Chiral molecules split light: Reflection and refraction in a chiral liquid

A light beam changes direction as it enters a liquid at an angle from another medium, such as air. Should the liquid contain molecules that lack mirror symmetry, then it has been predicted by Fresnel that the light beam will not only change direction, but will actually split into two separate beams with a small difference in the respective angles of refraction. Here we report the observation of this phenomenon. We also demonstrate that the angle of reflection does not equal the angle of incidence in a chiral medium. Unlike conventional optical rotation, which depends on the path-length through the sample, the reported reflection and refraction phenomena arise within a few wavelengths at the interface and thereby suggest a new approach to polarimetry that can be used in microfluidic volumes

Case Mix, Costs, and Outcomes: Differences Between Faculty and Community Services in a University Hospital

In order to gain insight into the possible consequences of prospective payment for university hospitals, we studied 2,025 admissions to the faculty and community services of a university hospital, measuring differences in case mix, costs, and outcomes. The faculty service case mix was disproportionately weighted toward the more costly diagnoses, but even after adjustment for diagnosis-related groups (DRGs), costs were 11 percent higher on the faculty service. The differential was proportionately greater for diagnostic costs than for routine or treatment costs, and the differential was particularly large (70 percent) for patients with a predicted probability of death (DTHRISK) of .25 or greater.The in-hospital mortality rate was appreciably lower on the faculty service after adjustment for case mix and patient characteristics. The mortality differential between the two services was particularly large for patients in the high death risk category. Comparison of a matched sample of 51 pairs of admissions from the high death risk category confirmed the above results with respect to costs and in-hospital mortality, but follow-up revealed that the mortality rates were equal for the two services at nine months after discharge.

NARRATIVE COMPREHENSION IN ADULTS WITH RIGHT HEMISPHERE BRAIN DAMAGE: THE ROLE OF COHERENCE AND THEME ORGANIZATION

Background: In 1990, Hough conducted a study investigating the role of theme organization on discourse comprehension in adults with right hemisphere brain damage (RHD). She reported that participants with RHD performed significantly worse when the theme of a narrative was delayed until the end, compared to when the theme was at the beginning. RHD participants also performed significantly worse on these tasks compared to participants with left hemisphere brain damage and normal controls. However, manipulations to delay the theme also resulted in narratives that lacked coherence and violated the rules of narrative structure. Aims: The current study examined if controlling for differences in coherence between original and delayed-theme narratives would eliminate discrepancies in comprehension in the two conditions.Methods & Procedures: Participants were 10 adults with unilateral RHD and five without brain damage. Participants listened to experimental and filler narratives. Experimental narratives consisted of original-theme narratives and delayed-theme narratives that were manipulated to delay the theme while maintaining story coherence. Filler narratives consisted of original-theme narratives and delayed-theme narratives that were not controlled for coherence. All narratives were followed by three yes/no questions pertaining to main ideas and details. Several ancillary tasks were also included to further classify participants and to analyze alternative explanations for performance. Outcomes & Results: Accuracy data revealed that as predicted, there was no significant difference in performance on experimental original-theme and delayed-theme narratives for the RHD group. There was a trend towards poorer comprehension of filler delayed-theme narratives compared to original-theme narratives. These results support the hypothesis that poor comprehension on delayed-theme narratives in Hough's study was a result of differences in coherence rather than theme organization. However, analysis of ancillary tasks revealed a significant correlation between estimated capacity for auditory working memory and performance on delayed-theme narratives. These results imply that even with coherence accounted for, delaying the theme of a narrative is more taxing on mental processing, thus decreasing comprehension in RHD participants with particularly low working memory capacity

