9,340 research outputs found
Iso-singlet Down Quark Mixing And CP Violation Experiments
We confront the new physics models with extra iso-singlet down quarks in the
new CP violation experimental era with and
measurements, events, and
limits. The closeness of the new experimental results to the standard
model theory requires us to include full SM amplitudes in the analysis. In
models allowing mixing to a new isosinglet down quark, as in E, flavor
changing neutral currents are induced that allow a mediated contribution
to mixing and which bring in new phases. In ,
, and plots we still find much
larger regions in the four down quark model than in the SM, reaching down to
, , , and down to zero, all at 1. We elucidate
the nature of the cancellation in an order four down quark mixing
matrix element which satisfies the experiments and reduces the number of
independent angles and phases. We also evaluate tests of unitarity for the
CKM submatrix.Comment: 14 pages, 16 figures, REVTeX
A Flux-Limited Sample of z~1 Ly-alpha Emitting Galaxies in the CDFS
We describe a method for obtaining a flux-limited sample of Ly-alpha emitters
from GALEX grism data. We show that the multiple GALEX grism images can be
converted into a three-dimensional (two spatial axes and one wavelength axis)
data cube. The wavelength slices may then be treated as narrowband images and
searched for emission-line galaxies. For the GALEX NUV grism data, the method
provides a Ly-alpha flux-limited sample over the redshift range z=0.67-1.16. We
test the method on the Chandra Deep Field South field, where we find 28
Ly-alpha emitters with faint continuum magnitudes (NUV>22) that are not present
in the GALEX pipeline sample. We measure the completeness by adding artificial
emitters and measuring the fraction recovered. We find that we have an 80%
completeness above a Ly-alpha flux of 10^-15 erg/cm^2/s. We use the UV spectra
and the available X-ray data and optical spectra to estimate the fraction of
active galactic nuclei in the selection. We report the first detection of a
giant Ly-alpha blob at z<1, though we find that these objects are much less
common at z=1 than at z=3. Finally, we compute limits on the z~1 Ly-alpha
luminosity function and confirm that there is a dramatic evolution in the
luminosity function over the redshift range z=0-1.Comment: 18 pages, in press at The Astrophysical Journa
Relativistic Kinetics of Phonon Gas in Superfluids
The relativistic kinetic theory of the phonon gas in superfluids is
developed. The technique of the derivation of macroscopic balance equations
from microscopic equations of motion for individual particles is applied to an
ensemble of quasi-particles. The necessary expressions are constructed in terms
of a Hamilton function of a (quasi-)particle. A phonon contribution into
superfluid dynamic parameters is obtained from energy-momentum balance
equations for the phonon gas together with the conservation law for superfluids
as a whole. Relations between dynamic flows being in agreement with results of
relativistic hydrodynamic consideration are found. Based on the kinetic
approach a problem of relativistic variation of the speed of sound under phonon
influence at low temperature is solved.Comment: 23 pages, Revtex fil
The Distribution of Nearby Stars in Velocity Space Inferred from Hipparcos Data
(abridged) The velocity distribution f(v) of nearby stars is estimated, via a
maximum- likelihood algorithm, from the positions and tangential velocities of
a kinematically unbiased sample of 14369 stars observed by the HIPPARCOS
satellite. f(v) shows rich structure in the radial and azimuthal motions, v_R
and v_phi, but not in the vertical velocity, v_z: there are four prominent and
many smaller maxima, many of which correspond to well known moving groups.
While samples of early-type stars are dominated by these maxima, also up to 25%
of red main-sequence stars are associated with them. These moving groups are
responsible for the vertex deviation measured even for samples of late-type
stars; they appear more frequently for ever redder samples; and as a whole they
follow an asymmetric-drift relation, in the sense that those only present in
red samples predominantly have large |v_R| and lag in v_phi w.r.t. the local
standard of rest (LSR). The question arise, how these old moving groups got on
their eccentric orbits. A plausible mechanism, known from solar system
dynamics, which is able to manage a shift in orbit space involves locking into
an orbital resonance.
Apart from these moving groups, there is a smooth background distribution,
akin to Schwarzschild's ellipsoidal model, with axis ratio of about 1:0.6:0.35
in v_R, v_phi, and v_z. The contours are aligned with the direction, but
not w.r.t. the v_phi and v_z axes: the mean v_z increases for stars rotating
faster than the LSR. This effect can be explained by the stellar warp of the
Galactic disk. If this explanation is correct, the warp's inner edge must not
be within the solar circle, while its pattern rotates with frequency of about
13 km/s/kpc or more retrograde w.r.t. the stellar orbits.Comment: 16 pages LaTeX (aas2pp4.sty), 6 figures, accepted by A
Image Coaddition with Temporally Varying Kernels
Large, multi-frequency imaging surveys, such as the Large Synaptic Survey
Telescope (LSST), need to do near-real time analysis of very large datasets.
