Iso-singlet Down Quark Mixing And CP Violation Experiments

We confront the new physics models with extra iso-singlet down quarks in the new CP violation experimental era with $\sin{(2\beta)}$ and $\epsilon'/\epsilon$ measurements, $K^+ \to \pi^+ \nu \bar{\nu}$ events, and $x_s$ limits. The closeness of the new experimental results to the standard model theory requires us to include full SM amplitudes in the analysis. In models allowing mixing to a new isosinglet down quark, as in E$_6$, flavor changing neutral currents are induced that allow a $Z^0$ mediated contribution to $B-\bar B$ mixing and which bring in new phases. In $(\rho,\eta)$, $(x_s,\sin{(\gamma)})$, and $(x_s, \sin{(2\phi_s)})$ plots we still find much larger regions in the four down quark model than in the SM, reaching down to $\eta \approx 0$, $0 \leq \sin{(\gamma)} \leq 1$, $-.75 \leq \sin{(2\alpha)} \leq 0.15$, and $\sin{(2\phi_s)}$ down to zero, all at 1$\sigma$. We elucidate the nature of the cancellation in an order $\lambda^5$ four down quark mixing matrix element which satisfies the experiments and reduces the number of independent angles and phases. We also evaluate tests of unitarity for the $3\times3$ CKM submatrix.Comment: 14 pages, 16 figures, REVTeX

A Flux-Limited Sample of z~1 Ly-alpha Emitting Galaxies in the CDFS

We describe a method for obtaining a flux-limited sample of Ly-alpha emitters from GALEX grism data. We show that the multiple GALEX grism images can be converted into a three-dimensional (two spatial axes and one wavelength axis) data cube. The wavelength slices may then be treated as narrowband images and searched for emission-line galaxies. For the GALEX NUV grism data, the method provides a Ly-alpha flux-limited sample over the redshift range z=0.67-1.16. We test the method on the Chandra Deep Field South field, where we find 28 Ly-alpha emitters with faint continuum magnitudes (NUV>22) that are not present in the GALEX pipeline sample. We measure the completeness by adding artificial emitters and measuring the fraction recovered. We find that we have an 80% completeness above a Ly-alpha flux of 10^-15 erg/cm^2/s. We use the UV spectra and the available X-ray data and optical spectra to estimate the fraction of active galactic nuclei in the selection. We report the first detection of a giant Ly-alpha blob at z<1, though we find that these objects are much less common at z=1 than at z=3. Finally, we compute limits on the z~1 Ly-alpha luminosity function and confirm that there is a dramatic evolution in the luminosity function over the redshift range z=0-1.Comment: 18 pages, in press at The Astrophysical Journa

The Distribution of Nearby Stars in Velocity Space Inferred from Hipparcos Data

(abridged) The velocity distribution f(v) of nearby stars is estimated, via a maximum- likelihood algorithm, from the positions and tangential velocities of a kinematically unbiased sample of 14369 stars observed by the HIPPARCOS satellite. f(v) shows rich structure in the radial and azimuthal motions, v_R and v_phi, but not in the vertical velocity, v_z: there are four prominent and many smaller maxima, many of which correspond to well known moving groups. While samples of early-type stars are dominated by these maxima, also up to 25% of red main-sequence stars are associated with them. These moving groups are responsible for the vertex deviation measured even for samples of late-type stars; they appear more frequently for ever redder samples; and as a whole they follow an asymmetric-drift relation, in the sense that those only present in red samples predominantly have large |v_R| and lag in v_phi w.r.t. the local standard of rest (LSR). The question arise, how these old moving groups got on their eccentric orbits. A plausible mechanism, known from solar system dynamics, which is able to manage a shift in orbit space involves locking into an orbital resonance. Apart from these moving groups, there is a smooth background distribution, akin to Schwarzschild's ellipsoidal model, with axis ratio of about 1:0.6:0.35 in v_R, v_phi, and v_z. The contours are aligned with the $v_r$ direction, but not w.r.t. the v_phi and v_z axes: the mean v_z increases for stars rotating faster than the LSR. This effect can be explained by the stellar warp of the Galactic disk. If this explanation is correct, the warp's inner edge must not be within the solar circle, while its pattern rotates with frequency of about 13 km/s/kpc or more retrograde w.r.t. the stellar orbits.Comment: 16 pages LaTeX (aas2pp4.sty), 6 figures, accepted by A

Relativistic Kinetics of Phonon Gas in Superfluids

The relativistic kinetic theory of the phonon gas in superfluids is developed. The technique of the derivation of macroscopic balance equations from microscopic equations of motion for individual particles is applied to an ensemble of quasi-particles. The necessary expressions are constructed in terms of a Hamilton function of a (quasi-)particle. A phonon contribution into superfluid dynamic parameters is obtained from energy-momentum balance equations for the phonon gas together with the conservation law for superfluids as a whole. Relations between dynamic flows being in agreement with results of relativistic hydrodynamic consideration are found. Based on the kinetic approach a problem of relativistic variation of the speed of sound under phonon influence at low temperature is solved.Comment: 23 pages, Revtex fil

