A standardized test for the second semester of world history

Not AvailableClinton M. SmithNot ListedNot ListedMaster of ArtsDepartment Not ListedCunningham Memorial library, Terre Haute, Indiana State University.isua-thesis-1931-smithMastersTitle from document title page. Document formatted into pages: contains 79p. : ill. Includes appendix and bibliography

FinDer v.2: Improved real-time ground-motion predictions for M2–M9 with seismic finite-source characterization

Recent studies suggest that small and large earthquakes nucleate similarly, and that they often have indistinguishable seismic waveform onsets. The characterization of earthquakes in real time, such as for earthquake early warning, therefore requires a flexible modeling approach that allows a small earthquake to become large as fault rupture evolves over time. Here, we present a modeling approach that generates a set of output parameters and uncertainty estimates that are consistent with both small/moderate (≤M6.5) and large earthquakes (>M6.5) as is required for a robust parameter interpretation and shaking forecast. Our approach treats earthquakes over the entire range of magnitudes (>M2) as finite line-source ruptures, with the dimensions of small earthquakes being very small (<100 m) and those of large earthquakes exceeding several tens to hundreds of kilometres in length. The extent of the assumed line source is estimated from the level and distribution of high-frequency peak acceleration amplitudes observed in a local seismic network. High-frequency motions are well suited for this approach, because they are mainly controlled by the distance to the rupturing fault. Observed ground-motion patterns are compared with theoretical templates modeled from empirical ground-motion prediction equations to determine the best line source and uncertainties. Our algorithm extends earlier work by Böse et al. for large finite-fault ruptures. This paper gives a detailed summary of the new algorithm and its offline performance for the 2016 M7.0 Kumamoto, Japan and 2014 M6.0 South Napa, California earthquakes, as well as its performance for about 100 real-time detected local earthquakes (2.2 ≤ M ≤ 5.1) in California. For most events, both the rupture length and the strike are well constrained within a few seconds (<10 s) of the event origin. In large earthquakes, this could allow for providing warnings of up to several tens of seconds. The algorithm could also be useful for resolving fault plane ambiguities of focal mechanisms and identification of rupturing faults for earthquakes as small as M2.5

Voting in the bicameral Congress: large majorities as a signal of quality

publication-status: Acceptedtypes: ArticleWe estimate a model of voting in Congress that allows for dispersed information about the quality of proposals in an equilibrium context. In equilibrium, the Senate only approves House bills that receive the support of a supermajority of members of the lower chamber. We estimate this endogenous supermajority rule to be about four-fifths on average across policy areas. Our results indicate that the value of information dispersed among legislators is significant, and that in equilibrium a large fraction of House members' (40–50%) votes following their private information. Finally, we show that the probability of a type I error in Congress (not passing a good bill) is on average about twice as high as the probability of a type II error (passing a low-quality bill)

Role of Sequence and Structure of the Hendra Fusion Protein Fusion Peptide in Membrane Fusion

Viral fusion proteins are intriguing molecular machines that undergo drastic conformational changes to facilitate virus-cell membrane fusion. During fusion a hydrophobic region of the protein, termed the fusion peptide (FP), is inserted into the target host cell membrane, with subsequent conformational changes culminating in membrane merger. Class I fusion proteins contain FPs between 20 and 30 amino acids in length that are highly conserved within viral families but not between. To examine the sequence dependence of the Hendra virus (HeV) fusion (F) protein FP, the first eight amino acids were mutated first as double, then single, alanine mutants. Mutation of highly conserved glycine residues resulted in inefficient F protein expression and processing, whereas substitution of valine residues resulted in hypofusogenic F proteins despite wild-type surface expression levels. Synthetic peptides corresponding to a portion of the HeV F FP were shown to adopt an α-helical secondary structure in dodecylphosphocholine micelles and small unilamellar vesicles using circular dichroism spectroscopy. Interestingly, peptides containing point mutations that promote lower levels of cell-cell fusion within the context of the whole F protein were less α-helical and induced less membrane disorder in model membranes. These data represent the first extensive structure-function relationship of any paramyxovirus FP and demonstrate that the HeV F FP and potentially other paramyxovirus FPs likely require an α-helical structure for efficient membrane disordering and fusion

What is the role of culture, diversity, and community engagement in transdisciplinary translational science?

Concepts of culture and diversity are necessary considerations in the scientific application of theory generation and developmental processes of preventive interventions; yet, culture and/or diversity are often overlooked until later stages (e.g., adaptation [T3] and dissemination [T4]) of the translational science process. Here, we present a conceptual framework focused on the seamless incorporation of culture and diversity throughout the various stages of the translational science process (T1-T5). Informed by a community-engaged research approach, this framework guides integration of cultural and diversity considerations at each phase with emphasis on the importance and value of "citizen scientists" being research partners to promote ecological validity. The integrated partnership covers the first phase of intervention development through final phases that ultimately facilitate more global, universal translation of changes in attitudes, norms, and systems. Our comprehensive model for incorporating culture and diversity into translational research provides a basis for further discussion and translational science development

FinDer v.2: Improved real-time ground-motion predictions for M2–M9 with seismic finite-source characterization

