THE POLVESE ISLAND (TRASIMENO LAKE-UMBRIA): A DIDACTIC AND SCIENTIFIC ROUTE

Le caratteristiche paesaggistiche, ambientali e culturali s.l. del Lago Trasimeno ne fanno uno dei più importanti geositi/geomorfositi dell’Italia centrale. La visita all’Isola Polvese, in particolare, rappresenta una tappa interessante sotto il profilo geologico- geomorfologico e naturalistico; si tratta dell’isola più estesa del lago che offre peculiarità importanti sotto questi aspetti e che possono essere colti e trasmessi in un percorso articolato sia lungo le sponde che al suo interno. Il “giro” dell’isola, che può essere percorso agevolmente permette, non solo di apprezzare l’articolato scenario geomorfologico attraverso una passeggiata costiera, ma di ammirare anche tutta la gamma di specie vegetali, diversamente distribuite nell’arco dell’anno. L’Isola, infatti, da molti anni è oggetto di escursioni didattiche a vario livello (dalle Scuole Elementari alle Università) e rappresenta una “palestra” ideale in cui attivare input alla ricerca, esercitare alla osservazione e riconoscimento dei vari elementi paesaggistici, fornendo le basi per l’elaborazione di dati acquisiti di vario ambito culturale. Sono presenti, inoltre, strutture monumentali legate alla presenza antropica, anche datata nell’isola, che rappresentano, pertanto, un valore aggiunto al percorso.The characteristics of the landscape of the Trasimeno Lake, both environmental and cultural, make it one of the most important geosites/geomorphosites of central Italy. The visit of the Polvese Island, in particular, represents an interesting step from the naturalistic and geologic-geomorphologic viewpoints. The Polvese Island is the largest of the Lake and offers important peculiarities which can be acquired through an articulated tour around the coast and across the island. The tour of the island, which can be easily covered, allows to appreciate the articulate geomorphologic scenery and all the richness of flora and fauna, throughout the year. The Island, in fact, is from many years the object of didactic excursions of different level (from the elementary school level to the university level) and represents an ideal “gym” for exercising the stimulus to search, a base for the elaboration of data in several cultural fields, an input to the observation, and an acknowledgment of several landscaped elements. As an added value to the itinerary, there are also monumental structures linked to the ancient anthropic presence

ONLINE ARCHIVE OF URBAN PUBLIC PARKS IN THE REGION UMBRIA

Oggetto di questo lavoro è realizzare di un prototipo per il censimento e la condivisione on line delle informazioni relative ai parchi urbani. L’importanza di poter disporre di informazioni relative ai parchi pubblici urbani è sempre maggiore sia per fini turistici che ricreativi. Grazie alla decisione di Google di rendere pubbliche le specifiche delle API (Application Programming Interface) di Google Maps, è ormai possibile aggiungere alle mappe del servizio Google Maps proprie informazioni nei più vari formati (es. testi, filmati, ecc). L’intento del nostro lavoro pertanto è di creare un “mashup” su base Google Maps con i dati relativi ai parchi urbani. Come aree prova su cui testare la scheda di acquisizione dati si sono utilizzati le i parchi urbani dell’Umbria. Tale prototipo di scheda potrà essere utilizzato in futuro da tutti quegli utenti che desiderano acquisire, produrre e condividere on line i dati dei parchi pubblici di loro interesse.The aim of this work is to develop a prototype for the identification and sharing online information relating to urban parks. Knowing the exact location and have a detailed description of urban public parks is important for tourism and recreation. Thanks to Google’s decision to publish the specifications of the API (Application Programming Interface) for Google Maps, you can add to the maps or satellite photos of Google Maps own information in various formats (eg. text, video, etc.). The aim of our work therefore is to create a “mashup” on a Google Maps with data relating to urban parks. The Umbria region (Italy) has been chosen as the area on which to test the data acquisition form. This prototype form and will be used in future by all those users who wish to acquire, produce, select the most relevant information online and share data from public parks to them

FROM SERRE TO CALABRIAN TYRRHENIAN COAST (COSTA DEGLI DEI): LANDSCAPES AND CULTURES

La Calabria centrale presenta una fisiografi a particolare: il Mar Tirreno e il Mar Ionio sono separati in linea d’aria da meno di 30 km di un territorio complesso e articolato dal punto geologico – geomorfologico. La diversità di ambiti geologici implica morfogenesi differenti, con un modellato superficiale che vede l’alternarsi di altopiani montani profondamente incisi da fiumare, ampie aree boscate, brulle dorsali collinari modellate da superfici terrazzate, piane costiere. Alla mutevolezza di paesaggi corrisponde, in analogia, una variabilità di culture e tradizioni. Dal paesaggio e dalle culture sostanzialmente integre delle aree interne si passa alle aree costiere e collinari dove gli effetti della trasformazione sociale ed economica hanno spesso devastato e obliterato i morfotipi originari, complicandone lettura e interpretazione.Calabria Central presents a very particular physiography: the Tyrrhenian Sea and the Ionian Sea are separated as the crow fl ies from less than 30 kilometers of territory with complex geological and geomorphological structure. The diversity of geological areas implies different morphogenesis, with a patterned surface in which are alternation of mountain plateaus deeply incised by rivers, large wooded areas, barren ridge hills shaped by terraced surfaces, coastal plains. To changing nature of landscapes corresponds, by analogy, a variability of cultures and traditions. The landscape and cultures substantially undamaged of internal areas switch to coastal and hilly areas where the effects of social and economic transformation have often devastated its original shapes, making very difficult reading and interpretation

