Student Career Choices before and during Quarantine Measures

Nowadays, in terms of the COVID-19 pandemic, there is a dramatic transformation of the professions in demand and labor market preferences. In this regard, universities need to review and pay special attention to young people’s professional development taking into account new conditions. In February 2020, before quarantine in the Russian Federation, the authors of the present research conducted a survey in order to study the students’ career preferences. The survey involved 616 students of Bachelor’s and Master’s programs of M. K. Ammosov North-Eastern Federal University (“My professional career”), 78 students of the Arctic State Agrotechnological University (“Labor values of youth”), 29 students of the Arctic State Institute of Culture and Arts (“Me and my professional career”). The results showed that the students consider career development as an opportunity to realize their material goals, to combine professional and personal interests, and to set up their own business. In addition, during a quarantine measures due to the COVID 19 pandemic in May 2020, an express survey of 437 students was conducted. The results of the survey showed that some students have changed their attitude to their future career, i.e., they wanted to get advanced professional education, improve their digital skills to make it easier to adapt for remote work. Some students expressed their thoughts regarding future employment, i.e., a budget organization or the sphere of small and medium businesses. The authors concluded that university programs for future specialists’ training should take into account students’ career preferences, desires, professional intentions and attitudes

STAFF TRAINING FOR MILITARY AND CIVIL SERVICE IN THE MIDDLE OF THE 19TH CENTURY: ACADEMIC YEARS OF HISTORIAN, GENERAL-LIEUTENANT N.K. SCHILDER

The purpose of the article is to replenish the information fi eld of Russian historians by introducing data about a little-known element in the historiography in the system of staff trai-ning in elite educational institutions of Russia in the middle of the 19th century. The object of the study is the young age of Nikolai Karlovich Schilder (1842-1902), who by honourable service in the military fi eld rose to the rank of Lieutenant General (1893) after completing two educational institutions. As a result of his historical studies, he became the corresponding mem-ber of the Petersburg Academy of Sciences (1900). Based on the information found in archival and published historical sources, as well as in the an-nexes to the published historical works, there is considered the process of N.K. Schilder’s acquiring not only a large body of knowledge, but also the process of his personality formation as a patriot of Russia.Five years (1857-1862) were a special period of his life as a future military engineer and historian - the time when he obtained secondary and special higher military education. The years of studies in the Pages Corps and the Nikolaev Engineering Academy were of great use for him. He showed good results in studies and extraordinary creative abilities. The article shows the scope of knowledge and quality of skills obtained by N.K. Shilder while studying, the degree of his preparedness to work both as a military engineer and historian-researcher. The article proves that he obtained professional knowledge necessary for a military engineer; he was accustomed to thinking big, to working systematically, independently and creatively. Self-discipline and acquired skills of research work were the key to his future success in the fi eld of military and military-political history and in the biographical genre

