ASSESSMENT OF FIRST AID KNOWLEDGE AMONG MEDICAL AND NON-MEDICAL UNIVERSITY STUDENTS

   INTRODUCTION: Cardiovascular diseases and the associated sudden cardiac arrest (SCA) are the main cause of death in Poland and around the world. The immediate reaction of bystanders to the event increases the survivor’s chances of survival. The aim of this study was to assess the knowledge and declared skills of medical and non-medical students regarding the methods and techniques of first aid. METHODS: During the period April–May 2017 at Collegium Mazovia Innovative University in Siedlce (Poland), a study was carried out using the anonymous questionnaire of author’s design on the principles of first aid. The survey was addressed to 200 part-time students of medical (medical emergency, nursing, physiotherapy) and non-medical (finance and construction) degrees. RESULTS: There were statistically significant differences between the self-assessment of knowledge about first aid and the field of study (p < 0.001). The question “How do you evaluate your knowledge about first aid” by comparing the medical, financial and construction fields of study showed that a level assessed as very good was indicated by: 38% vs. 7% vs. 8% students, respectively. A good level was indicated by 51% vs. 37% vs. 24% of students respectively while an average level was shown by: 11% vs. 49% vs. 64% of students respectively. In addition, a lack of knowledge was displayed by: 0% vs. 7% vs. 4% of students, respectively. CONCLUSIONS: Our data indicates that: (1) the state of non-medical students’ knowledge concerning first aid was unsatisfactory; (2) it is advisable to promote knowledge about current CPR guidelines in the non-medical student population

Restoring mucosal barrier function and modifying macrophage phenotype with an extracellular matrix hydrogel: potential therapy for ulcerative colitis

Background & Aims: Despite advances in therapeutic options, more than half of all patients with ulcerative colitis (UC) do not achieve long-term remission, many require colectomy, and the disease still has a marked negative impact on quality of life. Extracellular matrix (ECM) bioscaffolds facilitate the functional repair of many soft tissues by mechanisms that include mitigation of pro-inflammatory macrophage phenotype and mobilization of endogenous stem/progenitor cells. The aim of the present study was to determine if an ECM hydrogel therapy could influence outcomes in an inducible rodent model of UC. Methods: The dextran sodium sulfate (DSS)-colitis model was used in male Sprague Dawley rats. Animals were treated via enema with an ECM hydrogel and the severity of colitis was determined by clinical and histologic criteria. Lamina propria cells were isolated and the production of inflammatory mediators was quantified. Mucosal permeability was assessed in-vivo by administering TRITC-dextran and in-vitro using transepithelial electrical resistance (TEER). Results: ECM hydrogel therapy accelerated healing and improved outcome. The hydrogel was adhesive to colonic tissue, which allowed for targeted delivery of the therapy, and resulted in a reduction in clinical and histologic signs of disease. ECM hydrogel facilitated functional improvement of colonic epithelial barrier function and the resolution of the pro-inflammatory state of tissue macrophages. Conclusions: The present study shows that a nonsurgical and nonpharmacologic ECM-based therapy can abate DSS-colitis not by immunosuppression but by promoting phenotypic change in local macrophage phenotype and rapid replacement of the colonic mucosal barrie

EMPATHY AND BURNOUT SYNDROME IN THE PRACTICE OF EMERGENCY SERVICES — PILOT STUDY

  INTRODUCTION: The burnout syndrome is a result of stress on the work situation and most often concerns pro­fessions requiring emotional and direct contact with another human being. The level of empathy is closely related to the phenomenon of occupational burnout. The aim of the study was to determine the impact of socio-demo­graphic factors of emergency services employees on the level of empathy. METHOD: In the period January–March 2018, a survey was conducted using a questionnaire — Emphatic Sensi­tiveness Scale (ESC) and an anonymous author’s questionnaire containing questions regarding sex, age, length of employment, occupation, marital status and number of hours worked per month. The survey was addressed to 81 employees of emergency services: paramedics (n = 17) and firefighters (n = 23). The control group consisted of 16 nurses and 25 people performing non–medical professions. RESULTS: The average number of hours worked per month by the respondents was 189 ± 49. There were 50 fe­males (62%) and 31 males (38%). The questionnaire showed statistically significant differences in perspective taking domain between the control group composed of people working in non-medical professions (25.6 ± 4.3) and emergency services professionals: firefighter (28.7 ± 3.6) vs. paramedic (29.9 ± 3.5) vs. nurse (31.2 ± 3.0), p < 0.001. It has been shown a statistically significant effect of sex on personal distress domain: male (21.4 ± 4.2) vs. female (24.3 ± 4.7), p = 0.005. CONCLUSIONS: In conclusion, our data indicates that: (1) Nurses were characterised by the highest level of empathy amongst the surveyed professional groups; (2) Females were characterised by a higher level of personal distress; (3) Variables such as sex, age, and length of employment did not affect the level of empathy

Synthesis of Tris[2‐(dimethylamino)ethyl]amine with Regiospecific Deuterium Labels

International audienceSimple synthetic routes to regioselectively deuterated tris[2-(dimethylamino)ethyl]amine (Me6TREN) variants are described. Imine formation with formaldehyde-d2 from tris(2-aminoethyl)amine (TREN) and subsequent reductions with NaBD4 afforded N[CH2CH2N(CD3)2]3 or d18-Me6TREN in 79 % yield. A trisubstitution protocol from 2-bromo-N,N-dimethylacetamide and ammonium carbonate and subsequent reduction of the N(CH2CONMe2)3 intermediate by lithium aluminum deuteride has afforded N[CH2CD2N(CH3)2]3 or (d6-arm)-Me6TREN in three steps and 52 % overall yield. A similar protocol from 2-bromo-N,N-dimethyl-d2-acetamide, obtained in two steps from d4-acetic acid, with reduction of the N(CD2CONMe2)3 intermediate by lithium aluminum hydride has afforded N[CD2CH2N(CH3)2]3 or (d6-cap)-Me6TREN in four steps and 13 % overall yield from CD3COOD

Data from: Weekend admission as an independent predictor of mortality: an analysis of Scottish hospital admissions

OBJECTIVES: Weekend admissions have been shown to be associated with an increased risk of mortality compared with weekday admissions for many diagnoses. We analysed emergency department admissions within the Scottish National Health Service to investigate whether mortality is increased in case of weekend emergency department admissions. DESIGN: A cohort study. SETTING: Scotland National Health Service (NHS) emergency departments. PARTICIPANTS: 5 271 327 emergency department admissions between 1999 and 2009. We included all patients admitted via emergency departments recorded in the Scottish Morbidity Records (SMR01) in NHS, Scotland for whom complete demographic data were available. PRIMARY OUTCOME MEASURES: Death as recorded by the General Register Office (GRO). RESULTS: There was a significantly increased probability of death associated with a weekend emergency admission compared with admission on a weekday (unadjusted OR 1.27, 95% CI 1.26 to 1.28, p<0.0001; adjusted for year of admission, gender, age, deprivation quintile and number of comorbidities OR 1.42, 95% CI 1.40 to 1.43, p<0.0001). CONCLUSIONS: Despite a general reduction in mortality over the last 11 years, there is still a significant excess mortality associated with weekend emergency admissions. Further research should be undertaken to identify the precise mechanisms underlying this effect so that measures can be put in place to reduce patient mortality

Scottish weekend admissions for Dryad

See notes tab for description of data and source