Alongamentos no tratamento de fascite plantar

O objetivo deste trabalho foi determinar se exercícios de alongamento em pacientes com fascite plantar são benéficos na melhoria da dor. Para isso foram pesquisados estudos controlados aleatorizados, publicados nos últimos 10 anos nas bases de dados PubMed, Cochrane e PEDro. Foi investigado o efeito de exercícios de alongamento em doentes com fascite plantar na dor comparado com outros tipos de intervenção ou sem intervenção. Os artigos foram avaliados quanto ao risco de viés pela RoB2, o nível de evidência e força de recomendação pela SORT. Desta pesquisa resultaram 87 artigos dos quais, após aplicação dos critérios de inclusão, resultaram 3 artigos, analisados em diante. Os exercícios de alongamento da fáscia plantar mostram-se mais eficazes que anti-inflamatório não esteroide oral e alongamentos do gastrocnémio e tão eficazes como palmilhas de silicone associadas a calor. No entanto, quando se comparam os alongamentos da fáscia plantar e tendão de Aquiles com proloterapia com lidocaína, a primeira intervenção evidencia resultados inferiores. Por outro, o uso de foam roller apresentou melhores resultados em 2 dos outcomes estudados, não havendo diferença estatisticamente significativa nos restantes.  Conclusões: Os alongamentos parecem ter lugar no tratamento da fascite plantar, existindo métodos que podem ser mais eficazes

INFLUÊNCIA DAS MUDANÇAS CLIMÁTICAS NA PRODUÇÃO CAFEEIRA SEGUNDO A PERCEPÇÃO DAS CAFEICULTORAS

Na cafeicultura, as intempéries afetam não somente as plantas, mas também as mulheres que atuam no processo produtivo dessa commodity. Logo, é necessário que as mulheres que trabalham na produção do café tenham maior conhecimento acerca das influências das Mudanças Climáticas na cafeicultura. Objetivou-se analisar a percepção das mulheres que trabalham na cafeicultura em 15 municípios localizados na região das Matas de Minas sobre a influência das mudanças climáticas na produção de café. Foram aplicados 67 questionários semiestruturados às mulheres em 15 municípios da região das Matas de Minas, os dados foram tabulados e foi identificado que a maior parte delas têm a televisão como principal fonte de informação sobre as mudanças climáticas globais e acreditam que tais mudanças não irão contribuir para a melhoria do café na região bem como podem influenciar na extinção da cafeicultura da região no futuro, interferindo assim, de alguma forma no futuro delas. De modo geral as mulheres que declararam ter conhecimento médio sobre mudanças climáticas e aquecimento global

Influence of temperature and pressure on the density and speed of sound of 2-hydroxyethylammonium propionate ionic liquid

The alkanolammonium ILs are protic ionic liquids (PILs) with huge potential in a variety of industrial fields. Among other advantages, these PILs have low cost of preparation, simple synthesis and purification methodologies and low toxicity. This study aims at obtaining significant data on the fundamental thermophysical properties of hydroxyethylammonium-based PILs with carboxylate anions. The density was measured within the temperature and pressure intervals (298.15–343.15) K and (0.1–35.0) MPa for 2-hydroxyethylammonium propionate, [2-HEA][Pr]. The speed of sound was determined in the ranges (303.15–353.15) K and (0.1–20.0) MPa for the same substance. The estimated combined standard uncertainties are ±0.45 kg·m−3 for density and ±1.6 m·s−1 for speed of sound. The experimental pVT data were fitted using the Goharshadi–Morsali-Abbaspour equation of state (GMA EoS) with average relative absolute deviation (%AARD) of 0.03%. Thermomechanical coefficients as the thermal expansivity, isothermal compressibility, and internal pressure, were calculated using GMA EoS with the internal pressure being further compared with calculated values of cohesive energy density. The experimental pVT data were further successfully described by the predictive methods of Gardas and Coutinho and Paduszyńki and Domańska.publishe

Clinical and nutritional follow-up of cats with chronic kidney disease fed with a renal prescription diet

