Quadrotor multibody modelling by vehiclesim: adaptive technique for oscillations in a PVA control system

The work presented here covers the detailed modelling and trajectory control for an elastic bladed quadrotor vehicle. The benefits of using VehicleSim modelling software are also discussed. The authors present a full elastic structural and dynamical model as well as two different aerodynamic models. These two aerodynamic models differ from each other on their level of complexity and therefore, accuracy. The control methodology employed to stabilize and guide the vehicle is PVA (ProportionalVelocity-Acceleration), derived and implemented by using Simulink. As it will be shown, it stabilises and provides satisfactory quadrotor trajectory tracking. Since the control methodology feeds back the acceleration of the vehicle, and this acceleration has an oscillating nature, an adaptive process has been designed and introduced into the vehicle’s model in order to avoid the oscillations’ transmission to the control system, showing how it reduces the amplitude of the control actions oscillations. Results of simulations and discussion on them are also provided at the end of this article

Crowding y Overtourism en la literatura de turismo y cruceros

[EN] The purpose of this article is to make a small analysis of the situation of Crowding and Overtourism literature in the tourism sector. In addition, the paper makes a special review of this literature with emphasis on cruise ship literature. Using the Web of Science as a basis, the study makes a brief bibliometric analysis of this literature. The purpose is to know the state of the art and main trends in this literature. In addition, the work aims to lay the foundations for a subsequent in-depth analysis of this literature. The work has implications for researchers, as it analyses gaps in the literature and new future trends. In addition, the work can help professionals to observe new practices and issues to be developed and implemented in companies and organizations.[ES] El objeto de este artículo es realizar un pequeño análisis de la situación de la literatura de Crowding y Overtourism en el sector turístico. Además, el trabajo hace un repaso especial a esta literatura enfatizando en la literatura de cruceros. Utilizando como base la Web of Science, el estudio realiza un breve análisis bibliométrico de esta literatura. El propósito es conocer el estado del arte y principales tendencias en esta literatura. Además el trabajo pretende sentar las bases para un posterior análisis en profundidad de esta literatura. El trabajo tiene repercusiones para investigadores, dado que analiza las carencias en la literatura y las nuevas tendencias futuras. Además, el trabajo puede ayudar a profesionales para observar nuevas prácticas y cuestiones que deben desarrollar e implementar en empresas y organizaciones.Los autores agradecen financiación por parte de la Universitat Politècnica de Valencia, la Universitat Jaume I y la Universitat de València.Garrigós Simón, FJ.; Narangajavana Kaosiri, Y.; Sanz Blas, S.; Estelles Miguel, S.; Oltra Gutiérrez, JV.; Buzova, D. (2021). Crowding y Overtourism en la literatura de turismo y cruceros. En Proceedings INNODOCT/20. International Conference on Innovation, Documentation and Education. Editorial Universitat Politècnica de València. 773-780. https://doi.org/10.4995/INN2020.2020.11926OCS77378

Gamification & Education: Una Revisión Bibliomética

[ES] La Gamificación es una creciente area de investigación en la literature de Educación, debido a la necesidad y relevancia de nuevas metodologías innovadoras para enfrentar el nuevo entorno de aprendizaje. Sin embargo existe una carencia de investigación sobre la importancia y el desarrollo de la literature de Gamificación en el campo de la Educación (GE). Este artículo realiza una relevante contribución a la literature de Educación, al revisar esta literature, a través de un análisis bibliometro y gráfico de la misma. El documento presenta una descripción bibliométrica de la investigación sobre Gamificación y Educación. El trabajo estudia 635 referencias recopiladas de la Web of Science (WoS), analizando específicamente 483 trabajos de la base de datos de la WoS Core Collection. Además, el documento utiliza el programa de visualización de similitudes (VOS)viewer para mostrar gráficamente el material. El estudio realiza una revisión amplia de esta literatura, una co-occurencia de palabras clave y un análisis de las principales revistas y los artículos más relevantes. Los resultados muestran el estado y las principales tendencias de esta literatura, identificando los temas principales y el análisis principal, que puede ser significativo para que los investigadores comprendan mejor la situación y el estado del arte de la Gamificación en el campo de la Educació.[EN] Gamification is a Growing research topic in the literature of Education, due to the necessity and relevance of new innovative methodologies to face the new learning environment. However, there is a lack of research about the importance and development of the literature of Gamification in the Education field (GE). This paper makes a relevant contribution to the literature of Education by reviewing this literature, through a bibliometric and visualization analysis. The, the paper presents a bibliometric overview of Gamification and Education research. The work studies 635 references collected from the Web of Science (WoS), analycing specifically 483 works from the WoS Core Collection database. Moreover the paper uses the visualization of similarities (VOS)viewer program to graphically map the material. The study does a broad review of this literature, a co-ocurrence of keywords, and an analysis of the main journals and the most relevant papers. The results show the status and main trends of this literature, identifying the main topics and the leading analysis, which can be significant for researchers to better understand the situation and state of the art of Gamification in the field of Education.Garrigós Simón, FJ.; Narangajavana-Kaosiri, Y.; Estelles Miguel, S.; Oltra Gutiérrez, JV.; Sanz Blas, S.; Lengua Lengua, I.; Montesa Andrés, JO. (2020). Gamification & Education: Una Revisión Bibliomética. Editorial Universitat Politècnica de València. 927-937. https://doi.org/10.4995/INN2019.2019.10943OCS92793

Participación activa de las y los estudiantes en el diseño de su aprendizaje. Una experiencia educativa en Trabajo Social

