Age‐related white matter hyperintensities and overactive bladder: a systematic review

© 2023 The Authors. Neurourology and Urodynamics published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Introduction: Age-related white matter hyperintensities (ARWMHs) on brain magnetic resonance imaging have been associated with lower urinary tract symptoms/dysfunction (LUTS/LUTD), namely overactive bladder (OAB) and detrusor overactivity. We aimed to systematically review existing data on the association between ARWMH and LUTS and which clinical tools have been used for this assessment. Materials and methods: We searched PubMed/MEDLINE, Cochrane Library, and clinicaltrials.gov (from 1980 to November 2021) and considered original studies reporting data on ARWMH and LUTS/LUTD in patients of both sexes aged 50 or above. The primary outcome was OAB. We calculated the unadjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for the outcomes of interest using random-effects models. Results: Fourteen studies were included. LUTS assessment was heterogeneous and mainly based on the use of nonvalidated questionnaires. Urodynamics assessment was reported in five studies. ARWMHs were graded using visual scales in eight studies. Patients with moderate-to-severe ARWMHs were more likely to present with OAB and urgency urinary incontinence (UUI; OR = 1.61; 95% CI: 1.05-2.49, p = 0.03), I2 = 21.3%) when compared to patients with similar age and absent or mild ARWMH. Discussion and conclusions: High-quality data on the association between ARWMH and OAB is scarce. Patients with moderate to severe ARWMH showed higher levels of OAB symptoms, including UUI, when compared to patients with absent or mild ARWMH. The use of standardized tools to assess both ARWMH and OAB in these patients should be encouraged in future research.info:eu-repo/semantics/publishedVersio

Bond strength of adhesive resin cement with different adhesive systems

To assess the immediate bond strength of a dual-cure adhesive resin cement to the hybridized dentin with different bonding systems. Fifty-six healthy human molars were randomly divided into 7 groups (n=8). After 3 longitudinal sections, the central cuts were included in PVC matrix and were submitted to dentin hybridization according to the groups: G1 - etch & rinse system with 3-step (Apder™ Scotchbond™ Multi-Purpose, 3M ESPE), G2 - etch & rinse system with 3-step (Optibond™ FL, Kerr), G3 - etch & rinse system with 3-step (All-Bond 3®, Bisco), G4 - etch & rinse simplified system (Adper™ Single Bond 2, 3M ESPE), G5 - self-etching system with one step (Bond Force, Tokuyama), G6 - universal system in moist dentin (Single Bond Universal, 3M ESPE), G7 - universal system in dry dentin (Single Bond Universal, 3M ESPE). Then all groups received the cementing of a self-adhesive resin cement cylinder (Duo-link, Bisco) made from a polypropylene matrix. In the evaluation of bond strength, the samples were subjected to the microshear test and evaluated according to the fracture pattern by optical microscopy. The Kruskal-Wallis test suggests a statistically significant difference between groups (p=0,039), and Tukey for multiple comparisons, indicating a statistically significant difference between G3 and G4 (p<0.05). It was verified high prevalence of adhesive failures, followed by mixed failure and cohesive in dentin. The technique and the system used to dentin hybridization are able to affect the immediate bond strength of resin cement dual adhesive

Ambiente construído e mobilidade em cidades de média dimensão

A relação entre as características do ambiente construído e a mobilidade dos habitantes tem sido amplamente estudada. No entanto, a maioria desta investigação tem-se debruçado sobre contextos metropolitanos, e pouco se sabe sobre esta relação nas cidades de média dimensão, as quais possuem características de mobilidade muito próprias. Por um lado, a sua dimensão reduzida permite que grande parte das deslocações possa ser realizada a pé, mas por outro, o reduzido nível de tráfego e a fraca oferta de transportes públicos promovem as deslocações em veículo individual. Este artigo foca-se na relação entre características do ambiente construído e a mobilidade da população no contexto de cidades médias portuguesas, designadamente Castelo Branco, Faro, Santarém e Vila Real. Os dados resultam de um inquérito à mobilidade nas 4 cidades, com cerca de 4500 indivíduos, e de cálculos de indicadores para descrever as características do ambiente construído, designadamente a densidade, diversidade, design e acessibilidade. Os resultados das análises estatísticas reforçam a importância do ambiente construído como estímulo para uma mobilidade urbana mais sustentável.info:eu-repo/semantics/publishedVersio

Cabernet Sauvignon in tropical semi-arid climate (Pernambuco - Brasil): adaptation of some clones and their affinity to different rootstocks.

Resumo

Chemical and sensorial characterization of tropical syrah wines produced at different altitudes in northeast of the Brazil.