Student Career Choices before and during Quarantine Measures

Nowadays, in terms of the COVID-19 pandemic, there is a dramatic transformation of the professions in demand and labor market preferences. In this regard, universities need to review and pay special attention to young people’s professional development taking into account new conditions. In February 2020, before quarantine in the Russian Federation, the authors of the present research conducted a survey in order to study the students’ career preferences. The survey involved 616 students of Bachelor’s and Master’s programs of M. K. Ammosov North-Eastern Federal University (“My professional career”), 78 students of the Arctic State Agrotechnological University (“Labor values of youth”), 29 students of the Arctic State Institute of Culture and Arts (“Me and my professional career”). The results showed that the students consider career development as an opportunity to realize their material goals, to combine professional and personal interests, and to set up their own business. In addition, during a quarantine measures due to the COVID 19 pandemic in May 2020, an express survey of 437 students was conducted. The results of the survey showed that some students have changed their attitude to their future career, i.e., they wanted to get advanced professional education, improve their digital skills to make it easier to adapt for remote work. Some students expressed their thoughts regarding future employment, i.e., a budget organization or the sphere of small and medium businesses. The authors concluded that university programs for future specialists’ training should take into account students’ career preferences, desires, professional intentions and attitudes.Hoy en día, en términos de la pandemia COVID-19, hay una dramática transformación de las profesiones en demanda y preferencias del mercado laboral. En este sentido, las universidades deben revisar y prestar especial atención al desarrollo profesional de los jóvenes teniendo en cuenta las nuevas condiciones. En febrero de 2020, antes de la cuarentena en la Federación de Rusia, los autores de la presente investigación realizaron una encuesta para estudiar las preferencias profesionales de los estudiantes. En la encuesta participaron 616 estudiantes de los programas de licenciatura y maestría de la Universidad Federal del Nordeste M. K. Ammosov ("Mi carrera profesional"), 78 estudiantes de la Universidad Estatal Agrotecnológica del Ártico ("Valores laborales de la juventud"), 29 estudiantes del Instituto Estatal del Ártico de Cultura y Artes ("Yo y mi carrera profesional"). Los resultados mostraron que los estudiantes consideran el desarrollo de la carrera como una oportunidad para realizar sus objetivos materiales, combinar los intereses profesionales y personales y crear su propio negocio. Además, durante las medidas de cuarentena debidas a la pandemia de COVID 19 en mayo de 2020, se realizó una encuesta expresa a 437 estudiantes. Los resultados de la encuesta mostraron que algunos estudiantes han cambiado su actitud hacia su futura carrera, es decir, querían obtener una educación profesional avanzada, mejorar sus habilidades digitales para facilitar su adaptación al trabajo a distancia. Algunos estudiantes expresaron sus ideas sobre el futuro empleo, es decir, una organización presupuestaria o la esfera de las pequeñas y medianas empresas. Los autores concluyeron que los programas universitarios para la formación de futuros especialistas deberían tener en cuenta las preferencias de carrera, los deseos, las intenciones y las actitudes profesionales de los estudiante

Dendritic cells pulsed with tumor lysates induced by tetracyanotetra(aryl)porphyrazines-based photodynamic therapy effectively trigger anti-tumor immunity in an orthotopic mouse glioma model

Research in the past decade on immunogenic cell death (ICD) has shown that the immunogenicity of dying tumor cells is crucial for effective anticancer therapy. ICD induction leads to the emission of specific damage-associated molecular patterns (DAMPs), which act as danger signals and as adjuvants to activate specific anti-tumor immune responses, leading to the elimination of tumor cells and the formation of long-term immunological memory. ICD can be triggered by many anticancer treatment modalities, including photodynamic therapy (PDT). However, due to the variety of photosensitizers used and the lack of a universally adopted PDT protocol, there is a need to develop novel PDT with a proven ICD capability. In the present study, we characterized the abilities of two photoactive dyes to induce ICD in experimental glioma in vitro and in vivo. One dye was from the tetracyanotetra(aryl)porphyrazine group with 9-phenanthrenyl (pz I), and the other was from the 4-(4-fluorobenzyoxy)phenyl (pz III) group in the aryl frame of the macrocycle. We showed that after the photosensitizers penetrated into murine glioma GL261 cells, they localized predominantly in the Golgi apparatus and partially in the endoplasmic reticulum, providing efficient phototoxic activity against glioma GL261 cells upon light irradiation at a dose of 20 J/cm2 (lambda ex 630 nm; 20 mW/cm2). We demonstrated that pz I-PDT and pz III-PDT can act as efficient ICD inducers when applied to glioma GL261 cells, facilitating the release of two crucial DAMPs (ATP and HMGB1). Moreover, glioma GL261 cells stimulated with pz I-PDT or pz III-PDT provided strong protection against tumor growth in a prophylactic subcutaneous glioma vaccination model. Finally, we showed that dendritic cell (DC) vaccines pulsed with the lysates of glioma GL261 cells pre-treated with pz-I-PDT or pz-III-PDT could act as effective inducers of adaptive anti-tumor immunity in an intracranial orthotopic glioma mouse model

Proceedings Of The 23Rd Paediatric Rheumatology European Society Congress: Part Two

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