Automated Data Management Information System (ADMIS)

ADMIS stores and controls data and documents associated with manned space flight effort. System contains all data oriented toward a specific document; it is primary source of reports generated by the system. Each group of records is composed of one document record, one distribution record for each recipient of the document, and one summary record

Does slow and steady win the race? Investigating feedback processes in giant molecular clouds

We investigate the effects of gradual heating on the evolution of turbulent molecular clouds of mass $2\times 10^6$ M$_\odot$ and virial parameters ranging between $0.7-1.2$. This gradual heating represents the energy output from processes such as winds from massive stars or feedback from High Mass X-ray binaries (HMXBs), contrasting the impulsive energy injection from supernovae (SNe). For stars with a mass high enough that their lifetime is shorter than the life of the cloud, we include a SN feedback prescription. Including both effects, we investigate the interplay between slow and fast forms of feedback and their effectiveness at triggering/suppressing star formation. We find that SN feedback can carve low density chimneys in the gas, offering a path of least resistance for the energy to escape. Once this occurs the more stable, but less energetic, gradual feedback is able to keep the chimneys open. By funneling the hot destructive gas away from the centre of the cloud, chimneys can have a positive effect on both the efficiency and duration of star formation. Moreover, the critical factor is the number of high mass stars and SNe (and any subsequent HMXBs) active within the free-fall time of each cloud. This can vary from cloud to cloud due to the stochasticity of SN delay times and in HMXB formation. However, the defining factor in our simulations is the efficiency of the cooling, which can alter the Jeans mass required for sink particle formation, along with the number of massive stars in the cloud.Comment: 35 pages, 46 figures, accepted for publication in MNRA

Preventing and lessening exacerbations of asthma in school-age children associated with a new term (PLEASANT) : Study protocol for a cluster randomised control trial

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedBackground: Within the UK, during September, there is a pronounced increase in the number of unscheduled medical contacts by school-aged children (4-16 years) with asthma. It is thought that that this might be caused by the return back to school after the summer holidays, suddenly mixing with other children again and picking up viruses which could affect their asthma. There is also a drop in the number of prescriptions administered in August. It is possible therefore that children might not be taking their medication as they should during the summer contributing to them becoming ill when they return to school. It is hoped that a simple intervention from the GP to parents of children with asthma at the start of the summer holiday period, highlighting the importance of maintaining asthma medication can help prevent increased asthma exacerbation, and unscheduled NHS appointments, following return to school in September.Methods/design: PLEASANT is a cluster randomised trial. A total of 140 General Practices (GPs) will be recruited into the trial; 70 GPs randomised to the intervention and 70 control practices of "usual care" An average practice is expected to have approximately 100 children (aged 4-16 with a diagnosis of asthma) hence observational data will be collected on around 14000 children over a 24-month period. The Clinical Practice Research Datalink will collect all data required for the study which includes diagnostic, prescription and referral data.Discussion: The trial will assess whether the intervention can reduce exacerbation of asthma and unscheduled medical contacts in school-aged children associated with the return to school after the summer holidays. It has the potential to benefit the health and quality of life of children with asthma while also improving the effectiveness of NHS services by reducing NHS use in one of the busiest months of the year. An exploratory health economic analysis will gauge any cost saving associated with the intervention and subsequent impacts on quality of life. If results for the intervention are positive it is hoped that this could be adopted as part of routine care management of childhood asthma in general practice. Trial registration: Current controlled trials: ISRCTN03000938 (assigned 19/10/12) http://www.controlled-trials.com/ISRCTN03000938/.UKCRN ID: 13572.Peer reviewe

Physicians' experiences and perspectives regarding the use of continuous sedation until death for cancer patients in the context of psychological and existential suffering at the end of life

