Methodology of programming small watershed development

This is a study of some physical and economic aspects of planning for the conservation and development of soil and water resources on a small watershed basis. Specific problems covered are: (1) applying multipurpose concepts which have guided river-basin planning to the evaluation of conservation needs and development opportunities in much smaller drainages, (2) reconciling the economic objectives and management plans of farmers who control watershed uplands with the objectives and plans of other private or public economic subunits affected by upland use and (3) formulating optimal development programs for small watersheds, defined as programs that will maximize discounted net benefits without forcing any economic subunit to incur net losses. The study\u27s main objective was to treat these problems by illustrating procedures both for evaluating development possibilities and for devising alternative optimal development programs. Emphical investigations focused on the 480-acre Nepper Watershed, which includes parts of seven farms in Monona County of western Iowa and drains into the Maple, Little Sioux and Missouri rivers. Planning in the Nepper Watershed was directed toward determining particular combinations of land treatment and structural measures effective in achieving a community objective, or planning norm, from a complex of land, labor and capital resources available at a given point in time (specified as the year 1947). Potential beneficiaries of cooperative development were seven farm operating units, Monona County and the offsite area

INSTRUCTIONAL DESIGN AND ASSESSMENT A Simulated Interprofessional Rounding Experience in a Clinical Assessment Course

Objective. To implement a simulated interprofessional rounding experience using human patient simulators as a required activity for third-year pharmacy students in a clinical assessment course. Design. Interprofessional student teams consisting of pharmacy, medical, and physician assistant students participated in a simulated interprofessional rounding experience in which they provided comprehensive medical care for a simulated patient in an inpatient setting. Assessment. Students completed a survey instrument to assess interprofessional attitudes and satisfaction before and after participation in the simulated interprofessional rounding experience. Overall student attitudes regarding interprofessional teamwork and communication significantly improved; student satisfaction with the experience was high and students' self-perceived clinical confidence improved after participation. The mean team clinical performance scores were 65% and 75% for each simulated interprofessional rounding experience. Conclusion. Incorporating a simulated interprofessional rounding experience into a required clinical assessment course improved student attitudes regarding interprofessional teamwork and was associated with high student satisfaction

Intravenous immune globulin in hereditary inclusion body myopathy: a pilot study

BACKGROUND: Hereditary Inclusion Body Myopathy (HIBM) is an autosomal recessive, adult onset, non-inflammatory neuromuscular disorder with no effective treatment. The causative gene, GNE, codes for UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, which catalyzes the first two reactions in the synthesis of sialic acid. Reduced sialylation of muscle glycoproteins, such as α-dystroglycan and neural cell adhesion molecule (NCAM), has been reported in HIBM. METHODS: We treated 4 HIBM patients with intravenous immune globulin (IVIG), in order to provide sialic acid, because IgG contains 8 μmol of sialic acid/g. IVIG was infused as a loading dose of 1 g/kg on two consecutive days followed by 3 doses of 400 mg/kg at weekly intervals. RESULTS: For all four patients, mean quadriceps strength improved from 19.0 kg at baseline to 23.2 kg (+22%) directly after IVIG loading to 25.6 kg (+35%) at the end of the study. Mean shoulder strength improved from 4.1 kg at baseline to 5.9 kg (+44%) directly after IVIG loading to 6.0 kg (+46%) at the end of the study. The composite improvement for 8 other muscle groups was 5% after the initial loading and 19% by the end of the study. Esophageal motility and lingual strength improved in the patients with abnormal barium swallows. Objective measures of functional improvement gave variable results, but the patients experienced improvements in daily activities that they considered clinically significant. Immunohistochemical staining and immunoblotting of muscle biopsies for α-dystroglycan and NCAM did not provide consistent evidence for increased sialylation after IVIG treatment. Side effects were limited to transient headaches and vomiting. CONCLUSION: The mild benefits in muscle strength experienced by HIBM patients after IVIG treatment may be related to the provision of sialic acid supplied by IVIG. Other sources of sialic acid are being explored as treatment options for HIBM

A Transient Sub-Eddington Black Hole X-ray Binary Candidate in the Dust Lanes of Centaurus A

We report the discovery of a bright X-ray transient, CXOU J132527.6-430023, in the nearby early-type galaxy NGC 5128. The source was first detected over the course of five Chandra observations in 2007, reaching an unabsorbed outburst luminosity of 1-2*10^38 erg/s in the 0.5-7.0 keV band before returning to quiescence. Such luminosities are possible for both stellar-mass black hole and neutron star X-ray binary transients. Here, we attempt to characterize the nature of the compact object. No counterpart has been detected in the optical or radio sky, but the proximity of the source to the dust lanes allows for the possibility of an obscured companion. The brightness of the source after a >100 fold increase in X-ray flux makes it either the first confirmed transient non-ULX black hole system in outburst to be subject to detailed spectral modeling outside the Local Group, or a bright (>10^38 erg/s) transient neutron star X-ray binary, which are very rare. Such a large increase in flux would appear to lend weight to the view that this is a black hole transient. X-ray spectral fitting of an absorbed power law yielded unphysical photon indices, while the parameters of the best-fit absorbed disc blackbody model are typical of an accreting ~10 Msol black hole in the thermally dominant state.Comment: 8 pages, 6 figures, accepted for publication in Ap

The slim-disk state of the ultraluminous X-ray source in M83

The transient ULX in M83 that went into outburst in, or shortly before, 2010 is still active. Our new XMM-Newton spectra show that it has a curved spectrum typical of the upper end of the high/soft state or slim-disk state. It appears to be spanning the gap between Galactic stellar-mass black holes (BHs) and the ultraluminous state, at X-ray luminosities of ≈1-3 × 1039 erg s–1 (a factor of two lower than in the 2010 and 2011 Chandra observations). From its broadened disk-like spectral shape at that luminosity, and from the fitted inner-disk radius and temperature, we argue that the accreting object is an ordinary stellar-mass BH with M ~ 10-20 M ☉. We suggest that in the 2010 and 2011 Chandra observations, the source was seen at a higher accretion rate, resulting in a power-law-dominated spectrum with a soft excess at large radii

CEO international experience and foreign IPOs

International audienceThis paper examines listing location as a managerial decision by using a sample of IPOs of Chinese entrepreneurial firms in mainland China, the United States and Hong Kong. We find that Chinese entrepreneurial firms managed by CEOs with international experience are more likely to undertake foreign IPOs, especially those returned from countries with more advanced legal institutions and those operating in high-tech industries. The credibility crisis for Chinese firms in 2010 switched the focus of foreign IPOs from the US to Hong Kong. These results are consistent across returnee CFOs and other senior executives with international experience