Suzaku X-Ray Spectroscopy of a Peculiar Hot Star in the Galactic Center Region

We present the results of a Suzaku study of a bright point-like source in the 6.7 keV intensity map of the Galactic center region. We detected an intense FeXXV 6.7 keV line with an equivalent width of ~1 keV as well as emission lines of highly ionized Ar and Ca from a spectrum obtained by the X-ray Imaging Spectrometer. The overall spectrum is described very well by a heavily absorbed (~2x10^{23}cm^{-2}) thin thermal plasma model with a temperature of 3.8+/-0.6 keV and a luminosity of ~3x10^{34} erg s^{-1} (2.0--8.0 keV) at 8 kpc. The absorption, temperature, luminosity, and the 6.7 keV line intensity were confirmed with the archived XMM-Newton data. The source has a very red (J-Ks=8.2 mag) infrared spectral energy distribution (SED), which was fitted by a blackbody emission of ~1000 K attenuated by a visual extinction of ~31 mag. The high plasma temperature and the large X-ray luminosity are consistent with a wind-wind colliding Wolf-Rayet binary. The similarity of the SED to those of the eponymous Quintuplet cluster members suggests that the source is a WC-type source.Comment: Accepted for publication on PASJ Vol.60, SP-1, 200

MACULAR BLOOD FLOW CHANGES IN BRANCH RETINAL VEIN OCCLUSION EXAMINED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY VARIABLE INTERSCAN TIME ANALYSIS

Purpose: To examine the relationship between changes in retinal blood flow and the recurrence of macular edema in eyes with branch retinal vein occlusion. Methods: This observational study included 32 eyes in 32 patients (18 men and 14 women) with branch retinal vein occlusion who visited the Department of Ophthalmology at Kyoto University Hospital (February 2021–November 2021). At the time of inclusion in the study, each patient underwent optical coherence tomography angiography on a macular area measuring 4 × 4 mm2. For variable interscan time analysis, different interscan times were set at 7.6 (IST7.6) and 20.6 ms (IST20.6) for the optical coherence tomography angiography. The parafoveal vessel densities were measured sectorally at IST7.6 and IST20.6, and their relationship with the longitudinal changes evident in the retinal thicknesses during the variable interscan time analysis examination and 2 months later was evaluated. Results: The parafoveal vessel densities in the affected sector was significantly greater at IST20.6 than at IST7.6 (P = 0.011). At 2 months after the variable interscan time analysis examination, 6 patients (19%) showed recurrence of macular edema involving the fovea. The difference in the parafoveal vessel densities (IST20.6 − IST7.6) in the affected sector was significantly associated with longitudinal retinal thickening in the corresponding parafovea (P = 0.020) and fovea (P = 0.014). Conclusion: In eyes with branch retinal vein occlusion, optical coherence tomography angiography variable interscan time analysis facilitated the detection of retinal blood flow changes that might be predictive for the recurrence of macular edema

Naturalness Improvement Algorithm for Reconstructed Glossectomy Patient's Speech Using Spectral Differential Modification in Voice Conversion

In this paper, we propose an algorithm to improve the naturalness of the reconstructed glossectomy patient's speech that is generated by voice conversion to enhance the intelligibility of speech uttered by patients with a wide glossectomy. While existing VC algorithms make it possible to improve intelligibility and naturalness, the result is still not satisfying. To solve the continuing problems, we propose to directly modify the speech waveforms using a spectrum differential. The motivation is that glossectomy patients mainly have problems in their vocal tract, not in their vocal cords. The proposed algorithm requires no source parameter extractions for speech synthesis, so there are no errors in source parameter extractions and we are able to make the best use of the original source characteristics. In terms of spectrum conversion, we evaluate with both GMM and DNN. Subjective evaluations show that our algorithm can synthesize more natural speech than the vocoder-based method. Judging from observations of the spectrogram, power in high-frequency bands of fricatives and stops is reconstructed to be similar to that of natural speech

Home visits provide a better understanding of the psychopathology of a case of eating disorder