Recent studies suggest that small and large earthquakes nucleate similarly, and that they often have indistinguishable seismic waveform onsets. The characterization of earthquakes in real time, such as for earthquake early warning, therefore requires a flexible modeling approach that allows a small earthquake to become large as fault rupture evolves over time. Here, we present a modeling approach that generates a set of output parameters and uncertainty estimates that are consistent with both small/moderate (≤M6.5) and large earthquakes (>M6.5) as is required for a robust parameter interpretation and shaking forecast. Our approach treats earthquakes over the entire range of magnitudes (>M2) as finite line-source ruptures, with the dimensions of small earthquakes being very small (<100 m) and those of large earthquakes exceeding several tens to hundreds of kilometres in length. The extent of the assumed line source is estimated from the level and distribution of high-frequency peak acceleration amplitudes observed in a local seismic network. High-frequency motions are well suited for this approach, because they are mainly controlled by the distance to the rupturing fault. Observed ground-motion patterns are compared with theoretical templates modeled from empirical ground-motion prediction equations to determine the best line source and uncertainties. Our algorithm extends earlier work by Böse et al. for large finite-fault ruptures. This paper gives a detailed summary of the new algorithm and its offline performance for the 2016 M7.0 Kumamoto, Japan and 2014 M6.0 South Napa, California earthquakes, as well as its performance for about 100 real-time detected local earthquakes (2.2 ≤ M ≤ 5.1) in California. For most events, both the rupture length and the strike are well constrained within a few seconds (<10 s) of the event origin. In large earthquakes, this could allow for providing warnings of up to several tens of seconds. The algorithm could also be useful for resolving fault plane ambiguities of focal mechanisms and identification of rupturing faults for earthquakes as small as M2.5

A Novel Strategy for Development of Recombinant Antitoxin Therapeutics Tested in a Mouse Botulism Model

Antitoxins are needed that can be produced economically with improved safety and shelf life compared to conventional antisera-based therapeutics. Here we report a practical strategy for development of simple antitoxin therapeutics with substantial advantages over currently available treatments. The therapeutic strategy employs a single recombinant ‘targeting agent’ that binds a toxin at two unique sites and a ‘clearing Ab’ that binds two epitopes present on each targeting agent. Co-administration of the targeting agent and the clearing Ab results in decoration of the toxin with up to four Abs to promote accelerated clearance. The therapeutic strategy was applied to two Botulinum neurotoxin (BoNT) serotypes and protected mice from lethality in two different intoxication models with an efficacy equivalent to conventional antitoxin serum. Targeting agents were a single recombinant protein consisting of a heterodimer of two camelid anti-BoNT heavy-chain-only Ab VH (VHH) binding domains and two E-tag epitopes. The clearing mAb was an anti-E-tag mAb. By comparing the in vivo efficacy of treatments that employed neutralizing vs. non-neutralizing agents or the presence vs. absence of clearing Ab permitted unprecedented insight into the roles of toxin neutralization and clearance in antitoxin efficacy. Surprisingly, when a post-intoxication treatment model was used, a toxin-neutralizing heterodimer agent fully protected mice from intoxication even in the absence of clearing Ab. Thus a single, easy-to-produce recombinant protein was as efficacious as polyclonal antiserum in a clinically-relevant mouse model of botulism. This strategy should have widespread application in antitoxin development and other therapies in which neutralization and/or accelerated clearance of a serum biomolecule can offer therapeutic benefit

JWST mirror and actuator performance at cryo-vacuum

The James Webb Space Telescope (JWST) telescope’s Secondary Mirror Assembly (SMA) and eighteen Primary Mirror Segment Assemblies (PMSAs) are each actively controlled in rigid body position via six hexapod actuators. Each of the PMSAs additionally has a radius of curvature actuator. The mirrors are stowed to the mirror support structure to survive the launch environment and then must be deployed 12.5 mm to reach the nominally deployed position before the Wavefront Sensing & Control (WFSC) alignment and phasing process begins. JWST requires testing of the full optical system in a Cryogenic Vacuum (CV) environment before launch. The cryo vacuum test campaign was executed in Chamber A at the Johnson Space Center (JSC) in Houston Texas. The test campaign consisted of an ambient vacuum test, a cooldown test, a cryo stable test at 65 Kelvin, a warmup test, and finally a second ambient vacuum test. Part of that test campaign was the functional and performance testing of the hexapod actuators on the flight mirrors. This paper will describe the testing that was performed on all 132 hexapod and radius of curvature actuators. The test campaign first tests actuators individually then tested how the actuators perform in the hexapod system. Telemetry from flight sensors on the actuators and measurements from external metrology devices such as interferometers, photogrammetry systems and image analysis was used to demonstrate the performance of the JWST actuators. The mirror move commanding process was exercised extensively during the JSC CV test and many examples of accurately commanded moves occurred. The PMSA and SMA actuators performed extremely well during the JSC CV test, and we have demonstrated that the actuators are fully functional both at ambient and cryo temperatures and that the mirrors will go to their commanded positions with the accuracy needed to phase and align the telescope

The response of perennial and temporary headwater stream invertebrate communities to hydrological extremes

The headwaters of karst rivers experience considerable hydrological variability, including spates and streambed drying. Extreme summer flooding on the River Lathkill (Derbyshire, UK) provided the opportunity to examine the invertebrate community response to unseasonal spate flows, flow recession and, at temporary sites, streambed drying. Invertebrates were sampled at sites with differing flow permanence regimes during and after the spates. Following streambed drying at temporary sites, dewatered surface sediments were investigated as a refugium for aquatic invertebrates. Experimental rehydration of these dewatered sediments was conducted to promote development of desiccation-tolerant life stages. At perennial sites, spate flows reduced invertebrate abundance and diversity, whilst at temporary sites, flow reactivation facilitated rapid colonisation of the surface channel by a limited number of invertebrate taxa. Following streambed drying, 38 taxa were recorded from the dewatered and rehydrated sediments, with Oligochaeta being the most abundant taxon and Chironomidae (Diptera) the most diverse. Experimental rehydration of dewatered sediments revealed the presence of additional taxa, including Stenophylax sp. (Trichoptera: Limnephilidae) and Nemoura sp. (Plecoptera: Nemouridae). The influence of flow permanence on invertebrate community composition was apparent despite the aseasonal high-magnitude flood events