Should Congress Pass the Employee Free Choice Act? Some Neighborly Advice

American labour law is broken. As many as 60 percent of American workers would like to have a union, yet only 12 percent actually do. This is largely due to systematic employer interference, often in violation of existing laws. The Employee Free Choice Act (EFCA), currently before Congress, contains provisions to rectify this problem. Canada's experience with similar provisions can be helpful in evaluating the arguments surrounding this act. It suggests that the reforms proposed in EFCA can be expected to safeguard rather than deny employees' free choices. They will not alter the balance of power in collective bargaining, but only help to ensure that workers can exercise their basic right to meaningful representation at work and, potentially, to win gains that could help to reduce inequality and return America to prosperity

An individual randomised efficacy trial of autologous blood products, leukocyte and platelet-rich fibrin (L-PRF), to promote ulcer healing in leprosy in Nepal : the TABLE trial protocol

Background: Leprosy is curable with multidrug therapy and treatment in the early stages can prevent disability. However, local nerve damage can lead to injury and consequently recurring and disfiguring ulcers. The aim of this study is to evaluate the treatment of leprosy ulcers using an autologous blood product; leukocyte and platelet-rich fibrin (L-PRF) to promote healing. Methods: This is a single-centre study in the Anandaban Hospital, The Leprosy Mission Nepal, Kathmandu, Nepal. Consenting patients (n=130) will be individually randomised in a single-blinded, controlled trial. Participants will be 18 years of age or older, admitted to the hospital with a clean, dry and infection-free chronic foot ulcer between 2 and 20 cm2 in size. If the ulcer is infected, it will be treated before enrolment into the study. The intervention involves the application of leukocyte and platelet-rich fibrin (L-PRF) matrix on the ulcer beds during twice-weekly dressing changes. Controls receive usual care in the form of saline dressings only during their twice-weekly dressing changes. Primary outcomes are the rate of healing assessed using standardised photographs by observers blind to allocated treatment, and time to complete re-epithelialization. Follow-up is at 6 months from randomisation. Discussion: This research will provide valuable information on the clinical and cost-effectiveness of L-PRF in the treatment of leprosy ulcers. An additional benefit is the evaluation of the effects of treatment on quality of life for people living with leprosy ulcers. The results will improve our understanding of the scalability of this treatment across low-income countries for ulcer healing in leprosy and potentially other conditions such as diabetic ulcers. Trial registration: ClinicalTrials.govISRCTN14933421. Registered on 16 June 202

Modeling surf zone tracer plumes : 1. Waves, mean currents, and low-frequency eddies

Author Posting. © American Geophysical Union, 2011. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 116 (2011): C11027, doi:10.1029/2011JC007210.A model that accurately simulates surf zone waves, mean currents, and low-frequency eddies is required to diagnose the mechanisms of surf zone tracer transport and dispersion. In this paper, a wave-resolving time-dependent Boussinesq model is compared with waves and currents observed during five surf zone dye release experiments. In a companion paper, Clark et al. (2011) compare a coupled tracer model to the dye plume observations. The Boussinesq model uses observed bathymetry and incident random, directionally spread waves. For all five releases, the model generally reproduces the observed cross-shore evolution of significant wave height, mean wave angle, bulk directional spread, mean alongshore current, and the frequency-dependent sea surface elevation spectra and directional moments. The largest errors are near the shoreline where the bathymetry is most uncertain. The model also reproduces the observed cross-shore structure of rotational velocities in the infragravity (0.004 < f < 0.03 Hz) and very low frequency (VLF) (0.001 < f < 0.004 Hz) bands, although the modeled VLF energy is 2–3 times too large. Similar to the observations, the dominant contributions to the modeled eddy-induced momentum flux are in the VLF band. These eddies are elliptical near the shoreline and circular in the mid surf zone. The model-data agreement for sea swell waves, low-frequency eddies, and mean currents suggests that the model is appropriate for simulating surf zone tracer transport and dispersion.This research was supported by SCCOOS, CA Coastal Conservancy, NOAA, NSF, ONR, and CA Sea Grant.2012-05-1

O3oxidation of SO2in sea-salt aerosol water: Size distribution of non-sea-salt sulfate during the First Aerosol Characterization Experiment (ACE 1)

Non sea-salt sulfate (NSS) of 2.2-2.3 nmol m(-3) total magnitude in aerosols observed during the First Aerosol Characterization Experiment (ACE-1) at Cape Grim, Tasmania, was trimodally distributed with similar to 1 nmol NSS m(-3) in > 0.7 mu m ambient diameter (diam) coarse seasalt mode aerosols; despite this low NSS concentration, [H2SO4(g)] was so low that 0.7 mu m diam aerosols. The mechanism of O-3 oxidation of SO2 in sea-salt aerosol water (SSAW) is assessed for its capability to explain this coarse aerosol NSS. Limitation of this mechanism's NSS contribution is largely due to SSAW's buffering capacity since its reaction rate is reduced by 2 orders of magnitude at pH 6 versus the pH greater than or equal to 8 of unreacted SSAW. However, the buffering capacity of sea-salt aerosols may have been significantly enhanced over that of bulk seawater alkalinity. This appears to be due to carbonate resulting from small fragments of biogenic CaCO3 in the ocean's surface microlayer. Given the observed nonsoil calcium excess over that in bulk seawater, the estimated actual buffering capacity of sea-salt aerosols observed during ACE 1 was 50%, or more, enhanced over that due to bulk seawater alkalinity. Considering this enhanced buffering capacity, O-3 oxidation of SO2 in SSAW can produce sufficient NSS to explain 70-90% of the similar to 1 nmol m(-3) found in > 0.7 mu m diam coarse sea-salt aerosols with cloud processing and further oxidation of SO2 in SSAW (i.e., pH < 6) by other sea-salt conversion mechanisms contributing the remainder. The amount of NSS produced by sea-salt conversion mechanisms during the ACE 1 remote Southern Ocean experiment vied with homogeneous and cloud processing in their contribution to the total observed NSS of 2.2-2.3 nmol m(-3)

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection