1,748 research outputs found
A generalization of the q-Saalschutz sum and the Burge transform
A generalization of the q-(Pfaff)-Saalschutz summation formula is proved.
This implies a generalization of the Burge transform, resulting in an
additional dimension of the ``Burge tree''. Limiting cases of our summation
formula imply the (higher-level) Bailey lemma, provide a new decomposition of
the q-multinomial coefficients, and can be used to prove the Lepowsky and Primc
formula for the A_1^{(1)} string functions.Comment: 18 pages, AMSLaTe
Big-Data-Driven Materials Science and its FAIR Data Infrastructure
This chapter addresses the forth paradigm of materials research -- big-data
driven materials science. Its concepts and state-of-the-art are described, and
its challenges and chances are discussed. For furthering the field, Open Data
and an all-embracing sharing, an efficient data infrastructure, and the rich
ecosystem of computer codes used in the community are of critical importance.
For shaping this forth paradigm and contributing to the development or
discovery of improved and novel materials, data must be what is now called FAIR
-- Findable, Accessible, Interoperable and Re-purposable/Re-usable. This sets
the stage for advances of methods from artificial intelligence that operate on
large data sets to find trends and patterns that cannot be obtained from
individual calculations and not even directly from high-throughput studies.
Recent progress is reviewed and demonstrated, and the chapter is concluded by a
forward-looking perspective, addressing important not yet solved challenges.Comment: submitted to the Handbook of Materials Modeling (eds. S. Yip and W.
Andreoni), Springer 2018/201
The Other-Race Effect Develops During Infancy: Evidence of Perceptual Narrowing
Experience plays a crucial role in the development
of face processing. In the study reported here, we
investigated how faces observed within the visual environment
affect the development of the face-processing
system during the 1st year of life. We assessed 3-, 6-, and
9-month-old Caucasian infants’ ability to discriminate
faces within their own racial group and within three otherrace
groups (African, Middle Eastern, and Chinese).
The 3-month-old infants demonstrated recognition in all
conditions, the 6-month-old infants were able to recognize
Caucasian and Chinese faces only, and the 9-month-old
infants’ recognition was restricted to own-race faces. The
pattern of preferences indicates that the other-race effect
is emerging by 6 months of age and is present at 9 months
of age. The findings suggest that facial input from the
infant’s visual environment is crucial for shaping the
face-processing system early in infancy, resulting in differential
recognition accuracy for faces of different races in
adulthood
Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS
Congenital melanocytic nevi (CMN) can be associated with neurological abnormalities and an increased risk of melanoma. Mutations in NRAS, BRAF, and Tp53 have been described in individual CMN samples; however, their role in the pathogenesis of multiple CMN within the same subject and development of associated features has not been clear. We hypothesized that a single postzygotic mutation in NRAS could be responsible for multiple CMN in the same individual, as well as for melanocytic and nonmelanocytic central nervous system (CNS) lesions. From 15 patients, 55 samples with multiple CMN were sequenced after site-directed mutagenesis and enzymatic digestion of the wild-type allele. Oncogenic missense mutations in codon 61 of NRAS were found in affected neurological and cutaneous tissues of 12 out of 15 patients, but were absent from unaffected tissues and blood, consistent with NRAS mutation mosaicism. In 10 patients, the mutation was consistently c.181C>A, p.Q61K, and in 2 patients c.182A>G, p.Q61R. All 11 non-melanocytic and melanocytic CNS samples from 5 patients were mutation positive, despite NRAS rarely being reported as mutated in CNS tumors. Loss of heterozygosity was associated with the onset of melanoma in two cases, implying a multistep progression to malignancy. These results suggest that single postzygotic NRAS mutations are responsible for multiple CMN and associated neurological lesions in the majority of cases
Two faces of the other-race effect: Recognition and categorisation of Caucasian and Chinese faces
The other-race effect is a collection of phenomena whereby faces of one's own race are processed differently from those of other races. Previous studies have revealed a paradoxical mirror pattern of an own-race advantage in face recognition and an other-race advantage in race-based categorisation. With a well-controlled design, we compared recognition and categorisation of own-race and other-race faces in both Caucasian and Chinese participants. Compared with own-race faces, other-race faces were less accurately and more slowly recognised, whereas they were more rapidly categorised by race. The mirror pattern was confirmed by a unique negative correlation between the two effects in terms of reaction time with a hierarchical regression analysis. This finding suggests an antagonistic interaction between the processing of face identity and that of face category, and a common underlying processing mechanism
CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine
Recent transcriptome studies have revealed that a large number of transcripts in mammals and other organisms do not encode proteins but function as noncoding RNAs (ncRNAs) instead. As millions of transcripts are generated by large-scale cDNA and EST sequencing projects every year, there is a need for automatic methods to distinguish protein-coding RNAs from noncoding RNAs accurately and quickly. We developed a support vector machine-based classifier, named Coding Potential Calculator (CPC), to assess the protein-coding potential of a transcript based on six biologically meaningful sequence features. Tenfold cross-validation on the training dataset and further testing on several large datasets showed that CPC can discriminate coding from noncoding transcripts with high accuracy. Furthermore, CPC also runs an order-of-magnitude faster than a previous state-of-the-art tool and has higher accuracy. We developed a user-friendly web-based interface of CPC at http://cpc.cbi.pku.edu.cn. In addition to predicting the coding potential of the input transcripts, the CPC web server also graphically displays detailed sequence features and additional annotations of the transcript that may facilitate users’ further investigation
Substitutional Reality System: A Novel Experimental Platform for Experiencing Alternative Reality
We have developed a novel experimental platform, referred to as a substitutional reality (SR) system, for studying the conviction of the perception of live reality and related metacognitive functions. The SR system was designed to manipulate people's reality by allowing them to experience live scenes (in which they were physically present) and recorded scenes (which were recorded and edited in advance) in an alternating manner without noticing a reality gap. All of the naïve participants (n = 21) successfully believed that they had experienced live scenes when recorded scenes had been presented. Additional psychophysical experiments suggest the depth of visual objects does not affect the perceptual discriminability between scenes, and the scene switch during head movement enhance substitutional performance. The SR system, with its reality manipulation, is a novel and affordable method for studying metacognitive functions and psychiatric disorders
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