The CERN PS complex: a versatile particle factory

The CERN Proton Synchrotron started up in 1959, accelerating only protons from a 50 MeV Linac. Since then, it has evolved into a complex of nine machines, delivering in 1995 interleaved beams of protons, anti-protons, electrons, positrons and lead ions of various energies and intensities. It operates for about 7000 hours per year, sending beams to the SPS, to LEP via the SPS, and to four experimental facilities respectively supplied by the PSB, LEAR, LIL and the PS itself. Numerous original beam manipulation techniques are regularly applied and new ones are currently being implemented and tested to adapt the PS complex to its future role as the proton and ion injector for LHC. This paper summarizes the present status and describes the foreseeable future over the next twenty years

Born Digital / Grown Digital: Assessing the Future Competitiveness of the EU Video Games Software Industry

This report reflects the findings of the JRC-IPTS study on the Video games Industry, with a focus on two specific activities: online and mobile video games. The report starts by introducing the technologies, their characteristics, market diffusion and barriers to take up, and their potential economic impact, before moving to an analysis of their contribution to the competitiveness of the European ICT industry. The research is based on internal and external expertise, literature reviews and desk research, several workshops and syntheses of the current state of the knowledge. The results were reviewed by experts and in dedicated workshops. The report concludes that the general expectations for the next years foresee a speeded up migration of contents and services to digital, in a scenario of rapidly increasing convergence of digital technologies and integration of media services taking advantage of improved and permanent network connections. The role of the so-called creative content industry is expected to increase accordingly. Communication services and media industry will co-evolve on the playground of the Internet of services, along with a product to service transformation of the software market in general. In this general context the Video games Software industry plays and is expected to play a major role. The games industry may become a major driver of the development of networks as it has been in the past for the development of computer hardware.JRC.DDG.J.4-Information Societ

Propositions d'architecture de controleur ouvert pour la robotique

Disponible dans les fichiers attachés à ce documen

Internationalisation of ICT R&D

This report investigates the contrasting views on the process of R&D internationalisation. On the one hand, there is an abundance of anecdotal evidence of companies locating their R&D activities outside of their home countries in order to search for new sources of knowledge and locate themselves close to new markets. On the other hand, however, the levels of international patents lead one to conclude that the level of R&D internationalisation is negligible. Such discrepancies in the views on the new geography of R&D activity, together with the scarcity of data illustrating the developments in R&D activity, pose a challenge for informed policy making. This apparently contradictory evidence can be explained by the complexity of the inventive process and various motivations behind the decisions to do R&D abroad. To address these complexities related to the internationalisation of R&D, the report uses a methodology that divides the process of R&D into input and output side and, subsequently, analyses separately their levels of internationalisation. The results confirm that there is a discrepancy between them. The EU and the US have higher levels of internationalisation than Japan and Asia. However, according to which measures are taken into account, there are differences between the levels of internationalisation in the EU and the US. For example, these two regions have similar levels of R&D input internationalisation, but very different levels of R&D output internationalisation. A comparison of Japan and Asia also shows that these two regions follow different R&D internationalisation trajectories. On the one hand, these discrepancies may indicate that all regions follow different R&D internationalisation paths. On the other hand, they may also be a sign of the unequal capabilities of companies from different regions to ‘go global’.JRC.J.4-Information Societ

Structural role of PufX in the dimerization of the photosynthetic core complex of Rhodobacter sphaeroides.

Monomeric and dimeric PufX-containing core complexes have been purified from membranes of wild-type Rhodobacter sphaeroides. Reconstitution of both samples by detergent removal in the presence of lipids leads to the formation of two-dimensional crystals constituted of dimeric core complexes. Two-dimensional crystals were further analyzed by cryoelectron microscopy and atomic force microscopy. A projection map at 26-A resolution reveals that core complexes assemble in an "S"-shaped dimeric complex. Each core complex is composed of one reaction center, 12 light-harvesting 1 alpha/beta-heterodimers, and one PufX protein. The light-harvesting 1 assemblies are open with a gap of density of approximately 30-A width and surround oriented reaction centers. A maximum density is found at the dimer junction. Based on the projection map, a model is proposed, in which the two PufX proteins are located at the dimer junction, consistent with the finding of dimerization of monomeric core complexes upon reconstitution. This localization of PufX in the core complex implies that PufX is the structural key for the dimer complex formation rather than a channel-forming protein for the exchange of ubiquinone/ubiquinol between the reaction center and the cytochrome bc1 complex

Sur la première ligne : sondage pour un partage. Les omnipraticiens et la schizophrénie

