Political conversation in digital platforms: parodies, japanese animation and devices

Este trabajo presenta los avances de un estudio en curso centrado en la conversación política generada alrededor de discursos paródicos de coyuntura publicados en distintas plataformas de redes sociales. La hipótesis de base de dicho estudio sostiene que el dispositivo sociotécnico de las interfaces y las características del lenguaje audiovisual condicionan los modos en los que la conversación política contemporánea ocurre en estos sitios, y ejercen influencia en las formas en las que la expresión política se dinamiza en la actualidad. El artículo aborda los videos paródicos virales del prosumer Matías Mazzagatti. Estos textos retoman productos de animación japonesa y hechos y actores de la coyuntura política argentina. La metodología seguida es el análisis comparativo entre YouTube, Facebook y Twitter observando las operaciones de sentido tanto en producción como en recepción. En producción se observaron las operaciones en relación al uso del lenguaje audiovisual y en recepción las operaciones en relación a los comentarios de los/as usuarios/as. Se evalúa la circulación de los textos seleccionados teniendo en cuenta la injerencia del dispositivo en la conversación política paródica. Concluimos que se pueden observar diferencias sociotécnicas entre las plataformas que habilitan distintas modalidades de conversación política en las redes sociales.This article presents the early conclusions of an ongoing work focused on the political conversation generated around parodic discourses posted on different social networks. We hypothesize that the socio-technical device of the social networks’ interfaces and the characteristics of the audiovisual language condition how contemporary political conversation takes place on social media. This work focuses on the parodic viral videos made by the prosumer Matías Mazzagatti. These videos retake Japanese animation products and facts and actors of the current political scenery in Argentina. The methodology is a comparative analysis among YouTube, Facebook and Twitter that observes meaning operation both in production and reception. Analysis in production observes meaning operation regarding the use of audiovisual language and analysis in reception observes meaning operation concerning users comments. The circulation of the selected videos is evaluated taking into account the interference of the device in parody political conversation. Our conclusion is that differences in the social-technic device of the platforms enable different ways of political conversation.Facultad de Periodismo y Comunicación Socia

The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent.

BACKGROUND AND AIMS Alcohol-associated liver disease (ALD) accounts for 70% of liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial dysfunction is one of the earliest manifestations of alcohol-induced injury, restoring mitochondrial activity remains a problematic strategy due to oxidative stress. Here, we identify methylation-controlled J protein (MCJ) as a mediator for ALD progression and hypothesize that targeting MCJ may help in recovering mitochondrial fitness without collateral oxidative damage. APPROACH AND RESULTS C57BL/6 mice [wild-type (Wt)] Mcj knockout and Mcj liver-specific silencing (MCJ-LSS) underwent the NIAAA dietary protocol (Lieber-DeCarli diet containing 5% (vol/vol) ethanol for 10 days, plus a single binge ethanol feeding at day 11). To evaluate the impact of a restored mitochondrial activity in ALD, the liver, gut, and pancreas were characterized, focusing on lipid metabolism, glucose homeostasis, intestinal permeability, and microbiota composition. MCJ, a protein acting as an endogenous negative regulator of mitochondrial respiration, is downregulated in the early stages of ALD and increases with the severity of the disease. Whole-body deficiency of MCJ is detrimental during ALD because it exacerbates the systemic effects of alcohol abuse through altered intestinal permeability, increased endotoxemia, and dysregulation of pancreatic function, which overall worsens liver injury. On the other hand, liver-specific Mcj silencing prevents main ALD hallmarks, that is, mitochondrial dysfunction, steatosis, inflammation, and oxidative stress, as it restores the NAD + /NADH ratio and SIRT1 function, hence preventing de novo lipogenesis and improving lipid oxidation. CONCLUSIONS Improving mitochondrial respiration by liver-specific Mcj silencing might become a novel therapeutic approach for treating ALD.This work was supported by grants from Ministerio de Ciencia e Innovación, Programa Retos-Colaboración RTC2019-007125-1 (for Jorge Simon and Maria Luz Martinez-Chantar); Ministerio de Economía, Industria y Competitividad, Retos a la Sociedad AGL2017- 86927R (for F.M.); Instituto de Salud Carlos III, Proyectos de Investigación en Salud DTS20/00138 and DTS21/00094 (for Jorge Simon and Maria Luz Martinez-Chantar, and Asis Palazon. respectively); Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias co-founded by European Regional Development Fund/European Social Fund, “Investing in your future” PI19/00819, “Una manera de hacer Europa” FIS PI20/00765, and PI21/01067 (for Jose J. G. Marin., Pau Sancho-Bru,. and Mario F. Fraga respectively); Departamento de Industria del Gobierno Vasco (for Maria Luz Martinez-Chantar); Asturias Government (PCTI) co-funding 2018-2023/ FEDER IDI/2021/000077 (for Mario F. Fraga.); Ministerio de Ciencia, Innovación y Universidades MICINN: PID2020-117116RB-I00, CEX2021-001136-S PID2020-117941RB-I00, PID2020-11827RB-I00 and PID2019-107956RA-100 integrado en el Plan Estatal de Investigación Científica y Técnica y Innovación, cofinanciado con Fondos FEDER (for Maria Luz Martinez-Chantar, Francisco J Cubero., Yulia A Nevzorova and Asis Palazon); Ayudas Ramón y Cajal de la Agencia Estatal de Investigación RY2013-13666 and RYC2018- 024183-I (for Leticia Abecia and Asis Palazon); European Research Council Starting Grant 804236 NEXTGEN-IO (for Asis Palazon); The German Research Foundation SFB/TRR57/P04, SFB1382-403224013/ A02 and DFG NE 2128/2-1 (for Francisco J Cubero and Yulia A Nevzorova); National Institute of Health (NIH)/National Institute of Alcohol Abuse and Alcoholism (NIAAA) 1U01AA026972-01 (For Pau Sancho-Bru); Junta de Castilla y León SA074P20 (for Jose J. G. Marin); Junta de Andalucía, Grupo PAIDI BIO311 (for Franz Martin); CIBERER Acciones Cooperativas y Complementarias Intramurales ACCI20-35 (for Mario F. Fraga); Ministerio de Educación, Cultura y Deporte FPU17/04992 (for Silvia Ariño); Fundació Marato TV3 201916-31 (for Jose J. G. Marin.); Ainize Pena-Cearra is a fellow of the University of the Basque Country (UPV/ EHU); BIOEF (Basque Foundation for Innovation and Health Research); Asociación Española contra el Cáncer (Maria Luz Martinez-Chantar and Teresa C. Delgado.); Fundación Científica de la Asociación Española Contra el Cáncer (AECC Scientific Foundation) Rare Tumor Calls 2017 (for Maria Luz Martinez-Chantar); La Caixa Foundation Program (for Maria Luz Martinez-Chantar); Proyecto Desarrollo Tecnologico CIBERehd (for Maria Luz Martinez-Chantar); Ciberehd_ISCIII_MINECO is funded by the Instituto de Salud Carlos III.S

