3,882 research outputs found
How serotonin shapes moral judgment and behavior
Neuroscientists are now discovering how hormones and brain chemicals shape social behavior, opening potential avenues for pharmacological manipulation of ethical values. Here, we review recent studies showing how altering brain chemistry can alter moral judgment and behavior, focusing in particular on the neuromodulator serotonin and its role in shaping values related to harm and fairness. We synthesize previous findings and consider the potential mechanisms through which serotonin could increase the aversion to harming others. We present a process model whereby serotonin influences social behavior by shifting social preferences in the positive direction, enhancing the value people place on others’ outcomes. This model may explain previous findings relating serotonin function to prosocial behavior, and makes new predictions regarding how serotonin may influence the neural computation of value in social contexts
Double Field Theory Formulation of Heterotic Strings
We extend the recently constructed double field theory formulation of the
low-energy theory of the closed bosonic string to the heterotic string. The
action can be written in terms of a generalized metric that is a covariant
tensor under O(D,D+n), where n denotes the number of gauge vectors, and n
additional coordinates are introduced together with a covariant constraint that
locally removes these new coordinates. For the abelian subsector, the action
takes the same structural form as for the bosonic string, but based on the
enlarged generalized metric, thereby featuring a global O(D,D+n) symmetry.
After turning on non-abelian gauge couplings, this global symmetry is broken,
but the action can still be written in a fully O(D,D+n) covariant fashion, in
analogy to similar constructions in gauged supergravities.Comment: 28 pages, v2: minor changes, version published in JHE
Generalised Space-time and Gauge Transformations
We consider the generalised space-time introduced by the author in 2003 in
the context of the non-linear realisation of the semi-direct product of E11 and
its first fundamental representation. For all the fields we propose gauge
transformations which are compatible with the underlying E11 structure. A
crucial role is played by the generalised vielbein that the generalised
space-time possess. We work out the explicit form of the gauge transformations,
at low levels, in four, five and eleven dimensions.Comment: 33 page
Wide-field fluorescence lifetime imaging with optical sectioning and spectral resolution applied to biological samples
On the Riemann Tensor in Double Field Theory
Double field theory provides T-duality covariant generalized tensors that are
natural extensions of the scalar and Ricci curvatures of Riemannian geometry.
We search for a similar extension of the Riemann curvature tensor by developing
a geometry based on the generalized metric and the dilaton. We find a duality
covariant Riemann tensor whose contractions give the Ricci and scalar
curvatures, but that is not fully determined in terms of the physical fields.
This suggests that \alpha' corrections to the effective action require \alpha'
corrections to T-duality transformations and/or generalized diffeomorphisms.
Further evidence to this effect is found by an additional computation that
shows that there is no T-duality invariant four-derivative object built from
the generalized metric and the dilaton that reduces to the square of the
Riemann tensor.Comment: 36 pages, v2: minor changes, ref. added, v3: appendix on frame
formalism added, version to appear in JHE
Internal and external cooling methods and their effect on body temperature, thermal perception and dexterity
© 2018 The Authors. Published by PLOS. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1371/journal.pone.0191416© 2018 Maley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Objective The present study aimed to compare a range of cooling methods possibly utilised by occupational workers, focusing on their effect on body temperature, perception and manual dexterity. Methods Ten male participants completed eight trials involving 30 min of seated rest followed by 30 min of cooling or control of no cooling (CON) (34C, 58% relative humidity). The cooling methods utilised were: ice cooling vest (CV0), phase change cooling vest melting at 14C (CV14), evaporative cooling vest (CVEV), arm immersion in 10C water (AI), portable water-perfused suit (WPS), heliox inhalation (HE) and ice slushy ingestion (SL). Immediately before and after cooling, participants were assessed for fine (Purdue pegboard task) and gross (grip and pinch strength) manual dexterity. Rectal and skin temperature, as well as thermal sensation and comfort, were monitored throughout. Results Compared with CON, SL was the only method to reduce rectal temperature (P = 0.012). All externally applied cooling methods reduced skin temperature (P0.05). Conclusion The present study observed that ice ingestion or ice applied to the skin produced the greatest effect on rectal and skin temperature, respectively. AI should not be utilised if workers require subsequent fine manual dexterity. These results will help inform future studies investigating appropriate pre-cooling methods for the occupational worker.This project is financially supported by the US Government through the Technical Support Working Group within the Combating Terrorism Technical Support Office.Published versio
Pre-cooling for endurance exercise performance in the heat: a systematic review.
