355 research outputs found

    Marine Debris Composition On Tasik Ria Beach, Tombariri, Minahasa Regency

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    Indonesia disebut sebagai kontributor sampah plastik ke laut terbesar kedua di dunia setelah Tiongkok, dengan estimasi 0,48-1,29 juta metrik ton per tahun (Jambeck et al, 2015). Masalah utama dewasa ini adalah kurangnya informasi mengenai pencemaran sampah laut di pantai, khususnya di Sulawesi Utara. Penelitian ini bertujuan untuk mengidentifikasi jenis sampah laut di Pantai Tasik Ria dengan menggunakan metode pengamatan garis transek. Pengamatan sampah laut dilakukan sebanyak 5 kali dengan total 10 transek antara bulan Februari hingga April 2019. Analisis data dilakukan dengan menggunakan perangkat lunak yaitu Microsoft Excel, Statgraphics, dan JMP. Adapun tehnik analisis yang digunakan adalah EDA (Exploratory Data Analysis) dengan pendekatan utama yaitu, GDA (Graphical Data Analysis). Dari berbagai semua jenis sampah yang didapatkan, sampah plastik merupakan yang paling banyak ditemukan yaitu sebanyak 189 item, diikuti kaca 97 item, kayu dan turunannya 11 item, karet 5 item dan terakhir pakaian 2 item. Berdasarkan hasil penelitian, jenis sampah makro merupakan ukuran sampah yang paling banyak ditemukan di lokasi penelitian. Jumlah total makro-debris yang dikumpulkan di sepuluh transek pengamatan adalah sebanyak 316 item dengan bobot total 118,62 gr/m2, sedangkan meso-debris hanya terdapat 6 item dengan bobot total 7,18 gr/m2. Persentase komposisi makro-debris yang terdapat di pantai Tasik Ria adalah plastik (58,15%), kaca (29,85%), logam (6,52%), kayu dan turunannya (3,42%), karet (1,55%) dan pakaian (0,62%). Hasil ini dapat menggambarkan potensi kejadian dimana plastik menjadi komponen sampah laut dominan di pantai, secara khusus di Kecamatan Tombariri, Kabupaten Minahasa

    Refined saddle-point preconditioners for discretized Stokes problems

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    This paper is concerned with the implementation of efficient solution algorithms for elliptic problems with constraints. We establish theory which shows that including a simple scaling within well-established block diagonal preconditioners for Stokes problems can result in significantly faster convergence when applying the preconditioned MINRES method. The codes used in the numerical studies are available online

    Statistics of Magnetic Fields for OB Stars

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    Based on an analysis of the catalog of magnetic fields, we have investigated the statistical properties of the mean magnetic fields for OB stars. We show that the mean effective magnetic field B{\cal B} of a star can be used as a statistically significant characteristic of its magnetic field. No correlation has been found between the mean magnetic field strength B{\cal B} and projected rotational velocity of OB stars, which is consistent with the hypothesis about a fossil origin of the magnetic field. We have constructed the magnetic field distribution function for B stars, F(B)F({\cal B}), that has a power-law dependence on B{\cal B} with an exponent of 1.82\approx -1.82. We have found a sharp decrease in the function F(B)F({\cal B})F for {\cal B}\lem 400 G that may be related to rapid dissipation of weak stellar surface magnetic fields.Comment: 22 pages, 7 figures, accepted Astronomy Letters, 2010, vol.36, No.5, pp.370-379, contact E-mail: [email protected]

    Applicant perspectives during selection

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    We provide a comprehensive but critical review of research on applicant reactions to selection procedures published since 2000 (n = 145), when the last major review article on applicant reactions appeared in the Journal of Management. We start by addressing the main criticisms levied against the field to determine whether applicant reactions matter to individuals and employers (“So what?”). This is followed by a consideration of “What’s new?” by conducting a comprehensive and detailed review of applicant reaction research centered upon four areas of growth: expansion of the theoretical lens, incorporation of new technology in the selection arena, internationalization of applicant reactions research, and emerging boundary conditions. Our final section focuses on “Where to next?” and offers an updated and integrated conceptual model of applicant reactions, four key challenges, and eight specific future research questions. Our conclusion is that the field demonstrates stronger research designs, with studies incorporating greater control, broader constructs, and multiple time points. There is also solid evidence that applicant reactions have significant and meaningful effects on attitudes, intentions, and behaviors. At the same time, we identify some remaining gaps in the literature and a number of critical questions that remain to be explored, particularly in light of technological and societal changes

    'A good fit?' Bringing the Sociology of Footwear to the Clinical Encounter in Podiatry Services : A Narrative Review

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    Background: This narrative review explores the ways in which drawing on theories and methods used in sociological work on footwear and identity can contribute to healthcare research with podiatrists and their patients, highlighting recent research in this field, implications for practice and potential areas for future development. Traditionally, research within Podiatry Services has tended to adopt a quantitative, positivist focus, developing separately from a growing body of sociological work exploring the importance of shoes in constructing identity and self-image. Bringing qualitative research drawing on sociological theory and methods to the clinical encounter has real potential to increase our understanding of patient values, motivations and – crucially – any barriers to adopting ‘healthier’ footwear that they may encounter. Such work can help practitioners to understand why patients may resist making changes to their footwear practices, and help us to devise new ways for practitioners to explore and ultimately break down individual barriers to change (including their own preconceptions as practitioners). This, in turn, may lead to long-term, sustainable changes to footwear practices and improvements in foot health for those with complex health conditions and the wider population. Conclusion: A recognition of the complex links between shoes and identity is opening up space for discussion of patient resistance to footwear changes, and paving the way for future research in this field beyond the temporary ‘moment’ of the clinical encounter

    Anti-tumor activity without on-target off-tumor toxicity of GD2-Chimeric Antigen Receptor T cells in patients with neuroblastoma

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    The reprogramming of a patient’s immune system through genetic modification of the T cell compartment with chimeric antigen receptors (CARs) has led to durable remissions in chemotherapy-refractory B cell cancers. Targeting of solid cancers by CAR-T cells is dependent on their infiltration and expansion within the tumor microenvironment, and thus far, fewer clinical responses have been reported. Here, we report a phase 1 study (NCT02761915) in which we treated 12 children with relapsed/refractory neuroblastoma with escalating doses of second-generation GD2-directed CAR-T cells and increasing intensity of preparative lymphodepletion. Overall, no patients had objective clinical response at the evaluation point +28 days after CAR-T cell infusion using standard radiological response criteria. However, of the six patients receiving ≥108/meter2 CAR-T cells after fludarabine/cyclophosphamide conditioning, two experienced grade 2 to 3 cytokine release syndrome, and three demonstrated regression of soft tissue and bone marrow disease. This clinical activity was achieved without on-target off-tumor toxicity. Targeting neuroblastoma with GD2 CAR-T cells appears to be a valid and safe strategy but requires further modification to promote CAR-T cell longevity

    The COMPARE Data Hubs

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    Data sharing enables research communities to exchange findings and build upon the knowledge that arises from their discoveries. Areas of public and animal health as well as food safety would benefit from rapid data sharing when it comes to emergencies. However, ethical, regulatory and institutional challenges, as well as lack of suitable platforms which provide an infrastructure for data sharing in structured formats, often lead to data not being shared or at most shared in form of supplementary materials in journal publications. Here, we describe an informatics platform that includes workflows for structured data storage, managing and pre-publication sharing of pathogen sequencing data and its analysis interpretations with relevant stakeholders
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