A computational analysis of lower bounds for big bucket production planning problems

In this paper, we analyze a variety of approaches to obtain lower bounds for multi-level production planning problems with big bucket capacities, i.e., problems in which multiple items compete for the same resources. We give an extensive survey of both known and new methods, and also establish relationships between some of these methods that, to our knowledge, have not been presented before. As will be highlighted, understanding the substructures of difficult problems provide crucial insights on why these problems are hard to solve, and this is addressed by a thorough analysis in the paper. We conclude with computational results on a variety of widely used test sets, and a discussion of future research

Rochechouart 2017-Drilling Campaign: First Results

No abstract available

Coupled dark matter-dark energy in light of near Universe observations

Cosmological analysis based on currently available observations are unable to rule out a sizeable coupling among the dark energy and dark matter fluids. We explore a variety of coupled dark matter-dark energy models, which satisfy cosmic microwave background constraints, in light of low redshift and near universe observations. We illustrate the phenomenology of different classes of dark coupling models, paying particular attention in distinguishing between effects that appear only on the expansion history and those that appear in the growth of structure. We find that while a broad class of dark coupling models are effectively models where general relativity (GR) is modified --and thus can be probed by a combination of tests for the expansion history and the growth of structure--, there is a class of dark coupling models where gravity is still GR, but the growth of perturbations is, in principle modified. While this effect is small in the specific models we have considered, one should bear in mind that an inconsistency between reconstructed expansion history and growth may not uniquely indicate deviations from GR. Our low redshift constraints arise from cosmic velocities, redshift space distortions and dark matter abundance in galaxy voids. We find that current data constrain the dimensionless coupling to be |xi|<0.2, but prospects from forthcoming data are for a significant improvement. Future, precise measurements of the Hubble constant, combined with high-precision constraints on the growth of structure, could provide the key to rule out dark coupling models which survive other tests. We shall exploit as well weak equivalence principle violation arguments, which have the potential to highly disfavour a broad family of coupled models.Comment: 34 pages, 6 figures; changes to match published versio

Reviews

Rich and Poor in New Zealand: A Critique of Class, Politics and Ideology, Social Policy and the Welfare State in New Zealand, The Framework of Industrial Law in New Zealand, Industrial Society: Class Clevage and Control, The Control of Work, The Workless State: Studies in Umemployment, A Professional Union: the Evolution of the Institution of Professional Civil Servants, Strike

The PHENIX Experiment at RHIC

The physics emphases of the PHENIX collaboration and the design and current status of the PHENIX detector are discussed. The plan of the collaboration for making the most effective use of the available luminosity in the first years of RHIC operation is also presented.Comment: 5 pages, 1 figure. Further details of the PHENIX physics program available at http://www.rhic.bnl.gov/phenix

Membrane insertion and secretion of the Engrailed-2 (EN2) transcription factor by prostate cancer cells may induce antiviral activity in the stroma

YesEngrailed-2 (EN2) is a homeodomain-containing transcription factor that has roles in boundary formation and neural guidance in early development, but which is also expressed in a range of cancers. In addition to transcriptional regulation, it is secreted by cells and taken up by others through a mechanism that is yet to be fully elucidated. In this study, the distribution of EN2 protein in cells was evaluated using immunofluorescence with a set of antibodies raised against overlapping epitopes across the protein, and through the use of an EN2-GFP construct. MX2 expression in primary prostate tumors was evaluated using immunohistochemistry. We showed that EN2 protein is present in the cell membrane and within microvesicles that can be secreted from the cell and taken up by others. When taken up by normal cells from the stroma EN2 induces the expression of MX2 (MxB), a protein that has a key role in the innate immune response to viruses. Our findings indicate that EN2 secretion by tumors may be a means of preventing viral-mediated immune invasion of tissue immediately adjacent to the tumor.The Ringrose Family Trust supported this study through a studentship awarded to N.P

Limit cycles in uniform isochronous centers of discontinuous differential systems with four zones

We apply the averaging theory of first order for discontinuous differential systems to study the bifurcation of limit cycles from the periodic orbits of the uniform isochronous center of the differential systems ẋ = -y+x, y = x + xy, and ẋ = -y + xy, y = x + xy, when they are perturbed inside the class of all discontinuous quadratic and cubic polynomials differential systems with four zones separately by the axes of coordinates, respectively. Using averaging theory of first order the maximum number of limit cycles that we can obtain is twice the maximum number of limit cycles obtained in a previous work for discontinuous quadratic differential systems perturbing the same uniform isochronous quadratic center at origin perturbed with two zones separately by a straight line, and 5 more limit cycles than those achieved in a prior result for discontinuous cubic differential systems with the same uniform isochronous cubic center at the origin perturbed with two zones separately by a straight line. Comparing our results with those obtained perturbing the mentioned centers by the continuous quadratic and cubic differential systems we obtain 8 and 9 more limit cycles respectively