Multidimensional optical fractionation with holographic verification

The trajectories of colloidal particles driven through a periodic potential energy landscape can become kinetically locked in to directions dictated by the landscape's symmetries. When the landscape is realized with forces exerted by a structured light field, the path a given particle follows has been predicted to depend exquisitely sensitively on such properties as the particle's size and refractive index These predictions, however, have not been tested experimentally. Here, we describe measurements of colloidal silica spheres' transport through arrays of holographic optical traps that use holographic video microscopy to track individual spheres' motions in three dimensions and simultaneously to measure each sphere's radius and refractive index with part-per-thousand resolution. These measurements confirm previously untested predictions for the threshold of kinetically locked-in transport, and demonstrate the ability of optical fractionation to sort colloidal spheres with part-per-thousand resolution on multiple characteristics simultaneously.Comment: 4 pages, 2 figures. Accepted for publication in Physical Review Letter

Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders.

The laboratory rat is emerging as an attractive preclinical animal model of autism spectrum disorder (ASD), allowing investigators to explore genetic, environmental and pharmacological manipulations in a species exhibiting complex, reciprocal social behavior. The present study was carried out to compare two commonly used strains of laboratory rats, Sprague-Dawley (SD) and Long-Evans (LE), between the ages of postnatal day (PND) 26-56 using high-throughput behavioral phenotyping tools commonly used in mouse models of ASD that we have adapted for use in rats. We detected few differences between young SD and LE strains on standard assays of exploration, sensorimotor gating, anxiety, repetitive behaviors, and learning. Both SD and LE strains also demonstrated sociability in the 3-chamber social approach test as indexed by spending more time in the social chamber with a constrained age/strain/sex matched novel partner than in an identical chamber without a partner. Pronounced differences between the two strains were, however, detected when the rats were allowed to freely interact with a novel partner in the social dyad paradigm. The SD rats in this particular testing paradigm engaged in play more frequently and for longer durations than the LE rats at both juvenile and young adult developmental time points. Results from this study that are particularly relevant for developing preclinical ASD models in rats are threefold: (i) commonly utilized strains exhibit unique patterns of social interactions, including strain-specific play behaviors, (ii) the testing environment may profoundly influence the expression of strain-specific social behavior and (iii) simple, automated measures of sociability may not capture the complexities of rat social interactions

The X-Ray Zurich Environmental Study (X-ZENS). I. Chandra and XMM-Newton observations of active galactic nuclei in galaxies in nearby groups

We describe X-ray observations with Chandra and XMM-Newton of 18 galaxy groups (M_group ~ 1-6x10^13 Msolar, z~0.05) from the Zurich Environmental Study (ZENS). We aim to establish the frequency and properties, unaffected by host galaxy dilution and obscuration, of AGNs in central and satellite galaxy members, also as a function of halo-centric distance. X-ray point-source detections are reported for 22 of 177 observed galaxies, down to a limit of f_(0.5-8 keV) ~ 5x10^-15 erg cm^-2 s^-1, corresponding to a limiting luminosity of L_(0.5-8 keV)~3x10^40 erg s^-1. With the majority of the X-ray sources attributed to AGNs of low-to-moderate levels (L/L_Edd>~10^-4), we discuss the detection rate in the context of the occupation of AGNs to halos of this mass scale and redshift, and compare the structural/morphological properties between AGN-active and non-active galaxies of different rank and location within the group halos. We see a slight tendency for AGN hosts to have either relatively brighter/denser disks (or relatively fainter/diffuse bulges) than non-active galaxies of similar mass. At galaxy mass scales <10^11 Msolar, central galaxies appear to be a factor ~4 more likely to host AGNs than satellite galaxies of similar mass. This effect, coupled with the tendency for AGNs to reside in massive galaxies, explains the (weak) trend for AGNs to be preferentially found in the inner regions of groups, with no detectable trend with halo-centric distance in the frequency of AGNs within the satellite population. Finally, our data support other analyses in finding that the rate of decline with redshift of AGN activity in groups matches that of the global AGN population, indicating that either AGNs occur preferentially in groups, or that the evolution rate is independent of halo mass. These trends are of potential importance, and require X-ray coverage of a larger sample to be solidly confirmed.Comment: 18 pages, 13 figures, submitted to The Astrophysical Journal, this is a revised version that addresses the referee's comment

