EMPLOYEE RETENTION AS A CHALLENGE IN LEATHER INDUSTRY

Employee retention is the vital challenge in all organizations This papers focus on one industry that is the leather industry of Pakistan which is facing the same problem of retention of employees due to many reasons As Leather industry is the third largest export earning sector in Pakistan so these reasons are discussed in detail The turnover rate in Leather Industry of Pakistan is around 25 30 annually its observed that mostly second line managers change their job s for high salaries offer recognition authority and also to seek for more knowledge and to get more competitive edge in terms of processing In tanneries its critical and alarming because of the process and article secrecy In order to achieve competitive advantage maximum utilization of resources and to get organizational efficiency employees must be retained in a true spirit in order to cope with all these conditions In this paper the authors tried to know the reasons behind this dilemma that how employees can be retained and some suggestions were given to deal with it One edge of this paper is that one of the author belongs to the same industry i e leather industr

Implications of Cultural Capital in Women’s Higher Education Participation and Social Mobility

Equality of opportunity in higher education participation is a basic right of people in a society that leads to their social mobility in the long run. Benadusi (2002) endorsed Bourdieu’s explanations that cultural capital acts as an empowering force that predetermines equality/inequality of educational opportunity of people in a society. The study, thus, aimed to explore cultural capital as means of participation in higher education and eventually social mobility of women. A cross sectional survey was used to collect data from 103 working and 97 non-working women using purposive and convenience sampling. The study found positive relation of cultural capital of women with their participation in higher education and social mobility. Significant difference was also found between cultural capitals of working and non- working women, where cultural capital of working women was high as compared to non-working. The study therefore, concludes that education for women must be the core value of our society to enhance their cultural capital as well as social mobility in a society. Because higher is the cultural capital of women; higher would be their participation rate in higher education and social mobility for them.

In Silico Analysis of Differentially Expressed Genes in Colorectal Carcinoma

Background: Colorectal carcinoma (CRC) is a primary cause of morbidity and mortality worldwide. Resistance to therapy contributes to poor patient prognosis. The aim of our study is to identify the key proteins and interaction networks implicated in CRC which may serve as possible therapeutic targets and help in overcoming therapy resistance.Methods: The microarray dataset of 58 cases and 62 controls was used to identify Differentially Expressed Genes (DEGs).After constructing protein-protein interaction networks , Cytoscape analysis was done to identify the hub proteins. Based on sub graph centrality, between-ness and degree (≥10), hub proteins were selected for further literature search and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.Results: A total of 85 up-regulated genes and 95 down-regulated genes of CRC patients were selected based on criteria of P>0.05 and fold change>2.0. The PPI analysis revealed STAT3, HNRNPA2B1, RBM8A, RBM25, ATM, HIST1H2BK, SRSF5 and HNRNPDLas hub proteins. On the basis of criteria set for cytoscape analysis, STAT3 and HNRNPA2B1 were identified as key hub proteins. KEGG pathway analysis revealed vital role of STAT3 in carcinogenesis.Conclusion: In addition of HNRNPA2B1 activation by STAT3, cross talk of STAT3 with other oncogenic signaling pathways signifies its role in colorectal carcinogenesis. Our study highlights thatSTAT3may be a possible therapeutic target which may help in overcoming the dilemma of resistance to drug treatment in advanced cases.Keywords: STAT3, drug resistance, targeted therapy, bioinformatics    

THERAPEUTIC PROPERTIES OF CAPSAICIN: A MEDICINALLY IMPORTANT BIO-ACTIVE CONSTITUENT OF CHILLI PEPPER

Plants are the source of numerous pharmaceutically important compounds that have been employed to cure various human ailments since ancient times. With the assistance of modern chemistry and materials science, such pharmaceutically important compounds have been identified and isolated to produce new drugs. Alkaloids are one of the most significant classes of naturally occurring secondary-metabolites, which are synthesized and widely distributed in various parts of plants. They regulate various metabolic activities and induce physiological responses in the human body. Capsaicin is a naturally occurring alkaloid found in many species of peppers and is attributed to their spicy nature and pungent flavor. This alkaloid is a member of the Capsaicinoids group, which includes capsaicin, homocapsaicin, homodihydrocapsaicin, dihydrocapsaicin, and nordihydrocapsaicin. Capsaicin has a wide range of therapeutic potential against various human ailments. In this article, we provide a comprehensive overview of the capsaicin molecule as well as an examination of its medicinal properties in a variety of human disorders, including pain, various types of cancer, ulcers, diabetes, obesity, inflammation, cardiovascular diseases, and neurodegenerative diseases

Cardiopulmonary Resuscitation–attitudes and awareness among physical therapists of Karachi–A Cross-sectional Survey