Over the years, viticulture has expanded to new regions outside the temperate zones, such as Northeast Brazil, India, Thailand, Myanmar, Vietnam, Bangladesh and Venezuela, characterized by the production of tropical wines. It is important for the productive sector to comprehend the effects of grapevine interaction with the characteristics of each new region on wines composition. In this study, the composition of wines of Syrah from two regions with different altitudes in Northeast Brazil were analyzed by different methodologies to characterize chemical compounds as sugar, acids, minerals, phenolics (anthocyanins, flavonols, stilbenes and condensed tannins) and the sensory profile. The wines of the Bahia region (1100 m of altitude) obtained high concentrations for chemical parameters related to color, monomeric anthocyanins, stilbenes and monomeric and oligomeric tannins. Wines of the low altitude region, Pernambuco (350 m of altitude) were characterized by higher concentrations of flavonols (kaempferol, isorhamnetin, quercetin and rutin) and polymerized tannins. The chemical composition of wines from the two studied regions was influenced by altitude. A trend towards higher concentrations in most for phenolic compounds analyzed was observed in wines from the higher altitude region during the two years of study. Regarding the sensory profile, fruity, floral, herbaceous and empyreumatic attributes aromatic obtained highest scores in wines of the 350 m altitude region, the other attributes were dependent on the year of harvest

Evaluation of arterial pressure measurements comparing traditional and gold standard methods

OBJECTIVE: Evaluating arterial pressure measurements comparing the traditional and the gold standard methods in an emergency public service. METHODS: Cross-sectional study, in which arterial systolic, diastolic, mean and pulse pressure measurements obtained by nursing professionals by means of the traditional method were compared with those obtained using the gold standard technique. RESULTS: Study participants were 229 patients, 69% were women and the mean age was 50 years. The comparison between the two methods showed that the mean value of the arterial systolic, diastolic, mean and pulse pressures was higher using the gold standard technique. CONCLUSION: Divergences were found between the measurements obtained using the recommended technique and the risk classification.OBJETIVO: Avaliar as medidas de pressão arterial comparando o método tradicional e o padrão-ouro em um serviço público de pronto atendimento. MÉTODOS: Estudo transversal no qual as medidas das pressões arteriais sistólica, diastólica, média e de pulso aferidas pelos profissionais da enfermagem pelo método tradicional foram comparadas com aquelas realizadas de acordo com o padrão-ouro. RESULTADOS: Foram incluídos 229 clientes, 69% do sexo feminino e a média de idade foi de 50 anos. A comparação entre os dois métodos mostrou que o valor médio das pressões sistólica, diastólica, média e de pulso foi maior utilizando-se a técnica padrão-ouro. CONCLUSÃO: Houve divergências entre as medidas realizadas pela técnica recomendada e pela classificação de risco.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de EnfermagemUNIFESP, EPESciEL

Bond behaviour of NSM CFRP-concrete systems: adhesive and CFRP cross-section influences

Near Surface Mounted (NSM) strengthening technique has been used in a sustainable way for retrofitting existing structures. This technique, which utilizes CFRP laminates inserted in the concrete cover, has been used due to the several advantages when compared with the technique based on the application of these reinforcing materials on the concrete surface (EBR technique). Although several studies have been developed on this topic in the recent past, open issues still deserve research, such as the influence of the adhesive type on the performance of the NSM-CFRP system. The present work details an experimental program carried out in order to assess the effect of using three adhesives with distinct mechanical properties on the bond behavior of the NSM-CFRP system, through direct pullout tests (DPT). Thus, the following variables were considered in the present study: (i) the type of adhesive; (ii) the cross section of the laminate; and, (iii) the bond length. The experimental pullout force-slip responses were obtained and digital image correlation (DIC) was used for obtaining additional information about the bond mechanisms developed. In general, two of the three adhesives, with similar mechanical characteristics, provided essentially similar bond behavior, with high level of effectiveness, whereas the third adhesive, which had a much lower elastic modulus than the other two, provided the lowest effectiveness in terms of the investigated parameters.This work was supported by FEDER funds through the Operational Program for Competitiveness Factors – COMPETE and National Funds through FCT (Portuguese Foundation for Science and Technology) under the projects CutInDur FCOMP-01-0124-FEDER-014811 (FCT PTDC/ECM/112396/2009), FRPreDur FCOMP-01- 0124-FEDER-028865 (FCT PTDC/ECM-EST/2424/2012), FRPLongDur POCI-01-0145-FEDER-016900 (FCT PTDC/ECM-EST/1282/2014) and partly financed by the project POCI-01-0145-FEDER-007633.

Comportamento da aderência de sistema de reforço NSM-CFRP na presença de diferentes tipos de adesivos