Critica e letteratura. Studi di anglistica

Il volume, a cura di S. Bigliazzi e F. Gregori, raccoglie saggi dedicati a una articolata riflessione sulle prospettive e sul ruolo della critica e della letteratura nell'odierno panorama degli studi di anglistica in Italia e all'estero. Lo scopo è di riconsiderare le premesse teoriche, gli assunti e i modelli metodologici, le implicazioni ermeneutiche e l'impatto euristico delle 'lingue della letteratura' e delle metalingue che le esaminano: sia negli elementi di specificità che caratterizzano il letterario, sia un dibattito con i discorsi 'altri' che circondano e pervadono la letteratura. La silloge è articolata in tre sezioni dedicate al valore epistemologico della letteratura e al suo nesso con le pratiche critico-ermeneutiche; al rapporto delle lingue della letteratura con le altre lingue, gli altri codici espressivi e le altre pratiche artistiche e sociali; e, infine, all'analisi di alcune nuove tendenze letterarie in ambito anglofono

The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells

The immuno-regulatory mechanisms of IL-10-producing type 1 regulatory T (Tr1) cells have been widely studied over the years. However, several recent discoveries have shed new light on the cellular and molecular mechanisms that human Tr1 cells use to control immune responses and induce tolerance. In this review we outline the well known and newly discovered regulatory properties of human Tr1 cells and provide an in-depth comparison of the known suppressor mechanisms of Tr1 cells with FOXP3+ Treg. We also highlight the role that Tr1 cells play in promoting and maintaining tolerance in autoimmunity, allergy, and transplantation

HLA-G/LILRBs: A Cancer Immunotherapy Challenge.

Despite some success, many patients do not benefit from immunotherapy. New strategies to improve clinical efficacy include identification of novel immune-checkpoint (IC) targets or a combination of immunotherapy with antiangiogenic treatments. Here, we propose the therapeutic use of IC, HLA-G/LILRB, and explore its enhanced synergistic antitumor activity when combined with antiangiogenic therapies

A systematic review of quality attributes and measures for software product lines

[EN] It is widely accepted that software measures provide an appropriate mechanism for understanding, monitoring, controlling, and predicting the quality of software development projects. In software product lines (SPL), quality is even more important than in a single software product since, owing to systematic reuse, a fault or an inadequate design decision could be propagated to several products in the family. Over the last few years, a great number of quality attributes and measures for assessing the quality of SPL have been reported in literature. However, no studies summarizing the current knowledge about them exist. This paper presents a systematic literature review with the objective of identifying and interpreting all the available studies from 1996 to 2010 that present quality attributes and/or measures for SPL. These attributes and measures have been classified using a set of criteria that includes the life cycle phase in which the measures are applied; the corresponding quality characteristics; their support for specific SPL characteristics (e. g., variability, compositionality); the procedure used to validate the measures, etc. We found 165 measures related to 97 different quality attributes. The results of the review indicated that 92% of the measures evaluate attributes that are related to maintainability. In addition, 67% of the measures are used during the design phase of Domain Engineering, and 56% are applied to evaluate the product line architecture. However, only 25% of them have been empirically validated. In conclusion, the results provide a global vision of the state of the research within this area in order to help researchers in detecting weaknesses, directing research efforts, and identifying new research lines. In particular, there is a need for new measures with which to evaluate both the quality of the artifacts produced during the entire SPL life cycle and other quality characteristics. There is also a need for more validation (both theoretical and empirical) of existing measures. In addition, our results may be useful as a reference guide for practitioners to assist them in the selection or the adaptation of existing measures for evaluating their software product lines. © 2011 Springer Science+Business Media, LLC.This research has been funded by the Spanish Ministry of Science and Innovation under the MULTIPLE (Multimodeling Approach For Quality-Aware Software Product Lines) project with ref. TIN2009-13838.Montagud Gregori, S.; Abrahao Gonzales, SM.; Insfrán Pelozo, CE. (2012). A systematic review of quality attributes and measures for software product lines. Software Quality Journal. 20(3-4):425-486. https://doi.org/10.1007/s11219-011-9146-7S425486203-4Abdelmoez, W., Nassar, D. 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