254 research outputs found
FĂ©erie pour un scandale : lâart et la morale dans Lolita (1958) de Vladimir Nabokov
LâapothĂ©ose morale du personnage narrateur Humbert Humbert consiste en une mise en rĂ©cit dâactes transgressifs, la pĂ©dophilie et lâinceste. Comment rĂ©concilier lâart et la morale ? Dans la prĂ©face de Lolita, V. Nabokov pose, par lâentremise du prĂ©facier fictif John Ray, un regard ambigu oĂč le moralisme et le scientisme du clinicien sâentremĂȘlent. Dans la postface rĂ©digĂ©e par V. Nabokov, lâauteur revendique ouvertement ses choix esthĂ©tiques et affirme que Lolita nâest pas portĂ© par une intention morale. La lecture dĂ©taillĂ©e de la postface rĂ©vĂšle un auteur en butte au scandale qui Ă©clate. Les choix poĂ©tiques sont donc explicitĂ©s. La jouissance esthĂ©tique propre Ă lâart transcende ainsi le moralisme. V. Nabokov fait montre dâun formalisme rigoureux qui met en avant la puretĂ© de lâart et son hĂ©tĂ©ronomie. Un mouvement dialectique fait vaciller les assises morales du lecteur confrontĂ© Ă lâimmoralitĂ© du texte. Les arguments spĂ©cieux du narrateur font de Lolita un chef-dâĆuvre de casuistique. Lolita propose au lecteur une surmorale qui trouve Ă sâexercer dans le sanctuaire de lâart
A Comparison Between Different Cycle Decompositions for Metropolis Dynamics
In the last decades the problem of metastability has been attacked on
rigorous grounds via many different approaches and techniques which are briefly reviewed in this paper.
It is then useful to understand connections between different
point of views. In view of this
we consider irreducible, aperiodic and
reversible Markov chains with exponentially
small transition probabilities in the framework of Metropolis dynamics.
We compare two different cycle decompositions and prove their equivalence
Convergence to equilibrium for a directed (1+d)-dimensional polymer
We consider a flip dynamics for directed (1+d)-dimensional lattice paths with length L. The model can be interpreted as a higher dimensional version of the simple exclusion process, the latter corresponding to the case d=1. We prove that the mixing time of the associated Markov chain scales like L^2\log L up to a d-dependent multiplicative constant. The key step in the proof of the upper bound is to show that the system satisfies a logarithmic Sobolev inequality on the diffusive scale L^2 for every fixed d, which we achieve by a suitable induction over the dimension together with an estimate for adjacent transpositions. The lower bound is obtained with a version of Wilson's argument for the one-dimensional case. Keywords: exclusion process, adjacent transpositions, logarithmic Sobolev inequality, mixing tim
Packaging Texture and Shape as Enhancers for Brand Positioning: The Moderating Role of Need for Touch (NFT)
This research-in-progress investigates the influence of two structural elements of brandâs packaging design, accessible by haptic exploration: texture and shape. The proposed conceptual framework details how these elements can facilitate the transfer of meaning to the brand and enhance its positioning in the consumerâs mind, especially in the case of a coherent symbolic message between these packaging attributes. Thus, we manipulate textureâs and shapeâs gendered symbolic information and examine how they impact brand image and positioning. We will use two chocolate bar shapes (rectangular and oval) and two packaging textures (velvet-like and leather-like). According to previous research and researchersâ qualitative study, the rectangular shape and leather-like texture represent the masculine symbolic information while the oval and velvet-like represent the feminine one. The experimentâs main goal is to demonstrate the direct and interaction effects of texture and shape on gendered dimensions of brand personality, perceived quality, attitude towards the brand and purchase intention as well as the moderating role of Need for Touch. The authors argue that a clear packaging message with coherent symbolic cues will induce greater message accessibility by the customer, thus strengthening the brand image and positioning
La rĂ©action d âhĂ©magglutination type Middlebrook-Dubos dans le diagnostic de la tuberculose bovine
La rĂ©action dâhĂ©magglutination type Middlebrook- Dubos, effectuĂ©e chez 118 bovins avec des hĂ©maties de mouton et la tuberculine soit dite « prĂ©cipitĂ©e » soit I.P. 48 de l âInstitut Pasteur de Paris, a Ă©tĂ© positive dans 81 p. 100 des cas de tuberculose Ă©volutive, avec des pourcentages variables selon la nature des lĂ©sions puisquâelle a Ă©tĂ© maxima (100 p. 100) pour les lĂ©sions pleuro-pulmonaires, forte (87,3 p. 100) pour les lĂ©sions de plusieurs organes ou gĂ©nĂ©ralisĂ©es, et faible (50 p. 100) pour les lĂ©sions ganglio-pulmonaires . Par contre, elle a Ă©tĂ© le plus souvent nĂ©gative lorsque les lĂ©sions Ă©taient limitĂ©es aux ganglions pulmonaires et de type casĂ©o-calcaire. Cette rĂ©action a Ă©tĂ© trĂšs rarement (4,0 p. 100) positive chez des animaux apparemment sains, et toujours dâailleurs Ă des taux faibles. Bien que des recherches portant sur de nombreux sĂ©rums soient encore nĂ©cessaires (pour prĂ©ciser en particulier la signification des rĂ©actions positives chez les bovidĂ©s apparemment sains), on peut admettre, semble-t-il, dĂšs maintenant, quâune rĂ©action nettement positive (5> 1/147) traduit toujours une tuberculose Ă©volutive atteignant plusieurs organes. Elle paraĂźt pouvoir dĂšs maintenant rendre des services pour le diagnostic de la tuberculose et lâĂ©tude de la phtisiogenĂšse chez les bovidĂ©s