Eating disorders (ED) are characterized by abnormal eating behaviors that negatively affect the patient’s medical or psychiatric health, with symptoms usually developing during adolescence. Treatment for ED varies across patients and the disease time-course, reflecting differences in psychopathology and medical comorbidities. Here, we provide a brief review of the standard management strategy for ED and emphasize the importance of individualized treatment. To illustrate this, we present a case of ED in which a halt in development was observed during a home visit, which is an unusual component in the treatment of ED. Furthermore, as a result of our collective experience in treating ED, we recognize that discussion among multidisciplinary healthcare professionals is important to improve outcomes

Periodontal Tissue Regeneration Using Fibroblast Growth Factor -2: Randomized Controlled Phase II Clinical Trial

Background: The options for medical use of signaling molecules as stimulators of tissue regeneration are currently limited. Preclinical evidence suggests that fibroblast growth factor (FGF)-2 can promote periodontal regeneration. This study aimed to clarify the activity of FGF-2 in stimulating regeneration of periodontal tissue lost by periodontitis and to evaluate the safety of such stimulation. Methodology/Principal Findings: We used recombinant human FGF-2 with 3% hydroxypropylcellulose (HPC) as vehicle and conducted a randomized double-blinded controlled trial involving 13 facilities. Subjects comprised 74 patients displaying a 2- or 3-walled vertical bone defect as measured ?3 mm apical to the bone crest. Patients were randomly assigned to 4 groups: Group P, given HPC with no FGF-2; Group L, given HPC containing 0.03% FGF-2; Group M, given HPC cotaining 0.1% FGF-2; and Group H, given HPC Containing 0.3% FGF-2. Each patient underwent flap operation during which we administered 200 μL of the appropriate investigational drug to the bone defect. Before and for 36 weeks following administration, patients underwent periodontal tissue inspections and standardized radiography of the region under investigation. As a result, a significant difference (p = 0.021) in rate of increase in alveolar bone height was identified between Group P (23.92%) and Group H (58.62%) at 36 weeks. The linear increase in alveolar bone height at 36 weeks in Group P and H was 0.95 mm and 1.85 mm, respectively (p = 0.132). No serious adverse events attribute to the investigational drug were identified. Conclusions: Although no statistically significant differences were noted for gains in clinical attachment level and alveolar bone gain for FGF-2 groups versus Group P, the significant difference in rate of increase in alveolar bone height (p = 0.021) between Groups P and H at 36 weeks suggests that some efficacy could be expected from FGF-2 in stimulating regeneration of periodontal tissue in patients with periodontitis

Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist

The cholesterol biosynthetic pathway produces not only sterols but also non-sterol mevalonate metabolites involved in isoprenoid synthesis. Mevalonate metabolites affect transcriptional and post-transcriptional events that in turn affect various biological processes including energy metabolism. In the present study, we examine whether mevalonate metabolites activate PPARγ (peroxisome-proliferator-activated receptor γ), a ligand-dependent transcription factor playing a central role in adipocyte differentiation. In the luciferase reporter assay using both GAL4 chimaera and full-length PPARγ systems, a mevalonate metabolite, FPP (farnesyl pyrophosphate), which is the precursor of almost all isoprenoids and is positioned at branch points leading to the synthesis of other longer-chain isoprenoids, activated PPARγ in a dose-dependent manner. FPP induced the in vitro binding of a co-activator, SRC-1 (steroid receptor co-activator-1), to GST (glutathione transferase)–PPARγ. Direct binding of FPP to PPARγ was also indicated by docking simulation studies. Moreover, the addition of FPP up-regulated the mRNA expression levels of PPARγ target genes during adipocyte differentiation induction. In the presence of lovastatin, an HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitor, both intracellular FPP levels and PPARγ-target gene expressions were decreased. In contrast, the increase in intracellular FPP level after the addition of zaragozic acid, a squalene synthase inhibitor, induced PPARγ-target gene expression. The addition of FPP and zaragozic acid promotes lipid accumulation during adipocyte differentiation. These findings indicated that FPP might function as an endogenous PPARγ agonist and regulate gene expression in adipocytes

Local microbleeding facilitates IL-6– and IL-17–dependent arthritis in the absence of tissue antigen recognition by activated T cells

Local microbleeding induces the accumulation of Th17 cells and the development of IL-17– and IL-6–dependent arthritis in the absence of cognate antigen recognition by CD4+ T cells