The challenge of designing a computer network system: A snapshot of UK construction SMEs.

Information and Communication Technology (ICT) has been widely used in the UK construction industry for the last two decades. A prolific development in ICT with a wide range of IT applications is already witnessed by a divergent range of construction firms. However, the poor initial uptake of integrated ICT facilities remains a problem among Small to Medium Sized construction firms (SMEs). The issues of stand alone and ad-hoc IT systems and electronic communication systems continue to predominant ICT uptake within UK construction SMEs. This paper takes a fundamental view on the challenge of designing and implementing networking systems for construction SMEs in the current position. Such challenges include the network technology and its implementation for sustaining a highly reliable and integrated network. This requires a rigorous framework to design and implement extensible and cost efficient network systems for complicated construction processes even in SMEs. The paper also discusses fundamental computer network technology issues and its required performance to design construction SMEs networking systems

The challenge of designing a computer network system: A snapshot of UK construction SMEs.

Information and Communication Technology (ICT) has been widely used in the UK construction industry for the last two decades. A prolific development in ICT with a wide range of IT applications is already witnessed by a divergent range of construction firms. However, the poor initial uptake of integrated ICT facilities remains a problem among Small to Medium Sized construction firms (SMEs). The issues of stand alone and ad-hoc IT systems and electronic communication systems continue to predominant ICT uptake within UK construction SMEs. This paper takes a fundamental view on the challenge of designing and implementing networking systems for construction SMEs in the current position. Such challenges include the network technology and its implementation for sustaining a highly reliable and integrated network. This requires a rigorous framework to design and implement extensible and cost efficient network systems for complicated construction processes even in SMEs. The paper also discusses fundamental computer network technology issues and its required performance to design construction SMEs networking systems

Suction drain as a low carbon ground improvement technique : proof-of-concept at the laboratory scale

The most common soil reinforcement methods used in tunnelling, such as jet grouting, fiberglass reinforcement and ground freezing, leave spoils into the ground and have high costs of implementation. On the other hand, preloading methods for soils improvement require long construction periods and limit the enhancement of the undrained shear strength to the applied surcharge load or vacuum load. This paper presents the concept of suction drain as an innovative technique for temporary stabilisation of geostructures in soft clayey soils, which overcomes the inconvenience of current soil reinforcement techniques and the limitation of the preloading. Based on suction generated in the ground by the evaporation from pre-drilled holes, the suction drain enables the enhancement of the undrained shear strength in soft clayey soils. The concept and its validation at mock-up scale level are presented in this study. The experimental investigation assessed the capacity of the suction drain to reduce the soil water content via soil water evaporation induced by forced ventilation. The mock-up scale test was then validated numerically via FEM modelling. Finally, the suction drain modelling was extended to an ideal case of tunnelling for assessing the potential impact of the suction drain on undrained shear strength and, hence, on tunnel face stability

Enabling science from the Rubin alert stream with Lasair

Lasair is the UK Community Broker for transient alerts from the Legacy Survey of Space and Time from the Vera C. Rubin Observatory. We explain the system’s capabilities, how users can achieve their scientific goals, and how Lasair is implemented. Lasair offers users a kit of parts that they can use to build filters to concentrate their desired alerts. The kit has novel light-curve features, sky context, watchlists of special sky objects and regions of the sky, dynamic cross-matching with catalogues of known astronomical sources, and classifications and annotations from other users and partner projects. These resources can be shared with other users, copied, and modified. Lasair offers real-time machine-to-machine notifications of filtered transient alerts. Even though the Rubin Observatory is not yet complete, Lasair is a mature system: it has been processing and serving data from the similarly formatted stream of the Zwicky Transient Facility alerts

Views on social media and its linkage to longitudinal data from two generations of a UK cohort study

Background: Cohort studies gather huge volumes of information about a range of phenotypes but new sources of information such as social media data are yet to be integrated. Participant’s long-term engagement with cohort studies, as well as the potential for their social media data to be linked to other longitudinal data, could provide novel advances but may also give participants a unique perspective on the acceptability of this growing research area. Methods: Two focus groups explored participant views towards the acceptability and best practice for the collection of social media data for research purposes. Participants were drawn from the Avon Longitudinal Study of Parents and Children cohort; individuals from the index cohort of young people (N=9) and from the parent generation (N=5) took part in two separate 90-minute focus groups. The discussions were audio recorded and subjected to qualitative analysis. Results: Participants were generally supportive of the collection of social media data to facilitate health and social research. They felt that their trust in the cohort study would encourage them to do so. Concern was expressed about the collection of data from friends or connections who had not consented. In terms of best practice for collecting the data, participants generally preferred the use of anonymous data derived from social media to be shared with researchers. Conclusion: Cohort studies have trusting relationships with their participants; for this relationship to extend to linking their social media data with longitudinal information, procedural safeguards are needed. Participants understand the goals and potential of research integrating social media data into cohort studies, but further research is required on the acquisition of their friend’s data. The views gathered from participants provide important guidance for future work seeking to integrate social media in cohort studies

Why Do Some Molecules Form Hydrates or Solvates?