Anomalous Chromomagnetic Moments of Quarks and Large Transverse Energy Jets

We consider the jet cross sections for gluons coupling to quarks with an anomalous chromomagnetic moment. We then apply this to the deviation and bounds from QCD found in the CDF and D0 Fermilab data, respectively, to find a range of possible values for the anomalous moments. The quadratic and quartic terms in the anomalous moments can fit to the rise of a deviation with transverse energy. Since previous analyses have been done on the top quark total cross section, here we assume the same moment on all quarks except the top and find the range $|\kappa'| \equiv |\kappa/(2 m_q)| = 1.0\pm 0.3$ TeV$^{-1}$ for the CDF data. Assuming the anomalous moment is present only on a charm or bottom quark which is pair produced results in a range $|\kappa'_{b,c}| = 3.5 \pm 1.0$ TeV$^{-1}$. The magnitudes here are compared with anomalous magnetic moments that could account for $R_b$ and found to be in the same general range, as well as not inconsistent with LEP and SLD bounds on $\Delta \Gamma_{\text{had}}$.Comment: REVTeX, 11 pages, 2 postscript figure

Topological phase for entangled two-qubit states and the representation of the SO(3)group

We discuss the representation of the $SO(3)$ group by two-qubit maximally entangled states (MES). We analyze the correspondence between $SO(3)$ and the set of two-qubit MES which are experimentally realizable. As a result, we offer a new interpretation of some recently proposed experiments based on MES. Employing the tools of quantum optics we treat in terms of two-qubit MES some classical experiments in neutron interferometry, which showed the $\pi$-phase accrued by a spin-$1/2$ particle precessing in a magnetic field. By so doing, we can analyze the extent to which the recently proposed experiments - and future ones of the same sort - would involve essentially new physical aspects as compared with those performed in the past. We argue that the proposed experiments do extend the possibilities for displaying the double connectedness of $SO(3)$, although for that to be the case it results necessary to map elements of $SU(2)$ onto physical operations acting on two-level systems.Comment: 25 pages, 9 figure

Late-Time Circumstellar Interaction in a Spitzer Selected Sample of Type IIn Supernovae

Type IIn supernovae (SNe IIn) are a rare (< 10%) subclass of core-collapse SNe that exhibit relatively narrow emission lines from a dense, pre-existing circumstellar medium (CSM). In 2009, a warm Spitzer survey observed 30 SNe IIn discovered in 2003 - 2008 and detected 10 SNe at distances out to 175 Mpc with unreported late-time infrared emission, in some cases more than 5 years post-discovery. For this single epoch of data, the warm-dust parameters suggest the presence of a radiative heating source consisting of optical/X-ray emission continuously generated by ongoing CSM interaction. Here we present multi-wavelength follow-up observations of this sample of 10 SNe IIn and the well-studied Type IIn SN 2010jl. A recent epoch of Spitzer observations reveals ongoing mid-infrared emission from nine of the SNe in this sample. We also detect three of the SNe in archival WISE data, in addition to SNe 1987A, 2004dj, and 2008iy. For at least five of the SNe in the sample, optical and/or X-ray emission confirms the presence of radiative emission from ongoing CSM interaction. The two Spitzer nondetections are consistent with the forward shock overrunning and destroying the dust shell, a result that places upper limits on the dust-shell size. The optical and infrared observations confirm the radiative heating model and constrain a number of model parameters, including progenitor mass-loss characteristics. All of the SNe in this sample experienced an outburst on the order of tens to hundreds of years prior to the SN explosion followed by periods of less intense mass loss. Although all evidence points to massive progenitors, the variation in the data highlights the diversity in SN IIn progenitor evolution. While these observations do not identify a particular progenitor system, they demonstrate that future, coordinated, multi-wavelength campaigns can constrain theoretical mass-loss models.Comment: 10 pages, 6 figures, accepted to AJ (with comments