Effects of a low-carbohydrate diet on body composition and performance in road cycling: A randomized, controlled trial

Low-carbohydrate diets are frequently used to improve performance in endurance sports, often with contradictory results. This study aimed to assess whether a low-carbohydrate diet can outperform an isocaloric conventional diet for improving body composition and performance in a sample of twenty-six trained male road cyclists (previous experience in cyclosportive events, 7.6 ± 4.4 years; age, 26.9 ± 4.9 years; weekly training volume, 7.8 ± 2.9 hours; height, 176 ± 7 centimeters; body fat percentage, 9.7 ± 0.8 %; weight, 65.3 ± 2.3 kg). Detraining and pre-treatment periods in which nutrition and training were standardized were followed by an eight-week long intervention in which cyclists consumed either a low-carbohydrate diet (15 % of calories from carbohydrates) or a conventional endurance sports diet while maintaining the same training volumes and intensities. Body composition was assessed through electrical impedance, and performance was evaluated through a twenty-minute time trial performed on a smart bike trainer. The results revealed an overall improvement over time in absolute and relative power, body mass, and body fat for both groups, whilst the improvement in absolute power was comparable. The improvements seen in relative power (p = 0.042), body mass (p = 0.006), and body fat (p = 0.01) were significantly higher in the low-carbohydrate group. We concluded that eight weeks of a low-carbohydrate diet significantly reduced body weight and body fat percentage, and improved 20-minute relative power values in a sample of road cyclists when compared to an isocaloric conventional diet. Las dietas bajas en carbohidratos se usan con frecuencia para mejorar el rendimiento en los deportes de resistencia, a menudo con resultados contradictorios. Este estudio tuvo como objetivo evaluar si una dieta baja en carbohidratos puede superar a una dieta convencional isocalórica para mejorar la composición corporal y el rendimiento en una muestra de veintiséis ciclistas de carretera masculinos entrenados (experiencia previa en eventos cicloportivos, 7, 6 ± 4, 4 años; edad, 26, 9 ± 4, 9 años; volumen de entrenamiento semanal, 7, 8 ± 2, 9 horas; altura, 176 ± 7 centímetros; porcentaje de grasa corporal, 9, 7 ± 0, 8 %; peso, 65, 3 ± 2, 3 kg). Los períodos de desentrenamiento y pretratamiento, en los que se estandarizaron la nutrición y el entrenamiento, fueron seguidos por una intervención de ocho semanas de duración en la que los ciclistas consumieron una dieta de bajo contenido en carbohidratos (15 % de calorías de los carbohidratos) o una dieta convencional para deportes de resistencia, manteniendo los mismos volúmenes de entrenamiento e intensidades. La composición corporal se evaluó a través de la impedancia eléctrica y el rendimiento se evaluó a través de una prueba contrarreloj de veinte minutos realizada en un rodillo de bicicleta inteligente. Los resultados revelaron una mejora general en el tiempo en cuanto a potencia absoluta y relativa, masa corporal y grasa corporal para ambos grupos, mientras que la mejora en potencia absoluta fue comparable. Las mejoras de la potencia relativa (p = 0, 042), la masa corporal (p = 0, 006) y la grasa corporal (p = 0, 01) fueron significativamente mayores en el grupo bajo en carbohidratos. Se concluye que ocho semanas de una dieta baja en carbohidratos redujeron significativamente el peso corporal y el porcentaje de grasa corporal, y mejoraron los valores de potencia relativa de 20 minutos en una muestra de ciclistas de carretera en comparación con una dieta convencional isocalórica

A Novel TGFβ Modulator that Uncouples R-Smad/I-Smad-Mediated Negative Feedback from R-Smad/Ligand-Driven Positive Feedback

As some of the most widely utilised intercellular signalling molecules, transforming growth factor β (TGFβ) superfamily members play critical roles in normal development and become disrupted in human disease. Establishing appropriate levels of TGFβ signalling involves positive and negative feedback, which are coupled and driven by the same signal transduction components (R-Smad transcription factor complexes), but whether and how the regulation of the two can be distinguished are unknown. Genome-wide comparison of published ChIP-seq datasets suggests that LIM dom

