Brief communication "A prototype forecasting chain for rainfall induced shallow landslides"

Although shallow landslides are a very widespread phenomenon, large area (e.g. thousands of square kilometres) early warning systems are commonly based on statistical rainfall thresholds, while physically based models are more commonly applied to smaller areas. This work provides a contribution towards the filling of this gap: a forecasting chain is designed assembling a numerical weather prediction model, a statistical rainfall downscaling tool and a geotechnical model for the distributed calculation of the factor of safety on a pixel-by-pixel basis. The forecasting chain can be used to forecast the triggering of shallow landslides with a 48 h lead time and was tested on a 3200 km2 wide area

High-speed fixed-target serial virus crystallography

We report a method for serial X-ray crystallography at X-ray free-electron lasers (XFELs), which allows for full use of the current 120-Hz repetition rate of the Linear Coherent Light Source (LCLS). Using a micropatterned silicon chip in combination with the high-speed Roadrunner goniometer for sample delivery, we were able to determine the crystal structures of the picornavirus bovine enterovirus 2 (BEV2) and the cytoplasmic polyhedrosis virus type 18 polyhedrin, with total data collection times of less than 14 and 10 min, respectively. Our method requires only micrograms of sample and should therefore broaden the applicability of serial femtosecond crystallography to challenging projects for which only limited sample amounts are available. By synchronizing the sample exchange to the XFEL repetition rate, our method allows for most efficient use of the limited beam time available at XFELs and should enable a substantial increase in sample throughput at these facilities

Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology.

To establish whether 4-nitroquinoline N-oxide-induced carcinogenesis mirrors the heterogeneity of human oral squamous cell carcinoma (OSCC), we have performed genomic analysis of mouse tongue lesions. The mutational signatures of human and mouse OSCC overlap extensively. Mutational burden is higher in moderate dysplasias and invasive SCCs than in hyperplasias and mild dysplasias, although mutations in p53, Notch1 and Fat1 occur in early lesions. Laminin-α3 mutations are associated with tumour invasiveness and Notch1 mutant tumours have an increased immune infiltrate. Computational modelling of clonal dynamics indicates that high genetic heterogeneity may be a feature of those mild dysplasias that are likely to progress to more aggressive tumours. These studies provide a foundation for exploring OSCC evolution, heterogeneity and progression

Modeling Airlift Operations for Humanitarian Aid and Disaster Relief to Support Acquisition Decision-Making

In a fiscally constrained environment, it is crucial that both equipment manufacturers and defence invest in technology that shows marked operational improvement. A priori identification of cost-benefit at the early acquisition stage is often limited and incomplete, leading to poor value propositions. This conundrum motivates the need to develop a method to evaluate technologies such as levels of autonomy, stealth capability, improved engines, etc. and make tradeoffs against operational measures of performance and effectiveness (MOP/Es) rather than solely against vehicle performance characteristics. The objective of this study is to create an environment in which those trades against MOEs could be performed rapidly to inform technology investment and acquisition decision-making. This environment is built on top of representative models of a discrete event simulation of disaster relief airlift operations to compare technology modifications or vehicle acquisition options rapidly against operational measures of effectiveness

Revision of the Laonice bahusiensis complex (Annelida: Spionidae) with a description of three new species

The morphological reexamination of specimens previously identified as Laonice bahusiensis Söderström, 1920 from North European and Mediterranean collections, supported by the molecular analysis of freshly collected material, enabled the recognition of four different species in the region: the genuine L. bahusiensis, L. irinae n. sp. from North European waters, and L. grimaldii n. sp. and L. mediterranea n. sp. from the Mediterranean Sea. The morphology of these species is described and illustrated, and their distributions are clarified based on old and new materials. A key for their identification is also provided. The Bayesian analysis of the COI sequences (483 bp) showed that these four species form a clade, namely the L. bahusiensis species complex, morphologically characterized by the continuous dorsal crests on postbranchiate chaetigers in the adults. The genetic p-distances between the species of the complex ranged from 13.27% to 17.99%, while the intraspecific variability ranged from 0.6% to 1.57%. Together with the sister species Laonice cirrata (Sars, 1851), the L. bahusiensis complex formed the Laonice (Laonice) clade, which is morphologically characterized by the prostomium fused with the anterior peristomial margin. However, the monophyly of the L. bahusiensis complex, as well as that of the clade Laonice (Laonice), needs to be further supported through the analysis of a greater set of genes from a larger number of species