No contexto atual, o reforço de estruturas de betão armado assume uma importância cada vez maior devido a diversos fatores. A técnica de reforço de estruturas de betão armado que utiliza laminados de CFRP inseridos no betão de recobrimento (designada por NSM – Near Surface Mounted na literatura inglesa) tem vindo a ser alvo de vários estudos dadas as suas potencialidades. No entanto, o estudo da influência do tipo de adesivo na aplicação desta técnica apresenta conhecimento limitado. É sobretudo neste aspeto que o presente estudo incide. Foi desenvolvido um programa experimental constituído por ensaios de arranque direto com o objetivo de estudar o comportamento da ligação entre os laminados de CFRP e o betão de sistemas NSM-CFRP, utilizando três variáveis de estudo: (i) tipo de adesivo; (ii) comprimento de ancoragem; e, (iii) secção transversal do laminado de CFRP. Durante a realização dos ensaios, sob controlo de deslocamento, foi monitorizada a força de arranque bem como o deslizamento no final da zona carregada. Foi também utilizada a Correlação Digital de Imagem (DIC) como complemento para avaliação do comportamento da ligação. De uma forma geral, dois dos adesivos proporcionaram padrões de comportamento da ligação semelhantes, dada a semelhança das suas propriedades mecânicas. Um terceiro adesivo, de propriedades mecânicas bastante inferiores originou resultados menos promissores. A ligação tende a ser tanto mais resistente quanto maior for o seu comprimento. Em termos da influência da secção transversal do laminado, é notória a maior capacidade resistente da ligação para laminados com área de secção transversal superior. A utilização da metodologia DIC permitiu concluir que os mecanismos resistentes da ligação são fortemente dependentes das propriedades resistentes do adesivo.FCT e cofinanciado pelo Fundo Europeu de Desenvolvimento Regional (FEDER) através do Program a Operacional Fatores de Competitividade e internacionalização (POCI) e do Programa Regional d e Lisboa no âmbito dos projetos FRPLongDur POCI-01-0145-FEDER-016900 (PTDC/ECM-EST/1282/2014) e POCI-01-0145-FEDER-007633. S&P Clever Reinforcement (oferta do laminado de CFK e adesivo S&P Resin 220) e Sika (oferta do adesivo SikaDur 30

Durability of bond in NSM CFRP-concrete systems under different environmental conditions

This paper addresses the durability of bond between concrete and carbon fibre reinforced polymer (CFRP) strips installed according to the near-surface mounted (NSM) technique (NSM CFRP-concrete systems) under the effects of two main groups of environmental conditions: (i) laboratory-based ageing conditions; (ii) real outdoor ageing conditions. The bond degradation was evaluated by carrying out direct pullout tests on aged specimens that were previously subjected to distinct environmental conditions for different periods of exposure. Moreover, the degradation of the mechanical properties of the involved materials was investigated. The digital image correlation (DIC) method was used to document the evolution of the deformation fields at the surface over the whole region of interest consisting of concrete and epoxy adhesive at the ligament region. This information supported the discussion about the evolution of the bond resistant mechanism developed in NSM CFRP-concrete specimens during testing, as well as the assessment of the bond quality of the system. In general, the results obtained from the durability tests conducted have shown that the different exposure environments, which may be considered as quite severe, did not result in significant damage on NSM CFRP-concrete system. The maximum decrease of about 12% on bond strength was obtained for real outdoor environments. Conversely, a maximum increase of 8% on bond strength was obtained on the specimens exposed to the temperature cycles between –15 °C and +60 °C. DIC allowed to document the stress transfer mechanisms established between the CFRP and the concrete substrate, revealing the crack patterns and the influence widths of the CFRP reinforcement strips, which were shown to be important for avoiding group effect when using multiple parallel strengthening CFRP strips.FEDER funds through the Operational Program for Competitiveness Factors - COMPETE and National Funds through FCT - Portuguese Foundation for Science and Technology under the projects CutInDur FCOMP-01-0124-FEDER-014811 (PTDC/ECM/112396/2009), FRPLongDur POCI-01-0145-FEDER-016900 (PTDC/ECM-EST/1282/2014) and partly financed by the project POCI-01-0145-FEDER-007633. The authors also like to thank all the companies that have been involved supporting and contributing for the development of this study, mainly: S&P Clever Reinforcement Ibérica Lda., Artecanter - Indústria de Transformação de Granitos, Lda., Vialam – Indústrias Metalúrgicas e Metalomecânicas, Lda.info:eu-repo/semantics/publishedVersio

Q Fever: characteristics and reports of an important neglected zoonosis in Brazil / Febre Q: características e relatos de uma importante zoonose negligenciada no Brasil

The Q fever is a zoonotic disease neglected in many countries all over the world. This zoonosis is caused by the bacteria Coxiella burnetii, a pathogen that presents stability and environmental resistance with high capacity to cause human infection, which could be fatal. This literature review study aims to describe the general aspects of Q fever, presenting the main cases occurred in Brazil and discussing ways to avoid this zoonosis negligence and underreporting in Brazil. The Q fever is still a disease unknown by the larger part of healthcare professionals in Brazil. In addition, the disease in humans presents a clinical picture similar to that of other acute feverish diseases. Therefore, cases of Q fever cannot be diagnosed and their treatment can be erroneous, which can increase the chances of chronic Q fever occurrence. The inclusion of Q fever as a disease of mandatory notification in humans and the utilization of the "One Health" approach are essential for the confrontation of the disease. Moreover, measures for the control, investigation, and prevention of Q fever will contribute to avoid the occurrence of outbreaks and possible worsening resulting from this zoonosis