Using a patient prompt list to raise concerns in oncology clinics does not necessarily lead to longer consultations

Head and neck oncology post-treatment consultations form a critical component of care in terms of support and surveillance. They occur frequently in the first few years and can place substantial demands on healthcare resources. However, they provide useful opportunities for patients to raise issues and receive tailored information and support. The aim of this paper was to assess whether completion of a 56-item patient prompt list (PCI - the Patient Concerns Inventory) immediately prior to the consultation significantly increased its duration. This was a pragmatic cluster preference randomised controlled trial of 288 patients with 15 consultant clusters from two sites “using” (n = 8) or “not using” (n = 7) the PCI. Consultation times were known for 283 patients (136 PCI, 147 non-PCI) who attended their first post-treatment trial consultation a median (IQR) of 103 (70-160) days after the end of treatment. Consultations lasted a median (IQR) of 10 (7-13) minutes (mean 11) in non-PCI patients and a median (IQR) of 11 (8-15) minutes (mean 12) in PCI patients (p = 0.07). After adjustment for patient clustering and significant case mix, the 95% confidence interval for the mean difference was between 1.45 minutes shorter with the PCI and 2.98 minutes longer (p = 0.50). There was significant variation in duration by consultant, tumour stage, treatment mode, overall quality of life (QoL), and distress (all p < 0.001). In those who completed the PCI, duration increased with the total number of items selected (p < 0.001). In conclusion, the inclusion of a prompt list to help facilitate conversation with patients did not make a substantial difference to consultation times

Judicial activism and overreach in India

Article by R. Shunmugasundaram (Senior Advocate, Member of Parliament, Rajyasabha) published in Amicus Curiae - Journal of the Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London

Imbalanced Multiclass Data Classification Using Combined Data Sampling and Deep Learning Method

Multiclass Classification for finding pattern refers to classifying each data to part of the classes or labels that are generally more than two. The foremost challenge in classifying is with imbalanced data&nbsp; &nbsp;that have large portion data known to be majority class, and small portion known as minority class that leads to poor understanding of samples and less accurate results. The existing works discussed Random Upsampling, Random Downsampling, SMOTE methods individually with FeedForward Neural Network and found Random Oversampling gave better results&nbsp; .However, it generates more duplicate data and has less accuracy. Hence , this research work put forward Combined Random Over-Under Sampling approach that was preprocessed prior with Replacing Missing value with mean, Feature selection, Noise Filtering. Meanwhile this work extends the existing FeedForward Neural Network to Deep Learning . The proposed work is implemented in Rapidminer tool, assessed with appropriate evaluation measures for training and testing data individually

Structure-Reactivity Relationships in Nucleophilic Substitution Reactions of Phenacyl Bromide with Aliphatic Carboxylate Ions

71-7

Kinetics of Nucleophilic Substitution Reaction of Ethyl 4-Bromocrotonate with Anilines in Aqueous Acetone

827-83

Kinetics of Reaction of Phenacyl Bromide with 3- & 4-Substituted Pyridines & 4-Substituted 4-Styrylpyridines

775-77

Structure-reactivity correlations in the reactions of phenacyl bromide and ethyl bromoacetat with ortho-substituted cinnamate ions

707-708The second order rate constants in the title reactions in 90% acetone-10% water (v/v) mixture at three different temperatures indicate that electron-releasing substituents accelerate the rate while electron-withdrawing substituents retard the rate. A good Hammett correlation with σp constants is obtained for ortho-substituted cinnamate ions. The rate data have also been analysed using the method of Charton

Kinetics of addition of diethylamine to <em>para</em>-substituted ethyl ɑ-cyanocinnamates

1092-1094The kinetics of addition of diethylamine to ethyl ɑ-cyanocinnamates and para-substituted ethyl ɑ-cyanocinnamates in acetonitrile at four different temperatures have been followed spectrophotometrically. A step wise mechanism involving the formation of zwitteri-onic addition complex in an equilibrium step followed by conversion into the reaction product via proton transfer has been proposed for the second order addition reaction and this also accounts for the observed structure-reactivity pattern (ρ = 1.02 ±0.11 at 30ᵒC)

Kinetics of aminolysis of 2,4-dinitrophenyl acetate

757-760The second order rate constants for the reaction of 2,4-dinitrophenyl acetate with aniline and p- and o-substituted anilines have been reported in 10% acetonitrile-90% water (v/v) mixture at 25°, 30°, 35° and 40°C. In the reaction of p-substituted anilines, electron-releasing groups facilitate the reaction while electron-withdrawing groups retard it. The ρ-value is evaluated to be - 2.33 ± 0.16. The Bronsted plot is also linear with βN = 0.792 ± 0.027 at 30°C. The S≠ values are all negative as expected for bimolecular nucleophilic substitution reactions. In the case of o-substituted anilines, the rate data have been analysed in terms of electronic and steric effects