Sexual consent as an interactional achievement : Overcoming ambiguities and social vulnerabilities in the initiations of sexual activities

Sexual consent is advocated around the world to reduce sexual assault. The widespread affirmative consent model emphasizes a need for unambiguous consent. In this paper, we contribute to a deeper understanding of how ambiguities in the initiations of sexual activities are routinely solved to achieve consent. Drawing on conversation analytic research on joint decision-making, and a dataset of 80 cases of sexual initiation in contemporary TV-series and movies, we investigate the interactional practices by which sexual activities are presented as consensual and how consent is achieved across sequences of interaction. We found there to be social advantages of synchronous initiation, compared to sequential verbal initiations, which were associated with various social vulnerabilities. These vulnerabilities could however be circumvented by two practices, each of which made use of a distinct combination of verbal and embodied resources. While ambiguities exist, our results oppose the idea of sexual consent as a practically hopeless and awkward endeavor. Instead, consent consists of joint action that is achieved through recognizable and systematic ways.publishedVersionPeer reviewe

Counselling to distance forest owners : a market survey in North Sweden coastal area

Målet med denna studie är att undersöka begreppet distansskogsägare i en nordlig kontext och hur avstånd till fastigheten, mål och kunskap påverkar skogsägarskapet samt vilka rådgivningstjänster de efterfrågar. Datain-samlingen till studien har skett med kvantitativ postenkät samt digital enkät som skickats ut till 500 distansskogsägare, boende i Norrlands kustland. En-käten har sammanställts och analyserats utifrån insamlad data och jämförts med tidigare studier. Resultatet i studien visar att distansskogsägarna tycker att kvalitén på tjäns-terna och förtroende till rådgivaren är det viktigaste hos en skoglig samar-betspartner. Studien visar även att de två vanligaste målen med fastigheten är hög ekonomisk avkastning och att ha bra möjlighet till jakt och rekreat-ion. Kompetensbrist är viktigaste orsaken till att distansskogsägare köper rådgivning. Besöken på fastigheten och antalet arbetsdagar på fastigheten minskar med ett ökat avstånd till skogsfastigheten. Distansskogsägarna från Norrland i studien tar inte alltid hjälp av någon ex-tern rådgivare medan alla tillfrågade Stockholmarna i en annan studie alltid gör det vid skoglig rådgivning. Efterfrågan på ekonomiska tjänster som t.ex. bokföring och skatteplanering ser ut att öka i framtiden relativt andra tjäns-ter medan skogsbrukstjänsterna ser ut att vara kvar på samma nivå som tidi-gare, enligt respondenterna.The purpose of this thesis is to examine the concept of distance forest own-ers in a northern context, and how distance to the forest property, goals with the ownership and how knowledge about forest impact the ownership. Fur-ther, one look at what kind of counselling that is requested by these forest owners. Empirical data of the study is collected through a quantitative sur-vey, which has been sent to 500 distance forest owners in the coastal coun-try area in the northern part of Sweden. The survey was compiled and ana-lyzed. The result of this study shows that the quality of the services and trust to the advisor are the most important factors for the forest owners. The main goals with the forest property are high financial return and good access to hunting and recreation. Lack of expertise and knowledge are the most com-mon reason for forest owners to buy consulting services. Visits to the prop-erty and days of work decreases with increased distance. The distance forest owners in northern Sweden do not always take advice from foresters; in comparison to distance forest owners in Stockholm, which always consult a forester - concluded in a previous study. The proportion of economic ser-vices, e.g. accounting tax advices, that is requested increases, while the pro-portion of traditional forest services is constant

Heritability of Oral Microbiota and Immune Responses to Oral Bacteria

Maintaining a symbiotic oral microbiota is essential for oral and dental health, and host genetic factors may affect the composition or function of the oral microbiota through a range of possible mechanisms, including immune pathways. The study included 836 Swedish twins divided into separate groups of adolescents (n= 418) and unrelated adults (n= 418). Oral microbiota composition and functions of non-enzymatically lysed oral bacteria samples were evaluated using 16S rRNA gene sequencing and functional bioinformatics tools in the adolescents. Adaptive immune responses were assessed by testing for serum IgG antibodies against a panel of common oral bacteria in adults. In the adolescents, host genetic factors were associated with both the detection and abundance of microbial species, but with considerable variation between species. Host genetic factors were associated with predicted microbiota functions, including several functions related to bacterial sucrose, fructose, and carbohydrate metabolism. In adults, genetic factors were associated with serum antibodies against oral bacteria. In conclusion, host genetic factors affect the composition of the oral microbiota at a species level, and host-governed adaptive immune responses, and also affect the concerted functions of the oral microbiota as a whole. This may help explain why some people are genetically predisposed to the major dental diseases of caries and periodontitis

The concept of rebalanced hemostasis in patients with liver disease:Communication from the ISTH SSC working group on hemostatic management of patients with liver disease