The discovery of solvates (crystal structures where the solvent is incorporated into the lattice) dates back to the dawn of chemistry. The phenomenon is ubiquitous, with important applications ranging from the development of pharmaceuticals to the potential capture of CO2 from the atmosphere. Despite this interest, we still do not fully understand why some molecules form solvates. We have employed molecular simulations using simple models of solute and solvent molecules whose interaction parameters could be modulated at will to access a universe of molecules that do and do not form solvates. We investigated the phase behavior of these model solute–solvent systems as a function of solute–solvent affinity, molecule size ratio, and solute concentration. The simulations demonstrate that the primary criterion for solvate formation is that the solute–solvent affinity must be sufficient to overwhelm the solute–solute and solvent–solvent affinities. Strong solute–solvent affinity in itself is not a sufficient condition for solvate formation: in the absence of such strong affinity, a solvate may still form provided that the self-affinities of the solute and the solvent are weaker in relative terms. We show that even solvent-phobic molecules can be induced to form solvates by virtue of a pΔV potential arising either from a more efficient packing or because of high pressure overcoming the energy penalty

Predominance of multidrug-resistant bacteria causing urinary tract infections among symptomatic patients in East Africa : a call for action

Background In low- and middle-income countries, antibiotics are often prescribed for patients with symptoms of urinary tract infections (UTIs) without microbiological confirmation. Inappropriate antibiotic use can contribute to antimicrobial resistance (AMR) and the selection of MDR bacteria. Data on antibiotic susceptibility of cultured bacteria are important in drafting empirical treatment guidelines and monitoring resistance trends, which can prevent the spread of AMR. In East Africa, antibiotic susceptibility data are sparse. To fill the gap, this study reports common microorganisms and their susceptibility patterns isolated from patients with UTI-like symptoms in Kenya, Tanzania and Uganda. Within each country, patients were recruited from three sites that were sociodemographically distinct and representative of different populations. Methods UTI was defined by the presence of >104 cfu/mL of one or two uropathogens in mid-stream urine samples. Identification of microorganisms was done using biochemical methods. Antimicrobial susceptibility testing was performed by the Kirby–Bauer disc diffusion assay. MDR bacteria were defined as isolates resistant to at least one agent in three or more classes of antimicrobial agents. Results Microbiologically confirmed UTI was observed in 2653 (35.0%) of the 7583 patients studied. The predominant bacteria were Escherichia coli (37.0%), Staphylococcus spp. (26.3%), Klebsiella spp. (5.8%) and Enterococcus spp. (5.5%). E. coli contributed 982 of the isolates, with an MDR proportion of 52.2%. Staphylococcus spp. contributed 697 of the isolates, with an MDR rate of 60.3%. The overall proportion of MDR bacteria (n = 1153) was 50.9%. Conclusions MDR bacteria are common causes of UTI in patients attending healthcare centres in East African countries, which emphasizes the need for investment in laboratory culture capacity and diagnostic algorithms to improve accuracy of diagnosis that will lead to appropriate antibiotic use to prevent and control AMR.Peer reviewe

Human papillomavirus (HPV) related Oropharynx Cancer in the United Kingdom – An evolution in the understanding of disease aetiology

A rising incidence of oropharyngeal squamous cell carcinoma (OPSCC) incidence has occurred throughout the developed world, where it has been attributed to an increasing impact of human papillomavirus (HPV) on disease etiology. This report presents the findings of a multicenter cross-sectional retrospective study aimed at determining the proportion of HPV-positive and HPV-negative OPSCC within the United Kingdom. Archival tumor tissue blocks from 1,602 patients previously diagnosed with OPSCC (2002-2011) were collated from 11 centers. HPV status was determined with three validated commercial tests to provide valid data for 1,474 cases in total. Corresponding national incidence data from the same decade were obtained from UK Cancer registries. The overall proportion of HPV+ OPSCC between 2002 and 2011 was 51.8% [95% confidence interval (CI), 49.3-54.4], and this remained unchanged throughout the decade [unadjusted RR = 1.00 (95% CI, 0.99-1.02)]. However, over the same period, the incidence of OPSCC in the broader UK population underwent a 2-fold increase [age-standardized rate 2002: 2.1 (95% CI, 1.9-2.2); 2011: 4.1 (95% CI, 4.0-4.3)]. Although the number of OPSCCs diagnosed within the United Kingdom from 2002 to 2011 nearly doubled, the proportion of HPV+ cases remained static at approximately 50%. Our results argue that the rapidly increasing incidence of OPSCC in the United Kingdom cannot be solely attributable to the influence of HPV. The parallel increase in HPV+ and HPV- cases we documented warrants further investigation, so that appropriate future prevention strategies for both types of disease can be implemented.</p

Quantifying the combined effects of multiple extreme floods on river channel geometry and on flood hazards

Effects of flood-induced bed elevation and channel geometry changes on flood hazards are largely unexplored, especially in the case of multiple floods from the same site. This study quantified the evolution of river channel and floodplain geometry during a repeated series of hypothetical extreme floods using a 2D full hydro-morphodynamic model (LHMM). These experiments were designed to examine the consequences of channel geometry changes on channel conveyance capacity and subsequent flood dynamics. Our results revealed that extreme floods play an important role in adjusting a river channel to become more efficient for subsequent propagation of floods, and that in-channel scour and sediment re-distribution can greatly improve the conveyance capacity of a channel for subsequent floods. In our hypothetical sequence of floods the response of bed elevation was of net degradation, and sediment transport successively weakened even with floods of the same magnitude. Changes in river channel geometry led to significant impact on flood hydraulics and thereby flood hazards. We found that flood-induced in-channel erosion can disconnect the channel from its floodplain resulting in a reduction of floodwater storage. Thus, the frequency and extent of subsequent overbank flows and floodplain inundation decreased, which reduced downstream flood attenuation and increased downstream flood hazard. In combination and in summary, these results suggest that changes in channel capacity due to extreme floods may drive changes in flood hazard. The assumption of unchanging of river morphology during inundation modelling should therefore be open to question for flood risk management