Background: The prime objective of CPR is to maintain enough circulation to preserve existence till specialized treatment is provided. As mentioned, early CPR is an essential aspect in the chain of survival in Emergency Cardiovascular Care (ECC). Objective: To compare and study the attitude and awareness level related to Cardiopulmonary Resuscitation (CPR) among physical therapists in Karachi. Methods: The total sample was 126 physical therapists in this study. This was an observational study based on a cross-sectional design conducted for the assessment of CPR attitude and awareness of physical therapists through simple convenient sampling technique during the period of December 2020 to June 2021 from various public and private sector hospitals and rehabilitation centers of Karachi. Data collection was done through a questionnaire consisting 31 questions categorized into three sections including demographics, CPR attitudes and CPR awareness. Results: Results revealed more female physical therapists (76%). Most of them (70%) were aged less than 35 years and had less than 15 years of working experience. Most of them were engaged in musculoskeletal practice (40.5%). Almost 31% participants had CPR certifications. Less than half of the physical therapists (38.9%) reported ≤ 25% success rate of CPR. Majority of the participants stated that their ability to perform CPR was satisfactory (44.4%). Conclusion: The overall awareness of physical therapists regarding CPR was evident, but the attitude regarding CPR need improvement. It was also evident from the results that mandatory professional training programs should be conducted.   Keywords: Attitude, Awareness, Cardiac Arrest, Cardiopulmonary Resuscitation (CPR), Physical Therapist

Association of Serum Gamma-Glutamyl Transferase and C-Reactive Protein as a Biomarkers of Oxidative Stress in Patients of Type 2 Diabetes Mellitus

Objective: To compare Serum gamma-glutamyl transferase and serum C-reactive protein as biomarker of oxidative stress in patients of type 2 Diabetes Mellitus. Study Design: Comparative cross-sectional study. Place and Duration of Study: The study was conducted at Armed Forces Institute of Pathology, department of Chemical Pathology and Endocrinology Rawalpindi. The duration of study was 6 months i.e., 17 Nov 2021 – 17 May 2022 after approval from Institutional Review Board FC-CHP21-12/Read-IRB/22/846. Materials and Methods: An analytical, cross-sectional research was carried out at Armed Forces Institute of Pathology Rawalpindi. An overall 300 diabetic patients were included between ages of 45 – 65 years. Group I had 100 nondiabetic individuals of 45 – 65 years of age with HbA1c < 5.7 %. Group II and III included 100 patients each of DM of matched age with HbA1c 6.5 – 7 % and greater than 7 % respectively, without any other chronic disease. Serum gamma-glutamyl transferase, HbA1c, Serum C-Reactive Protein were analyzed. Moreover, some more biochemical investigations such as serum liver enzymes were measured to rule out any liver disease. One-way ANOVA was followed up by post-hoc Tukey analysis for intergroup comparison. Results: Mean serum gamma-glutamyl transferase levels were markedly increased in group III patients followed by group II and normal in group I. The mean of serum gamma-glutamyl transferase in group I was (9.38+4.05U/l), group II (34.27+15.07 U/l) and group III (47.08+20.56 U/l). The mean of Serum C-Reactive Protein in group I was (11+6.02 mg/l), group II (62.07+ 26.94 mg/l) and group III (107.73+57.03 mg/l). Pearson correlation revealed prominent positive correlation between HbA1c, serum gamma-glutamyl transferase and Serum C-Reactive Protein with r value of serum gamma-glutamyl transferase (0.838367) and Serum C-Reactive Protein (0.684722). One-way ANOVA and post-hoc Tukey analysis had p value of < 0.05 which was statistically significant. Conclusion: Serum gamma-glutamyl transferase is better marker of oxidative stress in patients of type 2 diabetes mellitus as compared to Serum C-Reactive Protein. The r value of serum gamma-glutamyl transferase is (0.838367) and Serum C-Reactive Protein is (0.684722) indicating strong positive correlation of serum gamma-glutamyl transferase with HbA1c. Therefore, Serum gamma-glutamyl transferase can be used for the prevention and monitoring of complications of type 2 Diabetes Mellitus

Sustainable Irrigation Management for Higher Yield

Sustainable irrigation is sensible application of watering to plants in agriculture, landscapes that aids in meeting current survival and welfare needs. Sustainable irrigation management can help with climate change adaptation, labor, energy savings, and the production of higher-value and yield of crops to achieve zero hunger in water-scarce world. To ensure equal access to water and environmental sustainability, investments in expanded and enhanced irrigation must be matched by improvements in water governance. Sustainable irrigation must be able to cope with water scarcity, and be resilient to other resource scarcities throughout time in context of energy and finance. The themes and SDGs related to clean water, water resources sustainability, sustainable water usage, agricultural and rural development are all intertwined in the concept of “sustainable irrigation for higher yield.” Sustainable irrigation management refers to the capability of using water in optimum quantity and quality on a local, regional, national, and global scale to meet the needs of humans and agro-ecosystems at present and in the future to sustain life, protect humans and biodiversity from natural and human-caused disasters which threaten life to exist. Resultantly higher yields will ensure food security

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries