38 research outputs found
Colletotrichum spp: SENSIBILIDADE Ă FUNGICIDAS E REAĂĂO Ă CULTIVARES DE SOJA
Antracnose Ă© uma das doenças economicamente mais importantes da soja e de difĂcil controle no Mato Grosso, causando perdas significativas de produtividade. Objetivo foi verificar a sensibilidade de fungicidas e reação de cultivares de soja a 30 isolados de Colletotrichum. A ação de sete fungicidas (azoxistrobina + ciproconazol, piraclostrobina + epoxiconazol, trifloxistrobina + protioconazol, piraclostrobina, carbendazim, fluxpiroxada + piraclostrobina e azoxistrobina) foi avaliada medindo o crescimento micelial in vitro. Todos os fungicidas afetaram o crescimento micelial, mas piraclostrobina + epoxiconazol e piraclostrobina foram os mais eficientes. AlĂ©m disso, 6 cultivares foram inoculadas com 27 isolados para anĂĄlise de tombamento prĂ© e pĂłs-emergĂȘncia, incidĂȘncia e severidade da doença. Os dados de incidĂȘncia e severidade foram submetidos Ă fĂłrmula da Ărea Abaixo da Curva de Progresso da Doença. Interação significativa foi observada entre isolados e cultivares em todas as variĂĄveis. Os isolados IT-4, IT-6, LU-3, MT-1, NU-5, PN-1, QU-2, SO-6, SO-11 e VR-1 apresentaram maior tombamento e AACPD. Exceto QU-2 todos os isolados apresentam conĂdios falcados. As cultivares 8866, 1179 e 9144 apresentaram menor incidĂȘncia e severidade da doença.
Palavras-chave: Glycine max; tombamento; incidĂȘncia; severidade; antracnose.
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Colletotrichum spp.: Sensibility to fungicides and reaction of commercial germoplasm of soybean
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ABSTRACT: Anthracnose is one of the most economically important disease of soybean and difficult to control at Mato Grosso State, causing significant yield losses. Objective was to verify the fungicides sensitivity and soybean cultivars reaction to 30 isolates of Colletotrichum. The action of seven fungicides (azoxystrobin+cyproconazole, pyraclostrobin+epoxiconazole, trifloxystrobin+protioconazole, pyraclostrobin, carbendazim, fluxpyroxade+pyraclostrobin and azoxystrobin) was evaluated measuring in vitro mycelial growth. All fungicides affected the mycelial growth development, but pyraclostrobin + epoxiconazole and pyraclostrobin were the most efficient. Besides, 6 soybean cultivars were inoculated with 27 isolates to analyze pre and post-emergence damping-off, disease incidence and severity. Incidence and severity data were submitted to the formula Area Under the Disease Progress Curve. Significant interaction was observed between isolates and cultivars in all variables. Isolates IT-4, IT-6, LU-3, MT-1, NU-5, PN-1, QU-2, SO-6, SO-11 and VR-1 showed higher damping-off and AUDPC. Excepting the QU-2, all isolates have falcate conidia. Cultivars 8866, 1179 and 9144 presented the lowest disease severity and incidence.
Keywords: Glycine max; damping-off; incidence; severity; anthracnose
(2E)-NâČ-[(E)-4-ChloroÂbenzylÂidene]-3-phenylÂprop-2-enohydrazide monohydrate
The conformation about each of the imine and ethene bonds in the title hydrazide hydrate, C16H13ClN2O·H2O, is E. The hydrazide molÂecule is approximately planar (r.m.s. deviation of the 20 non-H atoms = 0.172â
Ă
). The most significant twist occurs about the ethene bond [CâC=CâC = 164.1â
(5)°] and the dihedral angle formed between the benzene rings is 5.3â
(2)°]. In the crystal, the presence of NâHâŻOw and OâHâŻOc (Ă 2; w = water and c = carbonÂyl) hydrogen bonds leads to a supraÂmolecular array in the bc plane
Efeitos da administração exĂłgena de melatonina sobre o fĂgado da prole de ratas Wistar submetidas Ă corticoterapia durante a prenhez
A dexametasona vem sendo amplamente utilizada em casos de gestação com risco de prematuridade. Entretanto, doses suprafisiolĂłgicas podem acarretar complicaçÔes e afetar a embriogĂȘnese. A melatonina, por sua vez, apresenta efeitos antagĂŽnicos aos glicocorticoides. Assim, avaliou-se a ação da dexametasona administrada durante o perĂodo gestacional, e a influĂȘncia da melatonina sobre os efeitos decorrentes da corticoterapia. Foram utilizadas 20 ratas, divididas em 4 grupos: I - ratas prenhes que receberam solução placebo; II - ratas prenhes que receberam dexametasona (0,8mg/kg); III - ratas prenhes tratadas com melatonina (0,5mg/kg) e IV - ratas prenhes que receberam dexametasona e foram tratadas com melatonina. As amostras foram obtidas da prole com 10, 15 e 20 dias de vida pĂłs-natal. Os resultados mostraram que a dexametasona, administrada a partir do 10Âș dia do perĂodo gestacional, promoveu uma maior taxa de mortalidade, redução acentuada no ganho de peso desses animais, bem como alteraçÔes hepĂĄticas histopatolĂłgicas e morfomĂ©tricas, como esteatose, necrose, vacuolização celular, alĂ©m de diminuição nos grĂąnulos de glicogĂȘnio, carboidratos totais e aumento das fibras colĂĄgenas teciduais. Entretanto, os animais do grupo IV, apresentaram alteraçÔes mais atenuadas, com parĂąmetros semelhantes aos animais do grupo controle. Assim, conclui-se que a administração da melatonina exĂłgena pode proteger o fĂgado dos animais ou atenuar alguns efeitos decorrentes da corticoterapia
Produção cientĂfica no Brasil a respeito da brinquedoteca/brinquedoterapia em perĂodicos publicados no perĂodo de 1996 a 2012
Esta pesquisa caracterizou-se por ser uma pesquisa de revisĂŁo bibliogrĂĄfica, de abordagem qualitativa e retrospectiva, com o objetivo de levantar as produçÔes cientĂficas a respeito da brinquedoteca/brinquedoterapia em periĂłdicos publicados no perĂodo de 1996 a 2006. O levantamento de dados bibliogrĂĄficos se deu pela base de dados LILACS com a seleção de 09 artigos, os quais atenderam aos critĂ©rios de inclusĂŁo previamente estabelecidos. Dentre os artigos encontrados, constatou-se que cinco tratavam da temĂĄtica brinquedoterapia em ambiente hospitalar. O maior nĂșmero de publicaçÔes ocorreu no ano de 2005 (34%). SĂŁo Paulo foi o estado de origem da maioria dos estudos (56%). Conclui-se que o brincar Ă© considerado uma das atividades essenciais para o desenvolvimento fĂsico, emocional e social da criança e a brinquedoteca surge como uma ferramenta muito importante para o profissional que assiste a criança hospitalizada com o intuito de minimizar os danos provocados pela hospitalização na criança
(2E)-NâČ-Benzoyl-3-(4-nitroÂphenÂyl)prop-2-enohydrazide
In the title compound, C16H13N3O4, the dihedral angle between the terminal benzene rings is 14.02â
(7)°. The carbonyl groups are anti with respect to each other, which facilitates their participation in the formation of supraÂmolecular chains. Each side of the âC(=O)N(H)N(H)C(=O)â residue associates with a centrosymmetrically related molÂecule, resulting in the formation of essentially flat ten-membered {âŻO=CNN(H)}2 synthons. The resultant chains are further consolidated in the crystal structure via CâHâŻO contacts
Combination of Melatonin and Metformin Hydrochloride for Treatment Polycystic Ovarian in Female Rats
Background: Polycystic ovary syndrome (PCOS) is a gynecological endocrine disorder, results in menstrual abnormalities, androgynism and infertility. In the case of women or others animals with PCOS wishing to treat infertility with the aim of becoming pregnant, the most commonly used is metformin hydrochloride. Recent studies have analyzed the combination of metformin hydrochloride with melatonin in oncological treatment but not to treatment of polycystic ovary syndrome (PCOS). The aim of the present study was to analyze the effectiveness of the combination of metformin hydrochloride and melatonin in the treatment of PCOS to improve the fertility of rats and your hormonal alterations.Materials, Methods & Results: This study was carried out in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The protocol was approved by the Committee on the Ethics of Animal Experiments of the University of Federal Rural of Pernambuco (Permit Number: 23081.009130/2010). A total of 50 albino Wistar rats were used. The animal laboratory of an academic research environment, were randomly separated into five groups consisting of 10 females each. After inducing PCOS, the rats were treated with metformin hydrochloride, and/or melatonin, and the results compared with standard and ultrasound confirmed. The physiological similarities were confirmed by our academic researchers morphological science, and published to the association results of effects syndrome induction through constant lighting in reputable magazine recently. This article was analyzed histological of the implantation sites and ovaries, and the estradiol and progesterone levels on the seventh day of gestation, and the other rats for monitoring pregnancy and morphological identification of possible fetal abnormalities, weight measurement and quantification of offspring. The rats were anaesthetized with intraperitoneal injections of ketamine hydrochloride (80 mg/kg) and xylazine (6 mg/kg) to allow analysis of the reproductive organs. Main outcome measures: The study included histopathology, histochemical and quantitative (of the implantation sites) tests, ultrasound analysis, weight benchmarking and ovarian histology tests, as well as comparison of serum estradiol and progesterone levels, and the morphological assessment of offspring. Results paper shows pharmacological treatment reduced the time needed for pregnancy, increased the plasma progesterone levels, the number and weight of offspring, and reduced plasma estrogen levels and collagen fiber grade, improving blastocyst-endometrium interaction and fetal development.Discussion: Our team of researchers confirmed in a previous paper; in addition, the main experimental model used in research about PCOS in recent years, and considered appropriate combination of the drugs caused a physiological reaction similar to responses identified in healthy rats without induction of the POS control group. However, the clinical and physiological effectiveness of the combination should be further explored, especially with respect to the possible side effects on offspring. The treatment with a combination of metformin hydrochloride and melatonin was more effective against hormonal alterations produced by PCOS, allowing a normalization of biochemical parameters during pregnancy, than monotherapeutic treatment with these drugs. In conclusion, proposed drug combination is a viable option to treatment of polycystic ovary syndrome and improved fetal development. This article allows suggest that further research should be conducted to examine effects associated with these drugs in the treatment of diseases of the female reproductive system experimentally. Only such treatment later in animals and humans suggest
Estimativa da sobrepressĂŁo de uma explosĂŁo acidental de nuvem do gĂĄs acetileno em uma oficina mecĂąnica na UFCG / Estimation of overpressure from an accidental acetylene gas cloud explosion in a mechanical workshop at UFCG
O principal objetivo deste trabalho foi aplicar uma estimativa da mĂĄxima sobrepressĂŁo envolvidos na liberação repentina de energia de uma explosĂŁo acidental com gĂĄs acetileno na Unidade AcadĂȘmica de Engenharia MecĂąnica, da Universidade Federal de Campina Grande, baseado na simulação no software ALOHA e na regulamentação da norma CETESB (2011). Foram analisadas a ocorrĂȘncia de pequenos vazamentos e grandes vazamentos em cilindros contendo o gĂĄs acetileno, relacionando a pressĂŁo. Tal simulação permitiu dimensionar os impactos gerados em decorrĂȘncia de uma explosĂŁo. Dessa forma, o trabalho expĂ”e os riscos inerentes, pois um acidente com o transporte ou carga do gĂĄs acetileno decorrerĂĄ infalivelmente, em vĂtimas com elevados danos fĂsicos e atĂ© fatais, atingindo ĂĄreas circunvizinhas.
Combining the pharmacophore features of coumarins and 1,4-substituted 1,2,3-triazoles to design new acetylcholinesterase inhibitors : fast and easy generation of 4-methylcoumarins/1,2,3-triazoles conjugates via Click Chemistry
Coumarins are a large class of compounds that display a range of interesting biological properties, being considered privileged structures because of the ability of their 2H-chromen-2-one nuclei to bind to multiple pharmacological targets. We hypothesized that the linkage of a second pharmacophore nucleus to the 2H-chromen-2-one core, the 1,2,3-triazole moiety, would entail more selective and pharmacologically active coumarins. Therefore, we describe the synthesis of fourteen 4-methylcoumarins/1,4-substituted 1,2,3-triazole conjugates, which were predicted by in silico methods to inhibit acetylcholinesterase (AChE) and proved to be moderate in vitro inhibitors of this enzyme. Molecular docking simulations suggest that the most active of these compounds has a putative binding mode similar to donepezil, both occupying the peripheral anionic site of AChE, which is associated with the secondary noncholinergic functions of the enzyme. This highlights the potential of this series for further optimization in the search of new coumarins for the treatment of Alzheimerâs disease
Caderno da atenção bĂĄsica de nĂșmero 35: estratĂ©gias para o cuidado da pessoa com doença crĂŽnicas / Primary care notebook number 35: strategies for the care of persons with chronic disease
Tem por objetivo destacar os fatores de risco e proteção, descrever sobre as condiçÔes crĂŽnicas, as complexidades das doenças, conceitos comuns das doenças crĂŽnicas, apresenta diretrizes para a organização do cuidado. Este estudo configura-se como uma resenha de livro, no qual foram descritores as informaçÔes contidas no caderno de nÂș 35 da atenção bĂĄsica, proporcionando a possibilidade de sintetizar as ideais exploradas pelos autores, alĂ©m de recomendar a obra para os profissionais de saĂșde e estudantes da ĂĄrea
Caderno da atenção båsica de n° 28: acolhimento e demanda espontùnea / Primary care notebook n° 28: reception and spontaneous demand
Auxiliar as equipes de saĂșde e a gestĂŁo, na anĂĄlise e na intervenção das situaçÔes mais comuns dos usuĂĄrios que buscam a Unidade BĂĄsica de SaĂșde. Este artigo Ă© da modalidade resenha de livro, que descreve o caderno da atenção bĂĄsica de nÂș 28, acerca das condutas essenciais no acolhimento Ă demanda espontĂąnea na atenção bĂĄsica. Entende-se a importĂąncia dos profissionais de saĂșde acolherem os pacientes da forma correta, alĂ©m de classificar a assistĂȘncia ofertada, de acordo com suas vulnerabilidades e riscos