Political conversation in digital platforms: Parodies, japanese animation and devices

Este artigo apresenta as primeiras conclusões de um trabalho em andamento focado na conversa política gerada em torno de discursos paródicos publicados em diferentes redes sociais. Nossa hipótese é que o dispositivo sociotécnico das interfaces das redes sociais e as características da linguagem audiovisual condicionem como a conversa política contemporânea ocorre nas mídias sociais. Este trabalho enfoca os vídeos virais paródicos feitos pelo prosumer Matías Mazzagatti. Esses vídeos retomam produtos de animação japonesa, fatos e atores do cenário político atual na Argentina. A metodologia é uma análise comparativa entre YouTube, Facebook e Twitter que observa a operação de significado tanto na produção quanto na recepção. A análise em produção observa a operação de significado em relação ao uso da linguagem audiovisual e a análise em recepção observa a operação de significado em relação aos comentários dos usuários. A circulação dos vídeos selecionados é avaliada levando em consideração a interferência do dispositivo na conversa política da paródia. Concluímos que as diferenças no dispositivo técnico-social das plataformas permitem diferentes formas de conversação política.This article presents the early conclusions of an ongoing work focused on the political conversation generated around parodic discourses posted on different social networks. We hypothesize that the socio-technical device of the social networks’ interfaces and the characteristics of the audiovisual language condition how contemporary political conversation takes place on social media.  This work focuses on the parodic viral videos made by the prosumer Matías Mazzagatti. These videos retake Japanese animation products and facts and actors of the current political scenery in Argentina. The methodology is a comparative analysis among YouTube, Facebook and Twitter that observes meaning operation both in production and reception. Analysis in production observes meaning operation regarding the use of audiovisual language and analysis in reception observes meaning operation concerning users comments. The circulation of the selected videos is evaluated taking into account the interference of the device in parody political conversation. Our conclusion is that differences in the social-technic device of the platforms enable different ways of political conversation.Este trabajo presenta los avances de un estudio en curso centrado en la conversación política generada alrededor de discursos paródicos de coyuntura publicados en distintas plataformas de redes sociales. La hipótesis de base de dicho estudio sostiene que el dispositivo sociotécnico de las interfaces y las características del lenguaje audiovisual condicionan los modos en los que la conversación política contemporánea ocurre en estos sitios, y ejercen influencia en las formas en las que la expresión política se dinamiza en la actualidad.  El artículo aborda los videos paródicos virales del prosumer Matías Mazzagatti. Estos textos retoman productos de animación japonesa y hechos y actores de la coyuntura política argentina. La metodología seguida es el análisis comparativo entre YouTube, Facebook y Twitter observando las operaciones de sentido tanto en producción como en recepción. En producción se observaron las operaciones en relación al uso del lenguaje audiovisual y en recepción las operaciones en relación a los comentarios de los/as usuarios/as. Se evalúa la circulación de los textos seleccionados teniendo en cuenta la injerencia del dispositivo en la conversación política paródica. Concluimos que se pueden observar diferencias sociotécnicas entre las plataformas que habilitan distintas modalidades de conversación política en las redes sociales