This raises a host of statistical and computational problems where standard
methods do not work. In this paper, we study a proposed method for combining
stacks of images into a single summary image, sometimes referred to as a
template. This task is commonly referred to as image coaddition. In part, we
focus on a method proposed in previous work, which outlines a procedure for
combining stacks of images in an online fashion in the Fourier domain. We
evaluate this method by comparing it to two straightforward methods through the
use of various criteria and simulations. Note that the goal is not to propose
these comparison methods for use in their own right, but to ensure that
additional complexity also provides substantially improved performance
Inhaled insulin for controlling blood glucose in patients with diabetes
Diabetes mellitus is a significant worldwide health problem, with the incidence of type 2 diabetes increasing at alarming rates. Insulin resistance and dysregulated blood glucose control are established risk factors for microvascular complications and cardiovascular disease. Despite the recognition of diabetes as a major health issue and the availability of a growing number of medications designed to counteract its detrimental effects, real and perceived barriers remain that prevent patients from achieving optimal blood glucose control. The development and utilization of inhaled insulin as a novel insulin delivery system may positively influence patient treatment adherence and optimal glycemic control, potentially leading to a reduction in cardiovascular complications in patients with diabetes
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Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-Carboximidamides
The over production of nitric oxide in the brain by neuronal nitric oxide synthase (nNOS) is associated with a number of neurodegenerative diseases. Although inhibiting nNOS is an important therapeutic goal, it is important not to inhibit endothelial NOS (eNOS) owing to the critical role played by eNOS in maintaining vascular tone. While it has been possible to develop nNOS selective aminopyridine inhibitors, many of the most potent and selective inhibitors exhibit poor bioavailability properties. Our group and others have turned to more biocompatible thiophene-2-carboximidamides (T2C) inhibitors as potential nNOS selective inhibitors. We have used crystallography and computational methods to better understand how and why 2 commercially developed T2C inhibitors exhibit selectivity for human nNOS over human eNOS. As with many of the aminopyridine inhibitors, a critical active site Asp residue in nNOS vs Asn in eNOS is largely responsible for controlling selectivity. We also present thermodynamic integration results to better understand the change in pKa and thus charge of inhibitors once bound to the active site. In addition, relative free energy calculations underscore the importance of enhanced electrostatic stabilization of inhibitors bound to the nNOS active site compared to eNOS
A Systematic Review of Music Therapy Practice and Outcomes with Acute Adult Psychiatric In-Patients
PMCID: PMC3732280This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Feasibility of diffusion and probabilistic white matter analysis in patients implanted with a deep brain stimulator.
Deep brain stimulation (DBS) for Parkinson\u27s disease (PD) is an established advanced therapy that produces therapeutic effects through high frequency stimulation. Although this therapeutic option leads to improved clinical outcomes, the mechanisms of the underlying efficacy of this treatment are not well understood. Therefore, investigation of DBS and its postoperative effects on brain architecture is of great interest. Diffusion weighted imaging (DWI) is an advanced imaging technique, which has the ability to estimate the structure of white matter fibers; however, clinical application of DWI after DBS implantation is challenging due to the strong susceptibility artifacts caused by implanted devices. This study aims to evaluate the feasibility of generating meaningful white matter reconstructions after DBS implantation; and to subsequently quantify the degree to which these tracts are affected by post-operative device-related artifacts. DWI was safely performed before and after implanting electrodes for DBS in 9 PD patients. Differences within each subject between pre- and post-implantation FA, MD, and RD values for 123 regions of interest (ROIs) were calculated. While differences were noted globally, they were larger in regions directly affected by the artifact. White matter tracts were generated from each ROI with probabilistic tractography, revealing significant differences in the reconstruction of several white matter structures after DBS. Tracts pertinent to PD, such as regions of the substantia nigra and nigrostriatal tracts, were largely unaffected. The aim of this study was to demonstrate the feasibility and clinical applicability of acquiring and processing DWI post-operatively in PD patients after DBS implantation. The presence of global differences provides an impetus for acquiring DWI shortly after implantation to establish a new baseline against which longitudinal changes in brain connectivity in DBS patients can be compared. Understanding that post-operative fiber tracking in patients is feasible on a clinically-relevant scale has significant implications for increasing our current understanding of the pathophysiology of movement disorders, and may provide insights into better defining the pathophysiology and therapeutic effects of DBS
Patent No. US 9,090,589 B2: Specific NNOS Inhibitors for the Therapy and Prevention of Human Melanoma
Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies
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