The place of expert systems in a typology of information systems

This article considers definitions and claims of Expert Systems ( ES) and analyzes them in view of traditional Information systems (IS). It is argued that the valid specifications for ES do not differ fran those for IS. Consequently the theoretical study and the practical development of ES should not be a monodiscipline. Integration of ES development in classical mathematics and computer science opens the door to existing knowledge and experience. Aspects of existing ES are reviewed from this interdisciplinary point of view

A characterization of quadric constant mean curvature hypersurfaces of spheres

Let $\phi:M\to\mathbb{S}^{n+1}\subset\mathbb{R}^{n+2}$ be an immersion of a complete $n$-dimensional oriented manifold. For any $v\in\mathbb{R}^{n+2}$, let us denote by $\ell_v:M\to\mathbb{R}$ the function given by $\ell_v(x)=\phi(x),v$ and by $f_v:M\to\mathbb{R}$, the function given by $f_v(x)=\nu(x),v$, where $\nu:M\to\mathbb{S}^{n}$ is a Gauss map. We will prove that if $M$ has constant mean curvature, and, for some $v\ne{\bf 0}$ and some real number $\lambda$, we have that $\ell_v=\lambda f_v$, then, $\phi(M)$ is either a totally umbilical sphere or a Clifford hypersurface. As an application, we will use this result to prove that the weak stability index of any compact constant mean curvature hypersurface $M^n$ in $\mathbb{S}^{n+1}$ which is neither totally umbilical nor a Clifford hypersurface and has constant scalar curvature is greater than or equal to $2n+4$.Comment: Final version (February 2008). To appear in the Journal of Geometric Analysi

Fascial deformation in the lateral elbow region: A conceptual approach

Abstract In embalmed preparations, the antebrachial fascia in the lateral elbow region is shown to be deformed by load application to the triceps muscle. From this fascia, muscles arise which are primarily concerned with the extension of wrist and fingers. In the case of lateral epicondylitis (tennis elbow), the superficial site of attachment of these extensors at the lateral epicondyle is extremely painful. Triceps training may help to diminish (or prevent) this pain by altering the forces acting at the lateral epicondyle

Exactly solvable model of three interacting particles in an external magnetic field

The quantum mechanical problem of three identical particles, moving in a plane and interacting pairwise via a spring potential, is solved exactly in the presence of a magnetic field. Calculations of the pair--correlation function, mean distance and the cluster area show a quantization of these parameters. Especially the pair-correlation function exhibits a certain number of maxima given by a quantum number. We obtain Jastrow pre-factors which lead to an exchange correlation hole of liquid type, even in the presence of the attractive interaction between the identical electrons.Comment: 8 pages 3 figure

Effects of electrical stimulation of dorsal raphe nucleus on neuronal response properties of barrel cortex layer IV neurons following long-term sensory deprivation

Abstract: Objective To evaluate the effect of electrical stimulation of dorsal raphe nucleus (DRN) on response properties of layer IV barrel cortex neurons following long-term sensory deprivation. Methods: Male Wistar rats were divided into sensory-deprived (SD) and control (unplucked) groups. In SD group, all vibrissae except the D2 vibrissa were plucked on postnatal day one, and kept plucked for a period of 60 d. After that, whisker regrowth was allowed for 8-10 d. The D2 principal whisker (PW) and the D1 adjacent whisker (AW) were either deflected singly or both deflected in a serial order that the AW was deflected 20 ms before PW deflection for assessing lateral inhibition, and neuronal responses were recorded from layer IV of the D2 barrel cortex. DRN was electrically stimulated at inter-stimulus intervals (ISIs) ranging from 0 to 800 ms before whisker deflection. Results: PW-evoked responses increased in the SD group with DRN electrical stimulation at ISIs of 50 ms and 100 ms, whereas AW-evoked responses increased at ISI of 800 ms in both groups. Whisker plucking before DRN stimulation could enhance the responsiveness of barrel cortex neurons to PW deflection and decrease the responsiveness to AW deflection. DRN electrical stimulation significantly reduced this difference only in PW-evoked responses between groups. Besides, no DRN stimulation-related changes in response latency were observed following PW or AW deflection in either group. Moreover, condition test (CT) ratio increased in SD rats, while DRN stimulation did not affect the CT ratio in either group. There was no obvious change in 5-HT2A receptor protein density in barrel cortex between SD and control groups. Conclusion: These results suggest that DRN electrical stimulation can modulate information processing in the SD barrel cortex

Water Management Solution of Reservoir Storage Function Under Condition of Measurement Uncertainties in Hydrological Input Data

AbstractThe paper describes a possible procedure of the rate uncertainty implementation to the continuous water stage measurement and uncertainties of state - discharge rating curve point positions, which the stage -discharge rating curves were fitted into the uncertainties of the real discharge series members. Then the members of discharge series under uncertainty impact were tested on the calculated values of the reservoir storage volume. The next step was the implementation of the uncertainties of the real discharge series members on the generation of the artificial discharge series of mean monthly discharge using the AR and ARMA generators and the determination of their impact on the calculated values of the reservoir storage volume

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Separating the genetic and environmental drivers of body temperature during the development of endothermy in an altricial bird

When altricial birds hatch, they are unable to regulate their own temperature, but by the time they fledge they are thermally independent. Early-life conditions have been shown to be an important factor contributing to fitness. However, it is currently unknown to what extent body temperature during endothermy development is driven by genetic variation or by the early environment. We use thermal images of cross-fostered house sparrows (Passer domesticus) throughout the nestling period to separate genetic and environmental drivers of body temperature. We estimated negligible heritability of body temperature at all ages. We further found that there are effects from the natal environment that carry over into the late nestling stage. A correlation between the early- and mid-nestling periods was explained by the natal environment, and during this period body temperature and growth followed independent developmental trajectories. Furthermore, higher body temperature was under viability selection, independent of body mass. We, therefore, demonstrate that the natal environment influences future offspring phenotype via a novel measure; body temperature. Our study provides a novel investigation into the environmental and genetic drivers of body temperature variation in a wild bird, furthering our understanding of how traits evolve