Patients with liver diseases acquire complex alterations in their hemostatic system that may lead to abnormalities in routine diagnostic test of hemostasis. Thrombocytopenia, prolongations in the prothrombin time and activated partial thromboplastin time, and decreased plasma fibrinogen are common in patients with advanced liver disease. Historically, liver diseases therefore have been classified as an acquired bleeding disorder. Laboratory and clinical observations have demonstrated that although routine diagnostic tests of hemostasis suggest a hypocoagulable state, patients with liver disease also tend to develop thrombotic events. Overall, patients have commensurate changes in both pro- and antihemostatic pathways. This new hemostatic balance, however, appears much more fragile than the hemostatic balance in individuals with normal liver function, and patients with liver disease can readily experience both hemostasis-related bleeding and thrombotic events. These insights into the hemostatic balance in patients with liver disease have led to revised recommendations for clinical management of hemostasis. In 2020, an SSC working group within the ISTH has been founded with the aim to disseminate new concepts on prevention and treatment of bleeding and thrombosis in patients with liver disease. The current document will outline the hemostatic changes in patients with liver disease, the limitations of routine diagnostic tests of hemostasis, and the concept of rebalanced hemostasis

Periprocedural management of abnormal coagulation parameters and thrombocytopenia in patients with cirrhosis:Guidance from the SSC of the ISTH

Prolonged prothrombin time and thrombocytopenia are common in patients with cirrhosis. These parameters do not reflect the overall hemostatic rebalance or bleeding risk in the periprocedural setting; however, attempts to correct these parameters remain frequent. We review the literature on periprocedural bleeding risk, bleeding risk factors, and the risk and benefits of hemostatic interventions in patients with cirrhosis. We provide guidance recommendations on evaluating bleeding risk in this patient group and management of hemostatic abnormalities in the periprocedural setting

An adaptive design for updating the threshold value of a continuous biomarker

Potential predictive biomarkers are often measured on a continuous scale, but in practice, a threshold value to divide the patient population into biomarker ‘positive’ and ‘negative’ is desirable. Early phase clinical trials are increasingly using biomarkers for patient selection, but at this stage, it is likely that little will be known about the relationship between the biomarker and the treatment outcome. We describe a single-arm trial design with adaptive enrichment, which can increase power to demonstrate efficacy within a patient subpopulation, the parameters of which are also estimated. Our design enables us to learn about the biomarker and optimally adjust the threshold during the study, using a combination of generalised linear modelling and Bayesian prediction. At the final analysis, a binomial exact test is carried out, allowing the hypothesis that ‘no population subset exists in which the novel treatment has a desirable response rate’ to be tested. Through extensive simulations, we are able to show increased power over fixed threshold methods in many situations without increasing the type-I error rate. We also show that estimates of the threshold, which defines the population subset, are unbiased and often more precise than those from fixed threshold studies. We provide an example of the method applied (retrospectively) to publically available data from a study of the use of tamoxifen after mastectomy by the German Breast Study Group, where progesterone receptor is the biomarker of interest

Evidence-Based Professional Development of Science Teachers in Two Countries

The focus of this collaborative research project of King?s College London, and the Weizmann Institute, Israel. project is on investigating the ways in which teachers can demonstrate accomplished teaching in a specific domain of science and on the teacher learning that is generated through continuing professional development programs (CPD) that lead towards such practice. The interest lies in what processes and inputs are required to help secondary school science teachers develop expertise in a specific aspect of science teaching. `It focuses on the design of the CPD programmes and examines the importance of an evidence-based approach through portfolioconstruction in which professional dialogue pathes the way for teacher learning. The set of papers highlight the need to set professional challenge while tailoring CPD to teachers? needs to create the environment in which teachers can advance and transform their practice. The cross-culture perspective added to the richness of the development and enabled the researchers to examine which aspects were fundamental to the design by considering similarities and differences between the domains

Genome-associations of extended-spectrum ss-lactamase producing (ESBL) or AmpC producing E. coli in small and medium pig farms from Khon Kaen province, Thailand

Thailand is undergoing rapid intensification of livestock production where small subsistence farms and medium sized commercial farms coexist. In medium farms, antimicrobials are prescribed by a veterinarian, whereas in small farms antimicrobial use remains largely unsupervised. The impact of these differences as well as other farming practices on the emergence and composition of antimicrobial resistance genes (ARGs) remains largely unknown. We analyzed 363 genomes of extended-spectrum ss-lactamase producing (ESBL) and/or AmpC producing Escherichia coli recovered from humans and pigs at small and medium farms from the Khon Kaen province, Thailand. We tested for genome-wide associations to identify links between ARGs, host, and farm size. Pig isolates from small farms were associated with mcr and qnr genes conferring resistance to colistin and fluoroquinolones, respectively. In contrast, pig isolates from medium farms were associated with ARGs conferring resistance to drugs commonly used on medium farms (i.e., streptomycin). ESBL plasmids from small farms co-carried ARGs conferring resistance to critically important antimicrobials more frequently compared to plasmid from medium farms. Frequent ARG combinations included bla(CTX-M-55) + qnrS1 (29.8% vs 17.5% in small and medium farms, respectively), bla(CTX-M-55) + qnrS1 + mcr-3.19 (5% vs 0%), bla(CTX-M-14) + qnrS1 (9.3% vs 6.2%), and bla(CTX-M-14) + qnrS1 + mcr-1.1 (3.1% vs 0%). The co-location on plasmids of ARGs conferring resistance to critically important antimicrobials as defined by the World Health Organization is concerning, and actions to curb their spread are urgently needed. Legislation on limiting antimicrobial sales and initiatives to better inform farmers and veterinarians on appropriate antimicrobial usage and farm biosecurity could help reduce antimicrobial use on farms