Image Coaddition with Temporally Varying Kernels

Large, multi-frequency imaging surveys, such as the Large Synaptic Survey Telescope (LSST), need to do near-real time analysis of very large datasets. This raises a host of statistical and computational problems where standard methods do not work. In this paper, we study a proposed method for combining stacks of images into a single summary image, sometimes referred to as a template. This task is commonly referred to as image coaddition. In part, we focus on a method proposed in previous work, which outlines a procedure for combining stacks of images in an online fashion in the Fourier domain. We evaluate this method by comparing it to two straightforward methods through the use of various criteria and simulations. Note that the goal is not to propose these comparison methods for use in their own right, but to ensure that additional complexity also provides substantially improved performance

Inhaled insulin for controlling blood glucose in patients with diabetes

Diabetes mellitus is a significant worldwide health problem, with the incidence of type 2 diabetes increasing at alarming rates. Insulin resistance and dysregulated blood glucose control are established risk factors for microvascular complications and cardiovascular disease. Despite the recognition of diabetes as a major health issue and the availability of a growing number of medications designed to counteract its detrimental effects, real and perceived barriers remain that prevent patients from achieving optimal blood glucose control. The development and utilization of inhaled insulin as a novel insulin delivery system may positively influence patient treatment adherence and optimal glycemic control, potentially leading to a reduction in cardiovascular complications in patients with diabetes

Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-Carboximidamides

The over production of nitric oxide in the brain by neuronal nitric oxide synthase (nNOS) is associated with a number of neurodegenerative diseases. Although inhibiting nNOS is an important therapeutic goal, it is important not to inhibit endothelial NOS (eNOS) owing to the critical role played by eNOS in maintaining vascular tone. While it has been possible to develop nNOS selective aminopyridine inhibitors, many of the most potent and selective inhibitors exhibit poor bioavailability properties. Our group and others have turned to more biocompatible thiophene-2-carboximidamides (T2C) inhibitors as potential nNOS selective inhibitors. We have used crystallography and computational methods to better understand how and why 2 commercially developed T2C inhibitors exhibit selectivity for human nNOS over human eNOS. As with many of the aminopyridine inhibitors, a critical active site Asp residue in nNOS vs Asn in eNOS is largely responsible for controlling selectivity. We also present thermodynamic integration results to better understand the change in pKa and thus charge of inhibitors once bound to the active site. In addition, relative free energy calculations underscore the importance of enhanced electrostatic stabilization of inhibitors bound to the nNOS active site compared to eNOS

A Systematic Review of Music Therapy Practice and Outcomes with Acute Adult Psychiatric In-Patients

PMCID: PMC3732280This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Feasibility of diffusion and probabilistic white matter analysis in patients implanted with a deep brain stimulator.

Deep brain stimulation (DBS) for Parkinson\u27s disease (PD) is an established advanced therapy that produces therapeutic effects through high frequency stimulation. Although this therapeutic option leads to improved clinical outcomes, the mechanisms of the underlying efficacy of this treatment are not well understood. Therefore, investigation of DBS and its postoperative effects on brain architecture is of great interest. Diffusion weighted imaging (DWI) is an advanced imaging technique, which has the ability to estimate the structure of white matter fibers; however, clinical application of DWI after DBS implantation is challenging due to the strong susceptibility artifacts caused by implanted devices. This study aims to evaluate the feasibility of generating meaningful white matter reconstructions after DBS implantation; and to subsequently quantify the degree to which these tracts are affected by post-operative device-related artifacts. DWI was safely performed before and after implanting electrodes for DBS in 9 PD patients. Differences within each subject between pre- and post-implantation FA, MD, and RD values for 123 regions of interest (ROIs) were calculated. While differences were noted globally, they were larger in regions directly affected by the artifact. White matter tracts were generated from each ROI with probabilistic tractography, revealing significant differences in the reconstruction of several white matter structures after DBS. Tracts pertinent to PD, such as regions of the substantia nigra and nigrostriatal tracts, were largely unaffected. The aim of this study was to demonstrate the feasibility and clinical applicability of acquiring and processing DWI post-operatively in PD patients after DBS implantation. The presence of global differences provides an impetus for acquiring DWI shortly after implantation to establish a new baseline against which longitudinal changes in brain connectivity in DBS patients can be compared. Understanding that post-operative fiber tracking in patients is feasible on a clinically-relevant scale has significant implications for increasing our current understanding of the pathophysiology of movement disorders, and may provide insights into better defining the pathophysiology and therapeutic effects of DBS

Top Quark Physics at the Tevatron

We review the field of top-quark physics with an emphasis on experimental techniques. The role of the top quark in the Standard Model of particle physics is summarized and the basic phenomenology of top-quark production and decay is introduced. We discuss how contributions from physics beyond the Standard Model could affect top-quark properties or event samples. The many measurements made at the Fermilab Tevatron, which test the Standard Model predictions or probe for direct evidence of new physics using the top-quark event samples, are reviewed here.Comment: 50 pages, 17 figures, 2 tables; version accepted by Review of Modern Physic