PMCID: PMC3568721The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1741-7015/10/166.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Endurance exercise capacity diminishes under hot environmental conditions. Time to exhaustion can be increased by lowering body temperature prior to exercise (pre-cooling). This systematic literature review synthesizes the current findings of the effects of pre-cooling on endurance exercise performance, providing guidance for clinical practice and further research
Supermembrane interaction with dynamical D=4 N=1 supergravity. Superfield Lagrangian description and spacetime equations of motion
We obtain the complete set of equations of motion for the interacting system
of supermembrane and dynamical D=4 N = 1 supergravity by varying its complete
superfield action and writing the resulting superfield equations in the special
gauge where the supermembrane Goldstone field is set to zero. We solve the
equations for auxiliary fields and discuss the effect of dynamical generation
of cosmological constant in the Einstein equation of interacting system and its
renormalization due to some regular contributions from supermembrane. These two
effects (discussed in late 70th and 80th, in the bosonic perspective and in the
supergravity literature) result in that, generically, the cosmological constant
has different values in the branches of the spacetime separated by the
supermembrane worldvolume.Comment: 23 pages, no figures. V2 two references added, 24 page
The endothelial glycocalyx prefers albumin for evoking shear stress-induced, nitric oxide-mediated coronary dilatation
Background: Shear stress induces coronary dilatation via production of nitric oxide ( NO). This should involve the endothelial glycocalyx ( EG). A greater effect was expected of albumin versus hydroxyethyl starch ( HES) perfusion, because albumin seals coronary leaks more effectively than HES in an EG-dependent way. Methods: Isolated hearts ( guinea pigs) were perfused at constant pressure with Krebs-Henseleit buffer augmented with 1/3 volume 5% human albumin or 6% HES ( 200/0.5 or 450/0.7). Coronary flow was also determined after EG digestion ( heparinase) and with nitro-L-arginine ( NO-L-Ag). Results: Coronary flow ( 9.50 +/- 1.09, 5.10 +/- 0.49, 4.87 +/- 1.19 and 4.15 +/- 0.09 ml/ min/ g for `albumin', `HES 200', `HES 450' and `control', respectively, n = 5-6) did not correlate with perfusate viscosity ( 0.83, 1.02, 1.24 and 0.77 cP, respectively). NO-L-Ag and heparinase diminished dilatation by albumin, but not additively. Alone NO-L-Ag suppressed coronary flow during infusion of HES 450. Electron microscopy revealed a coronary EG of 300 nm, reduced to 20 nm after heparinase. Cultured endothelial cells possessed an EG of 20 nm to begin with. Conclusions: Albumin induces greater endothelial shear stress than HES, despite lower viscosity, provided the EG contains negative groups. HES 450 causes some NO-mediated dilatation via even a rudimentary EG. Cultured endothelial cells express only a rudimentary glycocalyx, limiting their usefulness as a model system. Copyright (c) 2007 S. Karger AG, Basel
Quantum theory of massless (p,0)-forms
We describe the quantum theory of massless (p,0)-forms that satisfy a
suitable holomorphic generalization of the free Maxwell equations on Kaehler
spaces. These equations arise by first-quantizing a spinning particle with a
U(1)-extended local supersymmetry on the worldline. Dirac quantization of the
spinning particle produces a physical Hilbert space made up of (p,0)-forms that
satisfy holomorphic Maxwell equations coupled to the background Kaehler
geometry, containing in particular a charge that measures the amount of
coupling to the U(1) part of the U(d) holonomy group of the d-dimensional
Kaehler space. The relevant differential operators appearing in these equations
are a twisted exterior holomorphic derivative and its hermitian conjugate
(twisted Dolbeault operators with charge q). The particle model is used to
obtain a worldline representation of the one-loop effective action of the
(p,0)-forms. This representation allows to compute the first few heat kernel
coefficients contained in the local expansion of the effective action and to
derive duality relations between (p,0) and (d-p-2,0)-forms that include a
topological mismatch appearing at one-loop.Comment: 32 pages, 3 figure
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