OBJECTIVE: The use of continuous sedation until death for terminally ill cancer patients with unbearable and untreatable psychological and existential suffering remains controversial, and little in-depth insight exists into the circumstances in which physicians resort to it. METHODS: Our study was conducted in Belgium, the Netherlands, and the UK in hospitals, PCUs/hospices, and at home. We held interviews with 35 physicians most involved in the care of cancer patients who had psychological and existential suffering and had been continuously sedated until death. RESULTS: In the studied countries, three groups of patients were distinguished regarding the origin of their psychological and existential suffering. The first group had preexisting psychological problems before they became ill, the second developed psychological and existential suffering during their disease trajectory, and the third presented psychological symptoms that were characteristic of their disease. Before they resorted to the use of sedation, physicians reported that they had considered an array of pharmacological and psychological interventions that were ineffective or inappropriate to relieve this suffering. Necessary conditions for using sedation in this context were for most physicians the presence of refractory symptoms, a short life expectancy, and an explicit patient request for sedation. CONCLUSIONS: Physicians in our study used continuous sedation until death in the context of psychological and existential suffering after considering several pharmacological and psychological interventions. Further research and debate are needed on how and by whom this suffering at the end of life should be best treated, taking into account patients' individual preferences

The independent group looks at London's west end

In the early 1950s, British culture was dominated by welfare-state visions of urban reconstruction. These projections of a stable civic society were premised on a particular way of looking at and reading the metropolitan environment. At odds with this project, the Independent Group's discussions and collaborative work developed an alternative urban semiology, which found the city to be already rich in visual resources for fashioning a more profound form of social democracy. Soon, this critical engagement would develop in different directions, represented here by Lawrence Alloway's commentary on Piccadilly Circus in his essay 'City Notes' and the London footage inserted by John McHale into his film for the Smithsons' Berlin Hauptstadt project (both 1959). By the end of the 1950s, members of the erstwhile Independent Group had produced two contrasting critical accounts of how the metropolitan centre should be looked at, which challenged the strictures of post-war reconstruction in distinct and conflicting ways. © The Author(s), 2013

High seed protein percentage in chickpea. II. Comparative nitrogen accumulation patterns

In low-protein Annigeri, leaf nitrogen contents progressively declined after flowering but seed nitrogen contents increased. In high-protein T1A, leaf nitrogen contents increased up to 30 days after flowering but translocation to seeds was slower and seed nitrogen contents were much lower after 70 days than in Annigeri. Similar patterns were observed for soluble carbohydrates and starch. The seed yield of T1A was only one third of that of Annigeri. Data indicated that source was not limiting

The Acclaim Programme in the South Atlantic and Southern Oceans

The ACCLAIM sea level network consists of six coastal tide gauge sites and approximately a dozen bottom pressure stations in the South Atlantic and Southern Oceans. Since 1985, an extensive dataset of regional sea level and bottom pressure measurements has been acquired. This dataset is being employed at POL in a number of scientific analyses and is available to any interested research worker through the World Ocean Circulation Experiment. In this paper, a review is given of the development and status of the ACCLAIM network and the technology installed at each site. Plans are presented for developments over the next 1-2 years

Breeding for resistance, to Heliothis armigera in chickpea

Chickpea (Cicer ariethtim L) is a mandate crop of International Crops Research Institute for the Semi-Arid Tropics (ICRISAT). The crop has fewer pest problems khan other legumes, Heliothis arimgtra is the major past in most chickpea growing areas and is polyphagous attacking many crop species

Quiet Sun magnetic fields from simultaneous inversions of visible and infrared spectropolarimetric observations

We study the quiet Sun magnetic fields using spectropolarimetric observations of the infrared and visible Fe I lines at 6301.5, 6302.5, 15648 and 15653 A. Magnetic field strengths and filling factors are inferred by the simultaneous fit of the observed Stokes profiles under the MISMA hypothesis. The observations cover an intra-network region at the solar disk center. We analyze 2280 Stokes profiles whose polarization signals are above noise in the two spectral ranges, which correspond to 40% of the field of view. Most of these profiles can be reproduced only with a model atmosphere including 3 magnetic components with very different field strengths, which indicates the co-existence of kG and sub-kG fields in our 1.5" resolution elements. We measure an unsigned magnetic flux density of 9.6 G considering the full field of view. Half of the pixels present magnetic fields with mixed polarities in the resolution element. The fraction of mixed polarities increases as the polarization weakens. We compute the probability density function of finding each magnetic field strength. It has a significant contribution of kG field strengths, which concentrates most of the observed magnetic flux and energy. This kG contribution has a preferred magnetic polarity, while the polarity of the weak fields is balanced.Comment: 16 pages and 14 figure