Agregats supramoleculars de derivats sulfonats de la tetrafenilporfirina com a possibles contraanions asimètrics en organocatàlisi

Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2016, Tutor: Joaquim Crusats AliguerOn this research project it has been studied the viability of using supramoleculary chiral aggregates of sulfonated self-assembling porphyrins as chiral counter anions on Michael and Diels-Alder organocatalytic reactions on water, which proceed through a cationic reaction intermediate to determinate the feasibility of using a ACDC (Assymetric counteranion directed catalysis) strategy to transfer the supramolecular chirality of the aggregates on an organic reaction product enantiomeric excess. To do so, a method to prepare the chiral aggregates of the meso-5,10,15,20-tetrakis(4-sulfonatofenil)porphyrin on its zwitterionic form has been optimized in order to prevent the presence of other counter anions which could also interact with the cationic intermediates from the organocatalytic reactions. It has been proved that the zwitterionic porphyrin not only maintains the aggregation state of the sodium salt, also, the supramolecular chirality still remains even though the addition of the basic organocatalistys (pyrrolidine and isoindoline). Finally it has been shown for the studied Michael and Diels-Alder reactions, exists a narrow window of experimental conditions where it is possible to use this catalysts under ACDC conditions

Study of alternatives for obtaining statistical correlation models for modelling the rough honing process

In the present paper, in order to model rough honing operations, statistical regression correlation models are presented for surface roughness and material removal rate as a function of process variables. Several different models were studied: linear, quadratic, exponential, etc. In addition, Box-Cox transformations were performed to the models so as to improve their fit. Models were compared taking into account two different criteria: R2(Adjusted) coefficient and R2(Predicted) coefficient. Reduced second order models with Box-Cox transformations were found to be appropriate for modeling average roughness and reduced first order models with Box-Cox transformations for modeling material removal rate.Postprint (published version

Mycobacterium microti Infection in free-ranging wild boar, Spain, 2017-2019

Mycobacterium microti is a member of the Mycobacterium tuberculosis complex that causes pathology in many mammals. M. microti infections have been found in some countries in Europe. We report an outbreak of tuberculosis caused by M. microti in wild boars in Spain.info:eu-repo/semantics/publishedVersio

Land Use and Topography Influence in a Complex Terrain Area: A High Resolution Mesoscale Modelling Study over the Eastern Pyrenees using the WRF Model

Different types of land use (LU) have different physical properties which can change local energy balance and hence vertical fluxes of moisture, heat and momentum. This in turn leads to changes in near-surface temperature and moisture fields. Simulating atmospheric flow over complex terrain requires accurate local-scale energy balance and therefore model grid spacing must be sufficient to represent both topography and land-use. In this study we use both the Corine Land Cover (CLC) and United States Geological Survey (USGS) land use databases for use with the Weather Research and Forecasting (WRF) model and evaluate the importance of both land-use classification and horizontal resolution in contributing to successful modelling of surface temperatures and humidities observed from a network of 39 sensors over a 9 day period in summer 2013. We examine case studies of the effects of thermal inertia and soil moisture availability at individual locations. The scale at which the LU classification is observed influences the success of the model in reproducing observed patterns of temperature and moisture. Statistical validation of model output demonstrates model sensitivity to both the choice of LU database used and the horizontal resolution. In general, results show that on average, by a) using CLC instead of USGS and/or b) increasing horizontal resolution, model performance is improved. We also show that the sensitivity to these changes in the model performance shows a daily cycle

Novel sensing algorithm for linear read-out of bimodal waveguide interferometric biosensors

