2,872 research outputs found
Designing tree-structured organizations for computational agents
We describe a framework for defining the space of organization designs for computational agents, use our framework for analyzing the expected performance of a class of organizations, and describe how our analyses can be applied to predict performance for a distributed information gathering task. Our analysis specifically addresses the impact of the span of control (branching factor) in tree-structured hierarchical organizations on the response time of such organizations. We show quantitatively how the overall task size and granularity influence the design of the span of control for the organization, and that within the class of organizations considered the apropriate span of control is confined to a relatively narrow range. The performance predicted by our overall model correlates with the actual performance of a distributed organization for computer network monitoring. Consequently, we argue that our framework can support aspects of organizational self-design for computational agents, and might supply insights into the design of human organizations as well.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44720/1/10588_2004_Article_BF00127275.pd
Pulse-shape discrimination between electron and nuclear recoils in a NaI(Tl) crystal
We report on the response of a high light-output NaI(Tl) crystal to nuclear
recoils induced by neutrons from an Am-Be source and compare the results with
the response to electron recoils produced by Compton scattered 662 keV
-rays from a Cs source. The measured pulse-shape discrimination
(PSD) power of the NaI(Tl) crystal is found to be significantly improved
because of the high light output of the NaI(Tl) detector. We quantify the PSD
power with a quality factor and estimate the sensitivity to the interaction
rate for weakly interacting massive particles (WIMPs) with nucleons, and the
result is compared with the annual modulation amplitude observed by the
DAMA/LIBRA experiment. The sensitivity to spin-independent WIMP-nucleon
interactions based on 100 kgyear of data from NaI detectors is estimated
with simulated experiments, using the standard halo model.Comment: 11page
First Results from the AMoRE-Pilot neutrinoless double beta decay experiment
The Advanced Molybdenum-based Rare process Experiment (AMoRE) aims to search
for neutrinoless double beta decay (0) of Mo with
100 kg of Mo-enriched molybdenum embedded in cryogenic detectors
with a dual heat and light readout. At the current, pilot stage of the AMoRE
project we employ six calcium molybdate crystals with a total mass of 1.9 kg,
produced from Ca-depleted calcium and Mo-enriched molybdenum
(CaMoO). The simultaneous detection of
heat(phonon) and scintillation (photon) signals is realized with high
resolution metallic magnetic calorimeter sensors that operate at milli-Kelvin
temperatures. This stage of the project is carried out in the Yangyang
underground laboratory at a depth of 700 m. We report first results from the
AMoRE-Pilot search with a 111 kgd live exposure of
CaMoO crystals. No evidence for
decay of Mo is found, and a upper limit is set for the
half-life of 0 of Mo of y at 90% C.L.. This limit corresponds to an effective
Majorana neutrino mass limit in the range eV
Indications of Neutrino Oscillation in a 250 km Long-baseline Experiment
The K2K experiment observes indications of neutrino oscillation: a reduction
of flux together with a distortion of the energy spectrum. Fifty-six
beam neutrino events are observed in Super-Kamiokande (SK), 250 km from the
neutrino production point, with an expectation of .
Twenty-nine one ring -like events are used to reconstruct the neutrino
energy spectrum, which is better matched to the expected spectrum with neutrino
oscillation than without. The probability that the observed flux at SK is
explained by statistical fluctuation without neutrino oscillation is less than
1%.Comment: 5 pages, 3 figures embedded, LaTeX with RevTeX style, accepted for
publication in PRL on December 13, 200
Fracture Patterns Induced by Desiccation in a Thin Layer
We study a theoretical model of mud cracks, that is, the fracture patterns
resulting from the contraction with drying in a thin layer of a mixture of
granules and water. In this model, we consider the slip on the bottom of this
layer and the relaxation of the elastic field that represents deformation of
the layer. Analysis of the one-dimensional model gives results for the crack
size that are consistent with experiments. We propose an analytical method of
estimation for the growth velocity of a simple straight crack to explain the
very slow propagation observed in actual experiments. Numerical simulations
reveal the dependence of qualitative nature of the formation of crack patterns
on material properties.Comment: 37 pages,18 figures,REVTEX,submitted to Rhys.Rev.