New observations on airborne jet propulsion (flight) in squid with a review of previous reports

[No abstract available

The influence of freshwater runoff on biomass, morphometrics, and production of Thalassia testudinum

Efforts to restore more natural freshwater flows in South Florida will impact Biscayne Bay. In order to evaluate possible effects of decreased freshwater discharge on the seagrass Thalassia testudinum, we determined the biomass, density, morphometrics (width, length, number of blades per shoot) and production of T. testudinum twice a year for 2 year at sites exposed to varying degrees of freshwater runoff. Responses to freshwater discharge varied between the sampling years. The only morphometric variable to be influenced by freshwater runoff in both years was blade width with width of seagrass blades being less at sites influenced by freshwater runoff than at sites with limited influence of freshwater runoff. In 1996, no other parameters differed among the three freshwater conditions considered; canal discharge, sheet-flow runoff, and limited freshwater runoff. In addition, all measured parameters were greater in summer (wet season) than in winter (dry season) in 1996. In 1997, biomass, shoot weight, shoot production, and areal shoot production all were greater at sites on the eastern side of the bay that experience limited influence from freshwater runoff compared to sites on the western side of the bay that experience large amounts of freshwater runoff from sheet-flow and canal discharge. In 1997, only length of seagrass showed a significant increase from winter to summer. Factors thought to be responsible for these interannual differences are winter temperatures and seasonal rainfall amounts. The winter of 1996 was much colder than the winter of 1997, and 1997 experienced an unusually rainy dry season thus increasing the amount of time during the year that freshwater runoff would be influencing sites on the western side of the bay. Based on these results, reduced freshwater inflow to Biscayne Bay should have a positive effect on T. testudinum provided detrimental hypersaline conditions do not occur

Actividades de coordinación del Grado de Arquitectura Técnica y Fundamentos de la Arquitectura: Concurso de Estructuras

La organización del Concurso de Estructuras, actualmente en su decimoctava edición, es realizada por los profesores del Área de Mecánica de los Medios Continuos y Teoría de las Estructuras del Departamento de Ingeniería Civil (DIC). El contexto de esta actividad se dirige a todos los estudiantes de Grado, Máster y Doctorado que estén directamente relacionados en el ámbito del Cálculo de Estructuras de la Universidad de Alicante. Se espera una participación de 50 estudiantes lo que sería un dato muy superior y satisfactorio al de ediciones anteriores. Mediante la implementación del concurso de estructuras se busca paliar en parte las dificultades metodológicas detectadas, así como su coherencia. Además, el Concurso de Estructuras trata de motivar al estudiante en el ámbito del conocimiento de las estructuras como elementos resistentes. Asimismo, el estudiante puede valorar la importancia de las estructuras en el mundo profesional, tanto en la fase de diseño como en el de su construcción

Metabolic syndrome criteria and severity and carbon dioxide (CO2) emissions in an adult population

Background: Metabolic syndrome (MetS) has become a growing risk factor of some non-communicable diseases. Increase of greenhouse gas emissions affects the planet. Aims: To assess the association between MetS severity and amount of carbon dioxide (CO2) emitted in an adult population. Design: Cross-sectional study (n = 6646; 55-76-year-old-men; 60-75-year-old-women with MetS). Methods: Dietary habits were assessed using a pre-validated semi quantitative 143-item food frequency questionnaire. The amount of CO2 emitted due to the production of food consumed by person and day was calculated using a European database, and the severity of the MetS was calculated with the MetS Severity Score. Results: Higher glycaemia levels were found in people with higher CO2 emissions. The risk of having high severe MetS was related to high CO2 emissions. Conclusions: Low CO2 emissions diet would help to reduce MetS severity. Advantages for both health and the environment were found following a more sustainable diet. Trial registration: ISRCTN, ISRCTN89898870 . Registered 05 September 2013

Metabolic syndrome criteria and severity and carbon dioxide (CO) emissions in an adult population

Metabolic syndrome (MetS) has become a growing risk factor of some non-communicable diseases. Increase of greenhouse gas emissions affects the planet. To assess the association between MetS severity and amount of carbon dioxide (CO) emitted in an adult population. Cross-sectional study (n = 6646; 55-76-year-old-men; 60-75-year-old-women with MetS). Dietary habits were assessed using a pre-validated semi quantitative 143-item food frequency questionnaire. The amount of CO emitted due to the production of food consumed by person and day was calculated using a European database, and the severity of the MetS was calculated with the MetS Severity Score. Higher glycaemia levels were found in people with higher CO emissions. The risk of having high severe MetS was related to high CO emissions. Low CO emissions diet would help to reduce MetS severity. Advantages for both health and the environment were found following a more sustainable diet. ISRCTN, . Registered 05 September 2013