Uranium exploration methodology in cold climates

The uranium prospecting boom of the past decade had, as a major consequence, the rapid development and proliferation of exploration methods for source materials. Numerous established methods were developed and refined whilst new techniques were introduced proving, in some instances, to be highly successful. To the explorationist the proliferation of instrumental hardware and detection systems was something of a headache with the result that in uranium exploration, more so than in other types of prospecting, the choice of exploration method at the appropriate stage of prospecting was frequently ill founded. The situation also spawned ‘black box’ purveyors who made extravagant claims for their equipment. Money was wasted through over kill applications of exploration method accompanied in many instances by deficiencies in the interpretation of results. This project was originally conceived as a means of evaluating, reviewing and filtering from a burgeoning array of systems the most appropriate exploration techniques applicable to cold climate environments. This goal has been trimmed somewhat since it had been hoped to incorporate site investigation data assembled in the field by the writer as appropriate case history material. This was not possible and as a consequence this report is a 'state of the art review' of the applicability of currently available techniques in Arctic and Subarctic environments. Reference is made to published case history data, where appropriate, supportive of the techniques or methods reviewed.Abstract -- Introduction -- Prospecting methods in relation to Arctic and Subarctic environments -- Review of direct exploration methods -- Radiometric methods -- Airborne spectrometry -- Car borne and hand held instrumentation -- Geochemical methods -- Soil and stream sediment methods -- Geobotanical methods -- Water sampling - Hydrogeochemical methods -- Other metods -- Optimal exploration method selection -- References -- Table of exploration methods discussed in this report

Application of portable delayed neutron activation analysis equipment in the evaluation of gold deposits

The attributes of a gold analysis system which could act as a panacea for the needs of the explorationist and the miner alike would include: i) The capability of being used as a qualitative as well as a quantitative tool yielding accurate results in respect of large samples. ii) The capability of generating results on site either in the field or within a prospect or mine. iii) An identifiable cost effectiveness in relation to other methods. iv) The capability of being housed in an equipment package which combines ruggedness, portability and reliability with operational options which permit measurements to be made on outcrops, mine faces, borehole cores as well as direct in-situ down-the hole determinations. The portable x-ray fluorescence gold analyser is on the threshold of meeting all the criteria cited above. Since the system is non-destructive in so far as the sample is concerned check assays employing conventional techniques can be run on a small percentage of the sample population. This report by its very nature is a state of the art review which sets out to describe the current instrument package, the principles by which it functions, its performance compared with detailed chip channel sampling and then suggests how the system may evolve in terms of its application to the investigation of hard-rock and placer deposits.Introduction -- Development of the gold analyser -- Basic principles of the system -- The instrument package -- Hand held probe -- Electronic pack -- Control module -- Liquid nitrogen supply -- Operational safety -- Review of operating results -- Sampling practice -- Broader applications -- Conclusions and recommendations -- Costs -- Acknowledgements -- Appendixes 1 and 2 -- References and information sources

Exploring the experiences of parents of Autistic children when attending the diagnostic imaging department for an X-ray examination

Introduction Autism is a neuro-developmental condition which affects the social-emotional skills, behaviour, language, communication skills and flexibility of thoughts of an individual and their sensory processing. This can result in Autistic service users finding it difficult to navigate current healthcare provision and cope with the unpredictable environment. This paper explores the experiences of parents of Autistic children when attending the diagnostic imaging department for an X-ray examination. Methods A cross sectional, mixed methods approach was adopted and the initial phase consisting of an online survey for parents to complete is the subject of this paper. The quantitative data was analysed using descriptive statistics and cross comparison between questions was also completed. Thematic analysis was taken to analyse the data from the two open questions at the end of the survey. Results The online survey results are presented in this paper under four key themes; waiting times and environment, forms of communication, lack of understanding of staff regarding Autism and preparation for the X-ray examination. Conclusion The overall rating of the parents' experience whilst in the X-ray/diagnostic imaging department was positive, however there are several areas which received low scores which need further attention. These were waiting areas, waiting times, staff development and patient preparation. Implications for practice The development of more inclusive waiting areas is needed, more effective lines of communication between staff to expedite the patient journey where possible, staff development of both radiographers and also support staff and the review of design of more accessible and inclusive patient information

Leveraging open innovation to improve society: past achievements and future trajectories

Open innovation (OI) is an approach which describes a purposive attempt to draw together knowledge from different contributors to develop and exploit innovation. It has become clear that OI directly benefits organisations' economic performance and resilience, but researchers, practitioners, and policy makers became also convinced that OI might be the way forward to tackle the world’s most pressing societal challenges, representing unresolved Grand Challenges, which can only be weathered by diverse sets of collaborative partners that join forces. Although anecdotal evidence points at how OI practices can be employed to achieve societal impact not only in private firms but also in public organisations, very little understanding exists -beyond anecdotal- to link OI to societal impact. This special issue has the ambition to start the discussion and establish a framework as the stepping stone to tackle this complex research gap