Background: The use of prescription diets for cats with chronic kidney disease (CKD) is one of the main management approach of this disease in cats, and is considered a renoprotective strategy that may promote increased survival and/or improve quality of life, according to the stage of CKD. Besides that, nutritional assessment is important to monitor the maintenance of quality of life of the patients and their response to disease, especially those with chronic conditions. The aim of this study was to follow the clinical and nutritional status of cats with chronic kidney disease (CKD) IRIS stages II, III and IV fed with a renal prescription diet, followed for 12 months. Materials, Methods & Results: Patients were fed exclusively with a dry renal prescription diet and medications for the management of CKD were prescribed when needed. Exclusion criteria were cats that already received a renal prescription diet or medications for the treatment of CKD. Cats were evaluated every 2 months, considering body weight (BW), body condition score (BCS), muscle mass score (MMS), clinical and laboratory parameters. In all assessments, a complete blood count and biochemistry were performed by conventional methods with the patient fasted for 12 h. In addition, urinalysis, urine protein:creatinine ratio (UPC) and urine culture were performed from a urine sample collected by cystocentesis. The quantitative variables were tested for their stability on consecutive assessments using the non-parametric Friedman test, and did not present significant variation during follow-up, except for systolic blood pressure (SBP). Eight cats with a diagnosis of CKD were included in the study and 6 of them remained in the same CKD stage during follow-up. On cat died due to an unrelated CKD cause. Regarding nutritional assessment, 5 of 7 cats maintained BW during the 12 months. Of these, 4 also maintained MMS and BCS. Three of 7 cats presented a decrease in MMS, 2 of which presented also a decreased BW and one maintained BW. Discussion: IRIS staging results combined with Friedman’s analysis demonstrated that the diet and the clinical management were effective in the non-progression of CKD in this study. As renal injury is not expected to be reversed in CKD, the maintenance of cats in the same IRIS stages and the minimum variation of the parameters is considered a positive result in this study. Hypertensive cats started on antihypertensive therapy during the study, achieving adequate control of SBP in most cases, what can justify the variation of this clinical parameter over the 12 months. Hyperphosphatemia was a frequent alteration, included stage II cats, and presented a positive response to nutritional and medical therapy. Despite CKD staging progression was not observed in most cats using serum creatinine as a single parameter, some cats presented BW and MMS reduction, which may have influenced this result. Weight loss and muscle wasting may have occurred by several reasons, including periods of hyporexia, presence of concomitant diseases, aging process or reduced protein content on renal prescription diets. This study enhances the importance of the association of clinical and nutritional management in the maintenance of cats with CKD. We suggest that other studies are done during longer periods of time and with a larger sample to support the results found. We also suggest new studies to evaluate the protein requirements for cats with CKD

Clinical and Nutritional Follow-up of Cats with Chronic Kidney Disease Fed with a Renal Prescription Diet

Background: The use of prescription diets for cats with chronic kidney disease (CKD) is one of the main management approach of this disease in cats, and is considered a renoprotective strategy that may promote increased survival and/or improve quality of life, according to the stage of CKD. Besides that, nutritional assessment is important to monitor the maintenance of quality of life of the patients and their response to disease, especially those with chronic conditions. The aim of this study was to follow the clinical and nutritional status of cats with chronic kidney disease (CKD) IRIS stages II, III and IV fed with a renal prescription diet, followed for 12 months. Materials, Methods & Results: Patients were fed exclusively with a dry renal prescription diet and medications for the management of CKD were prescribed when needed. Exclusion criteria were cats that already received a renal prescription diet or medications for the treatment of CKD. Cats were evaluated every 2 months, considering body weight (BW), body condition score (BCS), muscle mass score (MMS), clinical and laboratory parameters. In all assessments, a complete blood count and biochemistry were performed by conventional methods with the patient fasted for 12 h. In addition, urinalysis, urinary protein:creatinine ratio (UPC) and urine culture were performed from a urine sample collected by cystocentesis. The quantitative variables were tested for their stability on consecutive assessments using the non-parametric Friedman test, and did not present significant variation during follow-up, except for systolic blood pressure (SBP). Eight cats with a diagnosis of CKD were included in the study and 6 of them remained in the same CKD stage during follow-up. On cat died due to an unrelated CKD cause. Regarding nutritional assessment, 5 of 7 cats maintained BW during the 12 months. Of these, 4 also maintained MMS and BCS. Three of 7 cats presented a decrease in MMS, 2 of which presented also a decreased BW and one maintained BW.Discussion: IRIS staging results combined with Friedman’s analysis demonstrated that the diet and the clinical management were effective in the non-progression of CKD in this study. As renal injury is not expected to be reversed in CKD, the maintenance of cats in the same IRIS stages and the minimum variation of the parameters is considered a positive result in this study. Hypertensive cats started on antihypertensive therapy during the study, achieving adequate control of SBP in most cases, what can justify the variation of this clinical parameter over the 12 months. Hyperphosphatemia was a frequent alteration, included stage II cats, and presented a positive response to nutritional and medical therapy. Despite CKD staging progression was not observed in most cats using serum creatinine as a single parameter, some cats presented BW and MMS reduction, which may have influenced this result. Weight loss and muscle wasting may have occurred by several reasons, including periods of hyporexia, presence of concomitant diseases, aging process or reduced protein content on renal prescription diets. This study enhances the importance of the association of clinical and nutritional management in the maintenance of cats with CKD. We suggest that other studies are done during longer periods of time and with a larger sample to support the results found. We also suggest new studies to evaluate the protein requirements for cats with CKD

