863 research outputs found
Individual Responses for Muscle Activation, Repetitions, and Volume during Three Sets to Failure of High- (80% 1RM) \u3cem\u3eversus\u3c/em\u3e Low-Load (30% 1RM) Forearm Flexion Resistance Exercise
This study compared electromyographic (EMG) amplitude, the number of repetitions completed, and exercise volume during three sets to failure of high- (80% 1RM) versus low-load (30% 1RM) forearm flexion resistance exercise on a subject-by-subject basis. Fifteen men were familiarized, completed forearm flexion 1RM testing. Forty-eight to 72 h later, the subjects completed three sets to failure of dumbbell forearm flexion resistance exercise with 80% (n = 8) or 30% (n = 7) 1RM. EMG amplitude was calculated for every repetition, and the number of repetitions performed and exercise volume were recorded. During sets 1, 2, and 3, one of eight subjects in the 80% 1RM group demonstrated a significant linear relationship for EMG amplitude versus repetition. For the 30% 1RM group, seven, five, and four of seven subjects demonstrated significant linear relationships during sets 1, 2, and 3, respectively. The mean EMG amplitude responses show that the fatigue-induced increases in EMG amplitude for the 30% 1RM group and no change in EMG amplitude for the 80% 1RM group resulted in similar levels of muscle activation in both groups. The numbers of repetitions completed were comparatively greater, while exercise volumes were similar in the 30% versus 80% 1RM group. Our results, in conjunction with those of previous studies in the leg extensors, suggest that there may be muscle specific differences in the responses to high- versus low-load exercise
Application of Optimal Control to CPMG Refocusing Pulse Design
We apply optimal control theory (OCT) to the design of refocusing pulses
suitable for the CPMG sequence that are robust over a wide range of B0 and B1
offsets. We also introduce a model, based on recent progress in the analysis of
unitary dynamics in the field of quantum information processing (QIP), that
describes the multiple refocusing dynamics of the CPMG sequence as a dephasing
Pauli channel. This model provides a compact characterization of the
consequences and severity of residual pulse errors. We illustrate the methods
by considering a specific example of designing and analyzing broadband OCT
refocusing pulses of length 10 t180 that are constrained by the maximum
instantaneous pulse power. We show that with this refocusing pulse, the CPMG
sequence can refocus over 98% of magnetization for resonance offsets up to 3.2
times the maximum RF amplitude, even in the presence of +/- 10% RF
inhomogeneity.Comment: 23 pages, 10 figures; Revised and reformatted version with new title
and significant changes to Introduction and Conclusions section
Wolbachia and DNA barcoding insects: patterns, potential and problems
Wolbachia is a genus of bacterial endosymbionts that impacts the breeding systems of their hosts. Wolbachia can confuse the patterns of mitochondrial variation, including DNA barcodes, because it influences the pathways through which mitochondria are inherited. We examined the extent to which these endosymbionts are detected in routine DNA barcoding, assessed their impact upon the insect sequence divergence and identification accuracy, and considered the variation present in Wolbachia COI. Using both standard PCR assays (Wolbachia surface coding protein – wsp), and bacterial COI fragments we found evidence of Wolbachia in insect total genomic extracts created for DNA barcoding library construction. When >2 million insect COI trace files were examined on the Barcode of Life Datasystem (BOLD) Wolbachia COI was present in 0.16% of the cases. It is possible to generate Wolbachia COI using standard insect primers; however, that amplicon was never confused with the COI of the host. Wolbachia alleles recovered were predominantly Supergroup A and were broadly distributed geographically and phylogenetically. We conclude that the presence of the Wolbachia DNA in total genomic extracts made from insects is unlikely to compromise the accuracy of the DNA barcode library; in fact, the ability to query this DNA library (the database and the extracts) for endosymbionts is one of the ancillary benefits of such a large scale endeavor – for which we provide several examples. It is our conclusion that regular assays for Wolbachia presence and type can, and should, be adopted by large scale insect barcoding initiatives. While COI is one of the five multi-locus sequence typing (MLST) genes used for categorizing Wolbachia, there is limited overlap with the eukaryotic DNA barcode region
Decoherence of quantum registers
The dynamical evolution of a quantum register of arbitrary length coupled to
an environment of arbitrary coherence length is predicted within a relevant
model of decoherence. The results are reported for quantum bits (qubits)
coupling individually to different environments (`independent decoherence') and
qubits interacting collectively with the same reservoir (`collective
decoherence'). In both cases, explicit decoherence functions are derived for
any number of qubits. The decay of the coherences of the register is shown to
strongly depend on the input states: we show that this sensitivity is a
characteristic of types of coupling (collective and independent) and not
only of the collective coupling, as has been reported previously. A non-trivial
behaviour ("recoherence") is found in the decay of the off-diagonal elements of
the reduced density matrix in the specific situation of independent
decoherence. Our results lead to the identification of decoherence-free states
in the collective decoherence limit. These states belong to subspaces of the
system's Hilbert space that do not get entangled with the environment, making
them ideal elements for the engineering of ``noiseless'' quantum codes. We also
discuss the relations between decoherence of the quantum register and
computational complexity based on the new dynamical results obtained for the
register density matrix.Comment: Typos corrected. Discussion and references added. 1 figure + 3 tables
added. This updated version contains 13 (double column) pages + 8 figures.