Obtention and characterization of coconut babassu derivatives

Babassu (Orbignya sp.) is a palm with extraordinary socioeconomic and ecologic importance found in humid tropical areas in Brazil, especially in frequently burned and degraded landscapes. There are several uses for babassu oil; however, its potential for providing other industrial products remains unexploited, due to the lack of scale and production structure. Oil and presscake extracted from kernels are industrially produced, while the remaining parts of the babassu coconut have the potential to add value as byproducts. This study aimed to establish conditions for the preparation of the raw material fruit of babassu for oil extraction by pressing and producing biodiesel by ethanolic transesterification. Babassu coconuts were dried at 75 and 90 °C. The separation of the fractions rich in fiber, starch, kernel and mesocarp was performed in appropriate equipments. The starch content in the mesocarp fractions of babassu coconuts dried at 75 and at 90 °C were 54 and 56 %, respectively and lipids represented 65 % of the kernel. Oil and press cake were obtained through hydraulic and continuous press, biodiesel was produced and the quality of products was compared. The total of saturated fatty acid in babassu oil was between 78 and 82 %, and the total of unsaturated fatty acids that promote good oxidative stability in the oil was in the range of 17 to 20 %. Oil obtained by cold pressing extraction and its biodiesel had better results in terms of quality. The quality of oils is within the Codex standard and biodiesel from oil extracted by cold pressing had higher oxidative stability

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Measurement of forward charged hadron flow harmonics in peripheral PbPb collisions at √sNN = 5.02 TeV with the LHCb detector

Flow harmonic coefficients, v n , which are the key to studying the hydrodynamics of the quark-gluon plasma (QGP) created in heavy-ion collisions, have been measured in various collision systems and kinematic regions and using various particle species. The study of flow harmonics in a wide pseudorapidity range is particularly valuable to understand the temperature dependence of the shear viscosity to entropy density ratio of the QGP. This paper presents the first LHCb results of the second- and the third-order flow harmonic coefficients of charged hadrons as a function of transverse momentum in the forward region, corresponding to pseudorapidities between 2.0 and 4.9, using the data collected from PbPb collisions in 2018 at a center-of-mass energy of 5.02 TeV . The coefficients measured using the two-particle angular correlation analysis method are smaller than the central-pseudorapidity measurements at ALICE and ATLAS from the same collision system but share similar features

Helium identification with LHCb

The identification of helium nuclei at LHCb is achieved using a method based on measurements of ionisation losses in the silicon sensors and timing measurements in the Outer Tracker drift tubes. The background from photon conversions is reduced using the RICH detectors and an isolation requirement. The method is developed using pp collision data at √(s) = 13 TeV recorded by the LHCb experiment in the years 2016 to 2018, corresponding to an integrated luminosity of 5.5 fb-1. A total of around 105 helium and antihelium candidates are identified with negligible background contamination. The helium identification efficiency is estimated to be approximately 50% with a corresponding background rejection rate of up to O(10^12). These results demonstrate the feasibility of a rich programme of measurements of QCD and astrophysics interest involving light nuclei

Curvature-bias corrections using a pseudomass method

Momentum measurements for very high momentum charged particles, such as muons from electroweak vector boson decays, are particularly susceptible to charge-dependent curvature biases that arise from misalignments of tracking detectors. Low momentum charged particles used in alignment procedures have limited sensitivity to coherent displacements of such detectors, and therefore are unable to fully constrain these misalignments to the precision necessary for studies of electroweak physics. Additional approaches are therefore required to understand and correct for these effects. In this paper the curvature biases present at the LHCb detector are studied using the pseudomass method in proton-proton collision data recorded at centre of mass energy √(s)=13 TeV during 2016, 2017 and 2018. The biases are determined using Z→μ + μ - decays in intervals defined by the data-taking period, magnet polarity and muon direction. Correcting for these biases, which are typically at the 10-4 GeV-1 level, improves the Z→μ + μ - mass resolution by roughly 18% and eliminates several pathological trends in the kinematic-dependence of the mean dimuon invariant mass

Study of CP violation in B0 → DK⋆(892)0 decays with D → Kπ(ππ), ππ(ππ), and KK final states

A measurement of CP-violating observables associated with the interference of B0 → D0K⋆ (892)0 and B0 → D¯ 0K⋆ (892)0 decay amplitudes is performed in the D0 → K∓π ±(π +π −), D0 → π +π −(π +π −), and D0 → K+K− fnal states using data collected by the LHCb experiment corresponding to an integrated luminosity of 9 fb−1 . CP-violating observables related to the interference of B0 s → D0K¯ ⋆ (892)0 and B0 s → D¯ 0K¯ ⋆ (892)0 are also measured, but no evidence for interference is found. The B0 observables are used to constrain the parameter space of the CKM angle γ and the hadronic parameters r DK⋆ B0 and δ DK⋆ B0 with inputs from other measurements. In a combined analysis, these measurements allow for four solutions in the parameter space, only one of which is consistent with the world average