Black Stain: studio clinico e microbiologico

Aim of the work. Objectives of the study are the following: quantify and identify microorganisms in the dental plaque of patients with black stain; test in vivo and in vitro efficacy of two mouthwashes; identify a protocol. Materials and methods. The research protocol included a clinical and a microbiological stage. 63 patients between 2 and 15 years with black stain were selected, then divided into three groups. In Group 1 (19 patients) no mouthwash was prescribed. In Group 2 (21 patients) was prescribed a fluoride mouthwash (Sodium Fluoride 0,05%). In Group 3 (23 patients) a chlorhexidine 0,12% mouthwash was prescribed. The microbiological stage provided analysis of pigmented plaque through bacterial count and identification tests and aura of inhibition on agar plate to evaluate the inhibitory power of the mouthwashes examined. Results. It was highlighted a strong decrease in index of pigmented plaque in Group 3 than Groups 1 and 2. The microbiological analysis revealed a decrease in bacterial count higher in Group 3 than Groups 1 and 2. The bacteria identified the most were Clostridia. The chlorhexidine mouthwash was more effective than fluorine mouthwash on bacterial growth. Conclusions. The use of mouthwash in conjunction with periodic specialist visits is essential to assist oral hygiene at home. It is assumed that the mouthwash with chlorhexidine 0,12% is the most effective in reducing black stain in vivo and in vitro

Scattering-based nonlinear macromodels of high-speed differential drivers

This paper introduces a scattering-based nonlinear macromodeling framework for high-speed differential drivers. Using an industrial test case, we show that the proposed scattering formulation enables more accurate and robust model identification with respect to standard voltage-current representations. The combination of proposed driver models with a Waveform Relaxation solver allows accurate and efficient transient channel simulation, including nonlinear and dynamic termination effect

PHP39 The "Weight" of Orphan Drugs in the European Pharmaceutical Policy. A Focus on the Expenditure and the Utilization of Orphan Drugs in Five European Union Countries

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Avaliação do potencial produtivo de genótipos de mandioca (Manihot esculenta Crantz).

O objetivo deste trabalho foi avaliar a reação de resistência à Phytophthora drechsleri, a produtividade de raiz e o percentual de amido de 102 genótipos de mandioca, pertencentes ao Banco de Germoplasma da Embrapa Acre

Near-infrared Observations of Nova V574 Puppis (2004)

We present results obtained from extensive near-infrared spectroscopic and photometric observations of nova V574 Pup during its 2004 outburst. The observations were obtained over four months, starting from 2004 November 25 (four days after the nova outburst) to 2005 March 20. The near-IR JHK light curve is presented - no evidence is seen from it for dust formation to have occurred during our observations. In the early decline phase, the JHK spectra of the nova are dominated by emission lines of hydrogen Brackett and Paschen series, OI, CI and HeI. We also detect the fairly uncommon Fe II line at 1.6872 micron in the early part of our observations. The strengths of the HeI lines at 1.0830 micron and 2.0585 micron are found to become very strong towards the end of the observations indicating a progression towards higher excitation conditions in the nova ejecta. The width of the emission lines do not show any significant change during the course of our observations. The slope of the continuum spectrum was found to have a lambda^{-2.75} dependence in the early stages which gradually becomes flatter with time and changes to a free-free spectral dependence towards the later stages. Recombination analysis of the HI lines shows deviations from Case B conditions during the initial stages. However, towards the end of our observations, the line strengths are well simulated with case B model values with electron density n_e = 10^{9-10} cm^{-3} and a temperature equal to 10^4 K. Based on our distance estimate to the nova of 5.5 kpc and the observed free-free continuum emission in the later part of the observations, we estimate the ionized mass of the ejecta to be between 10^{-5} and 10^{-6} solar-mass.Comment: 10 pages, 8 figures, Accepted for publication in MNRA

Swift X-ray Observations of Classical Novae

The new gamma-ray burst mission Swift has obtained pointed observations of several classical novae in outburst. We analyzed all the observations of classical novae from the Swift archive up to 30 June, 2006. We analyzed usable observations of 12 classical novae and found 4 non-detections, 3 weak sources and 5 strong sources. This includes detections of 2 novae exhibiting spectra resembling those of Super Soft X-ray binary Source spectra (SSS) implying ongoing nuclear burning on the white dwarf surface. With these new Swift data, we add to the growing statistics of the X-ray duration and characteristics of classical novae.Comment: Accepted for ApJ; this version contains additional material: 18 pages, 16 figure

Identification of globular cluster stars in RAVE data - I. Application to stellar parameter calibration