Altres ajuts: the ICN2 was supported by the CERCA programme of the Generalitat de Catalunya.Biosensors employing photonics integrated circuits, and specifically those that rely on interferometric evanescent wave working principles, have outstanding performances due to the extreme sensitivity exhibited in one-step and direct assay, without the need of amplification. Within the interferometric configurations, the Bimodal Waveguide (BiMW) interferometric sensor stands out due to its demonstrated sensitivity for real-life applications and the simplicity of its design. To overcome the ambiguities that arise from the periodic nature of interferometric read-outs, a new all-optical modulation and the subsequent trigonometry-based algorithm have been proposed and applied to the BiMW biosensor. This new algorithm has been successfully employed for the selective identification and quantification of the external Spike (S) protein of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Our biosensing results from this simple, quick, and user-friendly method demonstrate high sensitivity and specificity and pave the way towards a point-of-care device for general use

Prescription and integration of accredited mobile Apps in catalan health and social care: protocol for the AppSalut site design

mHealth; Information integration; Telemedicine; Telemonitoring; Mobile phonemSalud; Integración de la información; Telemedicina; Televigilancia; Teléfono móvilmSalut; Integració de la informació; Telemedicina; Televigilància; Telèfon mòbilBackground: The use of new mobile technologies in the health and social welfare sectors is already a reality. The ICT Social Health Foundation, in accordance with the technology strategy of the Catalan government's Ministry of Health and its Ministry of Labour, Social Affairs and Families, is leading an initiative to create a public library of apps for its AppSalut Site. Objective: The objective of this paper is to present an account of the design of the project, with a global perspective, applied to the Catalan ecosystem, which can be divided into 3 areas: the framework governing the recommendation and prescription of apps, the subset of interoperability for mobile environments, and the data storage infrastructure. Methods: The security and credibility of the apps included in the catalog is ensured by submitting them to an accreditation process in the public domain that provides users with the guarantee that they are fit for purpose and trustworthy for the management and care of their health, while providing health care professionals with the possibility of recommending the apps in the doctor's surgery, as well as adding the information generated by the users' mobile devices to the information systems of the various organizations concerned. Results: An examination of the abovementioned areas suggests possibilities for improvements in the future. The experience obtained from the development of this element has shown the heterogeneity of the vocabularies used, as expected, due to the lack of awareness on the part of the developers regarding the need to standardize the information generated by the app, requiring the foundation to take on the role of consultant. Conclusions: The project has evolved in keeping with changes in the technological and social paradigm and responds very satisfactorily to the needs posed to it. It can be seen as a landmark experience in mobile strategies in the fields of health and welfare of any public health system. The experience has shown itself to be feasible in organizational terms, necessary in any attempt to integrate mobile technologies into public health practice, and a global pioneer in the field.This study was conducted with the support of the Secretary of Universities and Research of the Department of Business and Knowledge at the Generalitat de Catalunya

Multi-sensor observations of an elevated rotor during a mountain wave event in the Eastern Pyrenees

The 15 January 2017 a strong northerly synoptic flow lead to the generation of mountain waves and heavy snowfall over the eastern Pyrenees, particularly over the Cerdanya valley near the border between France, Spain and Andorra. Measurements from several instruments deployed during the Cerdanya-2017 field campaign and satellite imagery revealed the presence of mountain waves and the formation of an associated rotor underneath the first mountain wave crest. The evolution and location of the mountain waves were studied using high temporal resolution data from a UHF wind-profiler and a vertically pointing K-band Doppler radar, separated a few kilometres in horizontal distance. A mountain wave with a wavelength about 18 km was detected in the morning and shortened slightly in the afternoon when a transient rotor, elevated approximately 140 m above the ground, was formed, disconnected from the surface flow. A strong turbulence zone was identified at the upper edge of the mountain wave, above the rotor, a feature observed in previous studies. The mountain wave and rotor induced circulation was favoured by the valley shape and the second mountain ridge location, in addition to the weak and variable winds, established during the sunset close to the valley surface.The Cerdanya-2017 field campaign is a research effort organised by the University of the Balearic Islands, the University of Barcelona, METEO-FRANCE and the Meteorological Service of Catalonia. It is funded by the Spanish projects CGL2015-65627-C3-1-R,CGL2015-65627-C3-2-R (MINECO/FEDER), CGL2016-81828-REDT and RTI2018-098693-B-C32 (AEI/FEDER)