Contexte : Les omnipraticiens (MFs) jouent un rôle prépondérant dans le traitement des patients atteints de schizophrénie. Buts : Découvrir le nombre de patients atteints de schizophrénie qui sont traités par les MFs ; les besoins et attitudes des MFs, leurs connaissances en matière de diagnostic, et le traitement qu’ils prodiguent. Méthodologie : Un sondage postal a été conduit auprès de MFs du Québec choisis de façon aléatoire. Résultats : Un total de 1 003 MFs ont répondu au sondage. Parmi eux, un faible pourcentage a à rencontrer une schizophrénie débutante et les MFs désirent être plus informés sur l’accessibilité aux services des spécialistes. Les résultats objectivés aux questions portant sur les diagnostics et les connaissances sur les traitements sont inconsistants. La majorité des MFs traite les premiers épisodes psychotiques avec des antipsychotiques. Seulement un tiers d’entre eux proposent de maintenir le traitement après un premier épisode psychotique, conformément aux recommandations internationales et au récent guide de pratique canadien qui préconisent au moins de 6 à 12 mois de traitement après la réponse clinique partielle ou complète. Le temps consacré par les MFs masculins à un premier contact s’étale entre 10 et 20 minutes, tandis que 80 % des MFs femmes y consacrent au moins 20 minutes Les effets secondaires des antipsychotiques les plus préoccupants sont les gains de poids avant les signes neurologiques. Conclusion : un certain nombre de données de ce sondage devraient être reprises par les différentes associations professionnelles et gouvernementales, afin de bonifier la place des MFs dans un plan de santé à l’égard de la schizophrénie.Context: General practitioners (GP) play a preponderant role in the treatment of patients suffering of schizophrenia. Objectives: Discovering the number of patients with schizophrenia who are treated by GPs ; the needs and attitudes of GPs, their knowledge concerning diagnosis, and the treatment they provide. Methodology: A postal survey was conducted with Quebec GPs who were randomly chosen. Results: A total of 1 003 GPs have participated in the survey. Among them, a small percentage have to treat an early onset schizophrenia and the GPs have expressed their wish to be more informed on the accessibility of specialized services. Results pertaining to questions on diagnoses and knowledge on treatments are inconsistent. The majority of GPs treat the first psychotic episodes with antipsychotic medication. Only a third of GPs surveyed propose maintaining the treatment after a first psychotic episode, in accordance with international recommendations and the recent Canadian guidelines on practices that recommends at least 6 to 12 months of treatment after a partial or complete clinical response. Time given by male GPs to a first contact varies between 10 and 20 minutes, while 80 % of female GPs spend at least 20 minutes. The adverse effects of antipsychotic medication that raise most concern is weight gain before neurological signs. Conclusion: some of this survey’s data should be considered by various professional and governmental associations, in order to improve the place of GPs in a health plan destined to treat schizophrenia.Contexto: Los médicos familiares (MFs) desempeñan un papel preponderante en el tratamiento de pacientes que sufren de esquizofrenia. Objetivos: Descubrir el número de pacientes que sufren de esquizofrenia y que son tratados por los MFs; las necesidades y actitudes de los MFs, sus conocimientos en materia de diagnóstico y el tratamiento que ofrecen. Metodología: Se realizó una encuesta por correo con los MFs de Quebec elegidos de modo aleatorio. Resultados: Un total de 1,003 MFs respondieron a la encuesta. Entre ellos, un porcentaje bajo han encontrado una esquizofrenia inicial y los MFs desean estar más informados sobre la accesibilidad a los servicios de los especialistas. Los resultados asociados a las preguntas sobre los diagnósticos y los conocimientos acerca de los tratamientos son inconsistentes. La mayoría de los MFs tratan los primeros episodios psicóticos con antipsicóticos. Solamente un tercio de ellos propone mantener el tratamiento después de un primer episodio psicótico, conforme a las recomendaciones internacionales y a la reciente guía de práctica canadiense que preconiza al menos de 6 a 12 meses de tratamiento después de la respuesta clínica parcial o completa. El tiempo consagrado por los MFs masculinos en un primer contacto se extiende de 10 a 20 minutos, mientras que el 80% de los MFs femeninas consagran al menos 20 minutos. Los efectos secundarios de los antipsicóticos más preocupantes son el aumento de peso antes que los signos neurológicos. Conclusión: un cierto número de datos de esta encuesta deberían ser retomados por las diferentes asociaciones profesionales y gubernamentales a fin de bonificar el lugar de los MFs en un plan de salud con respecto a la esquizofrenia.Contexto: os clínicos gerais (médicos de família - MFs) representam um papel preponderante no tratamento dos pacientes que sofrem de esquizofrenia. Objetivos: descobrir o número de pacientes que sofrem de esquizofrenia que são tratados por MFs, as necessidades e atitudes dos MFs, seus conhecimentos em matéria de diagnóstico, e o tratamento que prescrevem. Metodologia: uma sondagem postal foi realizada com MFs do Quebec, escolhidos de maneira aleatória. Resultados: um total de 1.003 MFs responderam à sondagem. Dentre eles, uma pequena porcentagem encontrou uma esquizofrenia inicial e os MFs desejam ser melhor informados sobre a acessibilidade aos serviços de especialistas. Os resultados obtidos com as questões sobre os diagnósticos e os conhecimentos sobre os tratamentos são inconsistentes. A maioria dos MFs trata os primeiros episódios psicóticos com antipsicóticos. Apenas um terço dentre eles propõe manter o tratamento após um primeiro episódio psicótico, conforme as recomendações internacionais e o recente guia de prática canadense, que preconiza pelo menos 6 a 12 meses de tratamento após a resposta clínica parcial ou completa. O tempo dedicado pelos MFs masculinos a um primeiro contato dura entre 10 e 20 minutos, ao passo que 80% das MFs femininas consagram, pelo menos, 20 minutos. O efeito colateral dos antipsicóticos mais inquietante é o aumento de peso antes dos sinais neurológicos. Conclusão: um certo número de dados desta sondagem deverão ser retomados por diferentes associações profissionais e governamentais, a fim de melhorar a importância dos MFs em um plano de saúde com respeito à esquizofrenia