We present the identification of potential members of nearby Galactic globular clusters using radial velocities from the RAdial Velocity Experiment Data Release 4 (RAVE-DR4) survey data base. Our identifications are based on three globular clusters – NGC 3201, NGC 5139 (ω Cen) and NGC 362 – all of which are shown to have ∣RV∣ > 100 km s⁻¹. The high radial velocity of cluster members compared to the bulk of surrounding disc stars enables us to identify members using their measured radial velocities, supplemented by proper motion information and location relative to the tidal radius of each cluster. The identification of globular cluster stars in RAVE DR4 data offers a unique opportunity to test the precision and accuracy of the stellar parameters determined with the currently available Stellar Parameter Pipelines used in the survey, as globular clusters are ideal test-beds for the validation of stellar atmospheric parameters, abundances, distances and ages. For both NGC 3201 and ω Cen, there is compelling evidence for numerous members (>10) in the RAVE data base; in the case of NGC 362 the evidence is more ambiguous, and there may be significant foreground and/or background contamination in our kinematically selected sample. A comparison of the RAVE-derived stellar parameters and abundances with published values for each cluster and with BASTI isochrones for ages and metallicities from the literature reveals overall good agreement, with the exception of the apparent underestimation of surface gravities for giants, in particular for the most metal-poor stars. Moreover, if the selected members are part of the main body of each cluster our results would also suggest that the distances from Binney et al., where only isochrones more metal rich than −0.9 dex were used, are typically underestimated by ∼40 per cent with respect to the published distances for the clusters, while the distances from Zwitter et al. show stars ranging from 1 to ∼6.5 kpc – with indications of a trend towards higher distances at lower metallicities – for the three clusters analysed in this study

Drug utilization, safety, and effectiveness of exenatide, sitagliptin, and vildagliptin for type 2 diabetes in the real world: Data from the Italian AIFA Anti-diabetics Monitoring Registry

AbstractBackground and aimsIn Italy, the reimbursed use of incretin mimetics and incretin enhancers was subject to enrollment of patients into a web-based system recording the general demographic and clinical data of patients. We report the utilization data of glucagon-like peptide 1 (GLP1) receptor agonists and dipeptidylpeptidase-4 (DPP4) inhibitors in clinical practice as recorded by the Italian Medicines Agency (AIFA) Monitoring Registry.Methods and resultsFrom February 2008 to August 2010, 75,283 patients with type 2 diabetes were entered into the registry and treated with exenatide, sitagliptin, or vildagliptin. The treatment was administered to patients in a wide range of ages (≥75 years, n = 6125 cases), body mass index (BMI) (≥35 kg/m2, n = 22,015), and metabolic control (HbA1c ≥ 11% ((96 mmol/mol), n = 3151). Overall, 1116 suspected adverse drug reactions were registered, including 12 cases of acute pancreatitis (six on exenatide). Hypoglycemic episodes mainly occurred in combination with sulfonylureas. Treatment discontinuation for the three drugs (logistic regression analysis) was negatively associated with the male gender and positively with baseline HbA1c, diabetes duration, and, limitedly to DPP-4 inhibitors, with BMI. Treatment discontinuation (including loss to follow-up, accounting for 21–26%) was frequent. Discontinuation for treatment failure occurred in 7.7% of cases (exenatide), 3.8% (sitagliptin), and 4.1% (vildagliptin), respectively, corresponding to 27–40% of all discontinuations, after excluding lost to follow-up. HbA1c decreased on average by 0.9–1.0% (9 mmol/mol). Body weight decreased by 3.5% with exenatide and by 1.0–1.5% with DPP-4 inhibitors.ConclusionsIn the real world of Italian diabetes centers, prescriptions of incretins have been made in many cases outside the regulatory limits. Nevertheless, when appropriately utilized, incretins may grant results at least in line with pivotal trials

The 2010 nova outburst of the symbiotic Mira V407 Cyg

The nova outburst experienced in 2010 by the symbiotic binary Mira V407 Cyg has been extensively studied at optical and infrared wavelengths with both photometric and spectroscopic observations. This outburst, reminiscent of similar events displayed by RS Oph, can be described as a very fast He/N nova erupting while being deeply embedded in the dense wind of its cool giant companion. The hard radiation from the initial thermonuclear flash ionizes and excites the wind of the Mira over great distances (recombination is observed on a time scale of 4 days). The nova ejecta is found to progressively decelerate with time as it expands into the Mira wind. This is deduced from line widths which change from a FWHM of 2760 km/s on day +2.3 to 200 km/s on day +196. The wind of the Mira is massive and extended enough for an outer neutral and unperturbed region to survive at all outburst phases.Comment: MNRAS Letter, in pres