γ -ray spectroscopy of astrophysically important states in Ca 39

Background: Nova explosions synthesize elements up to A≃40, and discrepancies exist between calculated and observed abundances of Ar and Ca created in the explosion. The K38(p,γ)Ca39 reaction rate has been shown to be influential on these isotopic abundances at the endpoint of nova nucleosynthesis. The energies of the three most important resonances, corresponding to Jπ=5/2+ excited states in the Ca39 nucleus above the proton separation threshold, are uncertain and one has been measured with conflicting values [Er=679(2) versus Er=701(2) keV] in previous experiments. Purpose: Reducing the uncertainties on the resonance energies would allow for a better understanding of the reaction rate. To improve these uncertainties, we searched for γ rays from the depopulation of the corresponding excited states in Ca39. Methods: We report a new measurement of these resonance energies via the observation of previously unobserved γ-ray transitions. These transitions were observed by studying the Ca40(3He,αγ)Ca39 reaction with Gammasphere ORRUBA Dual Detectors for Experimental Structure Studies (GODDESS). The updated resonance energies were then used to calculate the K38(p,γ)Ca39 reaction rate and assess its uncertainties. Results: In total, 23 new transitions were found, including three γ-ray transitions corresponding to the three Jπ=5/2+ states of astrophysical interest at energies of 6156.2(16), 6268.8(22), and 6470.8(19) keV. These correspond to resonance energies in the K38(p,γ)Ca39 reaction of 386(2), 498(2), and 701(2) keV. Conclusions: Updated K38(p,γ)Ca39 reaction rate calculations show a reduced upper limit at nova temperatures. However, the lower-than-previously-measured energy of the 498-keV resonance and uncertainty in its resonance strength increases the upper limit of the rate close to previous estimates at 0.4 GK

New γ -ray transitions observed in Ne 19 with implications for the O 15 (α,γ) Ne 19 reaction rate

The O15(α,γ)Ne19 reaction is responsible for breakout from the hot CNO cycle in type I x-ray bursts. Understanding the properties of resonances between Ex=4 and 5 MeV in Ne19 is crucial in the calculation of this reaction rate. The spins and parities of these states are well known, with the exception of the 4.14- and 4.20-MeV states, which have adopted spin-parities of 9/2- and 7/2-, respectively. γ-ray transitions from these states were studied using triton-γ-γ coincidences from the F19(He3,tγ)Ne19 reaction measured with the GODDESS (Gammasphere ORRUBA Dual Detectors for Experimental Structure Studies) at Argonne National Laboratory. The observed transitions from the 4.14- and 4.20-MeV states provide strong evidence that the Jπ values are actually 7/2- and 9/2-, respectively. These assignments are consistent with the values in the F19 mirror nucleus and in contrast to previously accepted assignments

Transient Polycomb activity represses developmental genes in growing oocytes

Published online: 21 December 2022BACKGROUND: Non-genetic disease inheritance and offspring phenotype are substantially influenced by germline epigenetic programming, including genomic imprinting. Loss of Polycomb Repressive Complex 2 (PRC2) function in oocytes causes non-genetically inherited effects on offspring, including embryonic growth restriction followed by post-natal offspring overgrowth. While PRC2-dependent non-canonical imprinting is likely to contribute, less is known about germline epigenetic programming of non-imprinted genes during oocyte growth. In addition, de novo germline mutations in genes encoding PRC2 lead to overgrowth syndromes in human patients, but the extent to which PRC2 activity is conserved in human oocytes is poorly understood. RESULTS: In this study, we identify a discrete period of early oocyte growth during which PRC2 is expressed in mouse growing oocytes. Deletion of Eed during this window led to the de-repression of 343 genes. A high proportion of these were developmental regulators, and the vast majority were not imprinted genes. Many of the de-repressed genes were also marked by the PRC2-dependent epigenetic modification histone 3 lysine 27 trimethylation (H3K27me3) in primary-secondary mouse oocytes, at a time concurrent with PRC2 expression. In addition, we found H3K27me3 was also enriched on many of these genes by the germinal vesicle (GV) stage in human oocytes, strongly indicating that this PRC2 function is conserved in the human germline. However, while the 343 genes were de-repressed in mouse oocytes lacking EED, they were not de-repressed in pre-implantation embryos and lost H3K27me3 during pre-implantation development. This implies that H3K27me3 is a transient feature that represses a wide range of genes in oocytes. CONCLUSIONS: Together, these data indicate that EED has spatially and temporally distinct functions in the female germline to repress a wide range of developmentally important genes and that this activity is conserved in the mouse and human germlines.Ellen G. Jarred, Zhipeng Qu, Tesha Tsai, Ruby Oberin, Sigrid Petautschnig, Heidi Bildsoe, Stephen Pederson, Qing, hua Zhang, Jessica M. Stringer, John Carroll, David K. Gardner, Maarten Van den Buuse, Natalie A. Sims, William T. Gibson, David L. Adelson and Patrick S. Wester