PRA in pres
AI ATAC 1: An Evaluation of Prominent Commercial Malware Detectors
This work presents an evaluation of six prominent commercial endpoint malware
detectors, a network malware detector, and a file-conviction algorithm from a
cyber technology vendor. The evaluation was administered as the first of the
Artificial Intelligence Applications to Autonomous Cybersecurity (AI ATAC)
prize challenges, funded by / completed in service of the US Navy. The
experiment employed 100K files (50/50% benign/malicious) with a stratified
distribution of file types, including ~1K zero-day program executables
(increasing experiment size two orders of magnitude over previous work). We
present an evaluation process of delivering a file to a fresh virtual machine
donning the detection technology, waiting 90s to allow static detection, then
executing the file and waiting another period for dynamic detection; this
allows greater fidelity in the observational data than previous experiments, in
particular, resource and time-to-detection statistics. To execute all 800K
trials (100K files 8 tools), a software framework is designed to
choreographed the experiment into a completely automated, time-synced, and
reproducible workflow with substantial parallelization. A cost-benefit model
was configured to integrate the tools' recall, precision, time to detection,
and resource requirements into a single comparable quantity by simulating costs
of use. This provides a ranking methodology for cyber competitions and a lens
through which to reason about the varied statistical viewpoints of the results.
These statistical and cost-model results provide insights on state of
commercial malware detection
Decoherence control in microwave cavities
We present a scheme able to protect the quantum states of a cavity mode
against the decohering effects of photon loss. The scheme preserves quantum
states with a definite parity, and improves previous proposals for decoherence
control in cavities. It is implemented by sending single atoms, one by one,
through the cavity. The atomic state gets first correlated to the photon number
parity. The wrong parity results in an atom in the upper state. The atom in
this state is then used to inject a photon in the mode via adiabatic transfer,
correcting the field parity. By solving numerically the exact master equation
of the system, we show that the protection of simple quantum states could be
experimentally demonstrated using presently available experimental apparatus.Comment: 13 pages, RevTeX, 8 figure
Phenotypic differentiation among native, expansive and introduced populations influences invasion success
Aim: Humans influence species distributions by modifying the environment and by dispersing species beyond their natural ranges. Populations of species that have established in disjunct regions of the world may exhibit trait differentiation from native populations due to founder effects and adaptations to selection pressures in each distributional region. We compared multiple native, expansive and introduced populations of a single species across the world, considering the influence of environmental stressors and transgenerational effects.
Location: United States Gulf and Atlantic coasts, United States interior, European Atlantic and Mediterranean coasts, east coast of Australia.
Taxon: Baccharis halimifolia L. (eastern baccharis).
Methods: We monitored seed germination, seedling emergence, survival and early growth in a common garden experiment, conducted with over 18,200 seeds from 80 populations. We also evaluated the influence of environmental stress and maternal traits on progeny performance.
Results: Introduced European Atlantic populations had faster germination and early growth than native populations. However, this was not the case for the more recently naturalized European Mediterranean populations. Introduced Australian populations grew faster than native populations in non-saline environments but had lower survival in saline conditions commonly encountered in the native range. Similarly, expansive inland US populations germinated faster than coastal native populations in non-saline environments but grew and germinated more slowly in saline environments. Maternal inflorescence and plant size were positively related with seed germination and seedling survival, whereas flower abundance was positively correlated with seedling early growth and survival. However, maternal traits explained a much lower fraction of the total variation in early demographic stages of B. halimifolia than did distributional range.
Main conclusions: Phenotypic differentiation could allow B. halimifolia to adapt to different biotic and abiotic selection pressures found in each distributional range, potentially contributing to its success in introduced and expansive ranges
Early satellite cell communication creates a permissive environment for long-term muscle growth
Using in vivo muscle stem cell (satellite cell)-specific extracellular vesicle (EV) tracking, satellite cell depletion, in vitro cell culture, and single-cell RNA sequencing, we show satellite cells communicate with other cells in skeletal muscle during mechanical overload. Early satellite cell EV communication primes the muscle milieu for proper long-term extracellular matrix (ECM) deposition and is sufficient to support sustained hypertrophy in adult mice, even in the absence of fusion to muscle fibers. Satellite cells modulate chemokine gene expression across cell types within the first few days of loading, and EV delivery of miR 206 to fibrogenic cells represses Wisp1 expression required for appropriate ECM remodeling. Late-stage communication from myogenic cells during loading is widespread but may be targeted toward endothelial cells. Satellite cells coordinate adaptation by influencing the phenotype of recipient cells, which extends our understanding of their role in muscle adaptation beyond regeneration and myonuclear donation
Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank
Background: Cognitive ability is a heritable trait with a polygenic architecture, for which several associated variants have been identified using genotype-based and candidate gene approaches. Haplotype-based analyses are a complementary technique that take phased genotype data into account, and potentially provide greater statistical power to detect lower frequency variants.
Methods: In the present analysis, three cohort studies (ntotal = 48,002) were utilised: Generation Scotland: Scottish Family Health Study (GS:SFHS), the English Longitudinal Study of Ageing (ELSA), and the UK Biobank. A genome-wide haplotype-based meta-analysis of cognitive ability was performed, as well as a targeted meta-analysis of several gene coding regions.
Results: None of the assessed haplotypes provided evidence of a statistically significant association with cognitive ability in either the individual cohorts or the meta-analysis. Within the meta-analysis, the haplotype with the lowest observed P-value overlapped with the D-amino acid oxidase activator (DAOA) gene coding region. This coding region has previously been associated with bipolar disorder, schizophrenia and Alzheimer’s disease, which have all been shown to impact upon cognitive ability. Another potentially interesting region highlighted within the current genome-wide association analysis (GS:SFHS: P = 4.09 x 10-7), was the butyrylcholinesterase (BCHE) gene coding region. The protein encoded by BCHE has been shown to influence the progression of Alzheimer’s disease and its role in cognitive ability merits further investigation.
Conclusions: Although no evidence was found for any haplotypes with a statistically significant association with cognitive ability, our results did provide further evidence that the genetic variants contributing to the variance of cognitive ability are likely to be of small effect
- …