7 research outputs found

    Compact and low-cost instrument for digital holographic microscopy of immobilized micro-particles

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    A compact and low-cost system capable of Digital Holographic Microscopic (DHM) imaging of immobilized micro-particles is presented. The proposed design, integration, and manufacturing can lead to wider use and increased accessibility of this device for research, education, and biomedical applications. The optical tweezer system for particle immobilization is built using the optical pickup unit taken from a DVD burner. DHM is integrated into the system through the addition of a glass plate which enables one arm of the system to operate as a lateral shearing digital holographic interferometer. The operation of the system is confirmed by trapping, quantitative phase imaging and analysis of polystyrene micro-spheres for which the corner frequency measurements, carried using an in-house developed low-cost Quadrant Photodiode, compare favorably with simulated results. Furthermore, the system is illustrated for trapping and simultaneous quantitative phase imaging of micro-particles, including biological specimen such as red blood cells. The use of a low-cost easily implementable DHM integrated optical tweezer system provides vast information content, which enable in-depth analysis of immobilized micro-particles

    Current Perspectives on Desmoid Tumors: The Mayo Clinic Approach

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    Desmoid tumors are a rare group of locally aggressive, non malignant tumors of fibroblastic origin that can lead to significant morbidity due to local invasion. Despite advances in the understanding of these tumors, their natural history is incompletely understood and the optimal treatment is still a matter of debate. Local control is the main goal of treatment and there has been a change in philosophy regarding the management of these tumors from aggressive surgical resection to function preservation. A multidisciplinary approach is essential to plan local control with acceptable morbidity. The current Mayo Clinic algorithm for the treatment of these tumors is based on institutional experience and the available evidence in the literature: asymptomatic/non progressive lesions away from vital structures are managed with observation and regular imaging; primary or recurrent desmoid tumors which are symptomatic or progressive or near vital structures are managed with wide surgical resection when wide surgical margins are possible with minimal functional and cosmetic loss. When positive or close surgical margins are likely, surgical resection with adjuvant radiotherapy or definitive radiotherapy is preferred. If likely functional or cosmetic deficit is unacceptable, radiotherapy is the treatment of choice. Unresectable lesions are considered for radiotherapy, chemotherapy or newer modalities however an unresectable lesion associated with a painful, functionless, infected extremity is managed with an amputation
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