Se presenta una reflexión teórico-práctica sobre experiencias docentes metodológicas y de aprendizaje en el Grado en Trabajo Social de la Universitat de València basadas en las teorías del aprendizaje significativo de Ausebel, del aprendizaje social de Bandura o Vigosky y las propuestas de intervención Social de Ander-Egg y De Robertis, comunidades de aprendizaje, Aprendizaje Servicio e Investigación-Acción Participativa. En las conclusiones se presentan algunas implicaciones para la docencia universitaria y para futuras investigaciones

The endothelial cell protein C receptor: its role in thrombosis

The protein C anticoagulant pathway plays a crucial role as a regulator of the blood clotting cascade. Protein C is activated on the vascular endothelial cell membrane by the thrombin-thrombomodulin complex. The endothelial protein C receptor binds protein C and further enhances protein C activation. Once formed, activated protein C down-regulates thrombin formation by inactivating factors Va and VIIIa and exerts cytoprotective effects through endothelial protein C receptor binding. An adequate generation of activated protein C depends on the precise assembly, on the surface of the endothelial cells, of thrombin, thrombomodulin, protein C, and endothelial protein C receptor. Therefore, any change in the efficiency of this assembly may cause a reduction or increase in activated protein C generation and modulate the risk of thrombosis. This review highlights the role of the endothelial protein C receptor in disease and discusses the association of its mutations with the risk of thrombosis

Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC) : Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group

In patients with early-stage endometrioid endometrial cancer, the presence of lymph vascular space involvement (LVSI) correlates with nodal metastases, shorter disease-free survival and overall survival. However, the effect of LVSI on recurrence patterns of these patients has been poorly studied, and the optimal adjuvant treatment remains unclear. Additionally, positive LVSI is indicative for nodal assessment, however, this parameter is usually not Known until a final pathology report. The main aim of our study was to analyze oncological outcomes and patterns of recurrence of these patients according to LVSI status, as well as to determine preoperative predictors of positive LVSI. We confirmed in a large multi-institutional cohort of patients (3546 participants), that positive LVSI is an independent prognostic factor for distant recurrences (HR 2.37) but not for local recurrence. In addition, deep myometrial invasion, high-grade tumors, cervical stroma invasion, and tumor diameter ≥ 2 cm are independent predictors of positive LVSI. The main aim is to compare oncological outcomes and patterns of recurrence of patients with early-stage endometrioid endometrial cancer according to lymphovascular space invasion (LVSI) status. The secondary objective is to determine preoperative predictors of LVSI. We performed a multicenter retrospective cohort study. A total of 3546 women diagnosed with postoperative early-stage (FIGO I-II, 2009) endometrioid endometrial cancer were included. Co-primary endpoints were disease-free survival (DFS), overall survival (OS), and pattern of recurrence. Cox proportional hazard models were used for time-to-event analysis. Univariate and multivariate logistical regression models were employed. Positive LVSI was identified in 528 patients (14.6%) and was an independent prognostic factor for DFS (HR 1.8), OS (HR 2.1) and distant recurrences (HR 2.37). Distant recurrences were more frequent in patients with positive LVSI (78.2% vs. 61.3%, p < 0.01). Deep myometrial invasion (OR 3.04), high-grade tumors (OR 2.54), cervical stroma invasion (OR 2.01), and tumor diameter ≥ 2 cm (OR 2.03) were independent predictors of LVSI. In conclusion, in these patients, LVSI is an independent risk factor for shorter DFS and OS, and distant recurrence, but not for local recurrence. Deep myometrial invasion, cervical stroma invasion, high-grade tumors, and a tumor diameter ≥ 2 cm are independent predictors of LVSI

Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC): Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group

The main aim is to compare oncological outcomes and patterns of recurrence of patients with early-stage endometrioid endometrial cancer according to lymphovascular space invasion (LVSI) status. The secondary objective is to determine preoperative predictors of LVSI. We performed a multicenter retrospective cohort study. A total of 3546 women diagnosed with postoperative early-stage (FIGO I-II, 2009) endometrioid endometrial cancer were included. Co-primary endpoints were disease-free survival (DFS), overall survival (OS), and pattern of recurrence. Cox proportional hazard models were used for time-to-event analysis. Univariate and multivariate logistical regression models were employed. Positive LVSI was identified in 528 patients (14.6%) and was an independent prognostic factor for DFS (HR 1.8), OS (HR 2.1) and distant recurrences (HR 2.37). Distant recurrences were more frequent in patients with positive LVSI (78.2% vs. 61.3%, p < 0.01). Deep myometrial invasion (OR 3.04), high-grade tumors (OR 2.54), cervical stroma invasion (OR 2.01), and tumor diameter ≥ 2 cm (OR 2.03) were independent predictors of LVSI. In conclusion, in these patients, LVSI is an independent risk factor for shorter DFS and OS, and distant recurrence, but not for local recurrence. Deep myometrial invasion, cervical stroma invasion, high-grade tumors, and a tumor diameter ≥ 2 cm are independent predictors of LVSI

Reproducibility of fluorescent expression from engineered biological constructs in E. coli

We present results of the first large-scale interlaboratory study carried out in synthetic biology, as part of the 2014 and 2015 International Genetically Engineered Machine (iGEM) competitions. Participants at 88 institutions around the world measured fluorescence from three engineered constitutive constructs in E. coli. Few participants were able to measure absolute fluorescence, so data was analyzed in terms of ratios. Precision was strongly related to fluorescent strength, ranging from 1.54-fold standard deviation for the ratio between strong promoters to 5.75-fold for the ratio between the strongest and weakest promoter, and while host strain did not affect expression ratios, choice of instrument did. This result shows that high quantitative precision and reproducibility of results is possible, while at the same time indicating areas needing improved laboratory practices.Peer reviewe