3,492 research outputs found
Movement Control Strategies in a Dynamic Balance Task in Children With and Without Developmental Coordination Disorder
Our study aimed to analyze movement control strategies using predefined criteria for amplitude and differences in these strategies between children with and without DCD. Children with (n = 28) and without DCD (n = 15) were included. A video-observation-tool was used to score the moving body parts during a Wii Fit slalom task over multiple time points. Two-step cluster analysis was used to extract distinct movement strategies. Two different movement strategies were identified that were independently validated by a measure of task performance and a subjective mark of quality of the movement. Initial differences between groups and changes over time toward the more successful strategy were found in both groups, albeit in a different percentage. This study shows that the more efficient movement strategy is seen in the majority of the TD children and only in a small number of children with DCD, even after practice
Indicatoren om dracht te meten in melk = Biomarkers in milk to predict pregnancy in dairy cattle
In this project the technical possibilities were investigated to use protein profiles in dairy milk as an indicator to improve fertility
Roughness-induced critical phenomena in a turbulent flow
I present empirical evidence that turbulent flows are closely analogous to
critical phenomena, from a reanalysis of friction factor measurements in rough
pipes. The data collapse found here corresponds to Widom scaling near critical
points, and implies that a full understanding of turbulence requires explicit
accounting for boundary roughness
Model-based asymptotically optimal dispersion measure correction for pulsar timing
In order to reach the sensitivity required to detect gravitational waves,
pulsar timing array experiments need to mitigate as much noise as possible in
timing data. A dominant amount of noise is likely due to variations in the
dispersion measure. To correct for such variations, we develop a statistical
method inspired by the maximum likelihood estimator and optimal filtering. Our
method consists of two major steps. First, the spectral index and amplitude of
dispersion measure variations are measured via a time-domain spectral analysis.
Second, the linear optimal filter is constructed based on the model parameters
found in the first step, and is used to extract the dispersion measure
variation waveforms. Compared to current existing methods, this method has
better time resolution for the study of short timescale dispersion variations,
and generally produces smaller errors in waveform estimations. This method can
process irregularly sampled data without any interpolation because of its
time-domain nature. Furthermore, it offers the possibility to interpolate or
extrapolate the waveform estimation to regions where no data is available.
Examples using simulated data sets are included for demonstration.Comment: 15 pages, 15 figures, submitted 15th Sept. 2013, accepted 2nd April
2014 by MNRAS. MNRAS, 201
The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β
It is currently unknown how mucosal adjuvants cause induction of secretory immunoglobulin A (IgA), and how T cell-dependent (TD) or -independent (TI) pathways might be involved. Mucosal dendritic cells (DCs) are the primary antigen presenting cells driving TI IgA synthesis, by producing a proliferation-inducing ligand (APRIL), B cell activating factor (BAFF), Retinoic Acid (RA), TGF-beta or nitric oxide (NO). We hypothesized that the mucosal adjuvant Cholera Toxin subunit B (CTB) could imprint non-mucosal DCs to induce IgA synthesis, and studied the mechanism of its induction. In vitro, CTB-treated bone marrow derived DCs primed for IgA production by B cells without the help of T cells, yet required co-signaling by different Toll-like receptor (TLR) ligands acting via the MyD88 pathway. CTB-DC induced IgA production was blocked in vitro or in vivo when RA receptor antagonist, TGF-beta signaling inhibitor or neutralizing anti-TGF-beta was added, demonstrating the involvement of RA and TGF-beta in promoting IgA responses. There was no major involvement for BAFF, APRIL or NO. This study highlights that synergism between CTB and MyD88-dependent TLR signals selectively imprints a TI IgA-inducing capacity in non-mucosal DCs, explaining how CTB acts as an IgA promoting adjuvant
Effect of dual tasking on a dynamic balance task in children with and without DCD
The purpose of this study was to compare performance of children with Developmental Coordination Disorder (DCD) and typically developing (TD) children in a dual task paradigm with a dynamic balance task on the Wii Fit as primary task and a concurrent cognitive (counting) or a concurrent bimanual fine motor task as secondary tasks. Using a cross-sectional design, 25 children with DCD and 38 TD children were assessed with the Movement Assessment Battery for Children, 2nd edition (MABC-2) and Divided Attention (DA) task of the KiTAP. Next, the single- and dual-tasks were performed and the level of interference or facilitation of the dual tasks was calculated. Regression analysis determined the predictive value of the DA and MABC-2 component balance outcomes on the dual task performance. On the motor and attentional tasks, the group of children with DCD scored significantly below the level of the TD children. The dual task effect showed similar interference and facilitation of tasks in the different dual-task conditions in both groups. In the dual task-cognitive condition, the divided attention abilities and the MABC-2 balance score predicted 25% of the Wii Fit dynamic balance task performance, whereas in the dual task-motor condition this was higher (31.6%). In both conditions, DA was a stronger predictor than MABC balance score and appears to be an important factor to consider when developing motor task training for children with DCD.</p
Very High Angular Resolution Science with the Square Kilometre Array
Preliminary specifications for the Square Kilometre Array (SKA) call for 25%
of the total collecting area of the dish array to be located at distances
greater than 180 km from the core, with a maximum baseline of at least 3000 km.
The array will provide angular resolution ~ 40 - 2 mas at 0.5 - 10 GHz with
image sensitivity reaching < 50 nJy/beam in an 8 hour integration with 500 MHz
bandwidth. Given these specifications, the high angular resolution component of
the SKA will be capable of detecting brightness temperatures < 200 K with
milliarcsecond-scale angular resolution. The aim of this article is to bring
together in one place a discussion of the broad range of new and important high
angular resolution science that will be enabled by the SKA, and in doing so,
address the merits of long baselines as part of the SKA. We highlight the fact
that high angular resolution requiring baselines greater than 1000 km provides
a rich science case with projects from many areas of astrophysics, including
important contributions to key SKA science.Comment: 13 pages, 6 figure
Radio Emission from GRO J1655-40 during the 1994 Jet Ejection Episodes
We report multifrequency radio observations of GRO J1655-40 obtained with the
Australia Telescope Compact Array, the Molonglo Observatory Synthesis Telescope
and the Hartebeesthoek Radio Astronomy Observatory at the time of the major
hard X-ray and radio outbursts in 1994 August-September. The radio emission
reached levels of the order of a few Jy and was found to be linearly polarized
by up to 10%, indicating a synchrotron origin. The light curves are in good
agreement with those measured with the VLA, but our closer time sampling has
revealed two new short-lived events and significant deviations from a simple
exponential decay. The polarization data show that the magnetic field is well
ordered and aligned at right angles to the radio jets for most of the
monitoring period. The time evolution of the polarization cannot be explained
solely in terms of a simple synchrotron bubble model, and we invoke a hybrid
`core-lobe' model with a core which contributes both synchrotron and free-free
emission and `lobes' which are classical synchrotron emitters.Comment: 36 pages, 5 tables, 9 figures; accepted for publication in Ap
Acute plasma amylase increase after glucagon-like peptide -1 receptor agonist exenatide administration in Type 2 diabetes
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