Fine-structural distribution of MMP-2 and MMP-9 activities in the rat skeletal muscle upon training: a study by high-resolution in situ zymography
Matrix metalloproteinases (MMPs) are key regulators of extracellular matrix remodeling, but have also important intracellular targets. The purpose of this study was to examine the activity and subcellular localization of the gelatinases MMP-2 and MMP-9 in skeletal muscle of control and physically trained rats. In control hind limb muscle, the activity of the gelatinases was barely detectable. In contrast, after 5 days of intense exercise, in Soleus (Sol), but not Extensor digitorum longus (EDL) muscle, significant upregulation of gelatinolytic activity in myofibers was observed mainly in the nuclei, as assessed by high resolution in situ zymography. The nuclei of quiescent satellite cells did not contain the activity. Within the myonuclei, the gelatinolytic activity colocalized with an activated RNA Polymerase II. Also in Sol, but not in EDL, there were few foci of mononuclear cells with strongly positive cytoplasm, associated with apparent necrotic myofibers. These cells were identified as activated satellite cells/myoblasts. No extracellular gelatinase activity was observed. Gel zymography combined with subcellular fractionation revealed training-related upregulation of active MMP-2 in the nuclear fraction, and increase of active MMP-9 in the cytoplasmic fraction of Sol. Using RT-PCR, selective increase in MMP-9 mRNA was observed. We conclude that training activates nuclear MMP-2, and increases expression and activity of cytoplasmic MMP-9 in Sol, but not in EDL. Our results suggest that the gelatinases are involved in muscle adaptation to training, and that MMP-2 may play a novel role in myonuclear functions
First Observation of CP Violation in B0->D(*)CP h0 Decays by a Combined Time-Dependent Analysis of BaBar and Belle Data
We report a measurement of the time-dependent CP asymmetry of B0->D(*)CP h0
decays, where the light neutral hadron h0 is a pi0, eta or omega meson, and the
neutral D meson is reconstructed in the CP eigenstates K+ K-, K0S pi0 or K0S
omega. The measurement is performed combining the final data samples collected
at the Y(4S) resonance by the BaBar and Belle experiments at the
asymmetric-energy B factories PEP-II at SLAC and KEKB at KEK, respectively. The
data samples contain ( 471 +/- 3 ) x 10^6 BB pairs recorded by the BaBar
detector and ( 772 +/- 11 ) x 10^6, BB pairs recorded by the Belle detector. We
measure the CP asymmetry parameters -eta_f S = +0.66 +/- 0.10 (stat.) +/- 0.06
(syst.) and C = -0.02 +/- 0.07 (stat.) +/- 0.03 (syst.). These results
correspond to the first observation of CP violation in B0->D(*)CP h0 decays.
The hypothesis of no mixing-induced CP violation is excluded in these decays at
the level of 5.4 standard deviations.Comment: 9 pages, 2 figures, submitted to Physical Review Letter
The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor
The effect of the dietary flavonoid galangin on the metabolism of 7,12-dimethylbenz[a]anthracene (DMBA), the activity of cytochrome P 450 1A1 (CYP1A1), and the expression of CYP1A1 in MCF-7 human breast carcinoma cells was investigated. Galangin inhibited the catabolic breakdown of DMBA, as measured by thin-layer chromatography, in a dose-dependent manner. Galangin also inhibited the formation of DMBA-DNA adducts, and prevented DMBA-induced inhibition of cell growth. Galangin caused a potent, dose-dependent inhibition of CYP1A1 activity, as measured by ethoxyresorufin-O-deethylase activity, in intact cells and in microsomes isolated from DMBA-treated cells. Analysis of the inhibition kinetics by double-reciprocal plot demonstrated that galangin inhibited CYP1A1 activity in a non-competitive manner. Galangin caused an increase in the level of CYP1A1 mRNA, indicating that it may be an agonist of the aryl hydrocarbon receptor, but it inhibited the induction of CYP1A1 mRNA by DMBA or by 2,3,5,7-tetrachlorodibenzo-p-dioxin (TCDD). Galangin also inhibited the DMBA- or TCDD-induced transcription of a reporter vector containing the CYP1A1 promoter. Thus, galangin is a potent inhibitor of DMBA metabolism and an agonist/antagonist of the AhR, and may prove to be an effective chemopreventive agent. © 1999 Cancer Research Campaig
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