum: 7d48279ffeed55da8dfe2f8e81f3b81f (MD5) floriano_silvajretal_IOC_2014.pdf: 1412917 bytes, checksum: efe4a373bbf1ee3722bc9e0e8338d523 (MD5) Previous issue date: 2014Universidade Federal Fluminense. Outeiro de São João Batista. Niterói, Brasil.Universidade Federal Fluminense. Outeiro de São João Batista. Niterói, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Modelagem Molecular e 3D QSAR (ModMolQSAR). Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. LABIEMol. Outeiro de São João Batista. Niterói, RJ, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Belém, PA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Proteinas e Peptídeos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Proteinas e Peptídeos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Proteinas e Peptídeos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Belém, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Belém, PA, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Modelagem Molecular e 3D QSAR (ModMolQSAR). Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Modelagem Molecular e 3D QSAR (ModMolQSAR). Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Outeiro de São João Batista. Niterói, Brasil.Universidade Federal Fluminense. Outeiro de São João Batista. Niterói, Brasil.Universidade Federal Fluminense. Outeiro de São João Batista. Niterói, Brasil.Universidade Federal Fluminense. Outeiro de São João Batista. Niterói, Brasil.As part of a continuing search for new potential anticancer candidates, we describe the synthesis, cytotoxicity and mechanistic evaluation of a series of 4-oxoquinoline-3-carboxamide derivatives as novel anticancer agents. The inhibitory activity of compounds 10–18 was determined against three cancer cell lines using the MTT colorimetric assay. The screening revealed that derivatives 16b and 17b exhibited significant cytotoxic activity against the gastric cancer cell line but was not active against a normal cell line, in contrast to doxorubicin, a standard chemotherapeutic drug in clinical use. Interestingly, no hemolytical activity was observed when the toxicity of 16b and 17b was tested against blood cells. The in silico and in vitro mechanistic evaluation indicated the potential of 16b as a lead for the development of novel anticancer agents against gastric cancer cells

Health-related quality of life in patients with type 1 diabetes mellitus in the different geographical regions of Brazil : data from the Brazilian Type 1 Diabetes Study Group

Background: In type 1 diabetes mellitus (T1DM) management, enhancing health-related quality of life (HRQoL) is as important as good metabolic control and prevention of secondary complications. This study aims to evaluate possible regional differences in HRQoL, demographic features and clinical characteristics of patients with T1DM in Brazil, a country of continental proportions, as well as investigate which variables could influence the HRQoL of these individuals and contribute to these regional disparities. Methods: This was a retrospective, cross-sectional, multicenter study performed by the Brazilian Type 1 Diabetes Study Group (BrazDiab1SG), by analyzing EuroQol scores from 3005 participants with T1DM, in 28 public clinics, among all geographical regions of Brazil. Data on demography, economic status, chronic complications, glycemic control and lipid profile were also collected. Results: We have found that the North-Northeast region presents a higher index in the assessment of the overall health status (EQ-VAS) compared to the Southeast (74.6 ± 30 and 70.4 ± 19, respectively; p < 0.05). In addition, North- Northeast presented a lower frequency of self-reported anxiety-depression compared to all regions of the country (North-Northeast: 1.53 ± 0.6; Southeast: 1.65 ± 0.7; South: 1.72 ± 0.7; Midwest: 1.67 ± 0.7; p < 0.05). These findings could not be entirely explained by the HbA1c levels or the other variables examined. Conclusions: Our study points to the existence of additional factors not yet evaluated that could be determinant in the HRQoL of people with T1DM and contribute to these regional disparities

Health-related quality of life in patients with type 1 diabetes mellitus in the different geographical regions of Brazil : data from the Brazilian Type 1 Diabetes Study Group

Background: In type 1 diabetes mellitus (T1DM) management, enhancing health-related quality of life (HRQoL) is as important as good metabolic control and prevention of secondary complications. This study aims to evaluate possible regional differences in HRQoL, demographic features and clinical characteristics of patients with T1DM in Brazil, a country of continental proportions, as well as investigate which variables could influence the HRQoL of these individuals and contribute to these regional disparities. Methods: This was a retrospective, cross-sectional, multicenter study performed by the Brazilian Type 1 Diabetes Study Group (BrazDiab1SG), by analyzing EuroQol scores from 3005 participants with T1DM, in 28 public clinics, among all geographical regions of Brazil. Data on demography, economic status, chronic complications, glycemic control and lipid profile were also collected. Results: We have found that the North-Northeast region presents a higher index in the assessment of the overall health status (EQ-VAS) compared to the Southeast (74.6 ± 30 and 70.4 ± 19, respectively; p < 0.05). In addition, North- Northeast presented a lower frequency of self-reported anxiety-depression compared to all regions of the country (North-Northeast: 1.53 ± 0.6; Southeast: 1.65 ± 0.7; South: 1.72 ± 0.7; Midwest: 1.67 ± 0.7; p < 0.05). These findings could not be entirely explained by the HbA1c levels or the other variables examined. Conclusions: Our study points to the existence of additional factors not yet evaluated that could be determinant in the HRQoL of people with T1DM and contribute to these regional disparities

Neotropical freshwater fisheries : A dataset of occurrence and abundance of freshwater fishes in the Neotropics

The Neotropical region hosts 4225 freshwater fish species, ranking first among the world's most diverse regions for freshwater fishes. Our NEOTROPICAL FRESHWATER FISHES data set is the first to produce a large-scale Neotropical freshwater fish inventory, covering the entire Neotropical region from Mexico and the Caribbean in the north to the southern limits in Argentina, Paraguay, Chile, and Uruguay. We compiled 185,787 distribution records, with unique georeferenced coordinates, for the 4225 species, represented by occurrence and abundance data. The number of species for the most numerous orders are as follows: Characiformes (1289), Siluriformes (1384), Cichliformes (354), Cyprinodontiformes (245), and Gymnotiformes (135). The most recorded species was the characid Astyanax fasciatus (4696 records). We registered 116,802 distribution records for native species, compared to 1802 distribution records for nonnative species. The main aim of the NEOTROPICAL FRESHWATER FISHES data set was to make these occurrence and abundance data accessible for international researchers to develop ecological and macroecological studies, from local to regional scales, with focal fish species, families, or orders. We anticipate that the NEOTROPICAL FRESHWATER FISHES data set will be valuable for studies on a wide range of ecological processes, such as trophic cascades, fishery pressure, the effects of habitat loss and fragmentation, and the impacts of species invasion and climate change. There are no copyright restrictions on the data, and please cite this data paper when using the data in publications