A cryogenic liquid-mirror telescope on the moon to study the early universe

We have studied the feasibility and scientific potential of zenith observing liquid mirror telescopes having 20 to 100 m diameters located on the moon. They would carry out deep infrared surveys to study the distant universe and follow up discoveries made with the 6 m James Webb Space Telescope (JWST), with more detailed images and spectroscopic studies. They could detect objects 100 times fainter than JWST, observing the first, high-red shift stars in the early universe and their assembly into galaxies. We explored the scientific opportunities, key technologies and optimum location of such telescopes. We have demonstrated critical technologies. For example, the primary mirror would necessitate a high-reflectivity liquid that does not evaporate in the lunar vacuum and remains liquid at less than 100K: We have made a crucial demonstration by successfully coating an ionic liquid that has negligible vapor pressure. We also successfully experimented with a liquid mirror spinning on a superconducting bearing, as will be needed for the cryogenic, vacuum environment of the telescope. We have investigated issues related to lunar locations, concluding that locations within a few km of a pole are ideal for deep sky cover and long integration times. We have located ridges and crater rims within 0.5 degrees of the North Pole that are illuminated for at least some sun angles during lunar winter, providing power and temperature control. We also have identified potential problems, like lunar dust. Issues raised by our preliminary study demand additional in-depth analyses. These issues must be fully examined as part of a scientific debate we hope to start with the present article.Comment: 35 pages, 11 figures. To appear in Astrophysical Journal June 20 200

Micromachine d'essais mécaniques de type traction et compression ayant une accessibilité optimisée

L'invention concerne une micromachine de traction destinée à être utilisée dans une enceinte de microscope électronique à balayage ou avec un appareil de diffraction, comportant deux mors (1) portés par deux supports, chaque mors (1) étant destiné à recevoir une extrémité d'une éprouvette mécanique (4), et des moyens pour exercer sur les supports des efforts tendant à les écarter l'un de l'autre ou à les rapprocher l'un de l'autre selon une direction longitudinale (AL), chaque mors (1) comprenant une embase (2) et une bride (3) pour fixer une extrémité (21) d'éprouvette (4) au mors (1) en l'enserrant entre la bride (3) et l'embase (2) au moyen d'au moins deux vis (12-15 ) traversant chacune la bride (3) et au moins une partie de l'embase (2), ces deux vis (12-15) étant situées de part et d'autre de l'extrémité d'éprouvette (21)

Heat distribution in the Southeast Pacific is only weakly sensitive to high-latitude heat flux and wind stress.

The Southern Ocean features regionally‐varying ventilation pathways that transport heat and carbon from the surface ocean to the interior thermocline on timescales of decades to centuries, but the factors that control the distribution of heat along these pathways are not well understood. In this study, we use a global ocean state estimate (ECCOv4) to (1) define the recently ventilated interior Pacific (RVP) using numerical passive tracer experiments over a 10‐year period and (2) use an adjoint approach to calculate the sensitivities of the RVP heat content (RVPh) to changes in net heat flux and wind stress. We find that RVPh is most sensitive to local heat flux and wind stress anomalies north of the sea surface height contours that delineate the Antarctic Circumpolar Current, with especially high sensitivities over the South Pacific Gyre. Surprisingly, RVPh is not especially sensitive to changes at higher latitudes. We perform a set of step response experiments over the South Pacific Gyre, the subduction region, and the high‐latitude SO. In consistency with the adjoint sensitivity fields, RVPh is most sensitive to wind stress curl over the subtropical gyre, which alter isopycnal heave, and it is only weakly sensitive to changes at higher latitudes. Our results suggest that despite the localized nature of mode water subduction hotspots, changes in basin‐scale pressure gradients are an important controlling factor on RVPh. Because basin‐scale wind stress is expected to change in the coming decades to centuries, our results may have implications for climate, via the atmosphere/ocean partitioning of heat