Evaluation of antitumoral and antimicrobial activity of Morinda lcitrifolia L. grown in Southeast Brazil

PURPOSE: To evaluate the antitumor and antimicrobial activity of ethanolic extract of Morinda citrifolia L. fruit cultivated in southeastern Brazil.METHODS: Preparation ethanolic extract of the fruit of Morinda citrifolia L. Culture of melanoma cells B16-F10 for treatment with ethanolic extract of Morinda citrifolia L. fruit to determine cell viability by MTT and determination temporal effect of ethanolic extract fruit on the cell growth B16-F10 for 8 days. Evaluation of antimicrobial activity of ethanolic extract fruit against Staphylococcus aureus and Escherichia coli by determination of Minimum Inhibitory Concentration (MIC).RESULTS: the ethanolic extract of Morinda citrifolia L. fruit (10mg/mL) decreased cellular activity and inhibited 45% the rate of cell proliferation of B16-F10 melanoma treated during period studied. the ethanolic extract of Morinda citrifolia L. fruit demonstrated antimicrobial activity inhibiting the growth of both microorganisms studied. Staphylococcus aureus was less resistant to ethanolic extract of Morinda citrifolia L. fruit than Escherichia coli, 1 mg/mL and 10 mg/mL, respectively.CONCLUSION: What these results indicate that the ethanolic extract of the fruit of Morinda citrifolia L. showed antitumor activity with inhibition of viability and growth of B16-F10 cells and also showed antibacterial activity as induced inhibition of growth of Staphylococcus aureus and Escherichia coli.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Bahia Research Foundation (FAPESB)Univ Estadual Santa Cruz UESC, Dept Ciencias Biol, BR-45662900 Ilheus, BA, BrazilUniv Estadual Santa Cruz, Dept Agr & Environm Sci, BR-45662900 Ilheus, BA, BrazilUniversidade Federal de São Paulo, Div Plast Surg, São Paulo, Brazil1A CNPq, São Paulo, BrazilMed III CAPES, São Paulo, BrazilUniversidade Federal de São Paulo, Div Plast Surg, São Paulo, BrazilWeb of Scienc

Nefrolitíase: diagnóstico e manejo: Nephrolithiasis: diagnosis and management

Introdução: A nefrolitíase é um grave problema de saúde pública que aflige toda a população no mundo, podendo ser assintomática ou se manifestar através de dor em flancos e/ou pélvica, hematúria e sintomas inespecíficos como febre, náusea e vômitos. Tal condição pode ser avaliada e explicada pelo fator ambiental dietético, atribuído pelo consumo indevido de sal e de proteínas tendo como consequência a hipercalciúria, além de outros fatores como baixa ingestão de líquidos, áreas de clima tropical e comorbidades como hipertensão e obesidade. Objetivos: Descrever os critérios diagnósticos e de manejo da doença. Métodos: Foi realizada uma revisão integrativa de literatura usando os descritores: nefrolitíase, tratamento da nefrolitíase, diagnóstico da nefrolitíase e fatores de risco da nefrolitíase nos últimos 5 anos em base de dados como Medline/PubMed, Lilacs, Scielo e UpToDate. Resultados: Essa busca resultou em 12 artigos para elaboração dessa revisão. Conclusões: O tratamento conservador do cálculo e seus sintomas é mais frequente. Quando, observa-se a terapia cirurgia, a litotripsia a laser é a primeira opção de escolha da maior parte dos pacientes com litíase renal. Dessa forma, conhecer suas indicações, contraindicações, cuidados pré, peri e pós-operatórios e complicações são de extrema importância para minimizar danos aos pacientes