Numerical study of an arcan tensile compression shear test in dynamic: application to bonded joints
This paper presents a numerical study of the Arcan TCS testing device under dynamic conditions. This test is commonly used to characterize the mechanical behavior of bonded joints subjected to combined quasi-static loadings. In this study, the question of its extensibility to dynamic loadings by the use of an impactor guided in a drop tower is investigated. A dedicated finite element model is built under the plane stress assumption. Stress distributions in the adhesive are analysed trought time ans space for several configurations
Exploring the complementarity of pancreatic ductal adenocarcinoma preclinical models
Purpose: Compare pancreatic ductal adenocarcinoma (PDAC), preclinical models, by their transcriptome and drug response landscapes to evaluate their complementarity. Experimental De-sign: Three paired PDAC preclinical modelsâpatientâderived xenografts (PDX), xenograftâderived pancreatic organoids (XDPO) and xenograftâderived primary cell cultures (XDPCC)âwere derived from 20 patients and analyzed at the transcriptomic and chemosensitivity level. Transcriptomic characterization was performed using the basalâlike/classical subtyping and the PDAC molecular gradient (PAMG). Chemosensitivity for gemcitabine, irinotecan, 5âfluorouracil and oxaliplatin was established and the associated biological pathways were determined using independent component analysis (ICA) on the transcriptome of each model. The selection criteria used to identify the different components was the chemosensitivity score (CSS) found for each drug in each model. Results: PDX was the most dispersed model whereas XDPO and XDPCC were mainly classical and basal-like, respectively. Chemosensitivity scoring determines that PDX and XDPO display a positive correlation for three out of four drugs tested, whereas PDX and XDPCC did not correlate. No match was observed for each tumor chemosensitivity in the different models. Finally, pathway analysis shows a significant association between PDX and XDPO for the chemosensitivityâassociated pathways and PDX and XDPCC for the chemoresistanceâassociated pathways. Conclusions: Each PDAC preclinical model possesses a unique basalâlike/classical transcriptomic phenotype that strongly in-fluences their global chemosensitivity. Each preclinical model is imperfect but complementary, sug-gesting that a more representative approach of the clinical reality could be obtained by combining them. Translational Relevance: The identification of molecular signatures that underpin drug sensitivity to chemotherapy in PDAC remains clinically challenging. Importantly, the vast majority of studies using preclinical in vivo and in vitro models fail when transferred to patients in a clinical setting despite initially promising results. This study presents for the first time a comparison between three preclinical models directly derived from the same patients. We show that their applica-bility to preclinical studies should be considered with a complementary focus, avoiding tumor-based direct extrapolations, which might generate misleading conclusions and consequently the overlook of clinically relevant features.Fil: Hoare, Owen. Centre National de la Recherche Scientifique; FranciaFil: Fraunhoffer Navarro, Nicolas Alejandro. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Centro de Estudios FarmacolĂłgicos y BotĂĄnicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios FarmacolĂłgicos y BotĂĄnicos; ArgentinaFil: Elkaoutari, Abdessamad. Centre National de la Recherche Scientifique; FranciaFil: Gayet, Odile. Centre National de la Recherche Scientifique; FranciaFil: Bigonnet, Martin. Centre National de la Recherche Scientifique; FranciaFil: Roques, Julie. Centre National de la Recherche Scientifique; FranciaFil: Nicolle, RĂ©my. No especifĂca;Fil: McGuckin, Colin. Cell Therapy Research Institute; FranciaFil: Forraz, Nico. Cell Therapy Research Institute; FranciaFil: Sohier, Emilie. Le Centre RĂ©gional de Lutte Contre Le Cancer LĂ©on BĂ©rard; FranciaFil: Tonon, Laurie. Le Centre RĂ©gional de Lutte Contre Le Cancer LĂ©on BĂ©rard; FranciaFil: Wajda, Pauline. Le Centre RĂ©gional de Lutte Contre Le Cancer LĂ©on BĂ©rard; FranciaFil: Boyault, Sandrine. Le Centre RĂ©gional de Lutte Contre Le Cancer LĂ©on BĂ©rard; FranciaFil: Attignon, ValĂ©ry. Le Centre RĂ©gional de Lutte Contre Le Cancer LĂ©on BĂ©rard; FranciaFil: Tabone, Luciana Belen. Le Centre RĂ©gional de Lutte Contre Le Cancer LĂ©on BĂ©rard; FranciaFil: Barbier, Sandrine. No especifĂca;Fil: Mignard, Caroline. No especifĂca;Fil: Duchamp, Olivier. No especifĂca;Fil: Iovanna, Juan. Centre National de la Recherche Scientifique; FranciaFil: Dusetti, Nelson J.. Centre National de la Recherche Scientifique; Franci
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