Evaluation of antimicrobial and antitumoral activity of Garcinia mangostana L. (mangosteen) grown in Southeast Brazil

PURPOSE:To characterize the anatomy of the fruit and leaf and the presence of phytocompounds. To evaluate the antitumor and antimicrobial activity of ethanolic extract of Garcinia mangostana L. (mangosteen) cultivated in southeastern Brazil.METHODS:Anatomical characterization and histochemical reactions were performed for structural identification and the presence of phytocompounds. Preparation of ethanolic extract of the fruit, leaf and resin of mangosteen. Culture B16-F10 melanoma cells for treatment with mangosteen ethanolic extract to determine cell viability by MTT and genotoxic effect by comet assay. Evaluation by antimicrobial activity against Staphylococcus aureus and Escherichia coli by agar diffusion test and by determination of Minimum Inhibitory Concentration (MIC).RESULTS:Our results showed many secretory canals in resin fruit and leaf; identifying lipids, starch, lignin and phenolic compounds. The leaf extract induced genotoxicity and apoptosis in B16-F10 cells, since the fragmentation of DNA in the comet assay. The ethanolic extract of mangosteen obtained in the resin, leaf and fruit showed antimicrobial activity against Staphylococcus aureus and Escherichia coli with a MIC at 0.1 mg/mL.CONCLUSION: In conclusion, we have demonstrated both antimicrobial and antitumor activity of ethanol extract of mangosteen emphasizing its therapeutic potential in infectious diseases and in cancer, such as melanoma.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Bahia Research Foundation (FAPESB)Universidade Estadual de Santa Cruz Department of Biological SciencesUniversidade Estadual de Santa Cruz Departament of Agricultural and Environmental SciencesUNIFESPUNIFESPSciEL

Tratamento das lesões dentárias traumáticas: perspectivas atuais¹ / Treatment of traumatic dental injuries: current perspectives

 As lesões dentárias traumáticas de dentes permanentes apresentam alta prevalência em crianças e adolescentes. As fraturas mais comuns são as envolvendo tecidos duros e luxações, apresentando uma etiologia multifatorial. É de extrema importância que o cirurgião dentista realize anamnese, exame clínico e radiográfico, para que consiga realizar um diagnóstico adequado e consequentemente um plano de tratamento para um resultado mais favorável, estando sempre atento as mudanças nas diretrizes e condutas. Dessa maneira, o presente estudo teve como objetivo apresentar as novas diretrizes acerca do atendimento de emergência de traumatismos dentários do International Association of Dental Traumatology. Nesse contexto, pode-se concluir que as diretrizes da IADT estão atualizadas e direcionam o dentista para o melhor atendimento possível dos casos de traumatismos dentários

Artificial neural network applied in the analysis of health-related quality of life of adolescents / Rede neural artificial aplicada na análise da qualidade de vida de adolescentes

Objetivo: construir um modelo que explique a qualidade de vida em adolescentes escolares a partir do instrumento KIDSCREEN-27 por meio da criação de uma rede neural artificial. Método: estudo transversal e analítico com 635 adolescentes utilizando-se o KIDSCREEN-27. Foi desenvolvida uma rede neural artificial com quatro camadas para avaliar a variável qualidade de vida por meio da média das respostas. Para as três primeiras camadas de neurônios foi utilizada função logística como função de transferência e para a ativação foi utilizada função linear. Resultados: a rede neural alcançou acurácia de 98,96% e quando comparadas as dimensões do KIDSCREEN-27 com sexo e prática de atividades físicas todas apresentaram associação estatística significativa, exceto as dimensões suporte social e grupo de pares e ambiente escolar. Conclusão: os resultados podem ter importantes consequências para a identificação de adolescentes em risco e o direcionamento de políticas públicas de saúde.